Games |
- Aliens: Colonial Marines - Survivor Multiplayer Trailer
- Nintendo offers advice for users experiencing Wii U problems – freezing, long load times
- JPM, Vol. 2, Pages 241-256: Developing a Prototype System for Integrating Pharmacogenomics Findings into Clinical Practice
- Pharmaceuticals, Vol. 5, Pages 1236-1264: The Biological Role of PI3K Pathway in Lung Cancer
- Materials, Vol. 5, Pages 2403-2422: A Novel Active Targeting Preparation, Vinorelbine Tartrate (VLBT) Encapsulated by Folate-Conjugated Bovine Serum Albumin (BSA) Nanoparticles: Preparation, Characterization and in Vitro Release Study
- Entropy, Vol. 14, Pages 2351-2374: Periodic Cosmological Evolutions of Equation of State for Dark Energy 
- Antibiotics, Vol. 1, Pages 25-28: Investigations into the Antibacterial Activity of the Silver-Based Antibiotic Drug Candidate SBC3
- Toxins, Vol. 4, Pages 1404-1414: Botulinum Toxin Physiology in Focal Hand and Cranial Dystonia
- Toxins, Vol. 4, Pages 1385-1403: Relationship between Aflatoxin Contamination and Physiological Responses of Corn Plants under Drought and Heat Stress
- Molbank, Vol. 2012, Pages M786: 4-{[(1-Phenyl-1H-pyrazol-3-yl)oxy]methyl}-1,3-dioxolan-2-one
- Minerals, Vol. 2, Pages 459-472: A Study of the Effect of Djurliete, Bornite and Chalcopyrite during the Dissolution of Gold with a Solution of Ammonia-Cyanide
- Materials, Vol. 5, Pages 2383-2402: Nopal Cactus (Opuntia Ficus-Indica) as a Holographic Material
- Marine Drugs, Vol. 10, Pages 2571-2583: Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis
- Coatings, Vol. 2, Pages 235-241: On the Porosity of Cu Coatings Formed in Earth-Based and Space Conditions
- Cancers, Vol. 4, Pages 1212-1224: dNTP Supply Gene Expression Patterns after P53 Loss
- Brain Sciences, Vol. 2, Pages 649-666: Cortical Activity during a Highly-Trained Resistance Exercise Movement Emphasizing Force, Power or Volume
- Typography Playing Cards
- Bartender 1.0.5 - Organize your menubar apps.. (Demo)
- Dragon Dictate 3.0.1 - Premium voice recognition solution.. (Updater)
- PDFpen Cloud Access 1.1 - Manage your PDFpen documents from the cloud.. (Commercial)
| Aliens: Colonial Marines - Survivor Multiplayer Trailer Posted: 20 Nov 2012 01:00 AM PST Get an exclusive look at Aliens: Colonial Marines frightful multiplayer mode, Survivor. Are you ready to fight the fear?
Read and Post Comments | Get the full article at GameSpot "Aliens: Colonial Marines - Survivor Multiplayer Trailer" was posted by sarahl on Tue, 20 Nov 2012 01:00:00 -0800 |
| Nintendo offers advice for users experiencing Wii U problems – freezing, long load times Posted: 20 Nov 2012 02:41 AM PST Nintendo has updated its website to offer support for users experiencing problems with its Wii U console, which launched 18 November. The troubleshooting |
| Posted: 20 Nov 2012 12:00 AM PST Findings from pharmacogenomics (PGx) studies have the potential to be applied to individualize drug therapy to improve efficacy and reduce adverse drug events. Researchers have identified factors influencing uptake of genomics in medicine, but little is known about the specific technical barriers to incorporating PGx into existing clinical frameworks. We present the design and development of a prototype PGx clinical decision support (CDS) system that builds on existing clinical infrastructure and incorporates semi-active and active CDS. Informing this work, we updated previous evaluations of PGx knowledge characteristics, and of how the CDS capabilities of three local clinical systems align with data and functional requirements for PGx CDS. We summarize characteristics of PGx knowledge and technical needs for implementing PGx CDS within existing clinical frameworks. PGx decision support rules derived from FDA drug labels primarily involve drug metabolizing genes, vary in maturity, and the majority support the post-analytic phase of genetic testing. Computerized provider order entry capabilities are key functional requirements for PGx CDS and were best supported by one of the three systems we evaluated. We identified two technical needs when building on this system, the need for (1) new or existing standards for data exchange to connect clinical data to PGx knowledge, and (2) a method for implementing semi-active CDS. Our analyses enhance our understanding of principles for designing and implementing CDS for drug therapy individualization and our current understanding of PGx characteristics in a clinical context. Characteristics of PGx knowledge and capabilities of current clinical systems can help govern decisions about CDS implementation, and can help guide decisions made by groups that develop and maintain knowledge resources such that delivery of content for clinical care is supported. |
| Pharmaceuticals, Vol. 5, Pages 1236-1264: The Biological Role of PI3K Pathway in Lung Cancer Posted: 20 Nov 2012 12:00 AM PST Lung cancer is the primary cause of cancer-related mortality worldwide and although improvements in treatment have been achieved over the last few years, long-term survival rates for lung cancer patients remain poor. Therefore, there is an imperative need for molecularly targeted agents that will achieve long-term disease control. Numerous downstream molecular pathways, such as EGF/RAS/RAF/MEK/ERK and PI3K/AKT/mTOR are identified as having a key role in the pathogenesis of various forms of human cancer, including lung cancer. PI3K/AKT/mTOR signal pathway is an important intracellular signal transduction pathway with a significant role in cell proliferation, growth, survival, vesicle trafficking, glucose transport, and cytoskeletal organization. Aberrations in many primary and secondary messenger molecules of this pathway, including mutations and amplifications, are accounted for tumor cell proliferation, inhibition of apoptosis, angiogenesis, metastasis and resistance to chemotherapy-radiotherapy. In this review article, we investigate thoroughly the biological role of PI3K pathway in lung cancer and its contribution in the development of future therapeutic strategies. |
| Posted: 20 Nov 2012 12:00 AM PST Vinorelbine tartrate (VLBT), as a kind of high hydrophilic and temperature-induced degradation drug, was prepared into nanoparticles by a desolvation procedure. Bovine serum albumin (BSA), as a drug carrier, was stabilized by chemical cross-linking with glutaraldehyde. Firstly, the optimization process of preparing VLBT-loaded BSA nanoparticles (VLBT-BSANPs) was accomplished using response surface methodology (RSM) by desolvation. Then VLBT-BSANPs were conjugated with folate, namely Fa-BSANPs-VLBT. Hence targeting drug carrier delivery system loading VLBT was produced. In this study, the characteristics of the nanoparticles, such as the amount of folate conjugation, surface morphology, surface chemistry, physical status of VLBT in Fa-BSANPs-VLBT, stability of Fa-BSANPs-VLBT with mannitol and in vitro drug release behavior were all investigated. The VLBT-BSANPs were obtained under optimum conditions, with a mean particle size (MPS) of 155.4 nm and a zeta potential (ZP) of −32.97 mV at a pH value of 5.4. Drug loading efficiency (DLE) and drug entrapment efficiency (DEE) of this obtained drug were approximately 45.6% and 90.6%, respectively. |
| Posted: 20 Nov 2012 12:00 AM PST We demonstrate two periodic or quasi-periodic generalizations of the Chaplygin gas (CG) type models to explain the origins of dark energy as well as dark matter by using the Weierstrass ξ(t), σ (t) and ζ  (t) functions with two periods being infinite. If the universe can evolve periodically, a non-singular universe can be realized. Furthermore, we examine the cosmological evolution and nature of the equation of state (EoS) of dark energy in the Friedmann–Lemaître–Robertson–Walker cosmology. It is explicitly illustrated that there exist three type models in which the universe always stays in the non-phantom (quintessence) phase, whereas it always evolves in the phantom phase, or the crossing of the phantom divide can be realized. The scalar fields and the corresponding potentials are also analyzed for different types of models. |
| Posted: 20 Nov 2012 12:00 AM PST The synthesis of N-heterocyclic carbene (NHC) silver(I) acetate complexes with varying lipophilic benzyl-substituents at the 1 and 3 positions starting from 4,5-diphenylimidazole, opened a new class of antibiotic drug candidates. These NHC-silver(I) acetate derivatives exhibit interesting structural motifs in the solid state and proved to be soluble and stable in biological media. The leading candidate, SBC3, which was known to exhibit good antibacterial activity in preliminary Kirby-Bauer tests, was tested quantitatively using minimum inhibitory concentrations. NHC-silver(I) acetate complexes were found to have MIC values ranging from 20 to 3.13 μg/mL for a variety of Gram-positive, Gram-negative and mycobacteria tested. These values represent good antibiotic activities against potential pathogens when compared to clinically approved antibiotics. Most striking is the fact that SBC3 is active against methicillin-resistant Staphylococcus aureus with a MIC value of 12.5 μg/mL. |
| Toxins, Vol. 4, Pages 1404-1414: Botulinum Toxin Physiology in Focal Hand and Cranial Dystonia Posted: 20 Nov 2012 12:00 AM PST The safety and efficacy of botulinum toxin for the treatment of focal hand and cranial dystonias are well-established. Studies of these adult-onset focal dystonias reveal both shared features, such as the dystonic phenotype of muscle hyperactivity and overflow muscle contraction and divergent features, such as task specificity in focal hand dystonia which is not a common feature of cranial dystonia. The physiologic effects of botulinum toxin in these 2 disorders also show both similarities and differences. This paper compares and contrasts the physiology of focal hand and cranial dystonias and of botulinum toxin in the management of these disorders. |
| Posted: 20 Nov 2012 12:00 AM PST Increased aflatoxin contamination in corn by the fungus Aspergillus flavus is associated with frequent periods of drought and heat stress during the reproductive stages of the plants. The objective of this study was to evaluate the relationship between aflatoxin contamination and physiological responses of corn plants under drought and heat stress. The study was conducted in Stoneville, MS, USA under irrigated and non-irrigated conditions. Five commercial hybrids, P31G70, P33F87, P32B34, P31B13 and DKC63-42 and two inbred germplasm lines, PI 639055 and PI 489361, were evaluated. The plants were inoculated with Aspergillus flavus (K-54) at mid-silk stage, and aflatoxin contamination was determined on the kernels at harvest. Several physiological measurements which are indicators of stress response were determined. The results suggested that PI 639055, PI 489361 and hybrid DKC63-42 were more sensitive to drought and high temperature stress in the non-irrigated plots and P31G70 was the most tolerant among all the genotypes. Aflatoxin contamination was the highest in DKC63-42 and PI 489361 but significantly lower in P31G70. However, PI 639055, which is an aflatoxin resistant germplasm, had the lowest aflatoxin contamination, even though it was one of the most stressed genotypes. Possible reasons for these differences are discussed. These results suggested that the physiological responses were associated with the level of aflatoxin contamination in all the genotypes, except PI 639055. These and other physiological responses related to stress may help examine differences among corn genotypes in aflatoxin contamination. |
| Molbank, Vol. 2012, Pages M786: 4-{[(1-Phenyl-1H-pyrazol-3-yl)oxy]methyl}-1,3-dioxolan-2-one Posted: 20 Nov 2012 12:00 AM PST The title compound was obtained by the reaction of tosylated glycerol carbonate with 1-phenyl-1H-pyrazol-3-ol in a good 71% yield. Detailed spectroscopic data (1H-NMR, 13C-NMR, 15N-NMR, IR, MS) are presented. |
| Posted: 20 Nov 2012 12:00 AM PST The high solubility of copper sulphide minerals is an issue in the cyanidation of gold ores. The objective of this study was to quantify the effect of individual copper sulphide minerals on the Hunt process, which showed advantages over cyanidation. High purity djurleite, bornite and chalcopyrite, with a P70 of 70–74 microns, were mixed with fine quartz and gold powder (3–8 micron) to obtain a copper concentration of 0.3%. The ammonia-cyanide leaching of slurry with djurleite proved to be more effective than cyanidation; producing comparable extraction of gold (99%), while reducing the cyanide consumption from 5.8 to 1.2 kg/t NaCN. Lead nitrate improved the Hunt leaching. The lower cyanide consumption is associated to a significant reduction of copper dissolved. XPS surface analysis of djurleite showed that lead nitrate favored the formation of Cu(OH)2 species. Lead was also detected on the surface (oxide or hydroxide). Sulphide and copper compounds (cyanide and sulphide) were reaction products responsible for inhibiting the dissolution of gold. Lead nitrate added in the Hunt leaching of bornite produced 99% gold extraction. Surface reaction products were similar to djurleite. The cyanide consumption (~4.4 kg/t NaCN) was not reduced by the addition of ammonia. Cyanidation of chalcopyrite showed a lower consumption of cyanide 0.33 kg/t NaCN compared to 0.21 kg/t NaCN for Hunt. No significant interferences were observed in gold leaching with a slurry containing chalcopyrite. |
| Materials, Vol. 5, Pages 2383-2402: Nopal Cactus (Opuntia Ficus-Indica) as a Holographic Material Posted: 20 Nov 2012 12:00 AM PST The nopal cactus (Opuntia ficus-indica) releases a substance through its mucilage, which comes from the degradation of pectic substances and chlorophyll. Combined in a polyvinyl alcohol matrix, this substance can be used as a recording medium. The resulting extract material has excellent photosensitizer properties, is easy to handle, has a low cost, and low toxicity. This material has the property of self-developing, and it can be used in holographic applications. The polyvinyl alcohol and extract from the nopal cactus was deposited by a gravity technique on a glass substrate, which dried to form a photosensitive emulsion. We show experimental results on a holographic grating using this material, written by a He-Cd laser (442 nm). We obtained diffraction gratings by transmission with a diffraction efficiency of approximately 32.3% to first order. |
| Posted: 20 Nov 2012 12:00 AM PST Four new polycyclic antibiotics, citreamicin θ A (1), citreamicin θ B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin θ A (1), citreamicin θ B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 μg/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. |
| Posted: 20 Nov 2012 12:00 AM PST This work surveys the structure, substructure and submicroporosity of Cu metal coatings following condensation both under the conditions of space flight of orbital stations (OS) and under Earth-based conditions. Small-angle X-ray scattering (SAXS) and the method of Ar low-temperature desorption were used for investigation. It has been shown that the condensates deposited in space contain less and relatively equiaxial submicropores (SMPs) distributed more homogeneously than Earth-based disperse films. |
| Cancers, Vol. 4, Pages 1212-1224: dNTP Supply Gene Expression Patterns after P53 Loss Posted: 20 Nov 2012 12:00 AM PST Loss of the transcription factor p53 implies mRNA losses of target genes such as the p53R2 subunit of human ribonucleotide reductase (RNR). We hypothesized that other genes in the dNTP supply system would compensate for such p53R2 losses and looked for this in our own data and in data of the Gene Expression Omnibus (GEO). We found that the de novo dNTP supply system compensates for p53R2 losses with increases in RNR subunit R1, R2, or both. We also found compensatory increases in cytosolic deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1) and in mitochondrial deoxyguanosine kinase (dGK), all of the salvage dNTP supply system; in contrast, the remaining mitochondrial salvage enzyme thymidine kinase 2 (TK2) decreased with p53 loss. Thus, TK2 may be more dedicated to meeting mitochondrial dNTP demands than dGK which may be more obligated to assist cytosolic dNTP supply in meeting nuclear DNA dNTP demands. |
| Posted: 20 Nov 2012 12:00 AM PST Cortical activity is thought to reflect the biomechanical properties of movement (e.g., force or velocity of movement), but fatigue and movement familiarity are important factors that require additional consideration in electrophysiological research. The purpose of this within-group quantitative electroencephalogram (EEG) investigation was to examine changes in cortical activity amplitude and location during four resistance exercise movement protocols emphasizing rate (PWR), magnitude (FOR), or volume (VOL) of force production, while accounting for movement familiarity and fatigue. EEG signals were recorded during each complete repetition and were then grouped by functional region, processed to eliminate artifacts, and averaged to compare overall differences in the magnitude and location of cortical activity between protocols over the course of six sets. Biomechanical, biochemical, and exertional data were collected to contextualize electrophysiological data. The most fatiguing protocols were accompanied by the greatest increases in cortical activity. Furthermore, despite non-incremental loading and lower force levels, VOL displayed the largest increases in cortical activity over time and greatest motor and sensory activity overall. Our findings suggest that cortical activity is strongly related to aspects of fatigue during a high intensity resistance exercise movement. |
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| Dragon Dictate 3.0.1 - Premium voice recognition solution.. (Updater) Posted: 19 Nov 2012 08:59 PM PST  With Dragon Dictate for Mac 3 speech recognition software, you can use your voice to create and edit text or interact with your favorite Mac applications. Far more than just speech-to-text, Dragon Dictate lets you create and edit documents, manage email, surf the Web, update social networks, and more - quickly, easily and accurately, all by voice. Open and close or navigate between applications, or even create your own custom voice commands to execute multiple steps with a simple word or phrase. Use your iPhone or iPod as a wireless microphone, or capture your notes on-the-go using a digital voice recorder and Dragon Dictate 3 will transcribe them for you. Ignite Productivity with Fast, Accurate Dictation Say words and watch them appear on your computer screen -- three times faster than typing -- with up to 99% recognition accuracy right out of the box. Correcting or revising your dictated text is simple with a new, more powerful correction interface that lets you quickly edit words or phrases. Dragon Dictate adapts to your voice and the words you use to deliver better recognition results over time. You can personalize Dragon Dictate with your own custom vocabulary of acronyms, proper names and other unique phrases that you frequently use. Dragon Dictate can even adapt its format rules by detecting your format corrections - abbreviations, numbers, and more -- so your dictated text looks the way you want it to every time. Review your work with Dragon Dictates Text-to-Speech feature, which reads back editable text for easy proofing or multi-tasking. Ignite Convenience Using Your Favorite Mac Applications Dragon Dictate for Mac 3 goes beyond simple speech-to-text, and gives you control in more applications so that you can simply speak to do more than ever before. Use Dragon Dictate in Mac OS X Lion or Mountain Lion with virtually any Mac application. Create and edit documents in Microsoft Word, TextEdit, Notepad and Pages, work with spreadsheets in Microsoft Excel and Numbers, create presentations in Microsoft PowerPoint and Keynote, manage email in Mail, search the Web or your Mac desktop, post to Facebook or Twitter, and more - all by voice. Dragon Dictates new Express Editor lets you dictate into a text field in any application on the Mac for which it does not have Full Text Control. After you finish dictating, simply transfer the text from the Express Editor to the desired application quickly and easily by voice. Ignite Proficiency & Ease of Use Right Out of the Box Thanks to the new interactive tutorials simulations, you can learn and practice good dictation, correction and editing habits so that you can create text efficiently within just a few minutes. Dragon Dictates help menu is within reach with a simple voice command, so assistance is always available when you need it. Ignite Freedom and Comfort at Your Mac Say goodbye to repetitive stress injuries. Use your Mac in a comfortable, ergonomic way without being tied to your keyboard and mouse. Open applications or folders, select menu items, click or move the mouse, press keys, switch from one application to another or create custom voice commands to execute multiple steps by voice. With our free Dragon Remote Microphone app, use your Apple(R) iPhone(R), iPad(R) or iPod(R) touch (4th gen) or your compatible Android device as a wireless microphone over Wi-Fi for optimal convenience. Wideband Bluetooth support delivers outstanding wireless performance with no training required. Ignite Mobility for Productivity on the Go Dictate into a Nuance-approved digital voice recorder or use the free Dragon Recorder app to capture high-quality audio files using your iPhone, iPad or iPod touch (4th gen). Dragon Dictate will transcribe the recorded audio files when you connect to your Mac. These mobile recording capabilities enable you to capture thoughts from anywhere, at any time while theyre still fresh in your mind to produce detailed, high-quality reports, papers, proposals, meeting minutes, and more.
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| PDFpen Cloud Access 1.1 - Manage your PDFpen documents from the cloud.. (Commercial) Posted: 19 Nov 2012 10:42 PM PST  PDFpen Cloud Access lets you manage your PDFpen documents on iCloud. The Mac OS X companion to PDFpen for iPad. The iCloud companion to PDFpen and PDFpenPro. (If you have PDFpen for Mac or PDFpenPro for Mac from the Mac App Store, the PDFpen Cloud Access functionality is already built-in, so you don't need PDFpen Cloud Access.) PDFpen Cloud Access helps you manage your PDFpen documents on iCloud. PDFpen has its own space to store your documents on iCloud. You can access PDFpen documents on iCloud via PDFpen for iPad, PDFpen for Mac, PDFpenPro for Mac, and PDFpen Cloud Access. Features:
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