Games |
- Cancers, Vol. 3, Pages 3525-3556: Epigenetics, Nervous System Tumors, and Cancer Stem Cells
- Cancers, Vol. 3, Pages 3506-3524: An Evidence-Based Approach to the Use of Predictive Biomarkers in the Treatment of Non- Small Cell Lung Cancer (NSCLC)
- Atmosphere, Vol. 2, Pages 510-532: Chemical Mechanism Solvers in Air Quality Models
- Shogun 2: Total War - Screenshots
- The Sims 3 Pets - Screenshots
- Pipe Riders
- CLBuilder 1.12 - Compile, execute and profile OpenCL kernels.. (Commercial)
- Fortix 2 1.1 - Reverse turret defense / puzzle game.. (Demo)
- Tuxera NTFS 2011.4.2 - NTFS driver developed from the popular open source NTFS-3G driver.. (Demo)
- QuickBooks Pro 2011 12.0.10 R11 - Small business financial management and accounting.. (Demo)
- MailShoot 2.3 - Keep track of visitors and collect e-mail addresses.. (Shareware)
- Cornerstone 2.5.2 - Take control of Subversion with a client built just for Mac.. (Demo)
- Google Chrome 14.0.835.162 - Modern and fast Web browser (Beta).. (Free)
- The Sunday Briefing: Jimmie 'AlusivPnkBny' Guinther Among Sunday Major Winners
- Get Up and Dance Screens
- DanceDanceRevolution II Screens
- Resistance 3 Screens
- Monster Hunter 4 headlines Nintendo TGS conference
- The Adventures of Tintin: The Game Screens
- Raving Rabbids: Alive & Kicking Screens
| Cancers, Vol. 3, Pages 3525-3556: Epigenetics, Nervous System Tumors, and Cancer Stem Cells Posted: 13 Sep 2011 12:00 AM PDT Recent advances have begun to elucidate how epigenetic regulatory mechanisms are responsible for establishing and maintaining cell identity during development and adult life and how the disruption of these processes is, not surprisingly, one of the hallmarks of cancer. In this review, we describe the major epigenetic mechanisms (i.e., DNA methylation, histone and chromatin modification, non-coding RNA deployment, RNA editing, and nuclear reorganization) and discuss the broad spectrum of epigenetic alterations that have been uncovered in pediatric and adult nervous system tumors. We also highlight emerging evidence that suggests epigenetic deregulation is a characteristic feature of so-called cancer stem cells (CSCs), which are thought to be present in a range of nervous system tumors and responsible for tumor maintenance, progression, treatment resistance, and recurrence. We believe that better understanding how epigenetic mechanisms operate in neural cells and identifying the etiologies and consequences of epigenetic deregulation in tumor cells and CSCs, in particular, are likely to promote the development of enhanced molecular diagnostics and more targeted and effective therapeutic agents for treating recalcitrant nervous system tumors. |
| Posted: 13 Sep 2011 12:00 AM PDT Recent advances in the treatment of non-small cell lung cancer (NSCLC) have led to improvements in patient survival and quality of life. It is unclear whether molecular abnormalities associated with NSCLC cell survival, growth and proliferation are useful in predicting treatment benefit. We conducted a systematic review to establish which biomarkers contribute meaningfully to the management of NSCLC. A team of researchers searched PubMed and conference proceedings (ASCO, ESMO, IASLC, USCAP) using MESH terms for NSCLC and randomized trials (RCT), plus keywords for variables of interest. Evidence from multiple RCTs confirmed that histologic subtype is prognostic for survival and predictive of treatment efficacy and/or toxicity in NSCLC. Likewise, activating mutations of the epidermal growth factor receptor (EGFR) are associated with benefit from EGFR tyrosine kinase inhibitors in patients with advanced non-squamous NSCLC and should be assessed routinely. No biomarkers to date reliably predict response to anti-Vascular Endothelial Growth Factor (VEGF) therapies. There are inconsistent data on the role of ERCC1, BRCA, Beta tubulin III, RRM1, K-RAS, or TP-53 in treatment decisions. These tests should not be routinely used in selecting treatment at this time, whereas EML4/ALK translocations predict responses to specific targeted agents, the optimal assessment of this molecular abnormality has yet to be established. Personalized care of patients with NSCLC based on biomarkers is increasingly important to both clinical practice and research. |
| Atmosphere, Vol. 2, Pages 510-532: Chemical Mechanism Solvers in Air Quality Models Posted: 13 Sep 2011 12:00 AM PDT The solution of chemical kinetics is one of the most computationally intensivetasks in atmospheric chemical transport simulations. Due to the stiff nature of the system,implicit time stepping algorithms which repeatedly solve linear systems of equations arenecessary. This paper reviews the issues and challenges associated with the construction ofefficient chemical solvers, discusses several families of algorithms, presents strategies forincreasing computational efficiency, and gives insight into implementing chemical solverson accelerated computer architectures. |
| Shogun 2: Total War - Screenshots Posted: 13 Sep 2011 03:55 AM PDT Game will feature enhanced full 3D battles via land and sea, which made a name for the series, as well as the tactical campaign map that many refer to as the heart and soul of Total War. Featuring a brand new AI system inspired by the scriptures that influenced Japanese warfare, the millennia old Chinese "Art of War", the Creative Assembly brings the wisdom of Master Sun Tsu to Shogun 2: Total War. Analysing this ancient text enabled the Creative Assembly to implement easy to understand yet deep strategical gameplay. |
| Posted: 13 Sep 2011 03:54 AM PDT Product DescriptionThe Sims 3 Pets comes to Xbox 360, PlayStation 3, 3DS and PC/Mac this holiday season! For the first time in franchise history, players will be able to take full control of their pet and play out their life story. They'll also be able to determine their pets' personality traits to create their perfect pet for their Sims. The Sims 3 Pets allows players to add a new member to their household to control and find new ways to play with life! As a new standalone game, The Sims 3 Pets<font ... |
| Posted: 13 Sep 2011 02:15 AM PDT |
| CLBuilder 1.12 - Compile, execute and profile OpenCL kernels.. (Commercial) Posted: 13 Sep 2011 12:25 AM PDT  CLBuilder allows users to compile, execute and profile OpenCL kernels.
Version 1.12:
Download Now |
| Fortix 2 1.1 - Reverse turret defense / puzzle game.. (Demo) Posted: 13 Sep 2011 12:17 AM PDT  Fortix 2 is a mash-up between a reverse turret defense and a constantly shifting puzzle game. Players control Knight Fortix, as he attempts to take back the land of Artalom from the clutches of the evil mage Xitrof. During his quest, the player will have to assist Sir Fortix from his base line (or safety line) as he runs across the shires boxing-off terrain to recapture it, while simultaneously running through a maze of relentless projectiles and aggressive enemies. Capturing dragons, outwitting ogres and vanquishing hordes of bats is all in a days work. Catapults and power-ups will aid the player in their constant struggle with the surroundings. But, even these great countermeasures can only do so much. Sometimes, the only thing standing between you and glory is a white knuckled mad dash to the other side. Version 1.1:
Mac OS X 10.6.6 or later Download Now |
| Tuxera NTFS 2011.4.2 - NTFS driver developed from the popular open source NTFS-3G driver.. (Demo) Posted: 13 Sep 2011 12:29 AM PDT  Tuxera NTFS for Mac is a commercial NTFS driver developed from the popular open source NTFS-3G driver, which is a natural part of all major Linux distributions, and also has lots of users on Mac OS X, FreeBSD, Solaris and NetBSD. It has been engineered to bring our customers maximum possible performance when accessing NTFS drives while keeping their data safe. It also offers some additional features to its open source counterpart, NTFS-3G, along with commercial support. Tuxera NTFS for Mac can be used as a full featured evaluation version for 15 days, after which the user can unlock the software with an official license key to retain full product functionality. This posting includes an audio/video/photo media file: Download Now |
| QuickBooks Pro 2011 12.0.10 R11 - Small business financial management and accounting.. (Demo) Posted: 12 Sep 2011 08:59 PM PDT  QuickBooks Pro ... Save time and easily manage your business on a Mac. Organize your finances all in one place, track money going in and out of your business, and spot areas where you can save.
Version 12.0.10 R11 (12.0f5415):
Mac OS X 10.6 or later. Download Now This posting includes an audio/video/photo media file: Download Now |
| MailShoot 2.3 - Keep track of visitors and collect e-mail addresses.. (Shareware) Posted: 12 Sep 2011 11:53 PM PDT  MailShoot... Keep in touch with your visitors using MailShoot, the fully featured newsletter and email management software. Now with MailShoot you can instantly create an online sign up form for your visitors and start collecting email addresses. Then send out periodic news and updates to your email list whenever you have something important to say. MailShoot is a great way to keep in touch with your customers and keep visitors returning to your website. It even works with iWeb and MobileMe hosted websites without any technical skill on your part. Download the demo to see how it can improve your visitor loyalty and improve website traffic.
Mac OS X 10.4.11 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Cornerstone 2.5.2 - Take control of Subversion with a client built just for Mac.. (Demo) Posted: 12 Sep 2011 08:59 PM PDT  Cornerstone allows you to take control of Subversion with a client application that was specifically designed for Mac users. Cornerstone integrates all of the features you need to interact with your repository and does so in an elegant and easy-to-use fashion. Whether you're new to versioning or a Subversion expert, Cornerstone will help streamline your workflow and make version control more transparent.
Version 2.5.2:
Mac OS X 10.5 or later Download Now |
| Google Chrome 14.0.835.162 - Modern and fast Web browser (Beta).. (Free) Posted: 12 Sep 2011 08:59 PM PDT  Google Chrome is a Web browser by Google, created to be a modern platform for web pages and applications. It utilizes very fast loading of web pages and has a V8 engine, which is a custom built JavaScript engine. Because Google has used parts from Apple's Safari and Firefox browsers, they made the project open source. Version 14.0.835.162:
Mac OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| The Sunday Briefing: Jimmie 'AlusivPnkBny' Guinther Among Sunday Major Winners Posted: 12 Sep 2011 11:40 PM PDT For the second consecutive week, the numbers for the PokerStars Sunday Majors were up more than normal across the board, thanks to the World Championship of Online Poker . This posting includes an audio/video/photo media file: Download Now |
| Posted: 12 Sep 2011 08:30 PM PDT 1 new shots posted.
Get the full article at GameSpot "Get Up and Dance Screens" was posted on Mon, 12 Sep 2011 20:30:00 -0700 |
| DanceDanceRevolution II Screens Posted: 12 Sep 2011 08:18 PM PDT 14 new shots posted.
Get the full article at GameSpot "DanceDanceRevolution II Screens" was posted on Mon, 12 Sep 2011 20:18:00 -0700 |
| Posted: 12 Sep 2011 08:12 PM PDT 8 new shots posted.
Get the full article at GameSpot "Resistance 3 Screens" was posted on Mon, 12 Sep 2011 20:12:00 -0700 |
| Monster Hunter 4 headlines Nintendo TGS conference Posted: 12 Sep 2011 07:33 PM PDT Mario maker kicks off Tokyo Game Show week with its own event; Monster Hunter Tri, Animal Crossing, and more shown for 3DS; Miyamoto talks Skyward Sword for Wii.
Last month, Nintendo stock spiked when it was discovered that the company was planning a pre-Tokyo Game Show press conference. Buoyed by speculation that the company would be introducing new games for the 3DS, or perhaps even a new model of the hardware itself, investors pushed Nintendo stock up 9 percent in a single day of trading. It was a welcome breath of optimism for Nintendo, which has endured a difficult stretch of late. The handheld failed to live up to initial sales expectations and was deeply discounted within half a year of its launch. Meanwhile, the Wii U unveiling at the Electronic Entertainment Expo received a lukewarm reaction from investors. The slashing of the 3DS' price was rivaled only by the slashing of Nintendo president Satoru Iwata's paycheck, as the executive took a voluntary 50 percent salary trim in the wake of the company's troubles. However, things have improved for Nintendo since the 3DS price cut, with the handheld now regularly topping hardware sales in Japan, and showing notable improvement at US retailers as well. The system also raised eyebrows with a recent Famitsu report that Capcom would be bringing Monster Hunter Tri to the handheld later this year. And that's not even mentioning the new cradle accessory for the system, which adds a right analog stick to the 3DS. [8:01] The Nintendo conference is kicking off. Street Fighter series producer Yoshinori Ono has tweeted that he's in attendance. [8:02] We start with a trailer for Skyward Sword, then Shigeru Miyamoto takes to the stage with Link's shield and sword. [8:02] He thanks the crowd for coming. [8:03] And then admits that he's a little embarrassed to be seen with a shield. It's been 25 years since Zelda was released, Miyamoto notes. [8:04] He takes a trip down memory lane with some clips of older Zelda games. Then he says there was a competition to make artwork for Zelda's anniversary and Nintendo received lots of entries. [8:04] Now he's moving on to talk about Skyward Sword. [8:05] Miyamoto is now demonstrating the gameplay with the prop sword and shield. [8:05] He says players can gather power in the game by pointing the sword skyward. [8:06] Now Miyamoto has a Wii Remote and nunchuk. He demonstrates the gameplay by swinging the controllers to the side and vertically, saying the game will have a big story. More than 100 people were involved in making it. [8:07] Moving on to look at some gameplay footage of Skyward Sword, Miyamoto demonstrates the rope swing showing Link swinging, balancing, and swimming. [8:07] Players can swing vertically or horizontally. [8:07] Now Miyamoto shows off a new boss, who is very strong with the sword. [8:08] He demonstrates some of the puzzle-solving elements in the game, and new items like a flamethrower-like item that melts snow. [8:09] Players can even catch butterflies. [8:10] Miyamoto says it's the culmination of 25 years of ideas in development. [8:10] Miyamoto says there will be 50-100 hours of gameplay in Skyward Sword. [8:11] The gameplay demo is over, and Miyamoto leaves the stage to applause. [8:12] We've reached the 3DS portion of the show, as Nintendo is showing a montage of 3DS games, including Mario 3D Land, Kid Icarus, Luigi's Mansion, Tekken, and Resident Evil. [8:13] Animal Crossing, Monster Hunter, and Mario Kart 3D were also featured in the montage. [8:13] Satoru Iwata walks onto the stage and thanks people for coming and for those watching at home. He says would like to talk about future of the 3DS. [8:14] Now he moves on to talk about Square Enix titles coming out for the Wii. The next Dragon Quest game hits September 15, with Just Dance Wii following on October 13. [8:15] Kirby is coming Oct. 27, with Taiko Drum Master on Nov. 23 and Skyward Sword Nov. 23. [8:16] He quickly details the special 25th anniversary Zelda pack with gold controller and disc, then mentions that the Sonic and Mario London Olympics game for the Wii hits December 8, with another Pokepark Pokemon spin-off by the end of December. [8:16] He says that people no longer need to worry about software for the Wii with all these titles coming out. Now he's going to move to talk about the 3DS. [8:17] The Wii has a 50/50 male/female audience, but the DS is more female, Iwata says. Then he announces the misty pink 3DS, and notes that the 3DS skews more male. [8:18] The misty pink 3DS comes out October 20. To go along with this new color, the Mii Plaza will be made better. [8:18] The Nintendo E-Shop will also have lots of added functions. [8:19] He says there will be more content for Street Pass, and reveals a November 3 release date for Super Mario 3D. [8:20] The game will feature added camera controls, giving players more freedom to move the view. Iwata shows gameplay footage for the game, then moves on to talk about Mario Kart 7. It will feature underwater levels, flying through the air, and car customisation. [8:21] The game will also feature international networking, so players can race with people around the world. Mario Kart 7 will be released December 1. [8:21] Now Iwata moves on to talk about Mario Tennis, due out 2012. [8:21] Paper Mario is also coming out in 2012. The game will include lots of new gimmicks that players haven't seen before in previous Paper Mario games. [8:22] Luigi's Mansion 2 is also coming out in 2012. Luigi will use a special strobe light to stop the ghosts. [8:22] Mario and Sonic at the London Olympics is coming out for the 3DS in 2012. [8:23] Animal Crossing is also coming out 2012 for the 3DS. Iwata says it's going to be better than ever before on the 3DS. [8:24] Players can arrange their entire environment in the game, from the garden and house to their surroundings. It will use Street Pass functionality to add people's houses to other players' games. [8:25] Now Iwata is showing a short video for Tomodachi Collection, a Japanese-exclusive game. [8:26] Nintendo is adding "Girls Mode" to the game, where players can choose fashion, etc. [8:26] This game was first released in 2009 for the DS. It was a life simulation game. [8:28] Next Iwata shows off a new soccer game for the 3DS, set for release in 2012. [8:29] Iwata moves on to show off the Magic: The Gathering-meets-Monopoly Culdcept game, then a new Fire Emblem, coming out in spring 2012. [8:30] These were all Nintendo first party titles. Now Iwata is talking about third-party titles, and shows off a short video for Dynasty Warriors Vs. [8:30] Dynasty Warriors Vs. is coming out in 2012. [8:31] Now he's showing a trailer for a Square Enix title. [8:32] The RPG specialist is making Bravery Default: Flying Fairy, a new RPG coming in 2012. [8:32] Onto the next video. It's Gundam! [8:33] SD Gundam G Generation 3D will be out December 22, 2011. [8:34] Now it's a trailer for Project Mirai, a Project Diva title for the 3DS. Vocaloid girls! [8:34] It's a rhythm game. [8:35] Correction: It's not a Project Diva title, it's called Project Mirai. But it's the Vocaloid girls. [8:35] That's coming out March 2012. [8:36] Biohazard Revelations is planned for release on 3DS in 2012, Iwata says. [8:36] Ace Combat 3D: Cross Rumble is planned for release "this Northern winter." [8:36] Tekken 3D: Prime Edition is also coming out this winter. [8:38] Theatrhythm Final Fantasy is also coming out this winter. It's a Final Fantasy rhythm game, if you couldn't guess from the title. [8:38] Slime MoriMori is coming out November 2, and Cinderlife (a new title) is coming out before end of 2011. [8:39] A new Loveplus game is coming out December 8, 2011 (featuring lots of new ways to communicate with girls). [8:39] And Metal Gear Solid 3D: Snake Eater is coming "this winter." [8:39] Now Iwata is talking about Kid Icarus. [8:40] He apologizes that it's taking longer than expected to make, and says it will be released in the first half of 2012. [8:41] Studio 4C, Shaft and Production IG have been added to Nintendo's list of software developers. [8:41] Iwata says he's talked a lot about software so far… [8:42] And adds Nintendo is planning to double the number of titles in the Nintendo eShop. [8:43] He leaves the stage and the lights go dark to show a mysterious clip. It looks like Monster Hunter 3DS! [8:43] The trailer shows a lot of underwater gameplay, bringing to mind Monster Hunter Tri for the Wii. [8:45] The logo looks like Monster Hunter 3G Tri. [8:45] Or perhaps that's Monster Hunter Tri 3G. [8:47] Iwata introduces one of the developers who worked on Monster Hunter. He started working on the game two years ago, and says he wanted to make it available to people on a handheld. [8:48] The developer, Sugimoto-san, talks about adding new regions to the game. [8:48] The game is coming out December 10 for 5,800 yen. [8:49] He says the 3D aspect will bring a lot of people back to Monster Hunter. [8:50] He says there is lots of hype about the underwater sequences, and shows one final video. [8:51] It's a trailer for the game that shows a lone hunter on the run from a very angry dragon-like monster. [8:52] It's a trailer for Monster Hunter 4! [8:52] It's an entirely new project for the 3DS. [8:53] Iwata says Nintendo didn't quite meet the expectations of the audience with the 3DS. [8:53] But now, with all these new titles, Iwata hopes Nintendo will make up for that. [8:54] And Iwata says he hopes the audience will stay with Nintendo. Iwata leaves the stage, and it's back to a montage. [8:56] And that looked like it might have been it, but now they're playing a Battle of the Planets/Gatchman video that ties into Monster Hunter 3G. [8:57] And another one. [8:58] Let's make it three straight. [9:02] It's starting to look less like this is an intermission and more like the show might be over. They did thank the crowd for watching before cutting to the ads, so the conference appears to have concluded. [9:03] Those holding out hope for an announcement of the 3DS right analog stick accessory will have to wait for another day, as there was no mention of it during the conference. [9:05] As the stream continues to rotate through 3DS commercials, that will bring the blog to a close. Read and Post Comments | Get the full article at GameSpot "Monster Hunter 4 headlines Nintendo TGS conference" was posted by Brendan Sinclair on Mon, 12 Sep 2011 19:33:33 -0700 |
| The Adventures of Tintin: The Game Screens Posted: 12 Sep 2011 06:36 PM PDT 8 new shots posted.
Get the full article at GameSpot "The Adventures of Tintin: The Game Screens" was posted on Mon, 12 Sep 2011 18:36:00 -0700 |
| Raving Rabbids: Alive & Kicking Screens Posted: 12 Sep 2011 06:18 PM PDT 16 new shots posted.
Get the full article at GameSpot "Raving Rabbids: Alive & Kicking Screens" was posted on Mon, 12 Sep 2011 18:18:01 -0700 |
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