четверг, 23 июня 2011 г.

Games

Games

NoSleep 1.2.1 - Close your MacBook without putting it to sleep.. (Free)

Posted: 23 Jun 2011 03:22 AM PDT



NoSleep makes closing of your MacBook lid possible without going into sleep mode. Now you shouldn't plug your mouse and monitor to stay computer awake - just check a tick in the System Preferences and continue downloading of huge files and watching favorite movies over the network with lid closed.

Version 1.2.1:
  • Fixed: a System Preferences crash
  • New style for the notification icon


Mac OS X 10.6.6 or later

Download Now

AMA MX: The Pit Board - Budds Creek

Posted: 23 Jun 2011 12:00 AM PDT


Brandon Short breaks down Chad Reed's latest triumph at Budds Creek while also taking a quick look ahead to this upcoming weekend's AMA Motocross event at Thunder Valley.

Freekick 2 - iPhone - Screenshots

Posted: 23 Jun 2011 03:36 AM PDT

GAME FEATURE:
- Stunning 3D graphics
- Endless GamePlay!! (Hours of fun!)
- Unlock the Super fun Challenge Mode (Never seen before T-rex and UFO scenes)
- Smooth and realistic Ball Play

Retro Pinball - iPhone - Screenshots

Posted: 23 Jun 2011 03:36 AM PDT

Features:
- Take a trip back in time and play on three classic tables – Super Android, Crash and Burn and Pangea from original creator James Schmalz
- Updated graphics and sound augment retro pinball action
- Compatible with iPhone, iPad, and iPod Touch (iOS v3.2 or better)
- Save and beat your high scores

Sea Battles Lite - iPhone - Screenshots

Posted: 23 Jun 2011 03:36 AM PDT

How to play: This is a simple game for two.
There is a field (10x10 squares) where each player places 10 ships of predefined size.
To win the game you have to sink all the enemy's ships first.
The opponents cannot see each other's fields.
The players shoot in turns, the player who damage his enemy's ship has the right for extra shot.
Each ship occupies a certain number of squares of the field, and can be places anywhere either vertically or horizontally without touching other ships.

Egg vs. Chicken - iPhone - Screenshots

Posted: 23 Jun 2011 03:36 AM PDT

Features:
3 DOZEN LEVELS OF GRADE AA FUN - Whip your way through hours and hours of eggs-hilarating fun and hilarious scenarios!
NEW! COLLECT LOOT TO UNLOCK EGGS-TRA LEVELS - Pick up star coins to unlock two cartons of addictive levels filled with new challenges and enemies!
SLIDE YOUR EGGS INTO READY POSITION - Prep your eggs by sliding them in all directions and matching groups of same-colored eggs.
FLICK AND LAUNCH EGGS INTO BATTLE - Repel the masses by launching the fearless eggs into the oncoming waves of chickens!
CAN'T GET THESE EGGS AND CHICKENS AT A FARMERS' MARKET - Battle over 10 unique chickens with 7 special eggs: Fire, ice, lightning all come into play as you strategize the best combo to fend off the chickens!
SCRAMBLE TO THE TOP WITH POWER-UPS - Gain over 25 power-ups including bombs, fort repair kits, and egg upgrades to tame the hordes!

FIFA Soccer 12 - PC - Screenshots

Posted: 23 Jun 2011 03:36 AM PDT

Key Features:
- Player Impact Engine—Two years in development, the new physics engine is built to deliver real-world physicality in every interaction on the pitch. Experience an infinite variety of natural and believable outcomes in every contact. Players feel more resilient on the ball, push and pull during the fight for possession, and recover from light challenges more easily, preserving their natural momentum.
- Pro Player Intelligence—CPU players have been infused with self-awareness and aptitude, enabling them to make decisions based on their own skills as well as the strengths and attributes of their teammates. Players who possess exceptional vision, for example, will see opportunities for through balls that other players won't. Real Madrid's Kaká will be more likely—and quicker—to pick out a run from a teammate farther away than a player with poorer vision. Additionally, teams will vary their attack based on the strengths of their players on the pitch, and the weaknesses of opposing players, creating a more authentic experience and greater variety of matches.
- Tactical Defending—Fundamentally changes the approach to defending by placing equal importance on positioning, intercepting passes and tackling at the right moment. Tactics and timing are crucial.
- Precision Dribbling—Enjoy new ways to take on opponents, more time on the ball to make decisions, and complete control of the pace of the game. Utilize close dribble touches in tight spaces, on the wings, and even while fending off an opponent.  
- True Injuries—The Player Impact Engine monitors contact between players in real-time, analyzing the force of the collision and impact on the body to detect real injuries, creating a deeper more challenging Career Mode. Manage new types of injuries and the risk of sending a player onto the ...

Mr Giggle Lite - iPhone - Screenshots

Posted: 23 Jun 2011 03:36 AM PDT

Features:
BE AWARE OF VILLAIN - Villain is the only block, which cannot be use to match the figure.
EXTRA BONUS WITH JOKER - Set up figure with Joker to get Extra Bonus.
GAME CENTER SUPPORT - Use Apple's Game Center network to store your records and compare yourself with players from all over the world.
MULTITASKING SUPPORT - Switch between your favorite apps instantly on iOS4 multitasking compatible devices.
THREE DIFFERENT MODES - If you're a novice play long mode. If you feel you're an expert choose short mode.
LIFEBUOY - If you can't match any shape you'll see an adviser. Note - do not wait for it too often because your time is limited.
DOUBLE TOUCH FOR PAUSE - Double tap the screen to pause game.
EVERY GAME MORE ADDICTIVE - You'll find out that every game is more and more addivtive. This is what I love about this game. I can play hours and never get bored!
LITE VERSION - This version is limited to 20th level

Danish police proposal: Ban anonymous Internet use

Posted: 23 Jun 2011 03:09 AM PDT

The Danish police had proposed abolishing all anonymous Internet access, under the rubric of fighting terrorism. ISPs and companies would be required to gather strong proof of identity (official ID cards and similar) before connecting users, and would be required to retain records.
Thus, a working group at the Ministry of Justice started with a recommendation to parliament that would require all persons on the open Internet connections from such libraries and the café's wireless network, identify with a personal code for being able to get online.

The idea is that the police or the police intelligence service, with data from the open network connections will be able to investigate terrorism more effectively when the police can see who is logged on to the open network and not least, what sites network users have visited and whom they interacted with.

Suggestion: You can no longer go the web anonymously (Computerworld.dk, via Google Translate) (Thanks, Agger!)

Sonic The Hedgehog: The incredible secrets left on the cutting room floor (Sonic Generations)

Posted: 23 Jun 2011 12:00 AM PDT

20 years ago today, Sonic the Hedgehog was unleashed onto an unsuspecting world, transforming the gaming landscape in a blur of blue. But while we'll be celebrating that classic original in its own right today, it was almost very different. Unused features buried in retail cartridges, preview screenshots and even instruction manuals all hint at features we never got to play in the very first Sonic game. But thanks to the avid Sonic fan community, we can now see them all! So roll up for the Sonic freak show - you won't believe your eyes.

Energies, Vol. 4, Pages 978-997: Petri Net Model and Reliability Evaluation for Wind Turbine Hydraulic Variable Pitch Systems

Posted: 23 Jun 2011 12:00 AM PDT

Based on an analysis of the working principles of the hydraulic variable pitch system of a wind turbine, a novel Petri net model and reliability evaluation method are proposed. First, Petri net theory is adopted to build a model for each discrete state of the operation of the hydraulic pitch system of the wind turbine and at the same time a fault Petri net model is established. Then through qualitative analysis and quantitative calculations based on the fault Petri net, the system reliability indexes are obtained. During the qualitative analysis process, in order to more conveniently find the minimal cut sets of the fault Petri net, a Visual C++ 6.0-based algorithm is compiled and the minimal cut sets are tested correctly with another method. During the quantitative calculation process, the fault probability has been obtained from the equations according to the fault probability of libraries and transitions between different states. Not only does the proposed Petri net describe the structure, function and operation of the hydraulic pitch system with a graphic language, but the fault Petri net model can also clearly express the logical relations among faults. The novel Petri net model offers simple calculations and the prospect of broad applicability and the new reliability evaluation method provides an important reference for the performance evaluation of these systems.

IJERPH, Vol. 8, Pages 2401-2417: Selected Morphological Characteristics, Lead Uptake and Phytochelatin Synthesis by Coffeeweed (Sesbania exaltata Raf.) Grown in Elevated Levels of Lead-Contaminated Soil

Posted: 23 Jun 2011 12:00 AM PDT

Remediation of lead-contaminated soil is significant due to the inherent toxicity of lead (Pb), and the quantity of Pb discharged into the soil. One of the most cost-effective and environmentally sound technologies for the cleanup of metal-contaminated soils is through the use of plants. While much is known about the ecological evolution of metal tolerance in plants, the physiological, biochemical, and genetic mechanisms of tolerance is not well understood in the majority of resistant ecotypes such as the legume, Sesbania exaltata Raf. This study was therefore conducted to determine the morphological and physiological characteristics of Sesbania that had been grown in Pb-contaminated soil, and to assess phytochelatin synthesis as a way of elucidating its relative Pb tolerance. Sesbania plants were grown in the greenhouse and exposed to various levels of Pb: 0, 1000, and 2000 mg Pb/kg soil. Plants were harvested after 6, 8, and 10 weeks of growth and morphological characteristics (e.g., root and shoot biomass, root length, number of root nodules, shoot height, number of leaves, number of flowers, number and length of pods) were recorded. Generally, there were no statistical differences in morphological characteristics among the treatments. Further, no discernible phytotoxic symptoms, such as chlorosis, wilting, or necrotic lesions, in neither roots nor shoots were observed. We concluded that while Sesbania did not fit the model of a hyperaccumulator, the plant was, nonetheless, tolerant to elevated Pb levels. Our assessment for phytochelatin synthesis as a tolerance mechanism was inconclusive and further investigations of tolerance mechanisms are warranted.

IJERPH, Vol. 8, Pages 2386-2400: Coliform and Metal Contamination in Lago de Colina, a Recreational Water Body in Chihuahua State, Mexico

Posted: 23 Jun 2011 12:00 AM PDT

Lago de Colina (Colina Lake) is located about 180 km south of the city of Chihuahua (Mexico), and during the Semana Santa (Holy Week) vacation period its recreational use is high. The objective of this study was to quantify coliform and heavy metal levels in this water body before and after the Holy Week vacation period in 2010. Twenty sampling points were randomly selected and two water samples were collected at each point near the surface (0.30 m) and at 1 m depth. After the Holy Week vacation the same twenty points were sampled at the same depths. Therefore, a total 80 water samples were analyzed for fecal and total coliforms and levels of the following metals: Al, As, B, Ca, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, Se, Si and Zn. It was hypothesized that domestic tourism contaminated this water body, and as a consequence, could have a negative impact on visitor health. An analysis of variance (ANOVA) study was performed for each element and its interactions considering a factorial design where factor A was sample date and factor B was sample depth. Fecal coliforms were only detected at eight sampling points in the first week, but after Holy Week, both fecal and total coliforms were detected at most sampling points. The concentrations of Al, B, Na, Ni and Se were only statistically different for factor A. The levels of Cr, Cu, K and Mg was different for both date and depth, but the dual factor interaction was not significant. The amount of Ca and Zn was statistically different due to date, depth and their interaction. No significant differences were found for any factor or the interaction for the elements As, Fe and Mn. Because of the consistent results, it is concluded that local tourism is contaminating the recreational area of Colina Lake, Chihuahua, Mexico.

Toxins, Vol. 3, Pages 721-736: Hemodynamic Effects of Anthrax Toxins in the Rabbit Model and the Cardiac Pathology Induced by Lethal Toxin

Posted: 23 Jun 2011 12:00 AM PDT

Anthrax lethal toxin (LeTx) and edema toxin (EdTx) have been shown to alter hemodynamics in the rodent model, while LeTx primarily is reported to induce extensive tissue pathology. However, the rodent model has limitations when used for comparison to higher organisms such as humans. The rabbit model, on the other hand, has gained recognition as a useful model for studying anthrax infection and its pathophysiological effects. In this study, we assessed the hemodynamic effects of lethal toxin (LeTx) and edema toxin (EdTx) in the rabbit model using physiologically relevant amounts of the toxins. Moreover, we further examine the pathological effects of LeTx on cardiac tissue. We intravenously injected Dutch-belted rabbits with either low-dose and high-dose recombinant LeTx or a single dose of EdTx. The animals' heart rate and mean arterial pressure were continuously monitored via telemetry until either 48 or 72 h post-challenge. Additional animals challenged with LeTx were used for cardiac troponin I (cTnI) quantitation, cardiac histopathology, and echocardiography. LeTx depressed heart rate at the lower dose and mean arterial pressure (MAP) at the higher dose. EdTx, on the other hand, temporarily intensified heart rate while lowering MAP. Both doses of LeTx caused cardiac pathology with the higher dose having a more profound effect. Lastly, left-ventricular dilation due to LeTx was not apparent at the given time-points. Our study demonstrates the hemodynamic effects of anthrax toxins, as well as the pathological effects of LeTx on the heart in the rabbit model, and it provides further evidence for the toxins' direct impact on the heart.

IJMS, Vol. 12, Pages 4165-4179: TNF-α-Induced VEGF and MMP-9 Expression Promotes Hemorrhagic Transformation in Pituitary Adenomas

Posted: 23 Jun 2011 12:00 AM PDT

Pituitary apoplexy is a clinical syndrome with unknown pathogenesis. Therefore, identifying the underlying mechanisms is of high clinical relevance. Tumor necrosis factor alpha (TNF-α) is a critical cytokine mediating various hemorrhagic events, but little is known about its involvement in pituitary apoplexy. Here we show that TNF-α may be an important regulator of hemorrhagic transformation in pituitary adenomas. In this study, sixty surgical specimens of hemorrhagic and non-hemorrhagic human pituitary adenomas were examined. Hemorrhagic pituitary adenomas displayed higher protein and mRNA levels of TNF-α, vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) compared with those of non-hemorrhagic tumors. Exposure of MMQ pituitary adenoma cells to TNF-α induced VEGF and MMP-9 expression in vitro. Additionally, TNF-α administration caused hemorrhagic transformation and enhanced VEGF and MMP-9 expression in MMQ pituitary adenoma cell xenografts in mice. Blockers of VEGF or MMP-9, either alone or in combination, attenuated but not abrogated TNF-α mediated hemorrhagic transformation in xenografts. This study suggests that TNF-α may play a role in the development of intratumoral hemorrhage in pituitary adenomas via up-regulation of VEGF and MMP-9.

Algorithms, Vol. 4, Pages 115-130: Alternatives to the Least Squares Solution to Peelle’s Pertinent Puzzle

Posted: 23 Jun 2011 12:00 AM PDT

Peelle's Pertinent Puzzle (PPP) was described in 1987 in the context of estimating fundamental parameters that arise in nuclear interaction experiments. In PPP, generalized least squares (GLS) parameter estimates fell outside the range of the data, which has raised concerns that GLS is somehow flawed and has led to suggested alternatives to GLS estimators. However, there have been no corresponding performance comparisons among methods, and one suggested approach involving simulated data realizations is statistically incomplete. Here we provide performance comparisons among estimators, introduce approximate Bayesian computation (ABC) using density estimation applied to simulated data realizations to produce an alternative to the incomplete approach, complete the incompletely specified approach, and show that estimation error in the assumed covariance matrix cannot always be ignored.

Marine Drugs, Vol. 9, Pages 1157-1165: Zorrimidazolone, a Bioactive Alkaloid from the Non-Indigenous Mediterranean Stolidobranch Polyandrocarpa zorritensis

Posted: 23 Jun 2011 12:00 AM PDT

Chemical analysis of the Mediterranean ascidian Polyandrocarpa zorritensis (Van Name 1931) resulted in the isolation of a series of molecules including two monoindole alkaloids, 3-indolylglyoxylic acid (3) and its methyl ester (4), 4-hydroxy-3-methoxyphenylglyoxylic acid methyl ester (1) and a new alkaloid we named zorrimidazolone (2). The structure of the novel compound 2 has been elucidated by spectroscopic analysis and bioactivity of all compounds has been investigated. Zorrimidazolone (2) showed a modest cytotoxic activity against C6 rat glioma cell line.

Marine Drugs, Vol. 9, Pages 1142-1156: Antioxidant and Antiproliferative Activities of Heated Sterilized Pepsin Hydrolysate Derived from Half-Fin Anchovy (Setipinna taty)

Posted: 23 Jun 2011 12:00 AM PDT

In this paper we studied the antioxidant and antiproliferative activities of the heated pepsin hydrolysate from a marine fish half-fin anchovy (HAHp-H). Furthermore, we compared the chemical profiles including the amino acid composition, the browning intensity, the IR and UV-visible spectra, and the molecular weight distribution between the half-fin anchovy pepsin hydrolysate (HAHp) and HAHp-H. Results showed that heat sterilization on HAHp improved the 1,1-diphenyl-2-picryl-hydrazil (DPPH) radical-scavenging activity and reducing power. In addition, the antiproliferative activities were all increased for HAHp-H on DU-145 human prostate cancer cell line, 1299 human lung cancer cell line and 109 human esophagus cancer cell line. The contents of free amino acid and reducing sugar of HAHp-H were decreased (P < 0.05). However, hydrophobic amino acid residues and the browning intensity of HAHp-H were increased. FT-IR spectroscopy indicated that amide I and amide III bands of HAHp-H were slightly modified, whereas band intensity of amide II was reduced dramatically. Thermal sterilization resulted in the increased fractions of HAHp-H with molecular weight of 3000–5000 Da and below 500 Da. The enhanced antioxidant and antiproliferative activities of HAHp-H might be attributed to the Maillard reaction.

First-ever Barbie ad

Posted: 23 Jun 2011 02:03 AM PDT

According to the description, this 1959 Barbie commercial was the first-ever advert for the doll; it's got a sweet naivete. Also, Barbie cost a lot when she shipped: $3 in 1959 is $23.30 in 2011 constant dollars -- today, her MSRP is about $10, and you can get discount mint-in-package versions for $6.

1959 First EVER Barbie Commercial High Quaility HQ! (via How to Be a Retronaut)

This posting includes an audio/video/photo media file: Download Now

Feed Me Oil - iPhone - Screenshots

Posted: 23 Jun 2011 03:03 AM PDT

Feed Me Oil Highlights
• A huge variety of mind-bending levels will test your mental skills.
• Different ways to solve each puzzle for endless replayability.
• Intuitive touch controls that make the game a breeze to play.
• Incredibly slick and realistic physics create oil like you've never seen.
• Unique, surreal art design that looks amazing on your iPhone.
• Use fans, magnets, wind, and more to beat each level.
• Gift free levels to your friends and family and share your experience.
• Stunning musical soundtrack that features jazz, emotive piano tracks, and more.
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