вторник, 26 июля 2011 г.

Games

Games

Games

Paper false eyelashes with wildlife

Posted: 26 Jul 2011 03:02 AM PDT

These paper-cut false eyelashes are so weirdly striking that I'll even forgive the vendor for claiming that they are "steeped in Chinese symbolic meaning." I can't claim to have much direct experience with false eyelashes, apart from a brief, early-teens fixation with Kubrick's Clockwork Orange adaptation, but if I saw someone wearing these at a fancy occasion, I think I'd be very impressed.


Inspired by the art of Chinese paper cutting, these delicately pretty and intricately cut paper eyelashes are so utterly exquisite. They come in a really neat little box with a display window and can be reused over and over again and they also make a fabulous and surprising gift and are just plain fun to wear.

nonesuch things

(via Neatorama)

Cancers, Vol. 3, Pages 3029-3054: Dual Targeting of the Insulin-Like Growth Factor and Collateral Pathways in Cancer: Combating Drug Resistance

Posted: 26 Jul 2011 12:00 AM PDT

The insulin-like growth factor pathway, regulated by a complex interplay of growth factors, cognate receptors, and binding proteins, is critically important for many of the hallmarks of cancer such as oncogenesis, cell division, growth, and antineoplastic resistance. Naturally, a number of clinical trials have sought to directly abrogate insulin-like growth factor receptor 1 (IGF-1R) function and/or indirectly mitigate its downstream mediators such as mTOR, PI3K, MAPK, and others under the assumption that such therapeutic interventions would provide clinical benefit, demonstrable by impaired tumor growth as well as prolonged progression-free and overall survival for patients. Though a small subset of patients enrolled within phase I or II clinical trials revealed dramatic clinical response to IGF-1R targeted therapies (most using monoclonal antibodies to IGF-1R), in toto, the anticancer effect has been underwhelming and unsustained, as even those with marked clinical responses seem to rapidly acquire resistance to IGF-1R targeted agents when used alone through yet to be identified mechanisms. As the IGF-1R receptor is just one of many that converge upon common intracellular signaling cascades, it is likely that effective IGF-1R targeting must occur in parallel with blockade of redundant signaling paths. Herein, we present the rationale for dual targeting of IGF-1R and other signaling molecules as an effective strategy to combat acquired drug resistance by carcinomas and sarcomas.

Molecules, Vol. 16, Pages 6313-6321: A Facile Synthesis of Highly Functionalized 4-Arylcoumarins via Kostanecki Reactions Mediated by DBU

Posted: 26 Jul 2011 12:00 AM PDT

An efficient synthesis of 4-arylcoumarins has been accomplished via Kostanecki reactions of 2-hydroxybenzophenones with acetic anhydride employing DBU at ambient temperature. Using the same strategy, several 2-acyloxybenzophenone derivatives were readily converted to 3,4-difunctionalized coumarins. This protocol offers a notable improvement in reaction conditions for coumarin synthesis and takes advantage of its synthetic capability, especially for highly functionalized 4-arylcoumarins with structural diversity.

Molecules, Vol. 16, Pages 6306-6312: Synthesis of Both Ionic Species of Ammonium Dithiocarbamate Derived Cholic Acid Moieties

Posted: 26 Jul 2011 12:00 AM PDT

The reaction of 3-aminopropylamide of cholic acid with CS2 produced a bile acid derivative of dithiocarbamic acid which further formed an ammonium salt with another molecule of 3-aminopropylamide of cholic acid. The cationic 3-ammonium propylamide of cholic acid did not react further with CS2 and the formed salt was stable in the reaction mixture, even when excess CS2 was used. When the reaction was carried out in the presence of aqueous sodium hydroxide, only the bile acid derivative of sodium dithiocarbamate was formed. The dithiocarbamate derivatives were characterized by 1H- and 13C-NMR spectroscopy and ESI-TOF mass spectrometry.

Molecules, Vol. 16, Pages 6271-6305: Design and Synthesis of Novel Antimicrobial Acyclic and Heterocyclic Dyes and Their Precursors for Dyeing and/or Textile Finishing Based on 2-N-Acylamino-4,5,6,7-tetrahydro-benzo[b]thiophene Systems

Posted: 26 Jul 2011 12:00 AM PDT

A series of novel polyfunctionalized acyclic and heterocyclic dye precursors and their respective azo (hydrazone) counterpart dyes and dye precursors based on conjugate enaminones and/or enaminonitrile moieties were synthesized. The dyes and their precursors are based on 2-cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-acetamide, 2-ethoxycarbonyl-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-acetamide or 2-phenylcarbamoyl-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-acetamide systems as precursors. The latter compounds were used to synthesize polyfunctional thiophene-, thiazole-, pyrazole, pyridine-, pyrimidine-, oxazine-, as well as acyclic moieties. The dyes and dye precursors were characterized by elemental analysis and spectral methods. All dyes and their precursors were screened in vitro and evaluated for both their antibacterial and antifungal activities. MIC data of the novel dye systems and their respective precursors showed significant antimicrobial activity against most tested organisms. Some compounds exhibited comparable or even higher efficiency than selected standards. Dyes were applied at 5% depth for disperse dyeing of nylon, acetate and polyester fabrics. Their spectral characteristics and fastness properties were measured and evaluated.

ColTest

Posted: 26 Jul 2006 12:23 AM PDT

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Motomouse Snow

Posted: 26 Jul 2011 12:33 AM PDT

Drive your awesome Motomouse through the treacherous snow. Check out the mini map on the bottom to succeed the challenging task.

HyperDock 1.1.3 - Select windows by moving the mouse over a dock item and more.. (Shareware)

Posted: 25 Jul 2011 08:59 PM PDT



HyperDock adds long awaited features to your Dock:
  • Preview and select windows&tabs just by moving the mouse on a dock item.
  • Use shortcuts to quickly open new windows and documents with a simple mouse click.
  • Improve your workflow by using advanced window management features like Window Snapping.


Version 1.1.3:
  • Fix: HyperDock didn't work on 32 bit Intel Core Duo Macs.
  • Fix: HyperDock did not show up when booting up after upgrading to Mac OS X 10.7
  • Fix: On some Macs HyperDock prevented iTunes from quitting
  • Fix: Sometimes the iTunes window couldn't be snapped by dragging
  • Fix: Windows from Stickies.app couldn't be moved/resized on Snow Leopard
  • Fix: Weird behavior after switching user sessions
  • Fix: Work around a bug in Mac OS X 10.7 that disabled the "Double-tab with three fingers" gesture when HyperDock was running.
  • The old down-snapping behavior (snap to bottom half screen) is now enabled when holding down the option key while dragging
  • Temporarily disabled the Safari tab preview plugin for Safari 5.1
Note: I'm about to restructure and simplify the shortcuts gui/functionality in one of the next releases. If there's something you really depend on (e.g. an applescript), drop me a mail.

Mac OS X 10.6 or later

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Mac OS X 10.6.8 Supplemental Update - Also for Mac OS X 10.6.8 Server.. (Free)

Posted: 25 Jul 2011 08:59 PM PDT

Mac OS X 10.6.8 Supplemental Update is recommended for all users running Mac OS X Snow Leopard 10.6.8 and resolves issues with:
  • Transferring personal data, settings, and compatible applications from a Mac running Mac OS X Snow Leopard to a new Mac running Mac OS X Lion
  • Certain network printers that pause print jobs immediately and fail to complete
  • System audio that stops working when using HDMI or optical audio out


Mac OS X 10.6.8.

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CrossOver 10.1.1 - Run Windows apps on your Intel Mac.. (Updater)

Posted: 25 Jul 2011 08:59 PM PDT



CrossOver allows you to install many popular Windows applications and games on Mac OS X. CrossOver includes an easy to use, single click interface, which makes installing Windows software simple and fast. Once installed, your application integrates seamlessly in OS X. Just click and run your application directly from the OS X Finder. Clicking a Windows file or document - including email attachments - will launch the appropriate Windows program, allowing you to work on the files. Best of all, you do it all easily and affordably, without needing a Microsoft operating system license.

Adding new Windows software is easy. Just place your install CD in your Mac, and CrossOver will recognize it and offer to begin the installation process. CrossOver then completes the installation and configures your application to run on your Mac. That's all there is to it.

CrossOver Mac will be the very best way to run your Windows applications on your Intel based Mac. It will let you install and run Windows programs as though they were native, all without having to buy or run a copy of Windows itself.

We strongly recommend that you review the list of Frequently Asked Questions prior to installing CrossOver. You may also want to browse the forums or search the Compatibility Center to see if your specific needs will be addressed.

At CodeWeavers, we believe strongly in truth in advertising. I have written a detailed description of our real world experience with CrossOver Mac through our rounds of testing. This way, you can be certain that this product will live up to your expectations...

Our guarantee: If you decide to purchase CrossOver Mac (even without reading the long description provided in the link above), and feel that you did not receive a fair value, we will refund your money, no questions asked.

Thank you for your interest in CrossOver and CodeWeavers,

Jeremy White, CEO, CodeWeavers, Inc.



Version 10.1.1:
  • Added a workaround for a bug in OSX 10.7 Lion. Many games running in a virtualdesktop cause a crash. This can be resolved by setting the CX_LEAK_XPLUGIN_SURFACESenvironment variable.
  • Work around a bug in OSX 10.6.8 Snow Leopard. 10.6.8 generated corrupt iconfiles which caused occasional Finder crashes. Now we use a different APIto generate icon files which bypasses the issue.
  • Changed behavior of group permissions on certain files. Resolves an issuewith .docx files on certain file systems.


Mac OS X 10.5 or later

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Sound Studio 4.2 - Audio recording and editing tool with automator Monbots.. (Demo)

Posted: 25 Jul 2011 08:59 PM PDT



Sound Studio is an easy-to-use Mac OS X application for recording and editing audio digitally on your computer. Digitize tapes and vinyl records, record live performances, create your own mixes with crossfades, tweak the levels and EQ, apply digital effects, and save in all major file formats with Sound Studio

Positioned perfectly between more expensive programs with steep learning curves, and far less robust apps, Sound Studio is for anyone who needs to record or edit audio. Some other possible applications include:

  • Lectures
  • Voice-notes
  • Sermons
  • Performances
  • and more

Detailed Features

Recording:

  • Multi-track support: layer stereo sounds and save in interleaved format
  • Audio Unit plug-in effect support
  • Saves in MPEG-4 AAC (advanced audio coding) m4a format
  • Saves in MP3 when the LAME framework is installed
  • Automator support (launch Automator to see the bundled actions)
  • Added "New Mono Document" command for quickly creating a monophonic document
  • 24-bit / 96 kHz sample quality, in stereo or mono
  • Low latency monitoring, using Core Audio
  • Automatic recording starting and stopping based on timers or audio levels (a.k.a. VOX)

Editing:

  • Sample-accurate edits
  • Markers (a.k.a. Cue Points) with text labels
  • Time ruler with units for video and film
  • Copy-and-paste editing
  • Basic mixing edits
  • AppleScript and Automator support

Effects:

  • Supports Audio Units
  • Dynamics: Compressor, Expander, and Noise Gate
  • Equalization: Graphic EQ, Low Pass Filter, and High Pass Filter
  • Delay: Chorus, Flanger, Echo, and Reverb
  • Volume: Amplify, Fade In/Out/Special, and Normalize
  • Repair: Interpolate, Silence, DC Offset, and Swap Channels
  • Repair clicks and pops by interpolating samples or silencing them
  • Tone, FM, and noise generators
  • Pitch adjustment
  • Backwards/Reverse Audio

File Formats:

  • AIFF (.aif) and AIFF-C (.aifc) with compression including IMA 4:1
  • AAC and MP3 (importing only).
  • Sound Designer II
  • Wave (.wav, PCM only)
  • Tab-delimited text (export only)
Version 4 adds many new features:
  • 64-bit app. (Also runs in 32-bit mode. Some plug-ins only available in 32-bit mode.)
  • New UI with everything you need in one window.
  • Output level meters.
  • Markers listed in the sidebar.
  • Simplified playback and recording transport.
  • Improved AudioUnit hosting.
  • Many bug fixes
  • Requires Intel CPU and Mac OS X Leopard 10.5 or higher. (Recommended: Snow Leopard 10.6.)


Version 4.2:
  • Fixed bug with saving Wave files with BWF data.
  • Fixed missing progress window during save.
  • Fixed bug with blank File Format popup with files with AAC and Apple Lossless files.
  • Fixed bug with canceling out of Save Selection As and subsequent save only saving the selection.
  • Fixed auto-scrolling during recording.
  • Fixed graphical bug with turning off input level meters.
  • Fixed bug with AppleScript Split command.


Mac OS X 10.5 or later

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This posting includes an audio/video/photo media file: Download Now

Apple iOS 4.3.5 - iPhone operating system; download with iTunes.. (Updater)

Posted: 25 Jul 2011 08:59 PM PDT



Apple iOS can be downloaded from iTunes by connecting your iPhone and clicking the Update button.

Version 4.3.5:
  • Fixes a security vulnerability with certificate validation.
Download iOS 4.2.10 for CDMA (Verizon) iPhone

iPhone 4 (GSM model), iPhone 3GS, iPad, iPod touch (3rd or 4th generation)

Download Now

Apple Mac OS X Server 10.6.8 v1.1 - Designed for the enterprise.. (Updater)

Posted: 25 Jul 2011 08:59 PM PDT



Mac OS X Server is catered specifically to meet the enterprise needs of Mac users.

Version 10.6.8 v1.1: Release notes were unavailable when this listing was updated.

Mac OS X Server 10.6.7.

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OnyX 2.4.0b2 - OS X maintenance & optimization tool.. (Free)

Posted: 25 Jul 2011 08:59 PM PDT



OnyX is a multifunction utility for Mac OS X. It allows you to verify the Startup Disk and the structure of its System files, to run miscellaneous tasks of system maintenance, to configure the hidden parameters of the Finder, Dock and of some of Apple's own applications, to delete caches, to remove a certain number of files and folders that may become cumbersome and more.

Version 2.4.0b2:
  • New version for OS X 10.7 only.


Mac OS X 10.7 or later

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Dragon Dictate 2.5 - Speech recognition software (was MacSpeech).. (Commercial)

Posted: 25 Jul 2011 08:59 PM PDT



With Dragon Dictate for Mac 2.5 speech recognition software, you can enter text just by speaking. Control your favorite Mac applications using only your voice. With Dragon Dictate you can produce reports, email, articles, books, research notes, online content, and more quickly, easily, and accurately. And great new features mean you'll get even more done, faster. With the introduction of the free Dragon Remote Microphone application (available in the Apple app store), you can achieve the same great accurate transcription using a device you already may have: your iPhone! And new social media commands make posting to Facebook or Twitter a breeze. Dragon Dictate provides amazing accuracy and requires just minutes of training to get started. Built upon the renowned Dragon 11 speech recognition engine, Dragon Dictate for Mac is Simply Smarter Speech Recognition.



Turn Talk into Text


Instead of a keyboard, use your voice to produce text. Speak your thoughts, then watch your words appear on screen in your favorite Mac applications with amazing recognition accuracy.



Unlock Your Creativity


Dragon Dictate for Mac keeps up with your brain. Transform ideas into text at the speed of thought. Start being creative and productive with only your voice -- don't let typing get in the way of your ideas or productivity.



Work Comfortably


Control your Mac in a relaxed, hands-free manner without being tied to your keyboard. Instead of using your mouse, just speak commands to launch and control applications. Move the cursor or click anywhere on screen simply by voice.



Multi-task Like Never Before


Tell your Mac what to do, like "Reply To This Message" or "Open Microsoft® Word" or "Jump To Google" to work faster and smarter. Create voice commands that automate complex workflows on your Mac.



Work Your Way


Create a digital world, powered by your own voice. Customize Dragon Dictate for Mac with personal vocabulary and voice commands that reflect the kind of work you do. 



Comfortable and Convenient Wireless Solution


Turn your iPhone or iPod into a wireless microphone for use with Dragon on your Mac. The free Dragon Remote Microphone app can be used with Dragon Dictate to generate the same great transcription accuracy

Version 2.5:

  • Word 2011 Compatibility
  • Numbers Mode
  • Autosleep Microphone
  • AutoFormatting Options
  • New Additional Voice Training Stories
  • Facebook and Twitter Commands
  • Dragon Remote Microphone Connectivity


  • Mac OS X 10.6 or later.
  • MacSpeech-certified noise-cancelling microphone (included with new purchase).


Download Now

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Apple Mac OS X 10.6.8 v1.1 - The 'Snow Leopard' operating system.. (Updater)

Posted: 25 Jul 2011 08:59 PM PDT



Apple Mac OS X Snow Leopard builds on a decade of OS X innovation and success with hundreds of refinements, new core technologies and out of the box support for Microsoft Exchange.

To create Snow Leopard, Apple engineers refined 90 percent of the more than 1,000 projects that make up Mac OS X. Users will notice refinements including a more responsive Finder; Mail that loads messages up to twice as fast; Time Machine with an up to 80 percent faster initial backup; a Dock with Expose integration; QuickTime X with a redesigned player that allows users to easily view, record, trim and share video; and a 64-bit version of Safari 4 that is up to 50 percent faster and resistant to crashes caused by plug-ins.

Snow Leopard is half the size of the previous version and frees up to 7GB of drive space once installed. For the first time, system applications including Finder, Mail, iCal, iChat and Safari are 64-bit and Snow Leopards support for 64-bit processors makes use of large amounts of RAM, increases performance and improves security while remaining compatible with 32-bit applications.

Grand Central Dispatch (GCD) provides a revolutionary new way for software developers to write applications that take advantage of multicore processors. OpenCL, a C-based open standard, allows developers to tap the incredible power of the graphics processing unit for tasks that go beyond graphics.



Version 10.6.8 v1.1:

Resolves issues with:

  • Transferring personal data, settings, and compatible applications from a Mac running Mac OS X Snow Leopard to a new Mac running Mac OS X Lion
  • Certain network printers that pause print jobs immediately and fail to complete
  • System audio that stops working when using HDMI or optical audio out



Mac OS X 10.6.6 or later

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iRip 2.1.2 - Transfer songs, videos, books, contacts, and more from your iPod or iPhone to your Mac.. (Shareware)

Posted: 25 Jul 2011 08:59 PM PDT



iRip (formerally iPodRip) is the definitive iPod companion application. iRip allows you to get the most out of your iPod, iPhone and iPad -- you can transfer music, videos, and books from your iDevice back to your iTunes Library, listen to music directly on your iPod (allowing you to save valuable disk space) -- plus much more. iRip supports all iPod Media Types -- MP3, AAC, Protected AAC or Audible.com Content. Upgrade to iRip 2.0 for only $9.95 with your license from iRip 1.x.

Version 2.1.2:
  • Bug fixes


  • Mac OS X 10.5 or later.
  • iTunes 8.0 or later.
  • any iPod, iPhone.


Download Now

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Firefox 6.0 - Popular Web browser (beta).. (Free)

Posted: 25 Jul 2011 08:59 PM PDT



Firefox is a web browser that empowers you to accomplish your online activities faster, more safely and efficiently than any other browser, period. Built with Tab browsing, popup blocking and a number of other seamless innovations, Firefox stands out ahead.

Version 6.0 (b3): Release notes were unavailable when this listing was updated.

Mac OS X 10.5 or later

Download Now

This posting includes an audio/video/photo media file: Download Now

iRip 2.1.2 - Transfer songs, videos, books, contacts, and more from your iPod or iPhone to your Mac.. (Shareware)

Posted: 25 Jul 2011 08:59 PM PDT



iRip (formerally iPodRip) is the definitive iPod companion application. iRip allows you to get the most out of your iPod, iPhone and iPad -- you can transfer music, videos, and books from your iDevice back to your iTunes Library, listen to music directly on your iPod (allowing you to save valuable disk space) -- plus much more. iRip supports all iPod Media Types -- MP3, AAC, Protected AAC or Audible.com Content. Upgrade to iRip 2.0 for only $9.95 with your license from iRip 1.x.

Version 2.1.2:
  • Bug fixes


  • Mac OS X 10.5 or later.
  • iTunes 8.0 or later.
  • any iPod, iPhone.


Download Now

This posting includes an audio/video/photo media file: Download Now

Firefox 6.0 - Popular Web browser (beta).. (Free)

Posted: 25 Jul 2011 08:59 PM PDT



Firefox is a web browser that empowers you to accomplish your online activities faster, more safely and efficiently than any other browser, period. Built with Tab browsing, popup blocking and a number of other seamless innovations, Firefox stands out ahead.

Version 6.0 (b3): Release notes were unavailable when this listing was updated.

Mac OS X 10.5 or later

Download Now

This posting includes an audio/video/photo media file: Download Now

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