вторник, 27 ноября 2012 г.

Games

Games

Hotline Miami 2 confirmed

Posted: 26 Nov 2012 09:59 PM PST

Game creator Jonatan Söderström says original intention for DLC shifted into a fully-fledged sequel to hit indie title; says the studio is still working on "fixing" Hotline Miami.

 

Hotline Miami creator Jonatan Söderström has revealed there will be a sequel to the hit indie title.

The developer took to Twitter this week to tell fans that a preliminary Hotline Miami 2 soundtrack was in the works.

"Working while listening to the sweet tunes of a preliminary Hotline Miami 2 soundtrack that we've put together during the weekend," Söderström said.

The comments were later clarified in a Eurogamer article, in which Söderström revealed the planned DLC for Hotline Miami eventually turned into a fully-fledged game, which the studio plans to reveal as Hotline Miami 2 rather than DLC for the first game.

However, Söderström later Tweeted that the team only has some "general plans" for the next game and that their main priority remains "fixing Hotline Miami".

For more on Hotline Miami, check out GameSpot's review.

Read and Post Comments | Get the full article at GameSpot

"Hotline Miami 2 confirmed" was posted by Laura Parker on Mon, 26 Nov 2012 21:59:21 -0800

BotBlast Pro - Screenshots

Posted: 27 Nov 2012 02:36 AM PST

If you're a fan of space, science, aliens or robots then our latest iPhone game is sure to be just what you've been searching for. There are three levels of play inside BotBlast Pro and this game will definitely appeal to casual game players. Robot fans will have fun selecting from four different Bots.  It's always fun to play with the awesome Gold Bot.

Dropple - Screenshots

Posted: 27 Nov 2012 02:30 AM PST

Use simple tilt controls to bounce Dropple from his garden home through 170+ levels in visually stunning worlds, avoiding obstacles from spikes to lasers utilizing parachutes, jetpacks, and anti-gravity.

Features:
-Simple tilt and one touch control
-Master over 170 levels avoiding spikes, fire, explosions, and more!
-Collect all Golden Droplets in as few bounces as possible for score multipliers
-Rewind time to get a second chance at difficult moves
-Become impervious to obstacles with the Invulnerability Shield
-Attract hard-to-reach Golden Droplets with the Magnet

Fun Steps - Screenshots

Posted: 27 Nov 2012 02:22 AM PST

Features:
- Monsters included: Zombie, T. Rex, Stregoceras.
- Motion Detection technology
- Step Sensitivity is customizable
- Zombie and dino voices
- Experience sharing capacity on Facebook
- Walking delay adjustable
- Instructions included
- Lot of fun, entertainment, and party.

Wizard Pro 1.1.1 - Tool for data analysis and exploration.. (Demo)

Posted: 27 Nov 2012 02:46 AM PST



Wizard Pro is a multivariate statistics program for data analysis and exploration. The software keeps all work (tables, results, predictions) in a single document with an iTunes-like navigator and provides interactive interfaces for querying data. It includes basic statistics tests, regression models and results, stacking and joining of tables, indicator variables with custom logic, import of XLS, CSV, and tab-delimited files, import/export of Stata, SPSS, and R files, export of models as Stata, SPSS, and R commands, and more.

Version 1.1.1:
  • Fix critical bug where saved multivariate models would not open on OS X 10.8.
  • Fix bug in tutorial.
Note: The demo is for version 1.1.0, but version 1.1.1 is available for purchase at the Mac App Store.

  • Mac OS X 10.6 or later
  • Intel
  • 64-bit processor


Download Now

Pharmaceutics, Vol. 4, Pages 590-606: Composition Influence on Pulmonary Delivery of Rifampicin Liposomes

Posted: 27 Nov 2012 12:00 AM PST

The effects of lipid concentration and composition on the physicochemical properties, aerosol performance and in vitro toxicity activity of several rifampicin-loaded liposomes were investigated. To this purpose, six liposome formulations containing different amounts of soy phosphatidylcholine and hydrogenated soy phosphatidylcholine, with and without cholesterol and oleic acid, were prepared and fully characterized. Uni- or oligo-lamellar, small (~100 nm), negatively charged (~60 mV) vesicles were obtained. Lipid composition affected aerosol delivery features of liposomal rifampicin; in particular, the highest phospholipid concentration led to a better packing of the vesicular bilayers with a consequent higher nebulization stability. The retention of drug in nebulized vesicles (NER%) was higher for oleic acid containing vesicles (55% ± 1.4%) than for the other samples (~47%). A549 cells were used to evaluate intracellular drug uptake and in vitro toxicity activity of rifampicin-loaded liposomes in comparison with the free drug. Cell toxicity was more evident when oleic acid containing liposomes were used.

Pharmaceuticals, Vol. 5, Pages 1282-1290: Synthesis and COX-2 Inhibitory Activity of 4-[(E)-2-(4-Oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethenyl]benzene-1-sulfonamide and Its Analogs

Posted: 27 Nov 2012 12:00 AM PST

Some novel 3-phenyl-2-[(E)-2-phenylethenyl]-3,4-dihydroquinazolin-4-one derivatives possessing para-sulfonamides groups on the phenyl ring of the 2-phenylethenyl moiety have been synthesized and their COX-2 inhibitory activity evaluated. The stuctures of the synthesized compounds were confirmed  on the basis of  FT-IR, 1H-NMR, 13C-NMR and mass spectral data. The COX-2 inhibition screening assay revealed that 4-[(E)-2-{3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl}ethenyl]benzene-1-sulfonamide had a  maximum COX-2 inhibition (47.1%), at a concentration of 20 μM.

Nanomaterials, Vol. 2, Pages 428-444: Spontaneous Deposition of Prussian Blue on Multi-Walled Carbon Nanotubes and the Application in an Amperometric Biosensor

Posted: 27 Nov 2012 12:00 AM PST

A simple method has been developed for the spontaneous deposition of Prussian blue (PB) particles from a solution containing only ferricyanide ions onto conducting substrates such as indium tin oxide glass, glassy carbon disk and carbon nanotube (CNT) materials. Formation of PB deposits was confirmed by ultraviolet-visible absorption spectrometry and electrochemical techniques. The surface morphology of the PB particles deposited on the substrates was examined by atomic force microscopy and scanning electron microscopy. CNT/PB composite modified glassy carbon electrodes exhibited an electrocatalytic property for hydrogen peroxide reduction. These modified electrodes exhibited a high sensitivity for electrocatalytic reduction of hydrogen peroxide at −0.05 V (vs. Ag|AgCl), probably due to the synergistic effect of CNT with PB. Then, CNT/PB modified electrodes were further developed as amperometric glucose biosensors. These biosensors offered a linear response to glucose concentration from 0.1 to 0.9 mM with good selectivity, high sensitivity of 0.102 A M−1 cm−2 and short response time (within 2 s) at a negative operation potential of −0.05 V (vs. Ag|AgCl). The detection limit was estimated to be 0.01 mM at a signal-to-noise ratio of 3.

Nutrients, Vol. 4, Pages 1851-1867: Dose and Latency Effects of Leucine Supplementation in Modulating Glucose Homeostasis: Opposite Effects in Healthy and Glucocorticoid-Induced Insulin-Resistance States

Posted: 27 Nov 2012 12:00 AM PST

Dexamethasone (DEXA) is a potent immunosupressant and anti-inflammatory agent whose main side effects are muscle atrophy and insulin resistance in skeletal muscles. In this context, leucine supplementation may represent a way to limit the DEXA side effects. In this study, we have investigated the effects of a low and a high dose of leucine supplementation (via a bolus) on glucose homeostasis, muscle mass and muscle strength in energy-restricted and DEXA-treated rats. Since the leucine response may also be linked to the administration of this amino acid, we performed a second set of experiments with leucine given in bolus (via gavage) versus leucine given via drinking water. Leucine supplementation was found to produce positive effects (e.g., reduced insulin levels) only when administrated in low dosage, both via the bolus or via drinking water. However, under DEXA treatment, leucine administration was found to significantly influence this response, since leucine supplementation via drinking water clearly induced a diabetic state, whereas the same effect was not observed when supplied via the gavage.

Nutrients, Vol. 4, Pages 1828-1850: The Use of Fish Oil Lipid Emulsion in the Treatment of Intestinal Failure Associated Liver Disease (IFALD)

Posted: 27 Nov 2012 12:00 AM PST

Since 2004, fish oil based lipid emulsions have been used in the treatment of intestinal failure associated liver disease, with a noticeable impact on decreasing the incidence of morbidity and mortality of this often fatal condition. With this new therapy, however, different approaches have emerged as well as concerns about potential risks with using fish oil as a monotherapy. This review will discuss the experience to date with this lipid emulsion along with the rational for its use, controversies and concerns.

Nutrients, Vol. 4, Pages 1812-1827: Retinal Spectral Domain Optical Coherence Tomography in Early Atrophic Age-Related Macular Degeneration (AMD) and a New Metric for Objective Evaluation of the Efficacy of Ocular Nutrition

Posted: 27 Nov 2012 12:00 AM PST

Purpose: A challenge in ocular preventive medicine is identification of patients with early pathological retinal damage that might benefit from nutritional intervention. The purpose of this study is to evaluate retinal thinning (RT) in early atrophic age-related macular degeneration (AMD) against visual function data from the Zeaxanthin and Visual Function (ZVF) randomized double masked placebo controlled clinical trial (FDA IND #78973). Methods: Retrospective, observational case series of medical center veterans with minimal visible AMD retinopathy (AREDS Report #18 simplified grading 1.4/4.0 bilateral retinopathy). Foveal and extra-foveal four quadrant SDOCT RT measurements were evaluated in n = 54 clinical and ZVF AMD patients. RT by age was determined and compared to the OptoVue SD OCT normative database. RT by quadrant in a subset of n = 29 ZVF patients was correlated with contrast sensitivity and parafoveal blue cone increment thresholds. Results: Foveal RT in AMD patients and non-AMD patients was preserved with age. Extrafoveal regions, however, showed significant slope differences between AMD patients and non-AMD patients, with the superior and nasal quadrants most vulnerable to retinal thinning (sup quad: −5.5 μm/decade thinning vs. Non-AMD: −1.1 μm/decade, P < 0.02; nasal quad: −5.0 μm/decade thinning vs. Non-AMD: −1.0 μm/decade, P < 0.04). Two measures of extrafoveal visual deterioration were correlated: A significant inverse correlation between % RT and contrast sensitivity (r = −0.33, P = 0.01, 2 Tailed Paired T) and an elevated extrafoveal increment blue cone threshold (r = +0.34, P = 0.01, 2 Tailed T). Additional SD OCT RT data for the non-AMD oldest age group (ages 82–91) is needed to fully substantiate the model. Conclusion: A simple new SD OCT clinical metric called “% extra-foveal RT” correlates well with functional visual loss in early AMD patients having minimal visible retinopathy. This metric can be used to follow the effect of repleting ocular nutrients, such as zinc, antioxidants, carotenoids, n-3 essential fats, resveratrol and vitamin D.

Entropy, Vol. 14, Pages 2408-2412: Natural/Unconventional Computing and Its Philosophical Significance

Posted: 27 Nov 2012 12:00 AM PST

In this special issue we present a selection of papers from the Symposium on Natural/Unconventional Computing and its Philosophical Significance, held during the AISB/IACAP 2012 World Congress in Birmingham (UK). This article is an editorial, introducing the special issue of the journal with the selected papers and the research program of Natural/Unconventional Computing.

X-Plane 10.20 - Ultra-realistic flight simulator (beta).. (Updater)

Posted: 27 Nov 2012 02:27 AM PST



X-Plane is the world's most comprehensive, powerful flight simulator, and has the most realistic flight model available for personal computers.

Welcome to the world of props, jets, single- and multi-engine airplanes, as well as gliders, helicopters and VTOLs such as the V-22 Osprey and AV8-B Harrier.

X-Plane comes with subsonic and supersonic flight dynamics, sporting aircraft from the Bell 206 Jet-Ranger helicopter and Cessna 172 light plane to the supersonic SR-71 and Space Shuttle. X-Plane comes with 35 aircraft spanning the aviation industry (and history), and several thousand more are freely downloadable from the internet. (See www.X-Plane.org as a good place to start).

X-Plane scenery is world-wide, with scenery for the entire planet Earth between 74 degrees north to 60 degrees south latitude. We also have MARS scenery! (thanks to the Mars Orbiting Laser Altimeter, which mapped that planet's elevation). On Earth, you can land at any of over 33,000 airports, as well as test your mettle on aircraft carriers, helipads on building tops, frigates that pitch and roll in the waves, and oil rigs.

Weather is variable from clear skies and high visibility to thunderstorms with controllable wind, wind shear, turbulence, and microbursts! Rain, snow and clouds are available for an instrument flying challenge, and thermals are available for the gliders! Real weather conditions can be downloaded from the internet, allowing you to fly in the actual weather that currently exists at the location of flight!

X-Plane also has detailed failure-modeling, with multitudes of systems that can be failed manually or randomly, when you least expect it! You can fail instruments, engines, flight controls, landing gear, or dozens of other systems at any moment.

While X-Plane is the world's most COMPREHENSIVE flight sim, your purchase also comes with Plane-Maker (to create your own airplanes) Airfoil-Maker (allowing users to create airfoil performance profiles), and Weather Briefer (to get a weather briefing before the flight if you use real weather conditions downloaded from the internet).

X-Plane is also extremely customizable, allowing you to easily create textures, sounds, and instrument panels for your own airplanes that you design or the planes that come with the sim.

X-Plane's accuracy (in flight model), scope (in aircraft and terrain coverage), versatility (in aircraft type and weather conditions), add-on programs (in aircraft and scenery editors), customizability, downloadable aircraft, and downloadable scenery makes it the ULTIMATE flight simulation experience for Mac, Windows, and Linux platforms.

BE SURE TO TURN ON THE BETA option in the installer before you run it to get the beta!

The demo contains a limited scenery area to keep the download size reasonable. It will run for 10 minutes before it begins to ignore the user's input, at which point the simulator must be restarted to fly more.



Version 10.20 (beta 5):
  • New autogen from Alex. This is not the complete autogen work he has done; it is an interim step.
  • New terrain textures from Albert.
  • Bug fixes to the Kingair and KSEA from Tom.
  • New 3-d exterior on the Harrier from Javier.


  • Mac OS X 10.5 or later
  • a 2 GHz, dual-core CPU
  • 2 GB of RAM
  • a DirectX 9-capable video card with 128 MB of on-board, dedicated video RAM (VRAM). See here for compatibility and graphics cards.


Download Now

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Safari Omnikey 1.0.3 - Chrome-like keyword search for Safari.. (Free)

Posted: 27 Nov 2012 02:06 AM PST



Safari Omnikey offers Chrome-like keyword search for Safari. Search Amazon, Wikipedia or any other site directly from your URL bar.

Features:

  • Works directly with Safari, no extra software required.
  • Search any site directly from the URL field, for example type amazon headphones on the URL to search Amazon directly for headphones.
  • Replace Safari's default search providers with custom ones; DuckDuckGo is a great alternative for example.
  • Bundled with common search sites: Amazon, Wikipedia, Youtube, Twitter and more.
  • Add any site from the Extension popup on the toolbar.
  • Force regular searches by prepending ! to the search query.



Version 1.0.3:
  • [Bugfix] Fix for searches with international characters.


  • OS X 10.7 or later
  • Intel
  • Safari 6 or later


Download Now

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Mass Effect 3: Omega DLC out today, launch trailer features shooting, biotics, chess

Posted: 27 Nov 2012 02:20 AM PST

EA has released a trailer for the Mass Effect 3: Omega downloadable content, which is released today for Xbox 360, PC, and PlayStation 3 (in Europe the

Entropy, Vol. 14, Pages 2397-2407: Entropy-Based Block Processing for Satellite Image Registration

Posted: 27 Nov 2012 12:00 AM PST

Image registration is an important task in many computer vision applications such as fusion systems, 3D shape recovery and earth observation. Particularly, registering satellite images is challenging and time-consuming due to limited resources and large image size. In such scenario, state-of-the-art image registration methods such as scale-invariant feature transform (SIFT) may not be suitable due to high processing time. In this paper, we propose an algorithm based on block processing via entropy to register satellite images. The performance of the proposed method is evaluated using different real images. The comparative analysis shows that it not only reduces the processing time but also enhances the accuracy.

IJMS, Vol. 13, Pages 15881-15900: Modulation of Adipogenic Conditions for Prospective Use of hADSCs in Adipose Tissue Engineering

Posted: 27 Nov 2012 12:00 AM PST

Modern strategies in adipose tissue engineering (ATE) take advantage of the easy harvest, abundance and differentiation potential towards mesenchymal lineages of hADSCs. The controlled conversion of hADSCs to committed adipogenic precursors and further mature adipocytes formation is important for good long-term results in soft tissue regeneration. Thus, in this study, we report: (i) the isolation of the processed lipoaspirate (PLA) cells from adipose tissue and sanguine fractions; (ii) the phenotypic characterization of the PLA descendants; (iii) the design of a novel protocol for the modulation of adipogenic conditions in the perspectives of ATE applications. To modulate the differentiation rate through our protocol, we propose to selectively modify the formulation of the adipogenic media in accordance with the evolution of the process. Therefore, we aimed to ensure the long-term proliferation of the precursor cells and to delay the late adipogenic events. The status of differentiation was characterized in terms of intracellular lipid accumulation and reorganization of the cytoskeleton simultaneously with perilipin protein expression. Moreover, we studied the sequential activation of PPARγ2, FAS, aP2 and perilipin genes which influence the kinetics of the adipogenic process. The strategies developed in this work are the prerequisites for prospective 3D regenerative systems.

IJMS, Vol. 13, Pages 15867-15880: Impact of Cyanidin-3-Glucoside on Glycated LDL-Induced NADPH Oxidase Activation, Mitochondrial Dysfunction and Cell Viability in Cultured Vascular Endothelial Cells

Posted: 27 Nov 2012 12:00 AM PST

Elevated levels of glycated low density lipoprotein (glyLDL) are frequently detected in diabetic patients. Previous studies demonstrated that glyLDL increased the production of reactive oxygen species (ROS), activated NADPH oxidase (NOX) and suppressed mitochondrial electron transport chain (mETC) enzyme activities in vascular endothelial cells (EC). The present study examined the effects of cyanidin-3-glucoside (C3G), a type of anthocyanin abundant in dark-skinned berries, on glyLDL-induced ROS production, NOX activation and mETC enzyme activity in porcine aortic EC (PAEC). Co-treatment of C3G prevented glyLDL-induced upregulation of NOX4 and intracellular superoxide production in EC. C3G normalized glyLDL-induced inhibition on the enzyme activities of mETC Complex I and III, as well as the abundances of NADH dehydrogenase 1 in Complex I and cytochrome b in Complex III in EC. Blocking antibody for the receptor of advanced glycation end products (RAGE) prevented glyLDL-induced changes in NOX and mETC enzymes. Combination of C3G and RAGE antibody did not significantly enhance glyLDL-induced inhibition of NOX or mETC enzymes. C3G reduced glyLDL-induced RAGE expression with the presence of RAGE antibody. C3G prevented prolonged incubation with the glyLDL-induced decrease in cell viability and the imbalance between key regulators for cell viability (cleaved caspase 3 and B cell Lyphoma-2) in EC. The findings suggest that RAGE plays an important role in glyLDL-induced oxidative stress in vascular EC. C3G may prevent glyLDL-induced NOX activation, the impairment of mETC enzymes and cell viability in cultured vascular EC.

IJMS, Vol. 13, Pages 15859-15866: Microsatellites in the Endangered Species Dyckia distachya (Bromeliaceae) and Cross-Amplification in Other Bromeliads

Posted: 27 Nov 2012 12:00 AM PST

Microsatellite markers were isolated in Dyckia distachya, an endangered bromeliad from southern Brazil, which will be useful to assess the population genetic structure and reproductive success in introduced and natural populations of this species. Twenty microsatellite loci were developed from an enriched genomic library, and nine of these were amplified. The loci were characterized in 43 individuals from introduced and wild D. distachya populations. All nine loci were polymorphic, with four to ten alleles per locus. In an introduced population the observed and expected heterozygosities ranged from 0.136–0.667 and 0.543–0.877, respectively, while in a wild population it ranged from 0.000 to 0.895 and from 0.050 to 0.811, respectively. The development of these microsatellite markers will contribute to investigations of the reproductive potential and viability of introduced populations of D. distachya as well as the single known wild population. Cross-amplification in other Bromeliaceae species was successful, with high rates in four loci, demonstrating the applicability of these microsatellite markers in other taxa.

IJMS, Vol. 13, Pages 15848-15858: Muscodor albus Volatiles Control Toxigenic Fungi under Controlled Atmosphere (CA) Storage Conditions

Posted: 27 Nov 2012 12:00 AM PST

Muscodor albus, a biofumigant fungus, has the potential to control post-harvest pathogens in storage. It has been shown to produce over 20 volatile compounds with fungicidal, bactericidal and insecticidal properties. However, M. albus is a warm climate endophyte, and its biofumigant activity is significantly inhibited at temperatures below 5 °C. Conidia of seven mycotoxin producing fungi, Aspergillus carbonarius, A. flavus, A. niger, A. ochraceus, Penicillium verrucosum, Fusarium culmorum and F. graminearum, were killed or prevented from germinating by exposure to volatiles from 2 g M. albus-colonized rye grain per L of headspace in sealed glass jars for 24 h at 20 °C. Two major volatiles of M. albus, isobutyric acid (IBA) and 2-methyl-1-butanol (2MB) at 50 µL/L and 100 µL/L, respectively, gave differential control of the seven fungi when applied individually at 20 °C. When the fungi were exposed to both IBA and 2MB together, an average of 94% of the conidia were killed or suppressed. In a factorial experiment with controlled atmosphere storage (CA) at 3 °C and 72 h exposure to four concentrations of IBA and 2MB combinations, 50 µL/L IBA plus 100 µL/L 2MB killed or suppressed germination of the conidia of all seven fungi. Controlled atmosphere had no significant effect on conidial viability or volatile efficacy. Major volatiles of M. albus may have significant potential to control plant pathogens in either ambient air or CA storage at temperatures below 5 °C. However, combinations of volatiles may be required to provide a broader spectrum of control than individual volatiles.
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