четверг, 15 сентября 2011 г.

Games

Games

PressPerCent 3.0.3 - Ink pre-setting solutions for offset presses.. (Shareware)

Posted: 15 Sep 2011 02:58 AM PDT



The development of PressPerCent application started in mid 1990's. The purpose was to create a simple ink key pre-setting software tool - a popular subject at the time when press manufacturers and printers were searching for less expensive, space-saving solutions to replace hardware plate scanners (that never were extremely reliable, among everything else). Since then PressPerCent evolved to include more features the customers and OEM partners required, such as: support for the job format of virtually every press type and model, total ink calculations, spot color preview, automatic job processing via hot folders, flexible press configurations, etc.

Technically the application itself is just an area coverage calculator. It converts jobs in various input formats into bitmap images with relatively low resolution (its internal file format), then it counts number of pixels that have different color values in these bitmaps. This calculation is done for certain areas specified by user: entire printable area of the printing press, or page area of the job, or stripes that correspond to ink zones of offset (litho) printing press, or any rectangle that user drawn on screen using mouse.

Version 3.0.3:

  • Another bunch of fixes for 3.0.x versions. This update fine-tunes parts of Cocoa interface code. Recommended for all PressPerCent users.


Mac OS X 10.5 or later.

Download Now

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Greenpeace celebrates all the corporate overlords they’ve upset over their 40 years

Posted: 15 Sep 2011 02:59 AM PDT

Brian from Greenpeace sez, "Greenpeace is 40 years old today, and one of the ad agencies we've worked with over the years made this for us. The agency asked to remain anonymous, so as not to lose any clients that might think they're represented here. Awww. We're truly touched."

40 years (Thanks, Brian!)

Third gender option added to Australian passports

Posted: 15 Sep 2011 02:45 AM PDT

Australians now have a third option for the "gender" field on their passports. Transgendered people and people of ambiguous gender are allowed to enter "X" for gender, rather than "F" or "M".
An Australian senator, Louise Pratt - whose partner was born female and is now identified as a man - said the reform was a huge step forward.

"There have been very many cases of people being detained at airports by immigration in foreign countries simply because their passports don't reflect what they look like," she told Australian radio.

"It's very distressing, highly inconvenient and frankly sometimes dangerous."

New Australian passports allow third gender option

Sensors, Vol. 11, Pages 8888-8909: Reconstruction of Self-Sparse 2D NMR Spectra from Undersampled Data in the Indirect Dimension

Posted: 15 Sep 2011 12:00 AM PDT

Reducing the acquisition time for two-dimensional nuclear magnetic resonance (2D NMR) spectra is important. One way to achieve this goal is reducing the acquired data. In this paper, within the framework of compressed sensing, we proposed to undersample the data in the indirect dimension for a type of self-sparse 2D NMR spectra, that is, only a few meaningful spectral peaks occupy partial locations, while the rest of locations have very small or even no peaks. The spectrum is reconstructed by enforcing its sparsity in an identity matrix domain with ℓp (p = 0.5) norm optimization algorithm. Both theoretical analysis and simulation results show that the proposed method can reduce the reconstruction errors compared with the wavelet-based ℓ1 norm optimization.

Materials, Vol. 4, Pages 1548-1563: Single Voxel Proton Spectroscopy for Neurofeedback at 7 Tesla

Posted: 15 Sep 2011 12:00 AM PDT

Echo-planar imaging (EPI) in fMRI is regularly used to reveal BOLD activation in presubscribed regions of interest (ROI). The response is mediated by relative changes in T2* which appear as changes in the image pixel intensities. We have proposed an application of functional single-voxel proton spectroscopy (fSVPS) for real-time studies at ultra-high MR field which can be comparable to the EPI BOLD fMRI technique. A spin-echo SVPS protocol without water suppression was acquired with 310 repetitions on a 7T Siemens MR scanner (TE/TR = 20/1000 ms, flip angle α = 90°, voxel size 10 × 10 × 10 mm3). Transmitter reference voltage was optimized for the voxel location. Spectral processing of the water signal free induction decay (FID) using log-linear regression was used to estimate the T2* change between rest and activation of a functional task. The FID spectrum was filtered with a Gaussian window around the water peak, and log-linear regression was optimized for the particular ROI by adoption of the linearization length. The spectroscopic voxel was positioned on an ROI defined from a real-time fMRI EPI BOLD localizer. Additional online signal processing algorithms performed signal drift removal (exponential moving average), despiking and low-pass filtering (modified Kalman filter) and, finally, the dynamic feedback signal normalization. Two functional tasks were used to estimate the sensitivity of the SVPS method compared to BOLD signal changes, namely the primary motor cortex (PMC, left hand finger tapping) and visual cortex (VC, blinking checkerboard). Four healthy volunteers performed these tasks and an additional session using real-time signal feedback modulating their activation level of the PMC. Results show that single voxel spectroscopy is able to provide a good and reliable estimation of the BOLD signal changes. Small data size and FID signal processing instead of processing entire brain volumes as well as more information revealed from the acquired total water spectrum, i.e., direct estimation of the T2* values and B0 changes, make SVPS proton spectroscopy suitable and advantageous for real-time neurofeedback studies. Particular challenges of ultra-high field spectroscopy due to the non-linearity in the spectral information, e.g., poor main magnetic field homogeneity and the absence of motion correction for the SVPS sequence may lead to the special artifacts in the control signal which still need to be addressed. The contrast to noise ratio (CNR), experimental statistic (t-values) and percent signal change were used as quality parameters to estimate the method performance. The potential and challenges of the spectroscopic approach for fMRI studies needs to be further investigated.

Cancers, Vol. 3, Pages 3610-3631: Strategies To Assess Hypoxic/HIF-1-Active Cancer Cells for the Development of Innovative Radiation Therapy

Posted: 15 Sep 2011 12:00 AM PDT

Local tumor recurrence and distant tumor metastasis frequently occur after radiation therapy and result in the death of cancer patients. These problems are caused, at least in part, by a tumor-specific oxygen-poor microenvironment, hypoxia. Oxygen-deprivation is known to inhibit the chemical ionization of both intracellular macro-molecules and water, etc., and thus reduce the cytotoxic effects of radiation. Moreover, DNA damage produced by free radicals is known to be more repairable under hypoxia than normoxia. Hypoxia is also known to induce biological tumor radioresistance through the activation of a transcription factor, hypoxia-inducible factor 1 (HIF-1). Several potential strategies have been devised in radiation therapy to overcome these problems; however, they have not yet achieved a complete remission. It is essential to reveal the intratumoral localization and dynamics of hypoxic/HIF-1-active tumor cells during tumor growth and after radiation therapy, then exploit the information to develop innovative therapeutic strategies, and finally damage radioresistant cells. In this review, we overview problems caused by hypoxia/HIF-1-active cells in radiation therapy for cancer and introduce strategies to assess intratumoral hypoxia/HIF-1 activity.

Cancers, Vol. 3, Pages 3601-3609: Type I Collagen Synthesis Marker Procollagen I N-Terminal Peptide (PINP) in Prostate Cancer Patients Undergoing Intermittent Androgen Suppression

Posted: 15 Sep 2011 12:00 AM PDT

Intermittent androgen suppression (IAS) therapy for prostate cancer patients attempts to maintain the hormone dependence of the tumor cells by cycles alternating between androgen suppression (AS) and treatment cessation till a certain prostate-specific antigen (PSA) threshold is reached. Side effects are expected to be reduced, compared to standard continuous androgen suppression (CAS) therapy. The present study examined the effect of IAS on bone metabolism by determinations of serum procollagen I N-terminal peptide (PINP), a biochemical marker of collagen synthesis. A total of 105 treatment cycles of 58 patients with prostate cancer stages ≥pT2 was studied assessing testosterone, PSA and PINP levels at monthly intervals. During phases of AS lasting for up to nine months PSA levels were reversibly reduced, indicating apoptotic regression of the prostatic tumors. Within the first cycle PINP increased at the end of the AS period and peaked in the treatment cessation phase. During the following two cycles a similar pattern was observed for PINP, except a break in collagen synthesis as indicated by low PINP levels in the first months off treatment. Therefore, measurements of the serum PINP concentration indicated increased bone matrix synthesis in response to >6 months of AS, which uninterruptedly continued into the first treatment cessation phase, with a break into each of the following two pauses. In summary, synthesis of bone matrix collagen increases while degradation decreases during off-treatment phases in patients undergoing IAS. Although a direct relationship between bone matrix turnover and risk of fractures is difficult to establish, IAS for treatment of biochemical progression of prostate tumors is expected to reduce osteoporosis in elderly men often at high risk for bone fractures representing a highly suitable patient population for this kind of therapy.

Genes, Vol. 2, Pages 640-660: Genes Involved in the Production of Antimetabolite Toxins by Pseudomonas syringae Pathovars

Posted: 15 Sep 2011 12:00 AM PDT

Pseudomonas syringae is pathogenic in a wide variety of plants, causing diseases with economic impacts. Pseudomonas syringae pathovars produce several toxins that can function as virulence factors and contribute to disease symptoms. These virulence factors include antimetabolite toxins, such as tabtoxin, phaseolotoxin and mangotoxin, which target enzymes in the pathways of amino acid metabolism. The antimetabolite toxins are generally located in gene clusters present in the flexible genomes of specific strains. These gene clusters are typically present in blocks of genes that appear to be integrated into specific sites in the P. syringae core genome. A general overview of the genetic organization and biosynthetic and regulatory functions of these genetic traits of the antimetabolite toxins will be given in the present work.

Molecules, Vol. 16, Pages 7980-7993: Thymidine Analogues for Tracking DNA Synthesis

Posted: 15 Sep 2011 12:00 AM PDT

Replicating cells undergo DNA synthesis in the highly regulated, S-phase of the cell cycle. Analogues of the pyrimidine deoxynucleoside thymidine may be inserted into replicating DNA, effectively tagging dividing cells allowing their characterisation. Tritiated thymidine, targeted using autoradiography was technically demanding and superseded by 5-bromo-2-deoxyuridine (BrdU) and related halogenated analogues, detected using antibodies. Their detection required the denaturation of DNA, often constraining the outcome of investigations. Despite these limitations BrdU alone has been used to target newly synthesised DNA in over 20,000 reviewed biomedical studies. A recent breakthrough in "tagging DNA synthesis" is the thymidine analogue 5-ethynyl-2′-deoxyuridine (EdU). The alkyne group in EdU is readily detected using a fluorescent azide probe and copper catalysis using 'Huisgen's reaction' (1,3-dipolar cycloaddition or 'click chemistry'). This rapid, two-step biolabelling approach allows the tagging and imaging of DNA within cells whilst preserving the structural and molecular integrity of the cells. The bio-orthogonal detection of EdU allows its application in more experimental assays than previously possible with other "unnatural bases". These include physiological, anatomical and molecular biological experimentation in multiple fields including, stem cell research, cancer biology, and parasitology. The full potential of EdU and related molecules in biomedical research remains to be explored.

Molecules, Vol. 16, Pages 7969-7979: Modulation of Animal and Human Hematopoiesis by β-Glucans: A Review

Posted: 15 Sep 2011 12:00 AM PDT

β-Glucans are cell wall constituents of bacteria, yeast, fungi, and plants. They are not expressed in mammalian cells, but they are recognized by mammalian cells as pathogen-associated molecular patterns by pattern recognition receptors and thus act as biological response modifiers. This review summarizes data on the hematopoiesis-stimulating effects of β-glucans, as well as on their ability to enhance bone marrow recovery after an injury. β-Glucans have been shown to support murine hematopoiesis suppressed by ionizing radiation or cytotoxic anti-cancer therapy. They also enhance stem cell homing and engraftment. Basically, two forms of β-glucan preparations have been investigated, namely particulate and soluble ones. β-Glucans are generally well tolerated, the particulate forms showing a higher incidence of undesirable side effects. Taken together, the hematopoiesis-stimulating properties of β-glucans predetermine these biological response modifiers to ever increasing use in human medicinal practice.

Genes, Vol. 2, Pages 627-639: Comparative Genomics of Erwinia amylovora and Related Erwinia Species—What do We Learn?

Posted: 15 Sep 2011 12:00 AM PDT

Erwinia amylovora, the causal agent of fire blight disease of apples and pears, is one of the most important plant bacterial pathogens with worldwide economic significance. Recent reports on the complete or draft genome sequences of four species in the genus Erwinia, including E. amylovora, E. pyrifoliae, E. tasmaniensis, and E. billingiae, have provided us near complete genetic information about this pathogen and its closely-related species. This review describes in silico subtractive hybridization-based comparative genomic analyses of eight genomes currently available, and highlights what we have learned from these comparative analyses, as well as genetic and functional genomic studies. Sequence analyses reinforce the assumption that E. amylovora is a relatively homogeneous species and support the current classification scheme of E. amylovora and its related species. The potential evolutionary origin of these Erwinia species is also proposed. The current understanding of the pathogen, its virulence mechanism and host specificity from genome sequencing data is summarized. Future research directions are also suggested.

Molecules, Vol. 16, Pages 7958-7968: Allicin Reduces the Production of α-Toxin by Staphylococcus aureus

Posted: 15 Sep 2011 12:00 AM PDT

Staphylococcus aureus causes a broad range of life-threatening diseases in humans. The pathogenicity of this micro-organism is largely dependent upon its virulence factors. One of the most extensively studied virulence factors is the extracellular protein α-toxin. In this study, we show that allicin, an organosulfur compound, was active against S. aureus with MICs ranged from 32 to 64 μg/mL. Haemolysis, Western blot and real-time RT-PCR assays were used to evaluate the effects of allicin on S. aureus α-toxin production and on the levels of gene expression, respectively. The results of our study indicated that sub-inhibitory concentrations of allicin decreased the production of α-toxin in both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) in a dose-dependent manner. Furthermore, the transcriptional levels of agr (accessory gene regulator) in S. aureus were inhibited by allicin. Therefore, allicin may be useful in the treatment of α-toxin-producing S. aureus infections.

Information, Vol. 2, Pages 528-545: Pearson-Fisher Chi-Square Statistic Revisited

Posted: 15 Sep 2011 12:00 AM PDT

The Chi-Square test (χ2 test) is a family of tests based on a series of assumptions and is frequently used in the statistical analysis of experimental data. The aim of our paper was to present solutions to common problems when applying the Chi-square tests for testing goodness-of-fit, homogeneity and independence. The main characteristics of these three tests are presented along with various problems related to their application. The main problems identified in the application of the goodness-of-fit test were as follows: defining the frequency classes, calculating the X2 statistic, and applying the χ2 test. Several solutions were identified, presented and analyzed. Three different equations were identified as being able to determine the contribution of each factor on three hypothesizes (minimization of variance, minimization of square coefficient of variation and minimization of X2 statistic) in the application of the Chi-square test of homogeneity. The best solution was directly related to the distribution of the experimental error. The Fisher exact test proved to be the "golden test" in analyzing the independence while the Yates and Mantel-Haenszel corrections could be applied as alternative tests.

Forests, Vol. 2, Pages 777-796: Increasing Drought Sensitivity and Decline of Atlas Cedar (Cedrus atlantica) in the Moroccan Middle Atlas Forests

Posted: 15 Sep 2011 12:00 AM PDT

An understanding of the interactions between climate change and forest structure on tree growth are needed for decision making in forest conservation and management. In this paper, we investigated the relative contribution of tree features and stand structure on Atlas cedar (Cedrus atlantica) radial growth in forests that have experienced heavy grazing and logging in the past. Dendrochronological methods were applied to quantify patterns in basal-area increment and drought sensitivity of Atlas cedar in the Middle Atlas, northern Morocco. We estimated the tree-to-tree competition intensity and quantified the structure in Atlas cedar stands with contrasting tree density, age, and decline symptoms. The relative contribution of tree age and size and stand structure to Atlas cedar growth decline was estimated by variance partitioning using partial-redundancy analyses. Recurrent drought events and temperature increases have been identified from local climate records since the 1970s. We detected consistent growth declines and increased drought sensitivity in Atlas cedar across all sites since the early 1980s. Specifically, we determined that previous growth rates and tree age were the strongest tree features, while Quercus rotundifolia basal area was the strongest stand structure measure related to Atlas cedar decline. As a result, we suggest that Atlas cedar forests that have experienced severe drought in combination with grazing and logging may be in the process of shifting dominance toward more drought-tolerant species such as Q. rotundifolia.

Another Day in the Country

Posted: 14 Sep 2011 11:42 PM PDT

I'm not sure that breasts are a topic up for discussion in this portion of The Marion Record, but I'm going to give it a try.

The lazy man's way to pickles: Fresh dill pickles need no canning

Posted: 14 Sep 2011 11:42 PM PDT

These crisp, lively fresh dill pickles get their flavor from dill, garlic, jalapeA o peppers, coriander, and mustard and fennel seeds.

This posting includes an audio/video/photo media file: Download Now

Quiz to mark 80 years of Abbey Road studios

Posted: 14 Sep 2011 11:42 PM PDT

IT IS one of the world's most famous music studios where some of the greatest albums have been recorded.

This posting includes an audio/video/photo media file: Download Now

Forests, Vol. 2, Pages 749-776: A Flexible Hybrid Model of Life Cycle Carbon Balance for Loblolly Pine (Pinus taeda L.) Management Systems

Posted: 15 Sep 2011 12:00 AM PDT

In this study we analyzed the effects of silvicultural treatments on carbon (C) budgets in Pinus taeda L. (loblolly pine) plantations in the southeastern United States. We developed a hybrid model that integrated a widely used growth and yield model for loblolly pine with published allometric and biometric equations to simulate in situ C pools. The model used current values of forest product conversion efficiencies and forest product decay rates to calculate ex situ C pools. Using the model to evaluate the effects of silvicultural management systems on C sequestration over a 200 year simulation period, we concluded that site productivity (site quality), which can be altered by silviculture and genetic improvement, was the major factor controlling stand C density. On low productivity sites, average net C stocks were about 35% lower than in stands with the default average site quality; in contrast, on high quality sites, C stocks were about 38% greater than average productivity stands. If woody products were incorporated into the accounting, thinning was C positive because of the larger positive effects on ex situ C storage, rather than smaller reductions on in situ C storage. The use of biological rotation age (18 years) was not suitable for C sequestration, and extended rotation ages were found to increase stand C stock density. Stands with an 18-year-rotation length had 7% lower net C density than stands with a 22-year-rotation length; stands with a 35-year-rotation length had only 4% more C than stands harvested at age 22 years. The C sequestered in woody products was an important pool of C storage, accounting for ~34% of the average net C stock. Changes in decomposition rate, associated with possible environmental changes resulting from global climate change, affected C storage capacity of the forest. When decay rate was reduced to 10% or increased to 20%, the C stock in the dead pool (forest floor and coarse woody debris) was reduced about 11.8 MgC∙ha−1 or increased about 13.3 MgC∙ha−1, respectively, compared to the average decay rate of 15%. The C emissions due to silvicultural and harvest activities were small (~1.6% of the gross C stock) compared to the magnitude of total stand C stock. The C model, based on empirical and biological relationships, appears appropriate for use in regional C stock assessments for loblolly pine plantation ecosystems in the southern U.S.

Diversity, Vol. 3, Pages 503-530: Frogs, Fish and Forestry: An Integrated Watershed Network Paradigm Conserves Biodiversity and Ecological Services

Posted: 15 Sep 2011 12:00 AM PDT

Successfully addressing the multitude of stresses influencing forest catchments, their native biota, and the vital ecological services they provide humanity will require adapting an integrated view that incorporates the full range of natural and anthropogenic disturbances acting on these landscapes and their embedded fluvial networks. The concepts of dendritic networks, disturbance domains, the stream continuum, and hydrologic connectivity can facilitate this integration. Managing catchments based on these combined concepts would better maintain all the components of watersheds and the interacting processes that comprise their ecological integrity. To examine these ideas, I review riparian protection regulations in the Pacific Northwest of the United States, regulations considered by many to be among the best available, and evaluate their ability to protect headwater amphibians. I present evidence for the inadequacy of these rules to maintain robust populations of these amphibians, and discuss the implications of these shortcomings for downstream-dwelling coho salmon. Emphasizing headwaters (1st to 3rd-order channels), I discuss disturbance regimes and how differences in their fluvial and geomorphic processes determine the structuring of channels, their internal environments, and the composition of the resident biota. I examine amphibian dependence on specific channel attributes, and discuss links between their abundances, altered attribute states, and natural and anthropogenic disturbances. Using these examples, I discuss the limitations of current protections to maintain key attributes necessary to support robust populations of headwater amphibians, and via hydrologic connectivity, many downstream organisms. I propose that the goal of maintaining whole catchment biodiversity and ecological services could be improved by managing watersheds based on integrating science-based network organizing concepts and evaluating and adjusting outcomes with a suite of responsive bio-indicators.

Google Chrome 14.0.835.163 - Modern and fast Web browser (Beta).. (Free)

Posted: 14 Sep 2011 08:59 PM PDT



Google Chrome is a Web browser by Google, created to be a modern platform for web pages and applications. It utilizes very fast loading of web pages and has a V8 engine, which is a custom built JavaScript engine. Because Google has used parts from Apple's Safari and Firefox browsers, they made the project open source.

Version 14.0.835.163:
  • Re-enables the enhanced completion functionality and takes some additional stability patches.


Mac OS X 10.5 or later

Download Now

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