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- Sensors, Vol. 13, Pages 1787-1835: Combining Wireless Sensor Networks and Semantic Middleware for an Internet of Things-Based Sportsman/Woman Monitoring Application
- Molecules, Vol. 18, Pages 1844-1856: Development and Molecular Characterization of 55 Novel Polymorphic cDNA-SSR Markers in Faba Bean (Vicia faba L.) Using 454 Pyrosequencing
- Molecules, Vol. 18, Pages 1826-1843: Pharmacological Actions of Multi-Target-Directed Evodiamine
- Molecules, Vol. 18, Pages 1819-1825: Two New Koumine-Type Indole Alkaloids from Gelsemium elegans Benth.
- IJMS, Vol. 14, Pages 3026-3049: Nature’s Timepiece—Molecular Coordination of Metabolism and Its Impact on Aging
- IJMS, Vol. 14, Pages 3011-3025: 2-(2-Hydroxy-5-nitrobenzylidene)-1,3-indanedione versus Fluorescein Isothiocyanate in Interaction with Anti-hFABP Immunoglobulin G1: Fluorescence Quenching, Secondary Structure Alteration and Binding Sites Localization
- IJMS, Vol. 14, Pages 2996-3010: Mitochondrial and Nuclear DNA Damage and Repair in Age-Related Macular Degeneration
- IJMS, Vol. 14, Pages 2980-2995: Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions
- Religions, Vol. 4, Pages 67-76: A Contribution to Comparative Theology: Probing the Depth of Islamic Thought
- Sustainability, Vol. 5, Pages 440-455: Asymptotic Behavior of a Delay Differential Neoclassical Growth Model
- Symmetry, Vol. 5, Pages 81-85: Perlman and Wellner’s Circular and Transformed Circular Copulas are Particular Beta and t Copulas
- Killzone: Mercenary release date and gameplay trailer
- Ads featuring guns pop up on apps meant for kids
- Agronomy, Vol. 3, Pages 86-116: Sustainable Phosphorus Measures: Strategies and Technologies for Achieving Phosphorus Security
- IJGI, Vol. 2, Pages 27-49: Improving the GIS-DRP Approach by Means of DelineatingRunoff Characteristics with New Discharge Relevant Parameters
- Materials, Vol. 6, Pages 421-436: Material Analysis of Coated Siliconized Silicon Carbide (SiSiC) Honeycomb Structures for Thermochemical Hydrogen Production
- Electronics, Vol. 2, Pages 41-56: Fault Tree Analysis for Safety/Security Verification in Aviation Software
- Diversity, Vol. 5, Pages 26-38: Dissimilarity of Ant Communities Increases with Precipitation, but not Reduced Land-Use Intensity, in Indonesian Cacao Agroforestry
- Battle Fight! Mario Kart Best Run Highlight
- Killzone: Mercenary preview
| Posted: 31 Jan 2013 12:00 AM PST Wireless Sensor Networks (WSNs) are spearheading the efforts taken to build and deploy systems aiming to accomplish the ultimate objectives of the Internet of Things. Due to the sensors WSNs nodes are provided with, and to their ubiquity and pervasive capabilities, these networks become extremely suitable for many applications that so-called conventional cabled or wireless networks are unable to handle. One of these still underdeveloped applications is monitoring physical parameters on a person. This is an especially interesting application regarding their age or activity, for any detected hazardous parameter can be notified not only to the monitored person as a warning, but also to any third party that may be helpful under critical circumstances, such as relatives or healthcare centers. We propose a system built to monitor a sportsman/woman during a workout session or performing a sport-related indoor activity. Sensors have been deployed by means of several nodes acting as the nodes of a WSN, along with a semantic middleware development used for hardware complexity abstraction purposes. The data extracted from the environment, combined with the information obtained from the user, will compose the basis of the services that can be obtained. |
| Posted: 31 Jan 2013 12:00 AM PST Faba bean (Vicia faba L.) is a major food source and fodder legume, popularly known for its high content of seed-protein. Its role is critical in crop rotation, and for fixing nitrogen effectively. Polymorphic simple sequence repeat markers from transcript sequences (cDNA; simple sequence repeat [SSR]) were developed for faba bean (Vicia faba). We found that 1,729 SSR loci from 81,333 individual sequence reads and 240 primer pairs were designed and synthesized. In total, 55 primer pairs were found to be polymorphic and scorable consistently when screened in 32 accessions. The number of alleles ranged from 2 to 15, frequency of major alleles per locus varied from 0.17 to 0.91, the genotypes number ranged from 2 to 17, observed and expected heterozycosity values ranged from 0.00 to 0.44 and 0.17 to 0.89 and overall PIC values ranged from 0.16 to 0.88 respectively. These markers will be a useful tool for assessing the genetic diversity, understanding the population structure, and breeding patterns of faba bean. |
| Molecules, Vol. 18, Pages 1826-1843: Pharmacological Actions of Multi-Target-Directed Evodiamine Posted: 31 Jan 2013 12:00 AM PST Evodiamine, a naturally occurring indole alkaloid, is one of the main bioactive ingredients of Evodiae fructus. With respect to the pharmacological actions of evodiamine, more attention has been paid to beneficial effects in insults involving cancer, obesity, nociception, inflammation, cardiovascular diseases, Alzheimer's disease, infectious diseases and themoregulative effects. Evodiamine has evolved a superior ability to bind various proteins, so we also argue that it is good starting point for multi-target drugs. This review is primarily addressed to the description of the recent advances in the biological activity studies of evodiamine, with a focus on pharmacological mechanism. The present review also includes the pharmacokinetics and the detailed exploration of target-binding properties of evodiamine in an attempt to provide a direction for further multi-target drug design |
| Posted: 31 Jan 2013 12:00 AM PST Two new indole alkaloids, 21-oxokoumine (1) and furanokoumine (2), were isolated from the roots of Gelsemium elegans Benth together with three known compounds. The structures of the two novel compounds were elucidated by spectroscopic methods, including NMR, HR-ESI-MS, UV, IR, CD and molecular modeling. Compound 1 is the first instance of a koumine-type alkaloid with a carbonyl at the C-21 position, while compound 2 possesses a tetrahydrofuran ring located on C-20 and C-21. |
| Posted: 31 Jan 2013 12:00 AM PST Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. In general, these rhythmic processes are under regulation of circadian clocks. The role of circadian clocks in regulating metabolism and consequently cellular and metabolic homeostasis is an intensively investigated area of research. However, the links between circadian clocks and aging are correlative and only recently being investigated. A physiological decline in most processes is associated with advancing age, and occurs at the onset of maturity and in some instances is the result of accumulation of cellular damage beyond a critical level. A fully functional circadian clock would be vital to timing events in general metabolism, thus contributing to metabolic health and to ensure an increased “health-span” during the process of aging. Here, we present recent evidence of links between clocks, cellular metabolism, aging and oxidative stress (one of the causative factors of aging). In the light of these data, we arrive at conceptual generalizations of this relationship across the spectrum of model organisms from fruit flies to mammals. |
| Posted: 31 Jan 2013 12:00 AM PST The first step in determining whether a fluorescent dye can be used for antibody labeling consists in collecting data on its physical interaction with the latter. In the present study, the interaction between the 2-(2-hydroxy-5-nitrobenzylidene)-1,3-indanedione (HNBID) dye and the IgG1 monoclonal mouse antibody anti-human heart fatty acid binding protein (anti-hFABP) has been investigated by fluorescence and circular dichroism spectroscopies and complementary structural results were obtained by molecular modeling. We have determined the parameters characterizing this interaction, namely the quenching and binding constants, classes of binding sites, and excited state lifetimes, and we have predicted the localization of HNBID within the Fc region of anti-hFABP. The key glycosidic and amino acid residues in anti-hFABP interacting with HNBID have also been identified. A similar systematic study was undertaken for the well-known fluorescein isothiocyanate fluorophore, for comparison purposes. Our results recommend HNBID as a valuable alternative to fluorescein isothiocyanate for use as a fluorescent probe for IgG1 antibodies. |
| Posted: 31 Jan 2013 12:00 AM PST Aging and oxidative stress seem to be the most important factors in the pathogenesis of age-related macular degeneration (AMD), a condition affecting many elderly people in the developed world. However, aging is associated with the accumulation of oxidative damage in many biomolecules, including DNA. Furthermore, mitochondria may be especially important in this process because the reactive oxygen species produced in their electron transport chain can damage cellular components. Therefore, the cellular response to DNA damage, expressed mainly through DNA repair, may play an important role in AMD etiology. In several studies the increase in mitochondrial DNA (mtDNA) damage and mutations, and the decrease in the efficacy of DNA repair have been correlated with the occurrence and the stage of AMD. It has also been shown that mitochondrial DNA accumulates more DNA lesions than nuclear DNA in AMD. However, the DNA damage response in mitochondria is executed by nucleus-encoded proteins, and thus mutagenesis in nuclear DNA (nDNA) may affect the ability to respond to mutagenesis in its mitochondrial counterpart. We reported that lymphocytes from AMD patients displayed a higher amount of total endogenous basal and oxidative DNA damage, exhibited a higher sensitivity to hydrogen peroxide and UV radiation, and repaired the lesions induced by these factors less effectively than did cells from control individuals. We postulate that poor efficacy of DNA repair (i.e., is impaired above average for a particular age) when combined with the enhanced sensitivity of retinal pigment epithelium cells to environmental stress factors, contributes to the pathogenesis of AMD. Collectively, these data suggest that the cellular response to both mitochondrial and nuclear DNA damage may play an important role in AMD pathogenesis. |
| Posted: 31 Jan 2013 12:00 AM PST Compound K (20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, CK), an intestinal bacterial metabolite of ginseng protopanaxadiol saponins, has been shown to inhibit cell growth in a variety of cancers. However, the mechanisms are not completely understood, especially in colorectal cancer (CRC). A xenograft tumor model was used first to examine the anti-CRC effect of CK in vivo. Then, multiple in vitro assays were applied to investigate the anticancer effects of CK including antiproliferation, apoptosis and cell cycle distribution. In addition, a qPCR array and western blot analysis were executed to screen and validate the molecules and pathways involved. We observed that CK significantly inhibited the growth of HCT-116 tumors in an athymic nude mouse xenograft model. CK significantly inhibited the proliferation of human CRC cell lines HCT-116, SW-480, and HT-29 in a dose- and time-dependent manner. We also observed that CK induced cell apoptosis and arrested the cell cycle in the G1 phase in HCT-116 cells. The processes were related to the upregulation of p53/p21, FoxO3a-p27/p15 and Smad3, and downregulation of cdc25A, CDK4/6 and cyclin D1/3. The major regulated targets of CK were cyclin dependent inhibitors, including p21, p27, and p15. These results indicate that CK inhibits transcriptional activation of multiple tumor-promoting pathways in CRC, suggesting that CK could be an active compound in the prevention or treatment of CRC. |
| Posted: 31 Jan 2013 12:00 AM PST Muslim theologians, as much as ordinary Muslims, will immediately agree with the characterization of God as all compassionate. However, it remains rather opaque how God’s compassion can be fully explained in terms of comparative theology. How can Muslims relate to God’s compassion? What role does God’s compassion precisely play in the Quranic revelation and the daily practice of Muslims? |
| Posted: 31 Jan 2013 12:00 AM PST A neoclassical growth model is examined with a special mound-shaped production function. Continuous time scales are assumed and a complete steady state and stability analysis is presented. Fixed delay is then assumed and it is shown how the asymptotic stability of the steady state is lost if the delay reaches a certain threshold, where Hopf bifurcation occurs. In the case of continuously distriubuted delays, we show that with small average delays stability is preserved, then lost at a threshold, then it is regained if the average delay becomes sufficiently large. The occurence of Hopf bifurcation is shown at both critical values. |
| Posted: 31 Jan 2013 12:00 AM PST All but one of the copulas in a recent paper in Symmetry by Perlman and Wellner can be identified as particular members of either the beta or t families of elliptical copulas. |
| Killzone: Mercenary release date and gameplay trailer Posted: 31 Jan 2013 01:22 AM PST Confirming previous reports, Sony has taken the wraps of Killzone: Mercenary, revealing new details about the Vita shooter, plus a release date and new |
| Ads featuring guns pop up on apps meant for kids Posted: 31 Jan 2013 01:08 AM PST An app that lets kids decorate cookies and cupcakes also features advertisements for violent games across the screen, leaving some parents to wonder if the content is age appropriate. |
| Posted: 31 Jan 2013 12:00 AM PST Phosphorus underpins the world’s food systems by ensuring soil fertility, maximising crop yields, supporting farmer livelihoods and ultimately food security. Yet increasing concerns around long-term availability and accessibility of the world’s main source of phosphorus—phosphate rock, means there is a need to investigate sustainable measures to buffer the world’s food systems against the long and short-term impacts of global phosphorus scarcity. While the timeline of phosphorus scarcity is contested, there is consensus that more efficient use and recycling of phosphorus is required. While the agricultural sector will be crucial in achieving this, sustainable phosphorus measures in sectors upstream and downstream of agriculture from mine to fork will also need to be addressed. This paper presents a comprehensive classification of all potential phosphorus supply- and demand-side measures to meet long-term phosphorus needs for food production. Examples range from increasing efficiency in the agricultural and mining sector, to technologies for recovering phosphorus from urine and food waste. Such measures are often undertaken in isolation from one another rather than linked in an integrated strategy. This integrated approach will enable scientists and policy-makers to take a systematic approach when identifying potential sustainable phosphorus measures. If a systematic approach is not taken, there is a risk of inappropriate investment in research and implementation of technologies and that will not ultimately ensure sufficient access to phosphorus to produce food in the future. The paper concludes by introducing a framework to assess and compare sustainable phosphorus measures and to determine the least cost options in a given context. |
| Posted: 31 Jan 2013 12:00 AM PST At present it is common to use geographic information system (GIS) applications to assess runoff generation. One of these GIS-based tools to generate maps of dominant runoff processes is the so called GIS-DRP approach. The tool, which has been developed mainly based on agricultural areas, uses commonly available input data like a digital elevation model (DEM), geological information as well as land use information. The aim of this study is to test, validate and improve this GIS-DRP method for forested and silviculture areas. Hence, soil-hydrologic investigations and several mapping techniques of dominant runoff processes were conducted on 25 test-plots in four forested catchments in Rhineland-Palatinate (Germany) and the Grand Duchy of Luxembourg. By comparing the results of the mapping techniques and those of the test plots, weak points in the original GIS-DRP method were detected. Subsequently, it was possible to enhance the GIS-DRP approach by incorporating new discharge relevant parameters like topsoil sealing, extreme weather events and semipermeability of the substratum. Moreover, the improved GIS-DRP approach can be widely used in different landscapes and for different fields of application. The adapted method can now support foresters and decision makers in forestry planning, answer questions concerning the landscape water balance and peripheral water retention or provide extra information for sustainable forest planning in times of a changing climate. |
| Posted: 31 Jan 2013 12:00 AM PST In the present work, thermochemical water splitting with siliconized silicon carbide (SiSiC) honeycombs coated with a zinc ferrite redox material was investigated. The small scale coated monoliths were tested in a laboratory test-rig and characterized by X-ray diffractometry (XRD) and Scanning Electron Microscopy (SEM) with corresponding micro analysis after testing in order to characterize the changes in morphology and composition. Comparison of several treated monoliths revealed the formation of various reaction products such as SiO2, zircon (ZrSiO4), iron silicide (FeSi) and hercynite (FeAl2O4) indicating the occurrence of various side reactions between the different phases of the coating as well as between the coating and the SiSiC substrate. The investigations showed that the ferrite is mainly reduced through reaction with silicon (Si), which is present in the SiSiC matrix, and silicon carbide (SiC). These results led to the formulation of a new redox mechanism for this system in which Zn-ferrite is reduced through Si forming silicon dioxide (SiO2) and through SiC forming SiO2 and carbon monoxide. A decline of hydrogen production within the first 20 cycles is suggested to be due to the growth of a silicon dioxide and zircon layer which acts as a diffusion barrier for the reacting specie. |
| Posted: 31 Jan 2013 12:00 AM PST The Next Generation Air Traffic Management system (NextGen) is a blueprint of the future National Airspace System. Supporting NextGen is a nation-wide Aviation Simulation Network (ASN), which allows integration of a variety of real-time simulations to facilitate development and validation of the NextGen software by simulating a wide range of operational scenarios. The ASN system is an environment, including both simulated and human-in-the-loop real-life components (pilots and air traffic controllers). Real Time Distributed Simulation (RTDS) developed at Embry Riddle Aeronautical University, a suite of applications providing low and medium fidelity en-route simulation capabilities, is one of the simulations contributing to the ASN. To support the interconnectivity with the ASN, we designed and implemented a dedicated gateway acting as an intermediary, providing logic for two-way communication and transfer messages between RTDS and ASN and storage for the exchanged data. It has been necessary to develop and analyze safety/security requirements for the gateway software based on analysis of system assets, hazards, threats and attacks related to ultimate real-life future implementation. Due to the nature of the system, the focus was placed on communication security and the related safety of the impacted aircraft in the simulation scenario. To support development of safety/security requirements, a well-established fault tree analysis technique was used. This fault tree model-based analysis, supported by a commercial tool, was a foundation to propose mitigations assuring the gateway system safety and security.  |
| Posted: 31 Jan 2013 12:00 AM PST Land-use degradation and climate change are well-known drivers of biodiversity loss, but little information is available about their potential interaction. Here, we focus on the effects of land-use and precipitation on ant diversity in cacao agroforestry. In Central Sulawesi, Indonesia, we selected 16 cacao agroforestry plots with a shaded vs. unshaded plot in each of eight villages differing in precipitation (1032–2051 mm annual rainfall). On each plot, 10 cacao trees with similar size and age (7–10 years) were selected for hand collection of ants on each cacao tree and the soil surface. In total, we found 80 ant species belonging to five subfamilies. Land-use intensification (removal of shade trees) and precipitation had no effect on species richness of ants per cacao tree (alpha diversity) and, in an additive partitioning approach, within-plot beta diversity. However, higher precipitation (but not shade) significantly increased ant species dissimilarity across cacao trees within a plot, with ant species showing contrasting responses to precipitation. Reduced precipitation causing drought stress appeared to contribute to convergence of ant community structure, presumably via reduced heterogeneity in cacao tree growth. In conclusion, reduced precipitation greatly influenced ant community dissimilarity and appeared to be more important for ant community structure than land-use intensification. |
| Battle Fight! Mario Kart Best Run Highlight Posted: 30 Jan 2013 10:01 PM PST The GameSpot AU team battle it out again, this week it is to find out who has the best Mario Kart skills. Submit your score to challenge the winner at tinyurl.com/gsbattlefight!
Read and Post Comments | Get the full article at GameSpot "Battle Fight! Mario Kart Best Run Highlight" was posted by JessicaM on Wed, 30 Jan 2013 22:01:45 -0800 |
| Posted: 31 Jan 2013 12:26 AM PST Guerrilla Games is bringing the war with the Helghast to the PlayStation Vita in their upcoming first-person shooter, Killzone: Mercenary. This time you |
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