понедельник, 26 ноября 2012 г.

Games

Games

JamesJr 2.8.0 - Assists with renaming and sorting photos and files.. (Shareware)

Posted: 26 Nov 2012 02:35 AM PST



JamesJr handles your digital images. From sorting, renaming, archiving, scaling, cropping over transforming colors, framing and converting file types to making photo galeries to publish over the Web or to be used as image catalogue.

Version 2.8.0:
  • OS X 10.8 version available.
  • New features on file renaming.
  • Performance boost on file renaming.
  • Bug fix on iPhoto module.
  • Bug fix on memory leak on file renaming module.


  • Mac OS X 10.6 or later
  • Intel
  • 64-bit processor


Download Now

This posting includes an audio/video/photo media file: Download Now

IJMS, Vol. 13, Pages 15801-15812: Cholesterol-Dependent Energy Transfer between Fluorescent Proteins—Insights into Protein Proximity of APP and BACE1 in Different Membranes in Niemann-Pick Type C Disease Cells

Posted: 26 Nov 2012 12:00 AM PST

Förster resonance energy transfer (FRET) -based techniques have recently been applied to study the interactions between β-site APP-cleaving enzyme-GFP (BACE1-GFP) and amyloid precursor protein-mRFP (APP-mRFP) in U373 glioblastoma cells. In this context, the role of APP-BACE1 proximity in Alzheimer’s disease (AD) pathogenesis has been discussed. FRET was found to depend on intracellular cholesterol levels and associated alterations in membrane stiffness. Here, NPC1 null cells (CHO-NPC1−/−), exhibiting increased cholesterol levels and disturbed cholesterol transport similar to that observed in Niemann-Pick type C disease (NPC), were used to analyze the influence of altered cholesterol levels on APP-BACE1 proximity. Fluorescence lifetime measurements of whole CHO-wild type (WT) and CHO-NPC1−/− cells (EPI-illumination microscopy), as well as their plasma membranes (total internal reflection fluorescence microscopy, TIRFM), were performed. Additionally, generalized polarization (GP) measurements of CHO-WT and CHO-NPC1−/− cells incubated with the fluorescence marker laurdan were performed to determine membrane stiffness of plasma- and intracellular-membranes. CHO-NPC1−/− cells showed higher membrane stiffness at intracellular- but not plasma-membranes, equivalent to cholesterol accumulation in late endosomes/lysosomes. Along with higher membrane stiffness, the FRET efficiency between BACE1-GFP and APP-mRFP was reduced at intracellular membranes, but not within the plasma membrane of CHO-NPC1−/−. Our data show that FRET combined with TIRF is a powerful technique to determine protein proximity and membrane fluidity in cellular models of neurodegenerative diseases.

IJMS, Vol. 13, Pages 15784-15800: Brain Metastases from Colorectal Cancer: Microenvironment and Molecular Mechanisms

Posted: 26 Nov 2012 12:00 AM PST

Colorectal cancer is one of the most common digestive tract malignancies in the world. Owing to the newer and more effective systemic therapies, the life of colorectal cancer patients can be remarkably prolonged, and the incidence of brain metastases is increasing. However, little is known about the underlying mechanisms of brain metastasis from colorectal cancer. Here we review the tumor microenvironment and metastasis associated molecules in brain metastases from colorectal cancer. A further understanding of these mechanisms will help us to propose better strategies for colorectal cancer patients with brain metastasis and improve their life quality.

IJMS, Vol. 13, Pages 15767-15783: The Role of Sox Genes in Lung Morphogenesis and Cancer

Posted: 26 Nov 2012 12:00 AM PST

The human lung consists of multiple cell types derived from early embryonic compartments. The morphogenesis of the lung, as well as the injury repair of the adult lung, is tightly controlled by a network of signaling pathways with key transcriptional factors. Lung cancer is the third most cancer-related death in the world, which may be developed due to the failure of regulating the signaling pathways. Sox (sex-determining region Y (Sry) box-containing) family transcriptional factors have emerged as potent modulators in embryonic development, stem cells maintenance, tissue homeostasis, and cancerogenesis in multiple processes. Recent studies demonstrated that the members of the Sox gene family played important roles in the development and maintenance of lung and development of lung cancer. In this context, we summarize our current understanding of the role of Sox family transcriptional factors in the morphogenesis of lung, their oncogenic potential in lung cancer, and their potential impact in the diagnosis, prognosis, and targeted therapy of lung cancer.

iTyper 1.0 - A light, quick but fully functional word processor.. (Commercial)

Posted: 26 Nov 2012 01:33 AM PST



iTyper is a simple as well as practical and effective word editor which helps you design elegant documents, practical reports, great-looking layout and more. More importantly, working on the new MacBook Pro with Retina display, your creation of words and graphics looks more charming and fascinating. You can create new documents with whatever images and tables placed wherever in the texts. It can be automatically saved by your setting time range as you make changes. Also it supports to export file to various formats, covering PDF, word, web, rtf, odt, txt. With this mobile app specially designed for OS X, it becomes convenient and trustworthy to make plain text files, rich text documents, resumes or reports, etc.

OS X 10.7 or later, Intel

Download Now

Beyond Good and Evil: Morality and consequence in The Walking Dead

Posted: 25 Nov 2012 08:48 PM PST

Jessica McDonell wrestles with tough decisions and her own emotions in The Walking Dead.

Get the full article at GameSpot

"Beyond Good and Evil: Morality and consequence in The Walking Dead" was posted by Jessica McDonell on Sun, 25 Nov 2012 20:48:12 -0800

IJMS, Vol. 13, Pages 15755-15766: RORα, a Potential Tumor Suppressor and Therapeutic Target of Breast Cancer

Posted: 26 Nov 2012 12:00 AM PST

The function of the nuclear receptor (NR) in breast cancer progression has been investigated for decades. The majority of the nuclear receptors have well characterized natural ligands, but a few of them are orphan receptors for which no ligand has been identified. RORα, one member of the retinoid orphan nuclear receptor (ROR) subfamily of orphan receptors, regulates various cellular and pathological activities. RORα is commonly down-regulated and/or hypoactivated in breast cancer compared to normal mammary tissue. Expression of RORα suppresses malignant phenotypes in breast cancer cells, in vitro and in vivo. Activity of RORα can be categorized into the canonical and non-canonical nuclear receptor pathways, which in turn regulate various breast cancer cellular function, including cell proliferation, apoptosis and invasion. This information suggests that RORα is a potent tumor suppressor and a potential therapeutic target for breast cancer.

IJMS, Vol. 13, Pages 15724-15754: Structure Prediction, Molecular Dynamics Simulation and Docking Studies of D-Specific Dehalogenase from Rhizobium sp. RC1

Posted: 26 Nov 2012 12:00 AM PST

Currently, there is no three-dimensional structure of D-specific dehalogenase (DehD) in the protein database. We modeled DehD using ab initio technique, performed molecular dynamics (MD) simulation and docking of D-2-chloropropionate (D-2CP), D-2-bromopropionate (D-2BP), monochloroacetate (MCA), monobromoacetate (MBA), 2,2-dichloropropionate (2,2-DCP), d,l-2,3-dichloropropionate (d,l-2,3-DCP), and 3-chloropropionate (3-CP) into the DehD active site. The sequences of DehD and D-2-haloacid dehalogenase (HadD) from Pseudomonas putida AJ1 have 15% sequence similarity. The model had 80% of the amino acid residues in the most favored region when compared to the crystal structure of DehI from Pseudomonas putida PP3. Docking analysis revealed that Arg107, Arg134 and Tyr135 interacted with D-2CP, and Glu20 activated the water molecule for hydrolytic dehalogenation. Single residue substitutions at 25–30 °C showed that polar residues of DehD were stable when substituted with nonpolar residues and showed a decrease in activity within the same temperature range. The molecular dynamics simulation of DehD and its variants showed that in R134A variant, Arg107 interacted with D-2CP, while in Y135A, Gln221 and Arg231 interacted with D-2CP. It is our emphatic belief that the new model will be useful for the rational design of DehDs with enhanced potentials.

Cowaboom

Posted: 26 Nov 2012 12:56 AM PST

The obnoxious bulls have invaded your farm and it's your task to stop them at any cost, will you prevail?

Molecules, Vol. 17, Pages 14002-14014: Novel Steroidal Components from the Underground Parts of Ruscus aculeatus L.

Posted: 26 Nov 2012 12:00 AM PST

Two new furostanol saponins 1–2 and three new sulphated glycosides 3a,b and 4 were isolated from the underground parts of Ruscus aculeatus L., along with four known furostanol and one spirostanol saponins 5–9 and three free sterols. All of the structures have been elucidated on the basis of spectroscopic data 1D and 2D NMR experiments, MS spectra and GC analyses.

Molecules, Vol. 17, Pages 13989-14001: Synthesis and Insecticidal Activity of an Oxabicyclolactone and Novel Pyrethroids

Posted: 26 Nov 2012 12:00 AM PST

Deltamethrin, a member of the pyrethroids, one of the safest classes of pesticides, is among some of the most popular and widely used insecticides in the World. Our objective was to synthesize an oxabicyclolactone 6 and five novel pyrethroids 8–12 from readily available furfural and D-mannitol, respectively, and evaluate their biological activity against four insect species of economic importance namely A. obtectus, S. zeamais, A. monuste orseis, and P. americana. A concise and novel synthesis of 6,6-dimethyl-3-oxabicyclo[3.1.0]hexan-2-one (6) from furfural is described. Photochemical addition of isopropyl alcohol to furan-2(5H)-one afforded 4-(1'-hydroxy-1'-methylethyl)tetrahydro-furan-2-one (3). The alcohol 3 was directly converted into 4-(1'-bromo-1'-methylethyl)-tetrahydrofuran-2-one (5) in 50% yield by reaction with PBr3 and SiO2. The final step was performed by cyclization of 5 with potassium tert-butoxide in 40% yield. The novel pyrethroids 8–12 were prepared from methyl (1S,3S)-3-formyl-2,2-dimethylcyclopropane-1-carboxylate (7a) by reaction with five different aromatic phosphorous ylides. Compounds 6–12 presented high insecticidal activity, with 6 and 11 being the most active. Compound 6 killed 90% of S. zeamais and 100% of all the other insects evaluated. Compound 11 killed 100% of all insects tested.

Molecules, Vol. 17, Pages 13969-13988: Novel Self-Dyed Wholly Aromatic Polyamide-Hydrazides Covalently Bonded with Azo Groups in Their Main Chains: 1. Structure-Property Relationships

Posted: 26 Nov 2012 12:00 AM PST

Twelve novel intrinsically colored wholly aromatic azopolyamide-hydrazides containing various proportions of para- and meta-phenylene units were successfully synthesized by a low temperature (−10 °C) solution polycondensation reaction of either 4-amino-3-hydroxybenzhydrazide (4A3HBH) or 3-amino-4-hydroxybenzhydrazide (3A4HBH) with an equimolar amount of either 4,4'-azodibenzoyl chloride (4,4'ADBC), 3,3'-azodibenzoyl chloride (3,3'ADBC), or mixtures of various molar ratios of 4,4'ADBC and 3,3'ADBC in anhydrous N,N-dimethyl acetamide (DMAc) containing 3% (wt/v) LiCl as a solvent. The structures of the polymers were proven by elemental analysis, FTIR, 1H- and 13C-NMR spectroscopy. The polymers’ properties were strongly affected by their various structures. The intrinsic viscosities of the polymers were ranged from 0.7 to 4.75 dL g−1 and increased with the para-phenylene units content. The polymers are partially soluble in DMAc, dimethyl formamide (DMF) and N-methyl-2-pyrrolidone (NMP). Their solubility increases with the introduction of meta-phenylene moieties into the polymer chains. The polymers exhibit a great affinity for water sorption. Their hydrophilicity increases as a function of the content of meta-phenylene rings incorporated into the polymer. Mechanical properties of the polymer films are improved markedly by substitution of para-phenylene units for meta-phenylene units. The completely para-oriented type polymer has the best thermal and thermo-oxidative stability relative to those of the other polymers.

Molecules, Vol. 17, Pages 13960-13968: A New Ursane-Type Nor-Triterpenoid from the Leaves of Eucommia ulmoides Oliv.

Posted: 26 Nov 2012 12:00 AM PST

A new ursane-type nortriterpenoid, (11S,12S)-4-methyl-11,12-epoxy-2-hydroxy-3-oxoursa-1,4-dine-28-oic acid γ-lactone (1), named ulmoidol A, together with ten known compounds: ulmoidol (2), corosolic acid (3), 2α,3α-dihydroxy-24-nor-4(23),12-oleanadien-28-oic acid (4), oleanolic acid (5), ursolic acid (6), cycloart-3β, 25-diol (7), foliasalacioside B1 (8), (6R,7E,9R)-9-hydroxy-4,7-megastigmadien-3-one-9-O-α-L-arabinopyranosyl-(1→6)-β-D-glucopyranoside (9), (6R,7E,9R)-9-hydroxy-4,7-megastigma-dien-3-one-9-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside (10), and quercetin 3-O-sambubioside (11) were isolated from the leaves of Eucommia ulmoides Oliv. The structure of compound 1 was determined by extensive spectroscopic analysis, and its absolute configuration was determined by CD experiments and a computational method. Compounds 3, 4, 7–10 were isolated from this plant for the first time. Compounds 3 and 4 showed inhibition to PTPIB activities, with IC50 values of 0.69 and 3.98 μM, respectively.

Molecules, Vol. 17, Pages 13948-13959: A Comparative Uptake Study of Multiplexed PET Tracers in Mice with Turpentine-Induced Inflammation

Posted: 26 Nov 2012 12:00 AM PST

The potential value of multiplexed positron emission tomography (PET) tracers in mice with turpentine-induced inflammation was evaluated and compared with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) for glucose metabolism imaging. These PET tracers included [18F]fluoromethylcholine ([18F]FCH) for choline metabolism imaging, (S-[11C]methyl)-D-cysteine ([11C]DMCYS) for amino acid metabolism imaging, [11C]bis(zinc(II)-dipicolylamine) ([11C]DPA-Zn2+) for apoptosis imaging, 2-(4-N-[11C]-methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB) for β amyloid binding imaging, and [18F]fluoride (18F−) for bone metabolism imaging. In mice with turpentine-induced inflammation mice, the biodistribution of all the tracers mentioned above at 5, 15, 30, 45, and 60 min postinjection was determined. Also, the time-course curves of the tracer uptake ratios for inflammatory thigh muscle (IM) to normal uninflammatory thigh muscle (NM), IM to blood (BL), IM to brain (BR), and IM to liver (LI) were acquired, respectively. Moreover, PET imaging with the tracers within 60 min postinjection on a clinical PET/CT scanner was also conducted. [18F]FDG and 18F− showed relatively higher uptake ratios for IM to NM, IM to BL, IM to BR, and IM to LI than [18F]FCH, [11C]DPA-Zn2+, [11C]DMCYS and [11C]PIB, which were highly consistent with the results delineated in PET images. The results demonstrate that 18F− seems to be a potential PET tracer for inflammation imaging. [18F]FCH and [11C]DMCYS, with lower accumulation in inflammatory tissue than [18F]FDG, are not good PET tracers for inflammation imaging. As a promising inflammatory tracer, the chemical structure of [11C]DPA-Zn2+ needs to be further optimized.

Remote Sensing, Vol. 4, Pages 3721-3740: Field Imaging Spectroscopy of Beech Seedlings under Dryness Stress

Posted: 26 Nov 2012 12:00 AM PST

In order to monitor dryness stress under controlled conditions, we set up an experiment with beech seedlings in plant pots and built a platform for observing the seedlings with field imaging spectroscopy. This serves as a preparation for multi-temporal hyperspectral air- and space-borne data expected to be available in coming years. Half of the trees were watered throughout the year; the other half were cut off from water supply for a five-week period in late summer. Plant health and soil, as well as leaf water status, were monitored. Moreover, hyperspectral images of the trees were acquired four times during the experiment. Results show that the experimental imaging setup is well suited for recording hyperspectral images of objects, like the beech pots, under natural illumination conditions. The high spatial resolution makes it feasible to discern between background, soil, wood, green leaves and brown leaves. Furthermore, it could be shown that dryness stress is detectable from an early stage even in the limited spectral range considered. The decline of leaf chlorophyll over time was also well monitored using imaging spectroscopy data.

Marine Drugs, Vol. 10, Pages 2661-2675: Inhibition of Bladder Tumor Growth by Chitooligosaccharides in an Experimental Carcinogenesis Model

Posted: 26 Nov 2012 12:00 AM PST

Urinary bladder cancer is one of the most common cancers worldwide, with the highest incidence in industrialized countries. Patients with cancer commonly use unconventional and complementary therapy including nutraceuticals. In this study we evaluated the efficacy of chitooligosaccharides (in orange juice) in rat bladder cancer chemoprevention and as therapeutic agent, on a rat model of urinary bladder carcinogenesis induced with N-butyl-N-(4-hydroxybutyl) nitrosamine. Results indicate that chitooligosaccharides may have a preventive effect on bladder cancer development and a curative effect upon established bladder tumors, dependent on the concentration ingested 500 mg/kg b.w., every three days, showed capacity to inhibit and prevent the proliferation of bladder cancer; however, this was associated with secondary effects such as hypercholesterolemia and hypertriglyceridemia. The use of lower doses (50 and 250 mg/kg b.w.) showed only therapeutic effects. It is further suggested that this antitumor effect might be due to its expected anti-inflammatory action, as well as by mechanisms not directly dependent of COX-2 inhibition, such as cellular proliferation control and improvement in antioxidant profile.

Magic Blaster

Posted: 26 Nov 2012 12:51 AM PST

Blast all the foul monsters using your deadly magic spells, in this intriguing puzzle game!

Seniors Find Mental Benefits From Everyday Activities

Posted: 26 Nov 2012 12:27 AM PST

Reading a book or playing a spirited game of chess could actually help seniors preserve the structural integrity of their brains, according to a new research presented Sunday at the Radiological Society of North America's annual meeting.

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JPM, Vol. 2, Pages 257-266: Aligning the Economic Value of Companion Diagnostics and Stratified Medicines

Posted: 26 Nov 2012 12:00 AM PST

The twin forces of payors seeking fair pricing and the rising costs of developing new medicines has driven a closer relationship between pharmaceutical companies and diagnostics companies, because stratified medicines, guided by companion diagnostics, offer better commercial, as well as clinical, outcomes. Stratified medicines have created clinical success and provided rapid product approvals, particularly in oncology, and indeed have changed the dynamic between drug and diagnostic developers. The commercial payback for such partnerships offered by stratified medicines has been less well articulated, but this has shifted as the benefits in risk management, pricing and value creation for all stakeholders become clearer. In this larger healthcare setting, stratified medicine provides both physicians and patients with greater insight on the disease and provides rationale for providers to understand cost-effectiveness of treatment. This article considers how the economic value of stratified medicine relationships can be recognized and translated into better outcomes for all healthcare stakeholders.

Information, Vol. 3, Pages 751-755: Information and Energy/Matter

Posted: 26 Nov 2012 12:00 AM PST

What can we hope for from studies of information related to energy/matter (as it appears for us in space/time)? Information is a concept known for its ambiguity in both common, everyday use and in its specific technical applications throughout different fields of research and technology. However, most people are unaware that matter/energy today is also a concept surrounded by a disquieting uncertainty. What for Democritus were building blocks of the whole universe appear today to constitute only 4% of its observed content. (NASA 2012) [1] The rest is labeled "dark matter" (conjectured to explain gravitational effects otherwise unaccounted for) and "dark energy" (introduced to account for the expansion of the universe). We do not know what "dark matter" and "dark energy" actually are. This indicates that our present understanding of the structure of the physical world needs re-examination. [...]
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