понедельник, 19 ноября 2012 г.

Games

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HDR Darkroom 2 1.00 - High-dynamic-range imaging software.. (Demo)

Posted: 19 Nov 2012 02:36 AM PST



HDR Darkroom is imaging software with a high dynamic range.

Splendid natural scenery and well-thought-out composition are sometimes not enough for a great final image. The final image is either too bright or too dark. Details once seen by the naked eye are completely lost in the shadows or in blown out highlights.

HDR Darkroom, a revolutionary high dynamic range imaging software can solve your problem, by squeezing extended details that would otherwise be lost into your image. Take three bracketed photos: one normal-exposed, one over-exposed and one under-exposed. HDR Darkroom can emulate the range of details that the human eye can detect by compressing the content of multiple frames into a single image. The results contain rich details and vivid colors without introducing anomalies such as halos or other blemishes. This is the strength of HDR Darkroom.

For those starting out in HDR photography, HDR Darkroom is a perfect fit. It has simple to understand controls, and you'll be on your way to create astonishing HDRs in no time!

Cutting Edge Local Tone Mapping Technology:

As photographers we have managed to improve our images using a myriad of manual techniques over the years, but now there is a much easier way to do it. And we at Everimaging, understand your need to achieve photo-realistic results on your HDRs. Using our Local Tone Mapping Technology, you will produce the most spectacular photo-realistic results.

Easy-to-use UI:

We have been working together with photographers to fully understand their workflow and include it in HDR Darkroom. It just keeps getting better.

Powerful Batch processing:

HDR Darkroom batch processing engine is dynamic. As each image is analyzed in the process, suitable defaults are applied. This allows you to use batch processing in a more powerful way, saving you countless hours of unnecessary manual adjustments. Those adjustments are still available for people who want to make them by hand.

Sophisticated Camera Raw File Converter:

HDR Darkroom supports RAW files captured by more than 150 camera models like Canon, Nikon, Sony, Olympus and Panasonic as well as Adobe (DNG). The newly released formats will be included in new releases once they become available.

Innovative workflows to choose from:

When you use HDR Darkroom you can choose from of the following professional workflows:

1. HDR Composition workflow (HDR Composition): In this workflow, multi-exposed 8-bit (jpeg, bmp, png etc) or 16-bit (CR2, NEF, etc) RAW image data is needed to combine into HDR photos through the steps of noise reduction, alignment, de-ghosting, merging into HDR negatives and tone mapping. This workflow usually produces the most spectacular photos. To see some examples, please use this link: http://www.everimaging.com/examples.htm

2. Tone Mapping based RAW converter workflow (RAW converter): HDR Darkroom is also a RAW converter. Different from conventional RAW converters, HDR Darkroom inserts Everimaging's sophisticated tone mapping engines DIRECTLY into the RAW conversion process and thus better reproducing the details, colors and contrast. To learn the difference between HDR Darkroom's Tone Mapping based RAW converter and other RAW converters, please use this link: http://www.everimaging.com/examples/RAWworkflow.aspx

Mac OS X 10.6 or later, Intel

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Remote Sensing, Vol. 4, Pages 3571-3595: Improving Wishart Classification of Polarimetric SAR Data Using the Hopfield Neural Network Optimization Approach

Posted: 19 Nov 2012 12:00 AM PST

This paper proposes the optimization relaxation approach based on the analogue Hopfield Neural Network (HNN) for cluster refinement of pre-classified Polarimetric Synthetic Aperture Radar (PolSAR) image data. We consider the initial classification provided by the maximum-likelihood classifier based on the complex Wishart distribution, which is then supplied to the HNN optimization approach. The goal is to improve the classification results obtained by the Wishart approach. The classification improvement is verified by computing a cluster separability coefficient and a measure of homogeneity within the clusters. During the HNN optimization process, for each iteration and for each pixel, two consistency coefficients are computed, taking into account two types of relations between the pixel under consideration and its corresponding neighbors. Based on these coefficients and on the information coming from the pixel itself, the pixel under study is re-classified. Different experiments are carried out to verify that the proposed approach outperforms other strategies, achieving the best results in terms of separability and a trade-off with the homogeneity preserving relevant structures in the image. The performance is also measured in terms of computational central processing unit (CPU) times.

Remote Sensing, Vol. 4, Pages 3544-3570: Estimating CO2 Sequestration by Forests in Oita Prefecture, Japan, by Combining LANDSAT ETM+ and ALOS Satellite Remote Sensing Data

Posted: 19 Nov 2012 12:00 AM PST

CO2 sequestration of the forests in Oita Prefecture, Japan, was estimated using satellite remote sensing data. First, hybrid classification of the optical LANDSAT ETM+ data was performed using GIS to produce a detailed land cover map. CO2 sequestration for each forest type was calculated using the sequestration rates per unit area multiplied by the forest areas obtained from the land cover map This results in 3.57 MtCO2/yr for coniferous, 0.77 MtCO2/yr for deciduous broadleaf, and 2.25 MtCO2/yr for evergreen broadleaf, equivalent to a total of 6.60 MtCO2/yr for all the forest covers in Oita. Then, two different methodologies were used to improve these estimates by considering tree ages: the Normalized Difference Vegetation Index (NDVI) and the stem volume methods. Calculation using the NDVI method shows the limitation of this method in providing detailed estimations for trees older than 15 years, because of NDVI saturation beyond this age. In the stem volume method, tree ages were deduced from stem volume values obtained by using PALSAR backscattering data. Sequestration based on tree age forest subclasses yields 2.96 MtCO2/yr (coniferous) and 0.31 MtCO2/yr (deciduous broadleaf forests). These results show the importance of using not only detailed forest types, but also detailed tree age information for more realistic CO2 sequestration estimates. In so doing, overestimation of the sequestration capacity of forests could be avoided, and the information on the status and location of forest resources could be improved, thereby leading to sounder decision making in sustainable management of forest resources.

Remote Sensing, Vol. 4, Pages 3528-3543: Estimating Aerosol Emissions by Assimilating Remote Sensing Observations into a Global Transport Model

Posted: 19 Nov 2012 12:00 AM PST

We present a fixed-lag ensemble Kalman smoother for estimating emissions for a global aerosol transport model from remote sensing observations. We assimilate AERONET AOT and AE as well as MODIS Terra AOT over ocean to estimate the emissions for dust, sea salt and carbon aerosol and the precursor gas SO2. For January 2009, globally dust emission decreases by 26% (to 3,244 Tg/yr), sea salt emission increases by 190% (to 9073 Tg/yr), while carbon emission increases by 45% (to 136 Tg/yr), compared with the standard emissions. Remaining errors in global emissions are estimated at 62% (dust), 18% (sea salt) and 78% (carbons), with the large errors over land mostly due to the sparseness of AERONET observations. The new emissions are verified by comparing a forecast run against independent MODIS Aqua AOT, which shows significant improvement over both ocean and land. This paper confirms the usefulness of remote sensing observations for improving global aerosol modelling.

Remote Sensing, Vol. 4, Pages 3501-3527: Analysis of MODIS LST Compared with WRF Model and in situ Data over the Waimakariri River Basin, Canterbury, New Zealand

Posted: 19 Nov 2012 12:00 AM PST

In this study we examine the relationship between remotely sensed, in situ and modelled land surface temperature (LST) over a heterogeneous land-cover (LC) enclosed in alpine terrain. This relationship can help to understand to what extent the remotely sensed data can be used to improve model simulations of land surface parameters such as LST in mountainous areas. LST from the MODerate resolution Imaging Spectro-radiometer (MODIS), the modelled surface skin temperature by the Weather Research and Forecasting (WRF) mesoscale numerical model and the in situ measurements of surface temperature are used in the analysis. The test-site is located in a mountain valley in the Southern Alps of New Zealand. Geospatial analysis in GIS is used to relate pixels, grid-cells and points from the MODIS LST, model simulations and the in situ data, respectively. Differences between LST from MODIS, the WRF model and the in situ data are presented with respect to surface LC at different times of day. Initial results from regression analysis of the three datasets showed a goodness of fit R2 coefficient of 0:77 for the model simulations and 0:35 for the MODIS LST. These values improved significantly when time-lags were considered and the few outliers were removed, giving R2 values of 0:80 for the model and 0:73 for the MODIS LST. These results show that the WRF model correlates better with the in situ measurements over various LC types in this region compared with the MODIS LST. Longer time-series, however, are required to draw more robust conclusions about the applicability of the MODIS LST product for improving WRF simulations over alpine complex terrain.

Molecules, Vol. 17, Pages 13656-13661: Clerodendranoic Acid, a New Phenolic Acid from Clerodendranthus spicatus

Posted: 19 Nov 2012 12:00 AM PST

Phenolic acid derivatives are typical constituents of Clerodendranthus spicatus which were considered to the active principles of this medicinal plant. These chemical constituents with their interesting frameworks and biological significance attracted our attention. As part of our ongoing chemical investigation of C. spicatus using various column chromatography techniques, a new phenolic compound, named clerodendranoic acid (1), was isolated from the aerial parts of C. spicatus together with five known ones, including rosmarinic acid (2), methyl rosmarinate (3), caffeic acid (4), methyl caffeate (5), ethyl caffeate (6). Their structures, including stereochemical configurations, were completely established by extensive spectroscopic methods, mainly inclvolving 1D, 2D NMR, as well as HRESIMS.

Molecules, Vol. 17, Pages 13642-13655: Synthesis and Antimicrobial Activity of Some New Pyrimidinone and Oxazinone Derivatives Fused with Thiophene Rings Using 2-Chloro-6-ethoxy-4-acetylpyridine as Starting Material

Posted: 19 Nov 2012 12:00 AM PST

A series of pyridines, pyrimidinones, oxazinones and their derivatives were synthesized as antimicrobial agents using citrazinic acid (2,6-dihydroxyisonicotinic acid) as a starting material. α,β-Unsaturated ketones 3a–c were condensed with cyanothio-acetamide in the presence of ammonium acetate to give 2-cyanopyridinethiones 4a–c, which were reacted with ethyl chloroacetate to yield the corresponding cyano esters 5a–c. The esters 5a–c were cyclized by action of sodium methoxide to aminoesters 6a–c, which were aminolyzed with ammonia to corresponding aminoamide derivatives 7a-c. Also, the esters 6a–c were hydrolyzed with NaOH to the corresponding sodium salt 8a–c, which were treated with acetic anhydride to afford 2-methyloxazinones 9a–c. The latter compounds were treated with ammonium acetate to afford 2-methylpyrimidinones 10a–c, followed by methylation with methyl iodide to yield 2,3-dimethyl-pyrimidinones 11a–c. The antimicrobial screening showed that many of these compounds have good antibacterial and antifungal activities comparable to streptomycin and fusidic acid used as reference drugs.

IJERPH, Vol. 9, Pages 4223-4240: Integral Dose and Radiation-Induced Secondary Malignancies: Comparison between Stereotactic Body Radiation Therapy and Three-Dimensional Conformal Radiotherapy

Posted: 19 Nov 2012 12:00 AM PST

The aim of the present paper is to compare the integral dose received by non-tumor tissue (NTID) in stereotactic body radiation therapy (SBRT) with modified LINAC with that received by three-dimensional conformal radiotherapy (3D-CRT), estimating possible correlations between NTID and radiation-induced secondary malignancy risk. Eight patients with intrathoracic lesions were treated with SBRT, 23 Gy × 1 fraction. All patients were then replanned for 3D-CRT, maintaining the same target coverage and applying a dose scheme of 2 Gy × 32 fractions. The dose equivalence between the different treatment modalities was achieved assuming α/β = 10Gy for tumor tissue and imposing the same biological effective dose (BED) on the target (BED = 76Gy10). Total NTIDs for both techniques was calculated considering α/β = 3Gy for healthy tissue. Excess absolute cancer risk (EAR) was calculated for various organs using a mechanistic model that includes fractionation effects. A paired two-tailed Student t-test was performed to determine statistically significant differences between the data (p ≤ 0.05). Our study indicates that despite the fact that for all patients integral dose is higher for SBRT treatments than 3D-CRT (p = 0.002), secondary cancer risk associated to SBRT patients is significantly smaller than that calculated for 3D-CRT (p = 0.001). This suggests that integral dose is not a good estimator for quantifying cancer induction. Indeed, for the model and parameters used, hypofractionated radiotherapy has the potential for secondary cancer reduction. The development of reliable secondary cancer risk models seems to be a key issue in fractionated radiotherapy. Further assessments of integral doses received with 3D-CRT and other special techniques are also strongly encouraged.

Metabolites, Vol. 2, Pages 959-982: Comparative Analysis of End Point Enzymatic Digests of Arabino-Xylan Isolated from Switchgrass (Panicum virgatum L) of Varying Maturities using LC-MSn

Posted: 19 Nov 2012 12:00 AM PST

Switchgrass (Panicum virgatum L., SG) is a perennial grass presently used for forage and being developed as a bioenergy crop for conversion of cell wall carbohydrates to biofuels. Up to 50% of the cell wall associated carbohydrates are xylan. SG was analyzed for xylan structural features at variable harvest maturities. Xylan from each of three maturities was isolated using classical alkaline extraction to yield fractions (Xyl A and B) with varying compositional ratios. The Xyl B fraction was observed to decrease with plant age. Xylan samples were subsequently prepared for structure analysis by digesting with pure endo-xylanase, which preserved side-groups, or a commercial carbohydrase preparation favored for biomass conversion work. Enzymatic digestion products were successfully permethylated and analyzed by reverse-phase liquid chromatography with mass spectrometric detection (RP-HPLC-MSn). This method is advantageous compared to prior work on plant biomass because it avoids isolation of individual arabinoxylan oligomers. The use of RP-HPLC- MSn differentiated 14 structural oligosaccharides (d.p. 3–9) from the monocomponent enzyme digestion and nine oligosaccharide structures (d.p. 3–9) from hydrolysis with a cellulase enzyme cocktail. The distribution of arabinoxylan oligomers varied depending upon the enzyme(s) applied but did not vary with harvest maturity.

Future Internet, Vol. 4, Pages 1016-1025: Supporting Trust and Privacy with an Identity-Enabled Architecture

Posted: 19 Nov 2012 12:00 AM PST

Cost reduction and a vastly increased potential to create new services, such as via the proliferation of the Cloud, have led to many more players and “end points”. With many of them being new entrants, possibly short-lived, the question of how to handle trust and privacy in this new context arises. In this paper, we specifically look at the underlying infrastructure that connects end-points served by these players, which is an essential part of the overall architecture to enable trust and privacy. We present an enhanced architecture that allows real people, objects and services to reliably interact via an infrastructure providing assured levels of trust.

Board games popular again

Posted: 19 Nov 2012 02:03 AM PST

From left, Kyle Heuer, Matt Hyra, Will Brinkman and Phil Cape play Hot Rod Creeps, a card-driven racing game, at Cryptozoic Entertainment in Irvine, Calif.

This posting includes an audio/video/photo media file: Download Now

RaiderZ officially launches this Tuesday

Posted: 18 Nov 2012 10:49 PM PST

New giveaway contests and Thanksgiving-themed event to be held starting next week.

 

Publisher Perfect World has announced that RaiderZ will officially launch on November 20.

In addition, the publisher will be hosting new giveaway contests for next week as well as introduce a new Thanksgiving event in-game. The free-to-play MMO recently went through an open beta phase that started on October 24. More details can be found on the official site for the game.

RaiderZ is an MMO following the style of Capcom's action RPG series Monster Hunter; players will need to band up with other online characters to defeat giant monsters and craft weapons out of their loot. For more information, check out GameSpot's recent coverage on the title.

Read and Post Comments | Get the full article at GameSpot

"RaiderZ officially launches this Tuesday" was posted by Jonathan Toyad on Sun, 18 Nov 2012 22:49:38 -0800

Indie devs team up to help fund LA game center

Posted: 18 Nov 2012 10:21 PM PST

Thirty indie developers, including the makers of Hotline Miami and Unfinished Swan, have teamed up for a Kickstarter campaign to develop 30 games for $15; proceeds will go toward funding LA Game Space.

 

Thirty independent game developers have teamed up to help fund a new creative space in Los Angeles that's dedicated to video games.

The LA Game Space will be designed as a non-profit centre for video game art, design, and research, offering exhibitions, workshops, and residencies available both at the site and online. The project has been underway for three years, and has enlisted the help of 30 independent game developers to launch a Kickstarter campaign to help with funding.

Each developer enlisted in the campaign, including the minds behind games such as Hotline Miami, Unfinished Swan, QWOP, and the Bit.Trip series, will develop a new game specifically for the project.

A game pack that will include all 30 games will be available for $15. For those wishing to donate more, other prizes include a founder credit, t-shirts, colour prints, and pixel portraits.

The campaign has amassed just over $35,000 of the $250,000 goal, and is due to finish on December 7. According to the developers, all 30 games in the pack will work with Windows, Mac, and, for the most part, Linux.

For more information, visit the LA Game Space Kickstarter page.

Read and Post Comments | Get the full article at GameSpot

"Indie devs team up to help fund LA game center " was posted by Laura Parker on Sun, 18 Nov 2012 22:21:49 -0800

Xbox World to reveal next-gen details in new issue - Report

Posted: 18 Nov 2012 10:01 PM PST

The magazine will reportedly use its penultimate issue to reveal details about the next-gen Xbox; the console is said to include Kinect 2.0, Blu-ray discs, and more.

 

The penultimate issue of Xbox World magazine will reportedly reveal new details about Microsoft's new Xbox console, according to CVG.

The magazine's editor reportedly told the site that the next-generation Xbox will most likely be called "Xbox" instead of "Xbox 720", and will ship with 8GB of RAM and a quad-core processor.

Other details about the new console that will reportedly be revealed by Xbox World include Kinect 2.0, Blu-ray discs, directional audio, a TV output and input, an "innovative" controller, and the possibility of augmented-reality (AR) glasses to be used at a later stage in the new console's life.

Microsoft has not officially confirmed that it is at work on a new console, but speculation about the new Xbox has been circulating for some time. In June, a 56-page document allegedly from Microsoft indicated that the company is planning to launch an Xbox 720 in 2013 at $299. An updated version of the Kinect was to be included, and AR glasses support would be added sometime after launch. The document has since been removed at the behest of Microsoft's legal team.

Earlier this month, Microsoft filed a patent for a new tech system designed to monitor viewers while they watch TV.

For more speculation regarding Microsoft's next home console, check out GameSpot's rumour roundup feature.

Read and Post Comments | Get the full article at GameSpot

"Xbox World to reveal next-gen details in new issue - Report" was posted by Laura Parker on Sun, 18 Nov 2012 22:01:19 -0800

Street Fighter X Tekken major patch arriving next year

Posted: 18 Nov 2012 09:54 PM PST

The version 2013 update will address frames for normal throws, quick combos, and feature character-specific tweaks; it will be out on January 29.

 

Capcom has announced the release date for the update of its major 2012 fighting game title, Street Fighter X Tekken.

According to a post by producer Tomoaki Ayano, the 2013 patch will be out on January 29. Concerning general changes, the patch will make recoverable health easier to spot, as it will change its colour from light yellow to red. Life-recovery speed will be adjusted so that players will rely less on timeout victories. Normal throws will have five frames instead of seven, so that they are viable against opponents playing defensively. The entire Tekken roster will have anti-air attacks improved.

For a few examples of character-specific tweaks, Kazuya's EX version of his Wind God Fist move makes him invincible throughout the entire attack. Ryu's heavy kick crouching sweep will have seven frames instead of the original attack's five frames, and Bryan's medium and heavy versions of his Fisherman's Slam cannot hit airborne opponents. For more detailed information, check out the Capcom Unity post.

Capcom will be hosting the grand finals of the Street Fighter 25th Anniversary tournament on December 8. The games featured in the tournament include Street Fighter X Tekken, Super Street Fighter IV Arcade Edition, Street Fighter III: 3rd Strike Online Edition, and Super Street Fighter II Turbo HD Remix.

Read and Post Comments | Get the full article at GameSpot

"Street Fighter X Tekken major patch arriving next year" was posted by Jonathan Toyad on Sun, 18 Nov 2012 21:54:50 -0800

Wii U users accidentally access console's debug mode

Posted: 18 Nov 2012 09:25 PM PST

NeoGAF posters claim to have stumbled across a debug menu on the newly released console.

 

Wii U users have reportedly stumbled across the console's debug menu just a day after the Wii U debuted in North America.

According to a NeoGAF post, user "Trike" was trying to set up his Miiverse friends list after purchasing a Wii U, and accidentally came across what appears to be the console's debug menu.

Screenshots posted by the user show how he was able to access a list of admins, with options to regenerate admin passwords and delete admin accounts. According to a follow-up post, he was also able to view messages from developers.

Another NeoGAF post by user "Tom_Cody" reported a similar problem. The user posted photos showing a test screen, which reportedly appeared when he tried to sync his Wii U GamePad with the system.

The Wii U launched in North America on November 18, beginning at $300 for an 8GB basic model and scaling to $350 for the 32GB deluxe version, which includes a copy of Nintendo Land.

The first high-definition system from Nintendo launched with 23 titles, including Call of Duty: Black Ops II and Assassin's Creed III.

GameSpot has reached out to Nintendo for comment.

Read and Post Comments | Get the full article at GameSpot

"Wii U users accidentally access console's debug mode" was posted by Laura Parker on Sun, 18 Nov 2012 21:25:48 -0800

Forests, Vol. 3, Pages 1034-1070: Fire Effects on Soils in Lake States Forests: A Compilation of Published Research to Facilitate Long-Term Investigations

Posted: 19 Nov 2012 12:00 AM PST

Fire-adapted forests of the Lake States region are poorly studied relative to those of the western and southeastern United States and our knowledge base of regional short- and long-term fire effects on soils is limited. We compiled and assessed the body of literature addressing fire effects on soils in Lake States forests to facilitate the re-measurement of previous studies for the development of new long-term datasets, and to identify existing gaps in the regional knowledge of fire effects on forest soils. Most studies reviewed addressed fire effects on chemical properties in pine-dominated forests, and long-term (>10 years) studies were limited. The major gaps in knowledge we identified include: (1) information on fire temperature and behavior information that would enhance interpretation of fire effects; (2) underrepresentation of the variety of forest types in the Lake States region; (3) information on nutrient fluxes and ecosystem processes; and (4) fire effects on soil organisms. Resolving these knowledge gaps via future research will provide for a more comprehensive understanding of fire effects in Lake States forest soils. Advancing the understanding of fire effects on soil processes and patterns in Lake States forests is critical for designing regionally appropriate long-term forest planning and management activities.

Viruses, Vol. 4, Pages 3227-3244: Safety and Immunogenicity of a Plant-Produced Recombinant Hemagglutinin-Based Influenza Vaccine (HAI-05) Derived from A/Indonesia/05/2005 (H5N1) Influenza Virus: A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study in Healthy Adults

Posted: 19 Nov 2012 12:00 AM PST

Recently, we have reported [1,2] on a subunit influenza vaccine candidate based on the recombinant hemagglutinin protein from the A/Indonesia/05/2005 (H5N1) strain of influenza virus, produced it using 'launch vector'-based transient expression technology in Nicotiana benthamiana, and demonstrated its immunogenicity in pre-clinical studies. Here, we present the results of a first-in-human, Phase 1 randomized, double-blind, placebo-controlled study designed to investigate safety, reactogenicity and immunogenicity of three escalating dose levels of this vaccine, HAI-05, (15, 45 and 90 µg) adjuvanted with Alhydrogel® (0.75 mg aluminum per dose) and the 90 µg dose level without Alhydrogel®. Vaccine was administered intramuscularly in two injections three weeks apart to healthy adults of 18–49 years of age. At all dose levels the vaccine was generally safe and well tolerated, with no reported serious adverse events or dose-limiting toxicities. Mild local and systemic reactions were observed in all vaccine dose groups and the placebo group and their occurrence was not dose related. The incidence rates were higher in the groups receiving vaccine with Alhydrogel®. The immune response elicited by the HAI-05 vaccine was variable with respect to both hemagglutination-inhibition and virus microneutralization antibody titers, with the highest responses observed in the 90 µg unadjuvanted group.

Viruses, Vol. 4, Pages 3209-3226: Virus Pathogen Database and Analysis Resource (ViPR): A Comprehensive Bioinformatics Database and Analysis Resource for the Coronavirus Research Community

Posted: 19 Nov 2012 12:00 AM PST

Several viruses within the Coronaviridae family have been categorized as either emerging or re-emerging human pathogens, with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) being the most well known. The NIAID-sponsored Virus Pathogen Database and Analysis Resource (ViPR, www.viprbrc.org) supports bioinformatics workflows for a broad range of human virus pathogens and other related viruses, including the entire Coronaviridae family. ViPR provides access to sequence records, gene and protein annotations, immune epitopes, 3D structures, host factor data, and other data types through an intuitive web-based search interface. Records returned from these queries can then be subjected to web-based analyses including: multiple sequence alignment, phylogenetic inference, sequence variation determination, BLAST comparison, and metadata-driven comparative genomics statistical analysis. Additional tools exist to display multiple sequence alignments, view phylogenetic trees, visualize 3D protein structures, transfer existing reference genome annotations to new genomes, and store or share results from any search or analysis within personal private ‘Workbench’ spaces for future access. All of the data and integrated analysis and visualization tools in ViPR are made available without charge as a service to the Coronaviridae research community to facilitate the research and development of diagnostics, prophylactics, vaccines and therapeutics against these human pathogens.

Viruses, Vol. 4, Pages 3179-3208: Insight into Alternative Approaches for Control of Avian Influenza in Poultry, with Emphasis on Highly Pathogenic H5N1

Posted: 19 Nov 2012 12:00 AM PST

Highly pathogenic avian influenza virus (HPAIV) of subtype H5N1 causes a devastating disease in poultry but when it accidentally infects humans it can cause death. Therefore, decrease the incidence of H5N1 in humans needs to focus on prevention and control of poultry infections. Conventional control strategies in poultry based on surveillance, stamping out, movement restriction and enforcement of biosecurity measures did not prevent the virus spreading, particularly in developing countries. Several challenges limit efficiency of the vaccines to prevent outbreaks of HPAIV H5N1 in endemic countries. Alternative and complementary approaches to reduce the current burden of H5N1 epidemics in poultry should be encouraged. The use of antiviral chemotherapy and natural compounds, avian-cytokines, RNA interference, genetic breeding and/or development of transgenic poultry warrant further evaluation as integrated intervention strategies for control of HPAIV H5N1 in poultry.
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