пятница, 11 января 2013 г.

Games

Games

SeaMonkey for PPC 2.15 - PPC port of the popular SeaMonkey browser.. (Free)

Posted: 11 Jan 2013 02:57 AM PST



SeaMonkey is a Web browser that shares much of the same base code as the popular Firefox Web browser. It also contains an advanced e-mail and newsgroup client, IRC chat client, and HTML editor.

Since Mozilla has stopped supporting PPC on Macs I have picked it up and provide the only SeaMonkey version runnable on G4/G5 based Macs.

The SeaMonkey project is a community effort to deliver production-quality releases of code derived from the application formerly known as "Mozilla Application Suite". Whereas the main focus of the Mozilla Foundation is on Mozilla Firefox and Mozilla Thunderbird, our group of dedicated volunteers works to ensure that you can have "everything but the kitchen sink" and have it stable enough for corporate use.

Get those PPCs out of the closets and back online !

Version 2.15:

  • Restores the functionality of the QuickTime 7.7 plugin which was broken by the transition to 2.15 from 2.14.1.
  • I would hazard a guess that this version will also allow any QuickDraw based Plugin to work once again.


Mac OS X 10.5

Download Now

RAD Soldiers - Screenshots

Posted: 11 Jan 2013 02:15 AM PST

Feature
• Send your squad into turn-based multiplayer battles
• Use the unique abilities of your soldiers to turn the tide
• Unlock new soldiers, weapons, and outfits for your ever-growing army
• Play whenever, wherever thanks to turn-based gameplay
• Hone your skills offline in single player challenges
• Supports GameCenter and Retina Displays including iPhone 5
• Developed with accessibility support from SpecialEffect

IJMS, Vol. 14, Pages 1383-1411: Role of the Blood-Brain Barrier in the Formation of Brain Metastases

Posted: 11 Jan 2013 12:00 AM PST

The majority of brain metastases originate from lung cancer, breast cancer and malignant melanoma. In order to reach the brain, parenchyma metastatic cells have to transmigrate through the endothelial cell layer of brain capillaries, which forms the morphological basis of the blood-brain barrier (BBB). The BBB has a dual role in brain metastasis formation: it forms a tight barrier protecting the central nervous system from entering cancer cells, but it is also actively involved in protecting metastatic cells during extravasation and proliferation in the brain. The mechanisms of interaction of cancer cells and cerebral endothelial cells are largely uncharacterized. Here, we provide a comprehensive review on our current knowledge about the role of junctional and adhesion molecules, soluble factors, proteolytic enzymes and signaling pathways mediating the attachment of tumor cells to brain endothelial cells and the transendothelial migration of metastatic cells. Since brain metastases represent a great therapeutic challenge, it is indispensable to understand the mechanisms of the interaction of tumor cells with the BBB in order to find targets of prevention of brain metastasis formation.

IJMS, Vol. 14, Pages 1370-1382: Anticancer Effects of Bufalin on Human Hepatocellular Carcinoma HepG2 Cells: Roles of Apoptosis and Autophagy

Posted: 11 Jan 2013 12:00 AM PST

The traditional Chinese medicine bufalin, extracted from toad’s skin, has been demonstrated to exert anticancer activities in various kinds of human cancers. The mechanisms of action lie in its capacity to induce apoptosis, or termed type I programmed cell death (PCD). However, type II PCD, or autophagy, participates in cancer proliferation, progression, and relapse, as well. Recent studies on autophagy seem to be controversial because of the dual roles of autophagy in cancer survival and death. In good agreement with previous studies, we found that 100 nM bufalin induced extensive HepG2 cell apoptosis. However, we also noticed bufalin triggered autophagy and enhanced Beclin-1 expression, LC3-I to LC3-II conversion, as well as decreased p62 expression and mTOR signaling activation in HepG2 cells. Blockage of autophagy by selective inhibitor 3-MA decreased apoptotic ratio in bufalin-treated HepG2 cells, suggesting a proapoptotic role of bufalin-induced autophagy. Furthermore, we investigated the underlying mechanisms of bufalin-induced autophagy. Bufalin treatment dose-dependently promoted AMPK phosphorylation while AMPK inhibition by compound C significantly attenuated bufalin-induced autophagy. Taken together, we report for the first time that bufalin induces HepG2 cells PCD, especially for autophagy, and the mechanism of action is, at least in part, AMPK-mTOR dependent.

IJMS, Vol. 14, Pages 1335-1369: Potential Applications of Carbohydrases Immobilization in the Food Industry

Posted: 11 Jan 2013 12:00 AM PST

Carbohydrases find a wide application in industrial processes and products, mainly in the food industry. With these enzymes, it is possible to obtain different types of sugar syrups (viz. glucose, fructose and inverted sugar syrups), prebiotics (viz. galactooligossacharides and fructooligossacharides) and isomaltulose, which is an interesting sweetener substitute for sucrose to improve the sensory properties of juices and wines and to reduce lactose in milk. The most important carbohydrases to accomplish these goals are of microbial origin and include amylases (α-amylases and glucoamylases), invertases, inulinases, galactosidases, glucosidases, fructosyltransferases, pectinases and glucosyltransferases. Yet, for all these processes to be cost-effective for industrial application, a very efficient, simple and cheap immobilization technique is required. Immobilization techniques can involve adsorption, entrapment or covalent bonding of the enzyme into an insoluble support, or carrier-free methods, usually based on the formation of cross-linked enzyme aggregates (CLEAs). They include a broad variety of supports, such as magnetic materials, gums, gels, synthetic polymers and ionic resins. All these techniques present advantages and disadvantages and several parameters must be considered. In this work, the most recent and important studies on the immobilization of carbohydrases with potential application in the food industry are reviewed.

Entropy, Vol. 15, Pages 220-233: Effects of Convective Heating on Entropy Generation Rate in a Channel with Permeable Walls

Posted: 11 Jan 2013 12:00 AM PST

This study deals with the combined effects of convective heating and suction/injection on the entropy generation rate in a steady flow of an incompressible viscous fluid through a channel with permeable walls. The model equations for momentum and energy balance are solved numerically using shooting quadrature. Both the velocity and temperature profiles are obtained and utilized to compute the entropy generation number. The effects of the key parameters on the fluid velocity, temperature, entropy generation rate and Bejan number are depicted graphically and analyzed in detail.

Entropy, Vol. 15, Pages 198-219: Compensated Transfer Entropy as a Tool for Reliably Estimating Information Transfer in Physiological Time Series

Posted: 11 Jan 2013 12:00 AM PST

We present a framework for the estimation of transfer entropy (TE) under the conditions typical of physiological system analysis, featuring short multivariate time series and the presence of instantaneous causality (IC). The framework is based on recognizing that TE can be interpreted as the difference between two conditional entropy (CE) terms, and builds on an efficient CE estimator that compensates for the bias occurring for high dimensional conditioning vectors and follows a sequential embedding procedure whereby the conditioning vectors are formed progressively according to a criterion for CE minimization. The issue of IC is faced accounting for zero-lag interactions according to two alternative empirical strategies: if IC is deemed as physiologically meaningful, zero-lag effects are assimilated to lagged effects to make them causally relevant; if not, zero-lag effects are incorporated in both CE terms to obtain a compensation. The resulting compensated TE (cTE) estimator is tested on simulated time series, showing that its utilization improves sensitivity (from 61% to 96%) and specificity (from 5/6 to 0/6 false positives) in the detection of information transfer respectively when instantaneous effect are causally meaningful and non-meaningful. Then, it is evaluated on examples of cardiovascular and neurological time series, supporting the feasibility of the proposed framework for the investigation of physiological mechanisms.

Remote Sensing, Vol. 5, Pages 238-253: Snow Grain-Size Estimation Using Hyperion Imagery in a Typical Area of the Heihe River Basin, China

Posted: 11 Jan 2013 12:00 AM PST

It is difficult and time consuming to use traditional measurement methods to estimate the physical properties of snow. However, the emergence of hyperspectral imagery for estimating the physical properties of snow provides a powerful tool. Snow albedo, grain size, and temperature are important factors for evaluating the surface energy balance. Using the spectrum-reflection curves of the different grain sizes of snow measured in the fields of the Binggou watershed of the Heihe River Basin, China, we analyzed the spectral reflection characteristics of snow. A statistical detection method was used to choose the most sensitive bands in the field spectra and find the corresponding band (band 89) in the Hyperion imagery. The bands near 1033 nm were sensitive to the snow grain size. According to the relationship between the snow grain size and the measured spectrum, we built a snow grain-size estimation model. The results showed that the snow reflectance had a good linear and exponential relationship with the snow grain size. The correlation coefficients  of the two models were 0.81 and 0.84, respectively. We obtained the location of the absorption valley at the near-infrared wavelength, and the results showed that 6.9% of the pixels were affected by the snow water content. The locations of the absorption valley moved 1–4 bands from band 89 to shorter wavelengths. The accuracy of the snow grain size estimates based on the Hyperion imagery was relatively high.

Remote Sensing, Vol. 5, Pages 224-237: Advanced Land Observing Satellite Phased Array Type L-Band SAR (ALOS PALSAR) to Inform the Conservation of Mangroves: Sundarbans as a Case Study

Posted: 11 Jan 2013 12:00 AM PST

Mangroves are an important bulkhead against climate change: they afford protection for coastal areas from tidal waves and cyclones, and are among the most carbon-rich forests in the tropics. As such, protection of mangroves is an urgent priority. This work provides some new information on patterns of degradation in the Sundarbans, the largest contiguous mangrove forest in the world, which are home to more than 35 reptile species, 120 commercial fish species, 300 bird species and 32 mammal species. Using radar imagery, we contrast and quantify the recent impacts of cyclone Sidr and anthropogenic degradation on this ecosystem. Our results, inferred from changes in radar backscatter, confirm already reported trends in coastline retreat for this region, with areas losing as much as 200 m of coast per year. They also suggest rapid changes in mangrove dynamics for Bangladesh and India, highlighting an overall decrease in mangrove health in the east side of the Sundarbans, and an overall increase in this parameter for the west side of the Sundarbans. As global environmental change takes its toll in this part of the world, more detailed, regular information on mangroves’ distribution and health is required: our study illustrates how different threats experienced by mangroves can be detected and mapped using radar-based information, to guide management action.

Molecules, Vol. 18, Pages 934-950: Total Flavonoids of Scutellaria barbata Inhibit Invasion of Hepatocarcinoma via MMP/TIMP in Vitro

Posted: 11 Jan 2013 12:00 AM PST

Metastasis is the major cause of cancer-related deaths. Targeting the process of metastasis has been proposed as a strategy to fight cancer. Scutellaria barbata D. Don (S. barbata), a traditional Chinese medicine, is used for treatment of many diseases, including cancer. This study aimed to determine the anti-metastatic effect of total flavonoids of S. barbata (TF-SB) using the human hepatocarcinoma MHCC97H cell line with high metastatic potential. Our results show that TF-SB could significantly inhibit the proliferation and invasion of MHCC97H cells in a dose-dependent manner. MMP-2 and MMP-9 expression were obviously decreased after TF-SB treatment at both the mRNA and protein level. TIMP-1 and TIMP-2 expression were simultaneously increased. The present study indicates that TF-SB could reduce the metastatic capability of MHCC97H cell, probably through decrease of the MMP expression, and simultaneous increase of the TIMP expression.

Molecules, Vol. 18, Pages 914-933: Synthesis of 5α-Androstane-17-spiro-δ-lactones with a 3-Keto, 3-Hydroxy, 3-Spirocarbamate or 3-Spiromorpholinone as Inhibitors of 17β-Hydroxysteroid Dehydrogenases

Posted: 11 Jan 2013 12:00 AM PST

We synthesized two series of androstane derivatives as inhibitors of type 3 and type 5 17β-hydroxysteroid dehydrogenases (17β-HSDs). In the first series, four monospiro derivatives at position C17 were prepared from androsterone (ADT) or epi-ADT. After the protection of the alcohol at C3, the C17-ketone was alkylated with the lithium acetylide of tetrahydro-2-(but-3-ynyl)-2-H-pyran, the triple bond was hydrogenated, the protecting groups hydrolysed and the alcohols oxidized to give the corresponding 3-keto-17-spiro-lactone derivative. The other three compounds were generated from this keto-lactone by reducing the ketone at C3, or by introducing one or two methyl groups. In the second series, two dispiro derivatives at C3 and C17 were prepared from epi-ADT. After introducing a spiro-δ-lactone at C17 and an oxirane at C3, an aminolysis of the oxirane with L-isoleucine methyl ester provided an amino alcohol, which was treated with triphosgene or sodium methylate to afford a carbamate- or a morpholinone-androstane derivative, respectively. These steroid derivatives inhibited 17β-HSD3 (14–88% at 1 μM; 46–94% at 10 μM) and 17β-HSD5 (54–73% at 0.3 μM; 91–92% at 3 μM). They did not produce any androgenic activity and did not bind steroid (androgen, estrogen, glucocorticoid and progestin) receptors, suggesting a good profile for prostate cancer therapy.

Karateka - Screenshots

Posted: 11 Jan 2013 01:49 AM PST

Features
- Rhythm-based combat mechanic
- Three playable characters. Three endings.
- Unique real-time musical score

Super Mega Worm Vs Santa 2 - Screenshots

Posted: 11 Jan 2013 01:35 AM PST

As Mother Earth's avenger, you will eat, jump, crawl, and crush your way to eradicated the evil forces of Earth. As you progress, you will grow bigger, jump higher, and gain new destructive super powers to become the unstoppable force, the Super Mega Worm! Can you save Mother Earth?

Features
- All new 15 Action Packed Levels
- 2 Chaotic Game Modes
- Epic Final Battle with Santa
- 3 Destructive Super Abilities
- 3 New Music Tracks
- Game Center Leaderboards and Achievements
- Full iCade controller Support

Badly Drawn Movies - Screenshots

Posted: 11 Jan 2013 01:29 AM PST

Feeling stuck? Feed Sharpy some fish and he will give you a clue, feed him even more fish and he will just tell you the answer; or ask your friends for help on Facebook and Twitter. Points are achieved for guessing the movies correctly and bonus points are given if you can do it before the movie is done being drawn.

Compare your scores on Game Center and remember, it is hard to draw with fins so if The Matrix looks a little too much like Tootsie, don't blame Sharpy.

Future of Xbox is “cloud centric” gaming - Microsoft

Posted: 11 Jan 2013 01:42 AM PST

The future of the Xbox gaming will be "cloud centric" rather than "device centric", a top executive from Microsoft's Interactive Entertainment Business

Take Advantage of Discounted Buy-ins in the $625,000 January Specials on bet365

Posted: 11 Jan 2013 01:38 AM PST

To celebrate the start of 2013, bet365 has made some exciting changes to its poker tournament schedule.

This posting includes an audio/video/photo media file: Download Now

Molecules, Vol. 18, Pages 894-913: Dibenzo[1,2,5]thiadiazepines Are Non-Competitive GABAA Receptor Antagonists

Posted: 11 Jan 2013 12:00 AM PST

A new process for obtaining dibenzo[c,f][1,2,5]thiadiazepines (DBTDs) and their effects on GABAA receptors of guinea pig myenteric neurons are described. Synthesis of DBTD derivatives began with two commercial aromatic compounds. An azide group was obtained after two sequential reactions, and the central ring was closed via a nitrene to obtain the tricyclic sulfonamides (DBTDs). Whole-cell recordings showed that DBTDs application did not affect the holding current but inhibited the currents induced by GABA (IGABA), which are mediated by GABAA receptors. These DBTDs effects reached their maximum 3 min after application and were: (i) reversible, (ii) concentration-dependent (with a rank order of potency of 2c = 2d > 2b), (iii) mediated by a non-competitive antagonism, and (iv) only observed when applied extracellularly. Picrotoxin (which binds in the channel mouth) and DBTDs effects were not modified when both substances were simultaneous applied. Our results indicate that DBTD acted on the extracellular domain of GABAA channels but independent of the picrotoxin, benzodiazepine, and GABA binding sites. DBTDs used here could be the initial model for synthesizing new GABAA receptor inhibitors with a potential to be used as antidotes for positive modulators of these receptors or to induce experimental epilepsy.

Molecules, Vol. 18, Pages 877-893: Synthesis, Crystal Structure, Vibration Spectral, and DFT Studies of 4-Aminoantipyrine and Its Derivatives

Posted: 11 Jan 2013 12:00 AM PST

Three compounds derived from 4-aminoantipyrine (AA) were synthesized and their structures confirmed by melting point, elemental analysis, FT-IR, and 1H-NMR. The molecular structures of the four compounds were characterized by single-crystal X-ray diffraction and calculated by using the density functional theory (DFT) method with 6-31G (d) basis set. The calculated molecular geometries and the vibration frequencies of the AA derivatives in the ground state have been compared with the experimental data. The results show that the optimized geometries can reproduce well the crystal structural parameters, and the theoretical vibration frequencies show good agreement with the experimental data, although the experimental data are different from the theoretical ones due to the intermolecular forces. Besides, the molecular electrostatic potential (MEP) and the frontier molecular orbital (FMO) analysis of the compounds were investigated by theoretical calculations.

Molecules, Vol. 18, Pages 859-876: Structural Characterization of de Novo Designed L5K5W Model Peptide Isomers with Potent Antimicrobial and Varied Hemolytic Activities

Posted: 11 Jan 2013 12:00 AM PST

In an effort to develop short antimicrobial peptides with simple amino acid compositions, we generated a series of undecapeptide isomers having the L5K5W formula. Amino acid sequences were designed to be perfectly amphipathic when folded into a helical conformation by converging leucines onto one side and lysines onto the other side of the helical axis. The single tryptophans, whose positions were varied in the primary structures, were located commonly at the critical amphipathic interface in the helical wheel projection. Helical conformations and the tryptophanyl environments of the 11 L5K5W peptides were confirmed and characterized by circular dichroism, fluorescence and nuclear magnetic resonance spectroscopy. All of the isomers exhibited a potent, broad-spectrum of antibacterial activity with just a slight variance in individual potency, whereas their hemolytic activities against human erythrocytes were significantly diversified. Interestingly, helical dispositions and fluorescence blue shifts of the peptides in aqueous trifluoroethanol solutions, rather than in detergent micelles, showed a marked linear correlation with their hemolytic potency. These results demonstrate that our de novo design strategy for amphipathic helical model peptides is effective for developing novel antimicrobial peptides and their hemolytic activities can be estimated in correlation with structural parameters.

Molecules, Vol. 18, Pages 845-858: Chamaejasmine Arrests Cell Cycle, Induces Apoptosis and Inhibits Nuclear NF-κB Translocation in the Human Breast Cancer Cell Line MDA-MB-231

Posted: 11 Jan 2013 12:00 AM PST

In this study, the anticancer activity of chamaejasmine was characterized in the human breast cancer cell line, MDA-MB-231. Cell viability and cell cycle distribution were determined by MTT assay and flow cytometry, respectively. Western blotting was performed to determine changes in levels of various proteins. Results showed that treatment with chamaejasmine (4–16 μM) inhibited cell proliferation, which correlated with G2/M phase arrest and apoptosis in MDA-MB-231 cells. Chamaejasmine treatment of MDA-MB-231 cells resulted in induction of WAF1/p21 and KIP1/p27, decrease in cyclins A and cyclins B1. Cyclin-dependent kinase (cdk) 2 and cdc2 was also decreased after chamaejasmine treatment. Moreover, inhibition of nuclear translocation, phosphorylation of NF-κB, activation of IKKα and IKKβ, inhibition of phosphorylation and degradation of IκBα were also detected in this work. Our findings suggested that chamaejasmine could be explored as a preventive and perhaps as a chemotherapeutic agent in the management of breast cancer.
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