вторник, 6 ноября 2012 г.

Games

Games

Spector Pro 4759 - Mac desktop surveillance snapshot tool.. ()

Posted: 06 Nov 2012 03:08 AM PST

Spector Pro is a computer surveillance application that takes snapshots of a Mac's desktop at high frequencies. This allows you to view exactly what has been going on on a certain computer.

Spector is appropriate for parents concerned about what their children do online, or worried about protecting their children from the dangers of the Internet. Spector is also ideal for businesses concerned about how their employees use company computers.

Version 4759: Release notes were unavailable when this listing was updated.

Mac OS X 10.5 or later, Intel 32

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Sensors, Vol. 12, Pages 15119-15132: Immuno-MALDI-MS in Human Plasma and On-Chip Biomarker Characterizations at the Femtomole Level

Posted: 06 Nov 2012 12:00 AM PST

Immuno-SPR-MS is the combination of immuno-sensors in biochip format with mass spectrometry. This association of instrumentation allows the detection and the quantification of proteins of interest by SPR and their molecular characterization by additional MS analysis. However, two major bottlenecks must be overcome for a wide diffusion of the SPR-MS analytical platform: (i) To warrant all the potentialities of MS, an enzymatic digestion step must be developed taking into account the spot formats on the biochip and (ii) the biological relevancy of such an analytical solution requires that biosensing must be performed in complex media. In this study, we developed a procedure for the detection and the characterization at ~1 µg/mL of the LAG3 protein spiked in human plasma. The analytical performances of this new method was established, particularly its specificity (S/N > 9) and sensitivity (100% of LAG3 identification with high significant mascot score >68 at the femtomole level). The collective and automated on-chip MALDI-MS imaging and analysis based on peptidic fragments opens numerous applications in the fields of proteomics and diagnosis.

Sensors, Vol. 12, Pages 15088-15118: Power Impact of Loop Buffer Schemes for Biomedical Wireless Sensor Nodes

Posted: 06 Nov 2012 12:00 AM PST

Instruction memory organisations are pointed out as one of the major sources of energy consumption in embedded systems. As these systems are characterised by restrictive resources and a low-energy budget, any enhancement in this component allows not only to decrease the energy consumption but also to have a better distribution of the energy budget throughout the system. Loop buffering is an effective scheme to reduce energy consumption in instruction memory organisations. In this paper, the loop buffer concept is applied in real-life embedded applications that are widely used in biomedical Wireless Sensor Nodes, to show which scheme of loop buffer is more suitable for applications with certain behaviour. Post-layout simulations demonstrate that a trade-off exists between the complexity of the loop buffer architecture and the energy savings of utilising it. Therefore, the use of loop buffer architectures in order to optimise the instructionmemory organisation from the energy efficiency point of view should be evaluated carefully, taking into account two factors: (1) the percentage of the execution time of the application that is related to the execution of the loops, and (2) the distribution of the execution time percentage over each one of the loops that form the application.

Sensors, Vol. 12, Pages 15078-15087: Simple, Fast and Selective Detection of Adenosine Triphosphate at Physiological pH Using Unmodified Gold Nanoparticles as Colorimetric Probes and Metal Ions as Cross-Linkers

Posted: 06 Nov 2012 12:00 AM PST

We report a simple, fast and selective colorimetric assay of adenosine triphosphate (ATP) using unmodified gold nanoparticles (AuNPs) as probes and metal ions as cross-linkers. ATP can be assembled onto the surface of AuNPs through interaction between the electron-rich nitrogen atoms and the electron-deficient surface of AuNPs. Accordingly, Cu2+ ions induce a change in the color and UV/Vis absorbance of AuNPs by coordinating to the triphosphate groups and a ring nitrogen of ATP. A detection limit of 50 nM was achieved, which is comparable to or lower than that achievable by the currently used electrochemical, spectroscopic or chromatographic methods. The theoretical simplicity and high selectivity reported herein demonstrated that AuNPs-based colorimetric assay could be applied in a wide variety of fields by rationally designing the surface chemistry of AuNPs. In addition, our results indicate that ATP-modified AuNPs are less stable in Cu2+, Cd2+ or Zn2+-containing solutions due to the formation of the corresponding dimeric metal-ATP complexes.

Crystal Caverns - Screenshots

Posted: 06 Nov 2012 02:42 AM PST

You have 150 different puzzles that will thrill and challenge you. We created each and every puzzle by hand to make sure they are as interesting as possible. We almost couldn't beat some of them, so if you want to finish them all you're in for a real challenge.

If you manage to beat all 150 levels, you can play Random mode, and test your wits against an infinite number of randomly generated levels. Also, Crystal Caverns has an Endless mode for gamers with quick reflexes. Try to stay alive as long as possible as endless layers of crystals descend on you faster and faster.

Features:
- 150 hand-designed puzzles
- Three levels of difficulty
- Random mode ensures you never run out of games
- Endless mode keeps you on the edge of your seat
- Tracks your stats
- Beautiful glowing marble graphics

Smugglers 5 - Screenshots

Posted: 06 Nov 2012 02:50 AM PST

The fifth instalment in the long-running Smugglers series features a completely revised turn-based combat system and a range of new ships to fly, as well as a host of exciting features:
- Explore the galaxy through a fast turn-based travel and combat system
- 4 factions; 6 professions with new, unique skill trees; 100+ different skills and a revised skill system
- 30+ spaceships and encounters ranging from fighters to battleships, cruise missiles and star bases
- Non-linear war and campaign system. You can influence the war!
- Manage a crew, board enemy ships, become an Admiral and command whole fleets
- Plunder planets and pirate outposts, conquer space systems and even rule your own empire!
- Supply and demand based trading with prices influenced by storyline and campaign
- Advanced text generation technology and new short stories for planet exploration make every game different
- Marry a beautiful wife and have children
- Optional compatibility mode to allow blind players to enjoy the game

Role-Playing Games

Posted: 06 Nov 2012 02:11 AM PST

I'm not ashamed to admit that I played a lot of pencil-and-paper role-playing games when I was in high school.

This posting includes an audio/video/photo media file: Download Now

Sensors, Vol. 12, Pages 15063-15077: Indirect Determination of Mercury Ion by Inhibition of a Glucose Biosensor Based on ZnO Nanorods

Posted: 06 Nov 2012 12:00 AM PST

A potentiometric glucose biosensor based on immobilization of glucose oxidase (GOD) on ZnO nanorods (ZnO-NRs) has been developed for the indirect determination of environmental mercury ions. The ZnO-NRs were grown on a gold coated glass substrate by using the low temperature aqueous chemical growth (ACG) approach. Glucose oxidase in conjunction with a chitosan membrane and a glutaraldehyde (GA) were immobilized on the surface of the ZnO-NRs using a simple physical adsorption method and then used as a potentiometric working electrode. The potential response of the biosensor between the working electrode and an Ag/AgCl reference electrode was measured in a 1mM phosphate buffer solution (PBS). The detection limit of the mercury ion sensor was found to be 0.5 nM. The experimental results provide two linear ranges of the inhibition from 0.5 × 10−6 mM to 0.5 × 10−4 mM, and from 0.5 × 10−4 mM to 20 mM of mercury ion for fixed 1 mM of glucose concentration in the solution. The linear range of the inhibition from 10−3 mM to 6 mM of mercury ion was also acquired for a fixed 10 mM of glucose concentration. The working electrode can be reactivated by more than 70% after inhibition by simply dipping the used electrode in a 10 mM PBS solution for 7 min. The electrodes retained their original enzyme activity by about 90% for more than three weeks. The response to mercury ions was highly sensitive, selective, stable, reproducible, and interference resistant, and exhibits a fast response time. The developed glucose biosensor has a great potential for detection of mercury with several advantages such as being inexpensive, requiring minimum hardware and being suitable for unskilled users.

Sensors, Vol. 12, Pages 15036-15062: Interfacial Structures and Properties of Organic Materials for Biosensors: An Overview

Posted: 06 Nov 2012 12:00 AM PST

The capabilities of biosensors for bio-environmental monitoring have profound influences on medical, pharmaceutical, and environmental applications. This paper provides an overview on the background and applications of the state-of-the-art biosensors. Different types of biosensors are summarized and sensing mechanisms are discussed. A review of organic materials used in biosensors is given. Specifically, this review focuses on self-assembled monolayers (SAM) due to their high sensitivity and high versatility. The kinetics, chemistry, and the immobilization strategies of biomolecules are discussed. Other representative organic materials, such as graphene, carbon nanotubes (CNTs), and conductive polymers are also introduced in this review.

Sensors, Vol. 12, Pages 15009-15035: A WSN-Based Tool for Urban and Industrial Fire-Fighting

Posted: 06 Nov 2012 12:00 AM PST

This paper describes a WSN tool to increase safety in urban and industrial fire-fighting activities. Unlike most approaches, we assume that there is no preexisting WSN in the building, which involves interesting advantages but imposes some constraints. The system integrates the following functionalities: fire monitoring, firefighter monitoring and dynamic escape path guiding. It also includes a robust localization method that employs RSSI-range models dynamically trained to cope with the peculiarities of the environment. The training and application stages of the method are applied simultaneously, resulting in significant adaptability. Besides simulations and laboratory tests, a prototype of the proposed system has been validated in close-to-operational conditions.

Sensors, Vol. 12, Pages 14983-15008: Scanning Ion Conductance Microscopy for StudyingBiological Samples

Posted: 06 Nov 2012 12:00 AM PST

Scanning ion conductance microscopy (SICM) is a scanning probe technique that utilizes the increase in access resistance that occurs if an electrolyte filled glass micro-pipette is approached towards a poorly conducting surface. Since an increase in resistance can be monitored before the physical contact between scanning probe tip and sample, this technique is particularly useful to investigate the topography of delicate samples such as living cells. SICM has shown its potential in various applications such as high resolution and long-time imaging of living cells or the determination of local changes in cellular volume. Furthermore, SICM has been combined with various techniques such as fluorescence microscopy or patch clamping to reveal localized information about proteins or protein functions. This review details the various advantages and pitfalls of SICM and provides an overview of the recent developments and applications of SICM in biological imaging. Furthermore, we show that in principle, a combination of SICM and ion selective micro-electrodes enables one to monitor the local ion activity surrounding a living cell.

Sensors, Vol. 12, Pages 14968-14982: Flow Injection Analysis of Mercury Using 4-(Dimethylamino) Benzaldehyde-4-Ethylthiosemicarbazone as the Ionophore of a Coated Wire Electrode

Posted: 06 Nov 2012 12:00 AM PST

A flow injection analysis (FIA) incorporating a thiosemicarbazone-based coated wire electrode (CWE) was developed method for the determination of mercury(II). A 0.1 M KNO3 carrier stream with pH between 1 and 5 and flow rate of 1 mL·min−1 were used as optimum parameters. A linear plot within the concentration range of 5 × 10−6–0.1 M Hg(II), slope of 27.8 ± 1 mV per decade and correlation coefficient (R2) of 0.984 were obtained. The system was successfully applied for the determination of mercury(II) in dental amalgam solutions and spiked environmental water samples. Highly reproducible measurements with relative standard deviation (RSD < 1% (n = 3)) were obtained, giving a typical throughput of 30 samples·h−1.

The Little Crane That Could - Screenshots

Posted: 06 Nov 2012 02:28 AM PST

Play the first six action packed levels for free, and with a single one time purchase you can unlock all 24 levels in the game.

- Top notch physics.
- 6 free levels.
- 18 premium levels.
- Support for tablet devices.
- Gorgeous high resolution visuals.
- High frame rates on all modern devices.
- Drive mobile cranes, dump trucks, skid loaders and fork lifts.
- Fly a Sky Crane.

Now Ending: Halo 4

Posted: 05 Nov 2012 11:10 PM PST

GameSpot's Jonathan and Randolph shows off the end of 343 Industries' new beginning in Microsoft's console FPS juggernaut. Major spoilers: watch at your own risk.

 

Read and Post Comments | Get the full article at GameSpot

"Now Ending: Halo 4" was posted by rreydebarros on Mon, 05 Nov 2012 23:10:43 -0800

Grand Theft Auto V preorders available for Australia

Posted: 05 Nov 2012 05:09 PM PST

Australian retailers are now accepting preorders for GTA V; no mention of PC platform or exclusive content.

 

Get the full article at GameSpot

"Grand Theft Auto V preorders available for Australia" was posted by Zorine Te on Mon, 05 Nov 2012 17:09:20 -0800

The OzSpot 06/11/12: HorseZ Edition

Posted: 05 Nov 2012 04:26 PM PST

On this week's show we mix things up a bit to celebrate Melbourne Cup day; join us for some in-depth discussion on gaming news and topics!

Get the full article at GameSpot

"The OzSpot 06/11/12: HorseZ Edition" was posted by Zorine Te on Mon, 05 Nov 2012 16:26:13 -0800

Executive committee to start public consultations on Toronto casino

Posted: 06 Nov 2012 01:12 AM PST

File photo of a blackjack dealer at Seneca Niagara casino in Niagara Falls, N.Y. THE ASSOCIATED PRESS/ Don Heupel The city's executive committee voted unanimously to begin public consultations on a casino in Toronto, Monday.

This posting includes an audio/video/photo media file: Download Now

Sensors, Vol. 12, Pages 14953-14967: Toward In Situ Monitoring of Water Contamination by Nitroenergetic Compounds

Posted: 06 Nov 2012 12:00 AM PST

We have previously described the application of novel porous organosilicate materials to the preconcentration of nitroenergetic targets from aqueous solution prior to HPLC analysis. The performance of the sorbents and the advantages of these types of materials over commercially available solid phase extraction sorbents have been demonstrated. Here, the development of systems for application of those sorbents to in situ monitoring is described. Considerations such as column pressure, particulate filtration, and component durability are discussed. The diameter of selected column housings, the sorbent bed depth, and the frits utilized significantly impact the utility of the sorbent columns in the prototype system. The impact of and necessity for improvements in the morphological characteristics of the sorbents as they relate to reduction in column pressure are detailed. The results of experiments utilizing a prototype system are presented. Data demonstrating feasibility for use of the sorbents in preconcentration prior to ion mobility spectrometry is also presented.

Molecules, Vol. 17, Pages 13235-13253: Azide-Alkyne Huisgen [3+2] Cycloaddition Using CuO Nanoparticles

Posted: 06 Nov 2012 12:00 AM PST

Recent developments in the synthesis of CuO nanoparticles (NPs) and their application to the [3+2] cycloaddition of azides with terminal alkynes are reviewed. With respect to the importance of click chemistry, CuO hollow NPs, CuO hollow NPs on acetylene black, water-soluble double-hydrophilic block copolymer (DHBC) nanoreactors and ZnO–CuO hybrid NPs were synthesized. Non-conventional energy sources such as microwaves and ultrasound were also applied to these click reactions, and good catalytic activity with high regioselectivity was observed. CuO hollow NPs on acetylene black can be recycled nine times without any loss of activity, and water-soluble DHBC nanoreactors have been developed for an environmentally friendly process.

Molecules, Vol. 17, Pages 13221-13234: Preparation of Candesartan and Atorvastatin Nanoparticles by Solvent Evaporation

Posted: 06 Nov 2012 12:00 AM PST

The solubility, absorption and distribution of a drug are involved in the basic aspects of oral bioavailability Solubility is an essential characteristic and influences the efficiency of the drug. Over the last ten years, the number of poorly soluble drugs has steadily increased. One of the progressive ways for increasing oral bioavaibility is the technique of nanoparticle preparation, which allows many drugs to thus reach the intended site of action. Candesartan cilexetil and atorvastatin, belonging to class II of the biopharmaceutical classification system, were chosen as model active pharmaceutical ingredients in this study. Forty samples were prepared either by antisolvent precipitation/solvent evaporation method or by the emulsion/solvent evaporation technique with various commonly used surface-active excipients as nanoparticle stabilizers. All samples were analyzed by means of dynamic light scattering. The particle size of the determined 36 nanoparticle samples was to 574 nm, whereas 32 samples contained nanoparticles of less than 200 nm. Relationships between solvents and excipients used and their amount are discussed. Based on the results the investigated solvent evaporation methods can be used as an effective and an affordable technique for the preparation of nanoparticles.
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