Games |
- Assassin's Creed 3 DLC: The Battle Hardened released
- The Sims 3 University Life - Screenshots
- IJMS, Vol. 14, Pages 1207-1217: Consequences of Morphology on Molecularly Imprinted Polymer-Ligand Recognition
- Humanities, Vol. 2, Pages 20-55: From Human Past to Human Future
- Sensors, Vol. 13, Pages 813-828: Arrhythmia Identification with Two-Lead Electrocardiograms Using Artificial Neural Networks and Support Vector Machines for a Portable ECG Monitor System
- Molecules, Vol. 18, Pages 778-788: Tricolorin A as a Natural Herbicide
- Molecules, Vol. 18, Pages 768-777: Effects of Selected Polysorbate and Sucrose Ester Emulsifiers on the Physicochemical Properties of Astaxanthin Nanodispersions
- IJMS, Vol. 14, Pages 1197-1206: Coumarins from the Herb Cnidium monnieri and Chemically Modified Derivatives as Antifoulants against Balanus albicostatus and Bugula neritina Larvae
- IJMS, Vol. 14, Pages 1179-1196: Hedgehog Signaling Pathway in Ovarian Cancer
- IJMS, Vol. 14, Pages 1164-1178: Interaction of Proteins Identified in Human Thyroid Cells
- IJMS, Vol. 14, Pages 1152-1163: Structural and Phylogenetic Analysis of Rhodobacter capsulatus NifF: Uncovering General Features of Nitrogen-fixation (nif)-Flavodoxins
- IJMS, Vol. 14, Pages 1132-1151: The Role of Altered Nucleotide Excision Repair and UVB-Induced DNA Damage in Melanomagenesis
- Symmetry, Vol. 5, Pages 54-80: Non-Crystallographic Symmetry in Packing Spaces
- More
- Best of 2012!
- New Sims 3 expansions landing in 2013
- Joe Biden appeals to games industry on gun control task force
- Evolution Tournament 2013 Line-Up Announced
- Sony unveils God of War: Ascension PS3 controller in Australia
- Forests, Vol. 4, Pages 28-42: Frequency of False Heartwood of Stems of Poplar Growing on Farmland in Sweden
| Assassin's Creed 3 DLC: The Battle Hardened released Posted: 09 Jan 2013 03:23 AM PST Ubisoft has released new Assassin's Creed 3 DLC in the form of the Battle Hardened multiplayer pack.The game's second add-on pack introduces three fresh |
| The Sims 3 University Life - Screenshots Posted: 09 Jan 2013 03:10 AM PST The Sims 3 University Life opens a new chapter for young adult to elder Sims and anyone in between. Once a Sim is enrolled in university, they will pick from one of six majors and work towards earning a degree. From class activities to major-specific objects, The Sims 3 University Life will poise Sims for multiple benefits in their careers, including accelerated pay, higher career entry, new opportunities and more. Available for pre-order is The Sims 3 University Life Limited Edition Expansion Pack, which includes the Party Pack consisting of the Partaeus Maximus statue, a toga outfit and a masquerade mask. The Partaeus Maximus statue is an all-new object that will appear in the university world and enable Sims to choose from six different party themes and throw the ultimate bash. |
| Posted: 09 Jan 2013 12:00 AM PST The relationship between molecularly imprinted polymer (MIP) morphology and template-rebinding over a series of warfarin-imprinted methacrylic acid co(ethylene dimethacrylate) polymers has been explored. Detailed investigations of the nature of template recognition revealed that an optimal template binding was obtained with polymers possessing a narrow population of pores (~3–4 nm) in the mesopore size range. Importantly, the warfarin-polymer rebinding analyses suggest strategies for regulating ligand binding capacity and specificity through variation of the degree of cross-linking, where polymers prepared with a lower degree of cross-linking afford higher capacity though non-specific in character. In contrast, the co-existence of specific and non-specific binding was found in conjunction with higher degrees of cross-linking and resultant meso- and macropore size distributions. |
| Humanities, Vol. 2, Pages 20-55: From Human Past to Human Future Posted: 09 Jan 2013 12:00 AM PST This paper begins with a refutation of the orthodox model of final Pleistocene human evolution, presenting an alternative, better supported account of this crucial phase. According to this version, the transition from robust to gracile humans during that period is attributable to selective breeding rather than natural selection, rendered possible by the exponential rise of culturally guided volitional choices. The rapid human neotenization coincides with the development of numerous somatic and neural detriments and pathologies. Uniformitarian reasoning based on ontogenic homology suggests that the cognitive abilities of hominins are consistently underrated in the unstable orthodoxies of Pleistocene archaeology. A scientifically guided review establishes developmental trajectories defining recent changes in the human genome and its expressions, which then form the basis of attempts to extrapolate from them into the future. It is suggested that continuing and perhaps accelerating unfavorable genetic changes to the human species, rather than existential threats such as massive disasters, pandemics, or astrophysical events, may become the ultimate peril of humanity. |
| Posted: 09 Jan 2013 12:00 AM PST An automatic configuration that can detect the position of R-waves, classify the normal sinus rhythm (NSR) and other four arrhythmic types from the continuous ECG signals obtained from the MIT-BIH arrhythmia database is proposed. In this configuration, a support vector machine (SVM) was used to detect and mark the ECG heartbeats with raw signals and differential signals of a lead ECG. An algorithm based on the extracted markers segments waveforms of Lead II and V1 of the ECG as the pattern classification features. A self-constructing neural fuzzy inference network (SoNFIN) was used to classify NSR and four arrhythmia types, including premature ventricular contraction (PVC), premature atrium contraction (PAC), left bundle branch block (LBBB), and right bundle branch block (RBBB). In a real scenario, the classification results show the accuracy achieved is 96.4%. This performance is suitable for a portable ECG monitor system for home care purposes. |
| Molecules, Vol. 18, Pages 778-788: Tricolorin A as a Natural Herbicide Posted: 09 Jan 2013 12:00 AM PST Tricolorin A acts as pre- and post-emergence plant growth inhibitor. In pre-emergence it displays broad-spectrum weed control, inhibiting germination of both monocotyledonous (Lolium mutliflorum and Triticum vulgare) and dicotyledonous (Physalis ixocarpa and Trifolium alexandrinum) seeds, being the dicotyledonous seeds the most inhibited. Tricolorin A also inhibited seedling growth, and seed respiration, and since the concentrations required for inhibiting both germination and respiration were similar, we suggest that respiration is one of its targets. Tricolorin A at 60 µM acts as a post- emergence plant growth inhibitor by reducing dry plant biomass by 62%, 37%, 33%, and 22% for L. multiflorum, T. alexandrinum, T. vulgare, and P. ixocarpa, respectively, 18 days after its application. In order to determine the potency of tricolorin A as a plant growth inhibitor, paraquat was used as control; the results indicate that tricolorin A acts as a non-selective post-emergence plant growth inhibitor similar to paraquat, since both reduced the biomass production in P. ixocarpa and T. alexandrinum. Therefore, we suggest that tricolorin A will be a good biodegradable herbicide for weeds. |
| Posted: 09 Jan 2013 12:00 AM PST The effects of selected nonionic emulsifiers on the physicochemical characteristics of astaxanthin nanodispersions produced by an emulsification/evaporation technique were studied. The emulsifiers used were polysorbates (Polysorbate 20, Polysorbate 40, Polysorbate 60 and Polysorbate 80) and sucrose esters of fatty acids (sucrose laurate, palmitate, stearate and oleate). The mean particle diameters of the nanodispersions ranged from 70 nm to 150 nm, depending on the emulsifier used. In the prepared nanodispersions, the astaxanthin particle diameter decreased with increasing emulsifier hydrophilicity and decreasing carbon number of the fatty acid in the emulsifier structure. Astaxanthin nanodispersions with the smallest particle diameters were produced with Polysorbate 20 and sucrose laurate among the polysorbates and the sucrose esters, respectively. We also found that the Polysorbate 80- and sucrose oleate-stabilized nanodispersions had the highest astaxanthin losses (i.e., the lowest astaxanthin contents in the final products) among the nanodispersions. This work demonstrated the importance of emulsifier type in determining the physicochemical characteristics of astaxanthin nano-dispersions. |
| Posted: 09 Jan 2013 12:00 AM PST In the search for new environmental friendly antifouling (AF) agents, four coumarins were isolated from the herbal plant Cnidium monnieri, known as osthole (1), imperatorin (2), isopimpinellin (3) and auraptenol (4). Furthermore, five coumarin derivatives, namely 8-epoxypentylcoumarin (5), meranzin hydrate (6), 2'-deoxymetranzin hydrate (7), 8-methylbutenalcoumarin (8), and micromarin-F (9) were synthesized from osthole. Compounds 1, 2, 4, 7 showed high inhibitory activities against larval settlement of Balanus albicostatus with EC50 values of 4.64, 3.39, 3.38, 4.67 μg mL−1. Compound 8 could significantly inhibit larval settlement of Bugula neritina with an EC50 value of 3.87 μg mL−1. The impact of functional groups on anti-larval settlement activities suggested that the groups on C-5' and C-2'/C-3' of isoamylene chian could affect the AF activities. |
| IJMS, Vol. 14, Pages 1179-1196: Hedgehog Signaling Pathway in Ovarian Cancer Posted: 09 Jan 2013 12:00 AM PST Despite advances in surgical and chemotherapeutic treatment options, less than 50% of patients with advanced-stage ovarian cancer survive five years after initial diagnosis. In this regard, novel treatment approaches are warranted utilizing molecularly targeted therapies directed against particular components of specific signaling pathways which are required for tumor development and progression. One molecular pathway of interest is the hedgehog (Hh) signaling pathway. Activation of the Hh pathway has been observed in several cancer types, including ovarian cancer. This review highlights the crucial role of Hh signaling in the development and progression of ovarian cancer and might lead to a better understanding of the Hh signaling in ovarian tumorigenesis, thus encouraging the investigation of novel targeted therapies. |
| IJMS, Vol. 14, Pages 1164-1178: Interaction of Proteins Identified in Human Thyroid Cells Posted: 09 Jan 2013 12:00 AM PST Influence of gravity forces on the regulation of protein expression by healthy and malignant thyroid cells was studied with the aim to identify protein interactions. Western blot analyses of a limited number of proteins suggested a time-dependent regulation of protein expression by simulated microgravity. After applying free flow isoelectric focusing and mass spectrometry to search for differently expressed proteins by thyroid cells exposed to simulated microgravity for three days, a considerable number of candidates for gravi-sensitive proteins were detected. In order to show how proteins sensitive to microgravity could directly influence other proteins, we investigated all polypeptide chains identified with Mascot scores above 100, looking for groups of interacting proteins. Hence, UniProtKB entry numbers of all detected proteins were entered into the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and processed. The program indicated that we had detected various groups of interacting proteins in each of the three cell lines studied. The major groups of interacting proteins play a role in pathways of carbohydrate and protein metabolism, regulation of cell growth and cell membrane structuring. Analyzing these groups, networks of interaction could be established which show how a punctual influence of simulated microgravity may propagate via various members of interaction chains. |
| Posted: 09 Jan 2013 12:00 AM PST Analysis of the crystal structure of NifF from Rhodobacter capsulatus and its homologues reported so far reflects the existence of unique structural features in nif flavodoxins: a leucine at the re face of the isoalloxazine, an eight-residue insertion at the C-terminus of the 50’s loop and a remarkable difference in the electrostatic potential surface with respect to non-nif flavodoxins. A phylogenetic study on 64 sequences from 52 bacterial species revealed four clusters, including different functional prototypes, correlating the previously defined as “short-chain” with the firmicutes flavodoxins and the “long-chain” with gram-negative species. The comparison of Rhodobacter NifF structure with other bacterial flavodoxin prototypes discloses the concurrence of specific features of these functional electron donors to nitrogenase. |
| Posted: 09 Jan 2013 12:00 AM PST UVB radiation is the most mutagenic component of the UV spectrum that reaches the earth’s surface and causes the development of DNA damage in the form of cyclobutane pyrimidine dimers and 6-4 photoproducts. UV radiation usually results in cellular death, but if left unchecked, it can affect DNA integrity, cell and tissue homeostasis and cause mutations in oncogenes and tumour-suppressor genes. These mutations, if unrepaired, can lead to abnormal cell growth, increasing the risk of cancer development. Epidemiological data strongly associates UV exposure as a major factor in melanoma development, but the exact biological mechanisms involved in this process are yet to be fully elucidated. The nucleotide excision repair (NER) pathway is responsible for the repair of UV-induced lesions. Patients with the genetic disorder Xeroderma Pigmentosum have a mutation in one of eight NER genes associated with the XP complementation groups XP-A to XP-G and XP variant (XP-V). XP is characterized by diminished repair capacity, as well as a 1000-fold increase in the incidence of skin cancers, including melanoma. This has suggested a significant role for NER in melanoma development as a result of UVB exposure. This review discusses the current research surrounding UVB radiation and NER capacity and how further investigation of NER could elucidate the role of NER in avoiding UV-induced cellular death resulting in melanomagenesis. |
| Symmetry, Vol. 5, Pages 54-80: Non-Crystallographic Symmetry in Packing Spaces Posted: 09 Jan 2013 12:00 AM PST In the following, isomorphism of an arbitrary finite group of symmetry, non-crystallographic symmetry (quaternion groups, Pauli matrices groups, and other abstract subgroups), in addition to the permutation group, are considered. Application of finite groups of permutations to the packing space determines space tilings by policubes (polyominoes) and forms a structure. Such an approach establishes the computer design of abstract groups of symmetry. Every finite discrete model of the real structure is an element of symmetry groups, including non-crystallographic ones. The set packing spaces of the same order N characterizes discrete deformation transformations of the structure. |
| Posted: 08 Jan 2013 11:52 PM PST State lawmakers now taking on the fight to clear up a loophole in illegal video gaming. This posting includes an audio/video/photo media file: Download Now |
| Posted: 09 Jan 2013 12:02 AM PST  It was the best of times, it was the worst of times... wait, wait no. It's totally just the best of times, because it's time for the Best of 2012! Tell you what, if Charles Dickens had had all the awesome games that came out this past year, his work would have been a darned sight cheerier. After all, how can you not be excited when you have games about uncoordinated unicorns, random fire hazards in space, stories as currency, ponies with a passion for dental hygeine, and kitties that force you to confront the harsh inevitability of death? Tagged as: bestof, blog |
| New Sims 3 expansions landing in 2013 Posted: 08 Jan 2013 10:03 PM PST EA announces Sims 3 expansions for 2013; new games will allow players to send their Sims to university, explore houseboats, and travel to the future.
The Sims 3 series will have new content this year. EA's Maxis label has announced additional expansions for the PC and Mac versions of the game, including The Sims 3: University Life and The Sims 3: Island Paradise. In addition to these, an untitled new expansion and a stuff pack are currently in development for release later this year.
 The Sims 3: University Life is expected to be available from March this year, and will allow players to enrol their Sims in university, attend classes, earn degrees and experience college lifestyle. In addition to new gameplay elements, players can also take their Sims through a new college town to explore new features. The announcement also revealed a limited edition pack that is available for pre-order, which includes a party pack with additional in-game items. The Sims 3: Island Paradise will allow players to take their Sims out on customisable houseboats and investigate uncharted islands, manage resorts, and explore the ocean. The expansion is slated for release in June this year. In addition to the new games, EA has also revealed an untitled expansion pack that will grant Sims the ability to travel to the future, and a stuff pack featuring iconic movie themes and settings. Both untitled games are expected to be released this year. The expansions and stuff packs will require The Sims 3 for PC/Mac to play. For more on the core game, check out GameSpot's review of The Sims 3. Read and Post Comments | Get the full article at GameSpot "New Sims 3 expansions landing in 2013" was posted by Zorine Te on Tue, 08 Jan 2013 22:03:02 -0800 |
| Joe Biden appeals to games industry on gun control task force Posted: 08 Jan 2013 09:47 PM PST US Vice President Joe Biden is set to meet with representatives from the video game industry to discuss the role of violent video games as part of a wider task force.
US Vice President Joe Biden is set to meet with video game industry leaders this week to discuss the link between violent video games and gun violence as part of a wider task force into gun control measures. The task force, formed by President Barack Obama in response to last month's mass shooting in Newtown, Connecticut, is aimed at coming with solutions for curbing gun violence in the United States.
 According to Reuters, the White House has confirmed that Biden will also meet with representatives from the National Rifle Association (NRA), victims' groups, hunting groups, and gun owners to discuss possible policy changes to reduce gun violence, including proposed legislation to ban assault rifles. Biden will reportedly meet with representatives of both the entertainment and video game industries to specifically investigate the role of violent media--including films and video games--in mass shootings. The task force is also set to look at access to mental health and disability services, and meet with parent, teacher, and education groups. Obama has ordered the task force to report back by the end of January, ahead of the annual State of the Union address. An NRA spokesman confirmed to Reuters that the group's top lobbyist, James J Baker, will attend Biden's task force meeting on Thursday this week. Last month, NRA executive vice president Wayne LaPierre stated that violent video games are partially to blame for the Newtown shooting at Sandy Hook Elementary, which left 20 children and six adults dead. West Virginia Senator Jay Rockefeller also entered the discussion when he introduced a Bill to Congress that would direct the National Academy of Sciences to investigate how violent games and other such programming affect children. Read and Post Comments | Get the full article at GameSpot "Joe Biden appeals to games industry on gun control task force" was posted by Laura Parker on Tue, 08 Jan 2013 21:47:30 -0800 |
| Evolution Tournament 2013 Line-Up Announced Posted: 08 Jan 2013 08:29 PM PST Tekken Tag Tournament 2 and Persona 4: Arena new additions; eighth game will be determined by community.
The line-up for this year's Evolution fighting game tournament (or Evo 2K13) has been announced. According to a recent livestream on Wakeup SRK's Twitch channel featuring EVO lead organizer Joey "Mr. Wizard" Cuellar, the games that will be on the tournament are Ultimate Marvel vs. Capcom 3, Super Street Fighter IV: Arcade Edition, Tekken Tag Tournament 2, Mortal Kombat (2011 version), Street Fighter X Tekken, The King of Fighters XIII, and Persona 4: Arena. TTT 2 and Persona 4: Arena are the new titles, while the rest are returning from last year's tournament. Unlike last year's tournament, Street Fighter X Tekken will be a one-on-one tournament instead of teams of two. In addition, an eighth game will be added and will be decided by the community via donation votes. The games on the player's choice voting poll are Capcom vs. SNK 2, Dead or Alive 5, Divekick, Guilty Gear XX Accent Core +R, Injustice, Melty Blood Actress Again Current Code, MLP: Fighting is Magic, PlayStation All-Stars Battle Royale, Skullgirls, Super Smash Bros. Melee and Super Smash Bros. Brawl. The proceeds will go to the Breast Cancer Research Foundation. The qualifier tournaments in North America, dubbed the Road to Evo 2013 tournaments, will be SoCal Regionals, NorCal Regionals, UFGT, and CEO. The seeding points system has also been changed for this year's tournament. According to Shoryuken.com, the top 16 players for each of the qualifier tournaments will get a seed point each. At the end of the season, the organizers at Evo 2k13 will manually assign seeds to all seeded players. The international Road to Evo events will be announced soon. Evo 2k13 will be held at the Paris Hotel and Casino in Las Vegas on July 12 to 14. Read and Post Comments | Get the full article at GameSpot "Evolution Tournament 2013 Line-Up Announced" was posted by Jonathan Toyad on Tue, 08 Jan 2013 20:29:35 -0800 |
| Sony unveils God of War: Ascension PS3 controller in Australia Posted: 08 Jan 2013 07:44 PM PST The Kratos-themed controller will launch alongside God of War: Ascension on March 14 this year.
Get the full article at GameSpot "Sony unveils God of War: Ascension PS3 controller in Australia" was posted by Zorine Te on Tue, 08 Jan 2013 19:44:39 -0800 |
| Posted: 09 Jan 2013 12:00 AM PST Swedish owners of poplar stands are interested in both the wood quality and the use of poplars that are soon to be harvested. An important concern is the frequency of false heartwood (FHW) in the stems. We have presented an overview of the factors causing discolored wood as well as the industrial use and quality of the end products. We have studied poplar stems growing at 22 sites in Sweden between latitudes 55° N and 60° N. The mean age of the poplar was 23 years (range 14–41), the mean stand density 1011 stems ha−1 (range 155–3493) and the diameter at breast height (DBH) (over bark) 246 mm (range 121–447). All stands were growing on clay soils (light and medium clay and light clay tills). All of the sampled stems (42) contained false heartwood. At 0%–50% of stem height, all sampled trees were discolored and at 90% of stem height, 33% were discolored. The percentage of false heartwood area by stem area was highest at 1% and 10% of stem height (26.6% and 24.7% respectively). The “FHW” part of the stem had a radius of 47 mm (range 9–93) at 30% of stem height, which corresponds to 50% of the total stem radius. A log of six meters represents about 30% of stem height. Equations describing the correlation between DBH and the diameter of FHW at different stem heights (1%, 10%, 30%, 50%, 70% and 90%) and table describing FHW volume % by total stem volume at the first 50% of stem height were constructed. These might be helpful for estimating the percentage of fresh wood in a stem. However, most of the fast-growing poplars will be harvested as biofuel. |
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