вторник, 8 января 2013 г.

Games

Games

Why Crysis 3 is skipping Wii U

Posted: 08 Jan 2013 03:07 AM PST

Crysis 3 won't be making an appearance on Wii U, the CEO of developer Crytek has confirmed.While it was touted by the studio as a possibility last year,

Sensors, Vol. 13, Pages 801-812: Development of a Novel Two Dimensional Surface Plasmon Resonance Sensor Using Multiplied Beam Splitting Optics

Posted: 08 Jan 2013 12:00 AM PST

A novel two dimensional surface plasmon resonance (SPR) sensor system with a multi-point sensing region is described. The use of multiplied beam splitting optics, as a core technology, permitted multi-point sensing to be achieved. This system was capable of simultaneously measuring nine sensing points. Calibration curves for sucrose obtained on nine sensing points were linear in the range of 0–10% with a correlation factor of 0.996–0.998 with a relative standard deviation of 0.090–4.0%. The detection limits defined as S/N = 3 were 1.98 × 10−6–3.91 × 10−5 RIU. This sensitivity is comparable to that of conventional SPR sensors.

Sustainability, Vol. 5, Pages 136-159: The North Cascadia Adaptation Partnership: A Science-Management Collaboration for Responding to Climate Change

Posted: 08 Jan 2013 12:00 AM PST

The U.S. Forest Service (USFS) and National Park Service (NPS) have highlighted climate change as an agency priority and issued direction to administrative units for responding to climate change. In response, the USFS and NPS initiated the North Cascadia Adaptation Partnership (NCAP) in 2010. The goals of the NCAP were to build an inclusive partnership, increase climate change awareness, assess vulnerability, and develop science-based adaptation strategies to reduce these vulnerabilities. The NCAP expanded previous science-management partnerships on federal lands to a larger, more ecologically and geographically complex region and extended the approach to a broader range of stakeholders. The NCAP focused on two national forests and two national parks in the North Cascades Range, Washington (USA), a total land area of 2.4 million ha, making it the largest science-management partnership of its kind. The NCAP assessed climate change vulnerability for four resource sectors (hydrology and access; vegetation and ecological disturbance; wildlife; and fish) and developed adaptation options for each sector. The NCAP process has proven to be a successful approach for implementing climate change adaptation across a region and can be emulated by other land management agencies in North America and beyond.

Minerals, Vol. 3, Pages 1-15: Integrated Approaches for the Study of Real Mineral Flotation Systems

Posted: 08 Jan 2013 12:00 AM PST

It is more common than not, for mineral processing studies to proceed via the examination of model flotation systems with the resulting data often lacking statistical verification. The resultant concentrates and tails may then be subjected to a restricted range of analyses, for diagnosis of the flotation behavior variations observed, that themselves bias the outcomes. For instance surface analysis may be undertaken without reference to solution speciation, or liberation may be studied but surface speciation may not be taken into account. We propose an integrated approach whereby firstly the flotation data are vigorously scrutinized and the mineralogy, liberation, surface and solution speciation are examined in parallel to establish a chemical over view of the system. It is proposed that to make progress in the understanding of flotation systems, in terms of the minerals chemistry, that a multi-dimensional analytical approach is utilized and that the focus shifts towards the analysis of real ores and industrial flotation systems.

Vitamin-R 1.93 - Personal productivity tool.. (Shareware)

Posted: 08 Jan 2013 01:40 AM PST



Vitamin-R creates the optimal conditions for your brain to work at its best by structuring your work into short bursts of distraction-free, highly focused activity alternating with opportunities for renewal, reflection and intuition.

The built-in task logging and statistics features create a positive momentum towards productivity by providing visible feedback on your progress and achievements.

Time Slice Your Work

Vitamin-R breaks down large, vaguely defined tasks into a series of short "time slices" of between 10 and 30 minutes, each with specific, easily reachable and actionable objectives. During these time slices it keeps you focused on accomplishing only this one objective and provides you with mechanisms for dealing with interruptions, poor concentration, etc.

Get Started

Vitamin-R concentrates on getting you started allowing you to break through the resistance of procrastination and create a positive feedback loop of small achievements that get you closer to your ultimate aims. You will experience less stress caused by looming deadlines and a lack of clear direction, thus enabling you to enjoy guilt-free breaks that allow your intuition and creativity to emerge.

Find Your Rhythm

Each one of us is different. Finding out what works best for you is the key to true productivity. Vitamin-R helps you by giving you the tools to gain more awareness of how you spend your time, what works for you and what does not. Armed with this new knowledge, you can eliminate unproductive work patterns and discover the work rhythm that suits you best.

Get It Out of Your Head Quickly

Did you know that your short term memory can only hold 4-6 "chunks" of information? The slightest interruption and it's all gone and you have to start from scratch. That's why Vitamin-R provides you with the "Now & Later Board", complete with FastType magic, to give you a place to quickly dump all those things that go through your head and allow you to quickly return to your task.

Make It Your Own

Vitamin-R plugs into your life rather than trying to take it over. You can use it occasionally to overcome procrastination or mental blocks or re-organize your entire working life around the concepts that it embodies. It complements rather than replaces traditional to-do list managers, such as Things or OmniFocus for which direct integrations exist.

Now With Cloud Synching!

If you routinely work on multiple Macs, you willlove Vitamin-R's new ability to effortlessly synch your time slice log across the cloud using the free Dropbox service. Setup is as easy as ticking a checkbox.

Recapture the lost of art of joyful concentration. Overcome procrastination. Rediscover the motivation within yourself.



Version 1.93:
  • This version fixes a rare startup problem.


OS X 10.7 or later

Download Now

Casual online games not online anymore

Posted: 08 Jan 2013 12:44 AM PST

Casual games are just that, casual. However, as more and more people get into gaming via Facebook or through mobile apps, more cases are being documented of people becoming addicted to their casual games .

Far Cry 2 - The B-List

Posted: 07 Jan 2013 08:31 PM PST

Tyler and Kevin revisit Far Cry 2 in all of its GPU intensive glory in the premiere episode of The B-List.

 

Read and Post Comments | Get the full article at GameSpot

"Far Cry 2 - The B-List" was posted by DanM on Mon, 07 Jan 2013 20:31:31 -0800

Hexius - Screenshots

Posted: 08 Jan 2013 01:06 AM PST

Game Features:
Time Attack Mode - connect matching hexagons as fast as possible, until time runs out – the faster you play, the higher the score multiplier goes!
Level Challenge Mode - collect all the targets to move onto progressively harder levels. The faster you go, the more time is carried over to the next level – find out how far can you go before time runs out!
Strategy Mode – take your time to score as highly as you can in 30 moves, making strategic use of your Multiplier bonuses.
Bonuses - make use of Bomb, Reveal, Freeze, and the new Multiplier bonuses to help maximize your score.
Online community - log in for free with OpenFeint to see your friends all-time high scores, global high scores, enter weekly score challenges, and collect achievements! Easily connect with your Facebook® and Twitter friends.
Addictive gameplay - with simple to learn rules, Hexius will appeal to the casual player and puzzle lovers, whilst the subtle tactics required to get really high scores will intrigue the more advanced gamer.
Universal App - runs on iPhone, iPod touch, and iPad – graphics and layout on iPad are optimized for the HD experience.

Piston revealed as first 'Steam Box'

Posted: 08 Jan 2013 01:09 AM PST

Valve opened up, and out came the Piston: A micro PC collaboration between Valve and computer manufacturer Xi3 was revealed as a development-stage "Steam

Metabolites, Vol. 3, Pages 1-23: The Metabolic Interplay between Plants and Phytopathogens

Posted: 08 Jan 2013 12:00 AM PST

Plant diseases caused by pathogenic bacteria or fungi cause major economic damage every year and destroy crop yields that could feed millions of people. Only by a thorough understanding of the interaction between plants and phytopathogens can we hope to develop strategies to avoid or treat the outbreak of large-scale crop pests. Here, we studied the interaction of plant-pathogen pairs at the metabolic level. We selected five plant-pathogen pairs, for which both genomes were fully sequenced, and constructed the corresponding genome-scale metabolic networks. We present theoretical investigations of the metabolic interactions and quantify the positive and negative effects a network has on the other when combined into a single plant-pathogen pair network. Merged networks were examined for both the native plant-pathogen pairs as well as all other combinations. Our calculations indicate that the presence of the parasite metabolic networks reduce the ability of the plants to synthesize key biomass precursors. While the producibility of some precursors is reduced in all investigated pairs, others are only impaired in specific plant-pathogen pairs. Interestingly, we found that the specific effects on the host’s metabolism are largely dictated by the pathogen and not by the host plant. We provide graphical network maps for the native plant-pathogen pairs to allow for an interactive interrogation. By exemplifying a systematic reconstruction of metabolic network pairs for five pathogen-host pairs and by outlining various theoretical approaches to study the interaction of plants and phytopathogens on a biochemical level, we demonstrate the potential of investigating pathogen-host interactions from the perspective of interacting metabolic networks that will contribute to furthering our understanding of mechanisms underlying a successful invasion and subsequent establishment of a parasite into a plant host.

Behavioral Sciences, Vol. 3, Pages 55-71: Problems of Teaching the Behaviorist Perspective in the Cognitive Revolution

Posted: 08 Jan 2013 12:00 AM PST

This article offers some personal reflections on the difficulty of teaching the behaviorist perspective in the psychology classroom. The problems focus on the inadequacy of introductory textbooks—which mischaracterize behaviorism, only present the most extreme behaviorist positions, make no mention of the neobehaviorist perspective, fail to discuss that there is no accepted criteria for determining what type of behavior is cognitive, and provide a definition of cognition that is, not only inconsistent across texts, but so broad as to overshadow the behaviorist contributions. Suggestions are provided for instructors on how to present to their students an accurate portrayal of behaviorism.

Sensors, Vol. 13, Pages 785-800: Cross-Coupled Control for All-Terrain Rovers

Posted: 08 Jan 2013 12:00 AM PST

Mobile robots are increasingly being used in challenging outdoor environments for applications that include construction, mining, agriculture, military and planetary exploration. In order to accomplish the planned task, it is critical that the motion control system ensure accuracy and robustness. The achievement of high performance on rough terrain is tightly connected with the minimization of vehicle-terrain dynamics effects such as slipping and skidding. This paper presents a cross-coupled controller for a 4-wheel-drive/4-wheel-steer robot, which optimizes the wheel motors’ control algorithm to reduce synchronization errors that would otherwise result in wheel slip with conventional controllers. Experimental results, obtained with an all-terrain rover operating on agricultural terrain, are presented to validate the system. It is shown that the proposed approach is effective in reducing slippage and vehicle posture errors.

Sensors, Vol. 13, Pages 769-784: Mechatronic Description of a Laser Autoguided Vehicle for Greenhouse Operations

Posted: 08 Jan 2013 12:00 AM PST

This paper presents a novel approach for guiding mobile robots inside greenhouses demonstrated by promising preliminary physical experiments. It represents a comprehensive attempt to use the successful principles of AGVs (auto-guided vehicles) inside greenhouses, but avoiding the necessity of modifying the crop layout, and avoiding having to bury metallic pipes in the greenhouse floor. The designed vehicle can operate different tools, e.g., a spray system for applying plant-protection product, a lifting platform to reach the top part of the plants to perform pruning and harvesting tasks, and a trailer to transport fruits, plants, and crop waste. Regarding autonomous navigation, it follows the idea of AGVs, but now laser emitters are used to mark the desired route. The vehicle development is analyzed from a mechatronic standpoint (mechanics, electronics, and autonomous control).

Molecules, Vol. 18, Pages 757-767: In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16

Posted: 08 Jan 2013 12:00 AM PST

The anti-tumor effect of aconitine in melanoma cell line B16 has been studied in this paper. We found that B16 cells showed significantly reduced growth rates and increased apoptotic effects in the presence of aconitine. Furthermore, aconitine inhibited the PI3K/AKT and MAPK/ERK1/2 signaling pathways, thus regulating the levels of protein and mRNA of PCNA and apoptotic related signaling molecules. Above all, we found that aconitine showed an anti-melanoma effect in suppressing tumor growth in vivo. In conclusion, we show that aconitine may be a useful anticancer drug in the future.

The War Z - Now Playing

Posted: 07 Jan 2013 07:14 PM PST

Aaron and Ryan test their survival skills and experience random acts of online kindness in this look at The War Z

 

Read and Post Comments | Get the full article at GameSpot

"The War Z - Now Playing" was posted by DanM on Mon, 07 Jan 2013 19:14:14 -0800

Molecules, Vol. 18, Pages 735-756: Benchmarking Ligand-Based Virtual High-Throughput Screening with the PubChem Database

Posted: 08 Jan 2013 12:00 AM PST

With the rapidly increasing availability of High-Throughput Screening (HTS) data in the public domain, such as the PubChem database, methods for ligand-based computer-aided drug discovery (LB-CADD) have the potential to accelerate and reduce the cost of probe development and drug discovery efforts in academia. We assemble nine data sets from realistic HTS campaigns representing major families of drug target proteins for benchmarking LB-CADD methods. Each data set is public domain through PubChem and carefully collated through confirmation screens validating active compounds. These data sets provide the foundation for benchmarking a new cheminformatics framework BCL::ChemInfo, which is freely available for non-commercial use. Quantitative structure activity relationship (QSAR) models are built using Artificial Neural Networks (ANNs), Support Vector Machines (SVMs), Decision Trees (DTs), and Kohonen networks (KNs). Problem-specific descriptor optimization protocols are assessed including Sequential Feature Forward Selection (SFFS) and various information content measures. Measures of predictive power and confidence are evaluated through cross-validation, and a consensus prediction scheme is tested that combines orthogonal machine learning algorithms into a single predictor. Enrichments ranging from 15 to 101 for a TPR cutoff of 25% are observed.

Molecules, Vol. 18, Pages 721-734: Synthesis and in Vitro Antiproliferative Activity of New Phenylaminoisoquinolinequinones against Cancer Cell Lines

Posted: 08 Jan 2013 12:00 AM PST

A variety of phenylaminoisoquinolinequinones were synthesized and tested for their antiproliferative activity against three human-tumor derived cancer cell lines. The new aminoquinones were prepared from 4-methoxycarbonyl-3-methylisoquinoline-5,8-quinone (1) via acid-induced amination and bromination reactions. Remarkable differences in antiproliferative activity were observed depending upon the location and donor capacity of the substituted phenylamino group at the quinone nucleus. The effect of the substituents on the biological activity is discussed in terms of the donor-acceptor interactions which were evaluated through the redox properties of the aminoquinones.

Molecules, Vol. 18, Pages 701-720: Curcumin Induces Cell Death and Restores Tamoxifen Sensitivity in the Antiestrogen-Resistant Breast Cancer Cell Lines MCF-7/LCC2 and MCF-7/LCC9

Posted: 08 Jan 2013 12:00 AM PST

Curcumin, a principal component of turmeric (Curcuma longa), has potential therapeutic activities against breast cancer through multiple signaling pathways. Increasing evidence indicates that curcumin reverses chemo-resistance and sensitizes cancer cells to chemotherapy and targeted therapy in breast cancer. To date, few studies have explored its potential antiproliferation effects and resistance reversal in antiestrogen-resistant breast cancer. In this study, we therefore investigated the efficacy of curcumin alone and in combination with tamoxifen in the established antiestrogen-resistant breast cancer cell lines MCF-7/LCC2 and MCF-7/LCC9. We discovered that curcumin treatment displayed anti-proliferative and pro-apoptotic activities and induced cell cycle arrest at G2/M phase. Of note, the combination of curcumin and tamoxifen resulted in a synergistic survival inhibition in MCF-7/LCC2 and MCF-7/LCC9 cells. Moreover, we found that curcumin targeted multiple signals involved in growth maintenance and resistance acquisition in endocrine resistant cells. In our cell models, curcumin could suppress expression of pro-growth and anti-apoptosis molecules, induce inactivation of NF-κB, Src and Akt/mTOR pathways and downregulate the key epigenetic modifier EZH2. The above findings suggested that curcumin alone and combinations of curcumin with endocrine therapy may be of therapeutic benefit for endocrine-resistant breast cancer.

IJMS, Vol. 14, Pages 1119-1131: Characterization of a Crabs Claw Gene in Basal Eudicot Species Epimedium sagittatum (Berberidaceae)

Posted: 08 Jan 2013 12:00 AM PST

The Crabs Claw (CRC) YABBY gene is required for regulating carpel development in angiosperms and has played an important role in nectary evolution during core eudicot speciation. The function or expression of CRC-like genes has been explored in two basal eudicots, Eschscholzia californica and Aquilegia formosa. To further investigate the function of CRC orthologous genes related to evolution of carpel and nectary development in basal eudicots, a CRC ortholog, EsCRC, was isolated and characterized from Epimedium sagittatum (Sieb. and Zucc.) Maxim. A phylogenetic analysis of EsCRC and previously identified CRC-like genes placed EsCRC within the basal eudicot lineage. Gene expression results suggest that EsCRC is involved in the development of sepals and carpels, but not nectaries. Phenotypic complementation of the Arabidopsis mutant crc-1 was achieved by constitutive expression of EsCRC. In addition, over-expression of EsCRC in Arabidopsis and tobacco gave rise to abaxially curled leaves. Transgenic results together with the gene expression analysis suggest that EsCRC may maintain a conserved function in carpel development and also play a novel role related to sepal formation. Absence of EsCRC and ElCRC expression in nectaries further indicates that nectary development in non-core eudicots is unrelated to expression of CRC-like genes.

Anarchy Reigns review

Posted: 08 Jan 2013 12:07 AM PST

Can you catch a missile and throw it back at the jet that fired it at you? No, probably not. It's also unlikely that you'd be able to sprint up a
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