среда, 7 ноября 2012 г.

Games

Games

iDeer Blu-ray Player 1.0.2.1035 - Universal media player.. (Shareware)

Posted: 07 Nov 2012 02:28 AM PST



iDeer Blu-ray Player is a universal media player software for playing Blu-ray, DVD, BD ISO, DVD ISO,video, auido, music, photos on the desktop of Mac and Windows PC. With Arix, It can also play Blu-ray on iPhone/iPad/iPod touch devices.

Version 1.0.2:
  • Optimize the quality on Mac OS 10.8.2


OS X 10.6 or later

Download Now

This posting includes an audio/video/photo media file: Download Now

Sensors, Vol. 12, Pages 15159-15191: Ubiquitous Monitoring of Electrical Household Appliances 

Posted: 07 Nov 2012 12:00 AM PST

The number of appliances at home is increasing continuously, mainly because they make our lives easier. Currently, technology is integrated in all objects of our daily life. TCP/IP let us monitor our home in real time and check ubiquitously if something is happening at home. Bearing in mind this idea, we have developed a low-cost system, which can be used in any type of electrical household appliance that takes information from the appliance and posts the information to the Twitter Social network. Several sensors placed in the household appliances gather the sensed data and send them wired or wirelessly, depending on the case, using small and cheap devices to a gateway located in the home. This gateway takes decisions, based on the received data, and sends notifications to Twitter. We have developed a software application that takes the values and decides when to issue an alarm to the registered users (Twitter friends of our smart home). The performance of our system has been measured taking into account the home network (using IEEE 802.3u and IEEE 802.11g) and the data publishing in Twitter. As a result, we have generated an original product and service for any electrical household appliance, regardless of the model and manufacturer, that helps home users improve their quality of life. The paper also shows that there is no system with the same innovative features like the ones presented in this paper.

Sensors, Vol. 12, Pages 15133-15158: A Secure Communication Suite for Underwater Acoustic Sensor Networks

Posted: 07 Nov 2012 12:00 AM PST

In this paper we describe a security suite for Underwater Acoustic Sensor Networks comprising both fixed and mobile nodes. The security suite is composed of a secure routing protocol and a set of cryptographic primitives aimed at protecting the confidentiality and the integrity of underwater communication while taking into account the unique characteristics and constraints of the acoustic channel. By means of experiments and simulations based on real data, we show that the suite is suitable for an underwater networking environment as it introduces limited, and sometimes negligible, communication and power consumption overhead.

Molecules, Vol. 17, Pages 13275-13289: Synthesis, Antioxidant and Antimicrobial Activity of a New Phloridzin Derivative for Dermo-Cosmetic Applications

Posted: 07 Nov 2012 12:00 AM PST

The phenolic compound phloridzin (phloretin 2′-O-glucoside, variously named phlorizin, phlorrhizin, phlorhizin or phlorizoside) is a prominent member of the chemical class of dihydrochalcones, which are phenylpropanoids. Phloridzin is specifically found in apple and apple juice and known for its biological properties. In particular we were attracted by potential dermo-cosmetic applications. Here we report the synthesis, stability studies and antimicrobial activity of compound F2, a new semi-synthetic derivative of phloridzin. The new derivative was also included in finished formulations to evaluate its stability with a view to a potential topical use. Stability studies were performed by HPLC; PCL assay and ORAC tests were used to determine the antioxidant activity. F2 presented an antioxidant activity very close to that of the parent phloridzin, but, unlike the latter, was more stable in formulations. To further explore potential health claims, antifungal activity of phloridzin and its derivative F2 were determined; the results, however, were rather low; the highest value was 31,6% of inhibition reached by F2 on Microsporum canis at the highest dose.

Molecules, Vol. 17, Pages 13266-13274: Radioiodination of Aryl-Alkyl Cyclic Sulfates

Posted: 07 Nov 2012 12:00 AM PST

Among the currently available positron emitters suitable for Positron Emission Tomography (PET), 124I has the longest physical half-life (4.2 days). The long half-life and well-investigated behavior of iodine in vivo makes 124I very attractive for pharmacological studies. In this communication, we describe a simple yet effective method for the synthesis of novel 124I labeled compounds intended for PET imaging of arylsulfatase activity in vivo. Arylsulfatases have important biological functions, and genetic deficiencies of such functions require pharmacological replacement, the efficacy of which must be properly and non-invasively evaluated. These enzymes, even though their natural substrates are mostly of aliphatic nature, hydrolyze phenolic sulfates to phenol and sulfuric acid. The availability of [124I]iodinated substrates is expected to provide a PET-based method for measuring their activity in vivo. The currently available methods of synthesis of iodinated arylsulfates usually require either introducing of a protected sulfate ester early in the synthesis or introduction of sulfate group at the end of synthesis in a separate step. The described method gives the desired product in one step from an aryl-alkyl cyclic sulfate. When treated with iodide, the source cyclic sulfate opens with substitution of iodide at the alkyl center and gives the desired arylsulfate monoester.

Molecules, Vol. 17, Pages 13253-13265: Effects of Taraxacum officinale on Fatigue and Immunological Parameters in Mice

Posted: 07 Nov 2012 12:00 AM PST

In Korean herbal medicine dandelion (Taraxacum officinale, TO) has been used to improve energy levels and health. However, the effects of TO in experimental models remain unclear. We examined the anti-fatigue and immune-enhancing effects of TO in mice by performing a forced swimming test (FST) and in vitro by using peritoneal macrophages, respectively. After daily oral administration of TO, blood biochemical parameters related to fatigue were measured after the FST. FST immobility time was significantly decreased in the TO-treated group (100 mg/kg) on the tenth day. TO (10 and 100 mg/kg) treatment significantly increased glucose levels, acting as an energy source. The level of lactic dehydrogenase, which is an accurate indicator of muscle damage, tended to decline after TO administration (10 and 100 mg/kg). When TO (100 mg/kg) was orally administered to mice, blood urea nitrogen levels decreased significantly. We also examined the effect of TO on the production of cytokines and nitric oxide (NO) in mouse peritoneal macrophages. When TO was used in combination with recombinant interferon-gamma (rIFN-γ), a noticeable cooperative induction of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-12p70, and IL-10 production was observed. Furthermore, in peritoneal macrophages, rIFN-γ plus TO treatment significantly increased the production of NO through inducible nitric oxide synthase (iNOS) induction. Taken together, these results suggest that TO improves fatigue-related indicators and immunological parameters in mice.

YourtTrip 1.2.4 - Smart, efficient trip planning.. (Commercial)

Posted: 07 Nov 2012 02:05 AM PST



YourtTrip is a program committed to satisfying you with easy trip planning and all of the precious memories that come with it. With the powerful share function, the itinerary can be shared via blog or email. With YourtTrip, you'll find making an itinerary has never been so easy or fun.

Get where you and your party want to go by using itinerary organizer with map search function! YourtTrip will help you to confirm the specific location of where you want to visit. No need to worry about not finding the places that you are looking for, because we integrated a Map Search function so you can go anywhere. Make a short description before you go there, such as what you are going to do, or not going to do. If you are with somebody else, share your itinerary via email or blog with that person and get some opinions on this journey. Then you can go on to make the full itinerary in detail.

Don't forget about packing! Fortunately, the usual items are listed in the Packing Folder. For the unusual items, the clever packing system has a function to add the rarely used yet important things you may need for a particular trip. Write down and share cautions and pins on the integrated map.

There is still one important thing to plan, and that's money! The Smart Budget tool can teach you about your own spending habits and help you to make better financial decisions. You'll find planning a budget is almost too easy! After you are back from a trip, the unplanned expenses can be added to the Expense Folder.

Please join our Clear Classification System. You can simply add a collection through the Collection Folder in the main interface. Make a special collection with the Smart Collection Folder. All of the collections are catalogued in a Time Line Bar, from which you can select a particular trip or a period of trips.

The wonderful and precious pictures from your trip can be elegantly put into YourtTrip, making it easy to manage all the pictures without any of the chaos.

YogurtTrip is designed for efficient users. This tiny plan management software is highly recommended for you to make your next trip run smoothly.

We need your advice to perfect YourtTrip in future updates. Don't hesitate to send us your reviews and comments.

Features:

  • Powerful share function that is to share the trip plans with others before you start the trip or back from the trip, via blog and email, or print them out as PDF files.
  • Flexible printing to guide you in making your itinerary.
  • Simple and powerful trip planner.
  • Itinerary with map search function.
  • Clever packing list.
  • Smart budget function.
  • Clear classification system.
  • Movable Time line Bar to catalogue trips.
  • Elegant photo management.
  • Last Update.


Version 1.2.4:
  • Add type feature and attachment feature for Itinerary's event.
  • Add trip cover editor.
  • Improved date editor.
  • New packing mode.
  • UI improvements.
  • Fixed the crash issue when runing YourtTrip without Itinernet access.
  • Fixed the flag's direction issue.
  • Fixed the stretch issue of photos.
  • Fixed issues on Mac OS X 10.6.
  • Several other bugs fixed.


Mac OS X 10.6 or later

Download Now

This posting includes an audio/video/photo media file: Download Now

Halo 4 addiction rewarded with Microsoft Points

Posted: 07 Nov 2012 02:38 AM PST

Xbox Live Rewards members who play more than 35 hours of Halo 4 multiplayer on Xbox Live during November will earn themselves Microsoft Points, thanks to

Life, Vol. 2, Pages 313-322: The Chemical Origin of Behavior is Rooted in Abiogenesis

Posted: 07 Nov 2012 12:00 AM PST

We describe the initial realization of behavior in the biosphere, which we term behavioral chemistry. If molecules are complex enough to attain a stochastic element to their structural conformation in such as a way as to radically affect their function in a biological (evolvable) setting, then they have the capacity to behave. This circumstance is described here as behavioral chemistry, unique in its definition from the colloquial chemical behavior.  This transition between chemical behavior and behavioral chemistry need be explicit when discussing the root cause of behavior, which itself lies squarely at the origins of life and is the foundation of choice.  RNA polymers of sufficient length meet the criteria for behavioral chemistry and therefore are capable of making a choice.

Brain Sciences, Vol. 2, Pages 589-604: Effects of Chronic Central Arginine Vasopressin (AVP) on Maternal Behavior in Chronically Stressed Rat Dams

Posted: 07 Nov 2012 12:00 AM PST

Exposure of mothers to chronic stressors during pregnancy or the postpartum period often leads to the development of depression, anxiety, or other related mood disorders. The adverse effects of mood disorders are often mediated through maternal behavior and recent work has identified arginine vasopressin (AVP) as a key neuropeptide hormone in the expression of maternal behavior in both rats and humans. Using an established rodent model that elicits behavioral and physiological responses similar to human mood disorders, this study tested the effectiveness of chronic AVP infusion as a novel treatment for the adverse effects of exposure to chronic social stress during lactation in rats. During early (day 3) and mid (day 10) lactation, AVP treatment significantly decreased the latency to initiate nursing and time spent retrieving pups, and increased pup grooming and total maternal care (sum of pup grooming and nursing). AVP treatment was also effective in decreasing maternal aggression and the average duration of aggressive bouts on day 3 of lactation. Central AVP may be an effective target for the development of treatments for enhancing maternal behavior in individuals exposed to chronic social stress.

Viruses, Vol. 4, Pages 2853-2901: Sharka: The Past, The Present and The Future

Posted: 07 Nov 2012 12:00 AM PST

Members the Potyviridae family belong to a group of plant viruses that are causing devastating plant diseases with a significant impact on agronomy and economics. Plum pox virus (PPV), as a causative agent of sharka disease, is widely discussed. The understanding of the molecular biology of potyviruses including PPV and the function of individual proteins as products of genome expression are quite necessary for the proposal the new antiviral strategies. This review brings to view the members of Potyviridae family with respect to plum pox virus. The genome of potyviruses is discussed with respect to protein products of its expression and their function. Plum pox virus distribution, genome organization, transmission and biochemical changes in infected plants are introduced. In addition, techniques used in PPV detection are accentuated and discussed, especially with respect to new modern techniques of nucleic acids isolation, based on the nanotechnological approach. Finally, perspectives on the future of possibilities for nanotechnology application in PPV determination/identification are outlined.

Toxins, Vol. 4, Pages 1196-1222: Emerging Opportunities for Serotypes of Botulinum Neurotoxins

Posted: 07 Nov 2012 12:00 AM PST

Background: Two decades ago, botulinum neurotoxin (BoNT) type A was introduced to the commercial market. Subsequently, the toxin was approved by the FDA to address several neurological syndromes, involving muscle, nerve, and gland hyperactivity. These syndromes have typically been associated with abnormalities in cholinergic transmission. Despite the multiplicity of botulinal serotypes (designated as types A through G), therapeutic preparations are currently only available for BoNT types A and B. However, other BoNT serotypes are under study for possible clinical use and new clinical indications; Objective: To review the current research on botulinum neurotoxin serotypes A-G, and to analyze potential applications within basic science and clinical settings; Conclusions: The increasing understanding of botulinal neurotoxin pathophysiology, including the neurotoxin's effects on specific neuronal populations, will help us in tailoring treatments for specific diagnoses, symptoms and patients. Scientists and clinicians should be aware of the full range of available data involving neurotoxin subtypes A-G.

Religions, Vol. 3, Pages 1075-1084: Globalization and Religion: The Case of Malacca and the Work of Robert Morrison

Posted: 07 Nov 2012 12:00 AM PST

Religion has long been a significant factor in the process of globalization. In this article, the author attempts to explore and review religious factors involved in the history of Malacca (Melaka) and in the missionary work of Robert Morrison in the early 19th century. Malacca has long been a meeting place for various religions in their respective processes of globalization. Robert Morrison was the first Protestant Missionary to come to the Chinese Mainland. He arrived in 1807. However, after 10 years of working in Canton and Macau, he made a proposal for setting up a mission school in Malacca, hence the Anglo-Chinese College of 1818. It was found that, indeed, Morrison had learned much from his experiences in China and in Malacca, especially in paying due respect to Chinese culture.

Pharmaceutics, Vol. 4, Pages 563-589: Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) in Preclinical Studies of Antivascular Treatments

Posted: 07 Nov 2012 12:00 AM PST

Antivascular treatments can either be antiangiogenic or targeting established tumour vasculature. These treatments affect the tumour microvasculature and microenvironment but may not change clinical measures like tumour volume and growth. In research on antivascular treatments, information on the tumour vasculature is therefore essential. Preclinical research is often used for optimization of antivascular drugs alone or in combined treatments. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an in vivo imaging method providing vascular information, which has become an important tool in both preclinical and clinical research. This review discusses common DCE-MRI imaging protocols and analysis methods and provides an overview of preclinical research on antivascular treatments utilizing DCE-MRI.

Nanomaterials, Vol. 2, Pages 366-378: Evaluation of the Mechanism of the Gold Cluster Growth during Heating of the Composite Gold-Polytetrafluoroethylene Thin Film

Posted: 07 Nov 2012 12:00 AM PST

Nanocomposite films consisting of gold inclusions in the polytetrafluoroethylene (PTFE) matrix were obtained by thermal vacuum deposition. Annealing of the obtained films with different temperatures was used to measure varying of film morphologies. The dependence of optical properties of the films on their morphology was studied. It was established that absorption and profile of the nanocomposite film obtained by thermal vacuum deposition can be changed with annealing owing to the fact that different annealing temperatures lead to different average particle sizes. A method to calculate the optical properties of nanocomposite thin films with inclusions of different sizes was proposed. Thus, comparison of experimental optical spectra with the spectra obtained during the simulation enables estimating average sizes of inclusions. The calculations give the possibility of understanding morphological changes in the structures.

Materials, Vol. 5, Pages 2190-2204: Strain Measurements within Fibreboard. Part III: Analyzing the Process Zone at the Crack Tip of Medium Density Fiberboards (MDF) Double Cantilever I-Beam Specimens

Posted: 07 Nov 2012 12:00 AM PST

This paper is the third part of a study dealing with the mechanical and fracture mechanical characterization of Medium Density Fiberboards (MDF). In the first part, an analysis of internal bond strength testing was performed and in the second part MDF was analyzed by means of the wedge splitting experiment; this part deals with the double cantilever I beam test, which is designed for measuring the fracture energy as well as stress intensity factor in Mode I. For a comparison of isotropic and orthotropic material behavior, finite element modeling was performed. In addition to the calculation of fracture energy the stress intensity factor was analyzed by means of finite elements simulation and calculation. In order to analyze strain deformations and the process zone, electronic speckle pattern interferometry measurements were performed. The results revealed an elongated process zone and lower results for KIC if compared to the wedge splitting experiment. The Gf numbers are higher compared to the wedge splitting results and can be explained by the thicker process zone formed during the crack propagation. The process zone width on its part is influenced by the stiff reinforcements and yields a similar crack surface as with the internal bond test.

IJMS, Vol. 13, Pages 14401-14420: Changes on the Caco-2 Secretome through Differentiation Analyzed by 2-D Differential In-Gel Electrophoresis (DIGE)

Posted: 07 Nov 2012 12:00 AM PST

Colorectal cancer is still a major health burden worldwide, and its diagnosis has not improved in recent years due to a lack of appropriate diagnostic serum markers. Aiming to find new diagnostic proteins, we applied the proteomic DIGE technology to analyze changes in the secretome before/after differentiation of the colon adenocarcinoma Caco-2 cell line, an accepted in vitro model to study colorectal tumorigenesis. When the secretomes from undifferentiated (tumor-like) and differentiated cells (resembling healthy enterocytes) were compared, we found 96 spots differentially expressed. After MS/MS analysis, 22 spots corresponding to 15 different proteins were identified. Principal component analysis demonstrated these 22 spots could serve as a discriminatory panel between the tumor-like and normal-like cells. Among the identified proteins, the translationally-controlled tumor protein (TCTP), the transforming growth factor-beta-induced protein ig-h3 (TGFβIp), and the Niemann-Pick disease type C2 protein (NPC2) are interesting candidates for future studies focused on their utility as serum biomarkers of colorectal cancer.

Red Ball 4

Posted: 07 Nov 2012 12:30 AM PST

The fourth installment of the popular Red Ball franchise features a new cool adventure with brand new graphics!

Into Space 2

Posted: 07 Nov 2012 12:20 AM PST

After you finally arrived space, it's time to to conquer the new front- Mars! Fly into space and collect cool upgrades.

Donald Trump calls for revolutionary overthrow of American government

Posted: 07 Nov 2012 12:19 AM PST
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