пятница, 30 ноября 2012 г.

Games

Games

Games

From trader to world's most syndicated word game creator

Posted: 30 Nov 2012 03:13 AM PST

As the most syndicated daily puzzle and word game creator in the world, David Hoyt's puzzles appear in more newspapers and magazines than anyone else.

This posting includes an audio/video/photo media file: Download Now

Greedy Dumble - Screenshots

Posted: 30 Nov 2012 03:36 AM PST

For some strange reasons they often find their hotdogs at odd places near some sort of floating objects. For the love of their hotdogs, Dumble and his fiends will bravely step onto them, work as a team, and reach for their prizes. To ensure their success and reduce the number of casualties, you can help by positioning them onto the platform with care and strategic planning.

The key is to utilize the properties of each dog, control the balance of each platform, and stack up the dogs to reach for the goal. So are you ready to challenge your stacking and balancing skills?

TreadRunner - Screenshots

Posted: 30 Nov 2012 03:26 AM PST

TreadRunner has two objectives:
1. Run as fast and as far as you can in 60 seconds!
2. Jump as many hurdles as you can in 60 seconds!
Intuitive swipe controls. Simple yet challenging!

TOUCH CONTROLS
1. Swipe down to run.
2. Swipe up to jump.

FEATURES
- Single Player Mode
- Two Player Online Match

Wombi Detective - Screenshots

Posted: 30 Nov 2012 03:41 AM PST

FEATURES and CONTENTS:
- Many different witnesses, suspects and environments. Every game is a new detective mystery!
- Several different game elements! Great variations!
- Illustrations with mysterious detective feeling!
- Mood setting animations!
- Beautiful noir music!

Word by ICSOFT 1.0.1 - A light, fully functional word processor.. (Commercial)

Posted: 30 Nov 2012 03:14 AM PST



Word by ICSOFT lets you design, edit and publish stunning documents. Loaded with a robust array of features and fully optimized for the sumptuous Retina display, no other desktop publishing app houses as much utility in such and immersive interface.

Word by ICSOFT is both intuitive and insanely capable. Create tables, import images, and perfect your documents with a host of powerful editing tools. Control how often your files are auto-saved, and export to common formats: .pdf, .doc, .rtf, .txt and odt.

Features

  • Beauty is in the eye of the Publisher: If a picture is worth a thousand words, the the Retina display is nothing less than epic. Word by ICSOFT takes full advantage of this gorgeous cutting-edge technology to give you the most immersive word-processing and desktop publishing environment imaginable.
  • Effortlessly edit and format your documents:
    • Inspector panels enable you to adjust fonts and formatting easily.

    • Word by ICSOFT is built to support multiple documents at the same time, for efficient editing and collaboration.

    • Spell check and grammar check make sure no embarrassing mistakes slip through.
  • Forget Photogenic, Word by ICSOFT is Photo-fantastic: Import, embed and manipulate as many images as your document requires. With anchor and text wrapping tools and the essential drag-to-resize feature, Word by ICSOFT allows you to design the pages that you envision. With support for all image formats (.jpg, .jpeg, .gif, .tiff and more), versatility of Word by ICSOFT makes it an essential tool in the desktop professional's repertoire.
  • Turn the tables on tables: Function and form are elegantly wed and endlessly modified through Word by ICSOFT's concise tables creator. Develop charts as alluring as they are informative. Finesse your reports to perfection and express the minutia of your data with aplomb. Edit columns, colors and text orientations through Word by ICSOFT's 's intuitive table management tools.
  • Lists and Special Characters: Word by ICSOFT is able to automatically format bulleted or numbered lists to make your documents crisp and clear. Utilize special characters to make documents more expressive and unique.
  • Find and Replace: Word by ICSOFT's lightning-fast Find and Replace feature allows you to update and modify your document without the need to manually scan the text yourself.
  • View: Word by ICSOFT gives you full access to multiple zoom and view settings. Hide or show layout elements, margins and rulers. Full screen view is also supported, to completely immerse you in your design work.
  • Auto-Saving on the fly: Word by ICSOFT is not only enabled with auto-save, but gives you control of how often you want your documents saved. Pick up where you left off and continue editing your document without worrying about lost work.
  • Infinite Office Interoperability: Word by ICSOFT has been built with the modern, multi-platform user in mind. Import and export into .itp, .doc, .pdf, .odt, .txt and .rft losslessly. Annoying losses of formatting and changed fonts are kept to a minimum when importing from one program into another. Word by ICSOFT is a quantum leap in desktop publishing.

Fully featured and visual stunning on the MacBook Pro's new Retina display, Word by ICSOFT is a top-notch design tool that is itself a marvel of pixel-perfection.

Version 1.0.1:

  • Some small bugs fixed.


OS X 10.7 or later, Intel

Download Now

Molecules, Vol. 17, Pages 14260-14274: Textile Dye Removal from Wastewater Effluents Using Bioflocculants Produced by Indigenous Bacterial Isolates

Posted: 30 Nov 2012 12:00 AM PST

Bioflocculant-producing bacteria were isolated from activated sludge of a wastewater treatment plant located in Durban, South Africa, and identified using standard biochemical tests as well as the analysis of their 16S rRNA gene sequences. The bioflocculants produced by these organisms were ethanol precipitated, purified using 2% (w/v) cetylpyridinium chloride solution and evaluated for removal of wastewater dyes under different pH, temperature and nutritional conditions. Bioflocculants from these indigenous bacteria were very effective for decolourizing the different dyes tested in this study, with a removal rate of up to 97.04%. The decolourization efficiency was largely influenced by the type of dye, pH, temperature, and flocculant concentration. A pH of 7 was found to be optimum for the removal of both whale and mediblue dyes, while the optimum pH for fawn and mixed dye removal was found to be between 9 and 10. Optimum temperature for whale and mediblue dye removal was 35 °C, and that for fawn and mixed dye varied between 40–45 °C and 35–40 °C, respectively. These bacterial bioflocculants may provide an economical and cleaner alternative to replace or supplement present treatment processes for the removal of dyes from wastewater effluents, since they are biodegradable and easily sustainable.

Molecules, Vol. 17, Pages 14249-14259: Recent Developments in the Reformatsky-Claisen Rearrangement

Posted: 30 Nov 2012 12:00 AM PST

The rearrangement of allyl a-bromoacetates with Zn dust is known as the Reformatsky-Claisen rearrangement. Whereas the Ireland-Claisen rearrangement has been widely used in the synthesis of a diverse range of natural products, the Zn-mediated Reformatsky-Claisen rearrangement has not been utilized so often. In this article, we will provide an overview of recent advances in the Reformatsky-Claisen rearrangement field, including the In-mediated Reformatsky-Claisen rearrangement we have recently developed.

Marine Drugs, Vol. 10, Pages 2741-2748: Five New Diterpenoids from an Okinawan Soft Coral, Cespitularia sp.

Posted: 30 Nov 2012 12:00 AM PST

Five new diterpenoids 1–5 were isolated from an Okinawan soft coral, Cespitularia sp., together with the known diterpenoid, alcyonolide (6). New diterpenoid structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Alcyonolide (6) was cytotoxic against HCT 116 cells (IC50 5.85 M), while these new diterpenoids 1–5 were much less active (IC50 28.2–91.4 μM).

Marine Drugs, Vol. 10, Pages 2729-2740: Rosmarinic Acid from Eelgrass Shows Nematicidal and Antibacterial Activities against Pine Wood Nematode and Its Carrying Bacteria

Posted: 30 Nov 2012 12:00 AM PST

Pine wilt disease (PWD), a destructive disease for pine trees, is caused by the pine wood nematode (PWN), Bursaphelenchus xylophilus and additional bacteria. In this study, extracts of Zostera marina showed a high nematicidal activity against PWN and some of the bacteria that it carries. Light yellow crystals were obtained from extracts of Z. marina through solvent extraction, followed by chromatography on AB-8 resin and crystallization. The NMR and HPLC analysis showed that the isolated compound was rosmarinic acid (RosA). RosA showed effective nematicidal activity, of which the LC50 (50% lethal concentration) to PWN at 24 h, 48 h and 72 h was 1.18 mg/g, 1.05 mg/g and 0.95 mg/g, respectively. To get a high yield rate of RosA from Z. marina, single factor experiments and an L9 (34) orthogonal experiment were performed. This extraction process involved 70% ethanol for 3 h at 40 °C. The extraction dosage was 1:50 (w/v). The highest yield of RosA from Zostera was 3.13 mg/g DW (dried weight). The crude extracts of Zostera marina (10 mg/mL) and RosA (1 mg/mL) also showed inhibitory effects to some bacterial strains carried by PWN: Klebsiella sp., Stenotrophomonas maltophilia, Streptomyces sp. and Pantoea agglomerans. The results of these studies provide clues for preparing pesticide to control PWD from Z. marina.

Marine Drugs, Vol. 10, Pages 2715-2728: Synthesis and Antitumor Activities of Derivatives of the Marine Mangrove Fungal Metabolite Deoxybostrycin

Posted: 30 Nov 2012 12:00 AM PST

Deoxybostrycin (1) is an anthraquinone compound derived from the marine mangrove fungus Nigrospora sp. No. 1403 and has potential to be a lead for new drugs because of its various biological properties. A series of new derivatives (2–22) of deoxybostrycin were synthesized. The in vitro cytotoxicity of all the new compounds was tested against MDA-MB-435, HepG2 and HCT-116 cancer cell lines. Most of the compounds exhibit strong cytotoxicity with IC50 values ranging from 0.62 to 10 μM. Compounds 19, 21 display comparable cytotoxicity against MDA-MB-435 to epirubicin, the positive control. The primary screening results indicate that the deoxybostrycin derivatives might be a valuable source of new potent anticancer drug candidates.

Rugby League Live 2 - Screenshots

Posted: 30 Nov 2012 02:54 AM PST

Features:
- 100+ Leagues & Teams: Super League, NRL, Co-operative Championships, NSW & QLD cups, Toyota Cup, Representative teams, England, Australia & New Zealand.
Dynamic Tackling System: Fend and break tackle your way past multiple defenders.
- Create, Customise and Share: Players and teams in the fully featured "Footy Factory".
- 34 High Detail Stadia from Europe, Australia and New Zealand.
- Massive 10-Year Career Mode: Sign sponsors, hire top-flight coaching staff, negotiate player contracts and set player training programmes, to build the ultimate team.
- Competitive or Co-operative: Multiplayer matches, with up to 8 players (4 aside) online.
- Experience System: Earn badges and experience both online and off, to rise to the top of the leader-boards.
- Tactical Passing: Perform defensive or attacking passes to best exploit your opponents.
- Strategic Defence: Set up to increase the likelihood of one, two or three-man, tackles!
- Spectacular High Ball Catching: Soar high to catch or tap the ball to fellow teammates.
- Superb detail: Includes dynamic pitch wear and tear; grass wears away in areas of action. Unique mud and sweat; players accumulate mud on their bodies specifically where they hit the ground. Players even show sweat based on their individual exertion levels.
- Double-Barrelled Experts: Commentary from Andrew Voss and Phil 'Gus' Gould.

Jelly All Stars - Screenshots

Posted: 30 Nov 2012 02:49 AM PST

Special star jellies will destroy any other jellies of the same color that are adjacent to one another. The more jellies are destroyed and the bigger they are the higher the points and the quicker you progress through the levels – but beware: the higher the level the faster those jellies will drop! Especially skillful players will be able to ramp up their scores even more by chaining up massive combos. To spice things up further there are five different special jellies that all have unique powers and applications. For example, the shiny diamond jellies will destroy all blocks of the same color, even if they are not connected. Thanks to local and online highscores you'll be able to see who is a true master of jelly and who is not!

GTA: Vice City anniversary trailer is full of violently happy Vice City memories

Posted: 30 Nov 2012 02:57 AM PST

Rockstar has released a trailer for its upcoming 10th anniversary remake of Grand Theft Auto: Vice City on iOS and Android devices. It's full of happy

Wedding Garden - Screenshots

Posted: 30 Nov 2012 02:31 AM PST

Game features engaging farm-style gameplay that challenges players not only to rebuild the island, but also cultivate crops, care for animals to bring new life to the island. Gameplay centers on the constant expansion of your island through new construction and agricultural endeavors. Unlock new titles as you persevere, from a simple gardener all the way to Duke! Strategy prevails as the island blossoms with players balancing needs of raw materials, factories and retail locations as they engineer the perfect wedding!

IJERPH, Vol. 9, Pages 4346-4364: Using the Gravity Model to Estimate the Spatial Spread of Vector-Borne Diseases

Posted: 30 Nov 2012 12:00 AM PST

The gravity models are commonly used spatial interaction models. They have been widely applied in a large set of domains dealing with interactions amongst spatial entities. The spread of vector-borne diseases is also related to the intensity of interaction between spatial entities, namely, the physical habitat of pathogens’ vectors and/or hosts, and urban areas, thus humans. This study implements the concept behind gravity models in the spatial spread of two vector-borne diseases, nephropathia epidemica and Lyme borreliosis, based on current knowledge on the transmission mechanism of these diseases. Two sources of information on vegetated systems were tested: the CORINE land cover map and MODIS NDVI. The size of vegetated areas near urban centers and a local indicator of occupation-related exposure were found significant predictors of disease risk. Both the land cover map and the space-borne dataset were suited yet not equivalent input sources to locate and measure vegetated areas of importance for disease spread. The overall results point at the compatibility of the gravity model concept and the spatial spread of vector-borne diseases.

IJERPH, Vol. 9, Pages 4333-4345: Snowmelt Runoff: A New Focus of Urban Nonpoint Source Pollution

Posted: 30 Nov 2012 12:00 AM PST

Irregular precipitation associated with global climate change had been causing various problems in urban regions. Besides the runoff due to rainfall in summer, the snowmelt runoff in early spring could also play an important role in deteriorating the water quality of the receiving waters. Due to global climate change, the snowfall has increased gradually in individual regions, and snowstorms occur more frequently, which leads to an enhancement of snowmelt runoff flow during the melting seasons. What is more, rivers just awaking from freezing cosntitute a frail ecosystem, with poor self-purification capacity, however, the urban snowmelt runoff could carry diverse pollutants accumulated during the winter, such as coal and/or gas combustion products, snowmelting agents, automotive exhaust and so on, which seriously threaten the receiving water quality. Nevertheless, most of the research focused on the rainfall runoff in rainy seasons, and the study on snowmelt runoff is still a neglected field in many countries and regions. In conclusion, due to the considerable water quantity and the worrisome water quality, snowmelt runoff in urban regions with large impervious surface areas should be listed among the important targets in urban nonpoint source pollution management and control.

IJMS, Vol. 13, Pages 16255-16266: Isolation and Characterization of Saponin-Producing Fungal Endophytes from Aralia elata in Northeast China

Posted: 30 Nov 2012 12:00 AM PST

The purpose of this study was to investigate the diversity of endophytic fungi of Aralia elata distributed in Northeast China as well as their capacity to produce saponins. Ninety-six strains of endophytic fungi were isolated, and polymerase chain reaction (PCR) and sequencing were employed to identify the isolates. The saponin concentrations of the culture filtrates of representative strains were measured. The agar diffusion method was used to test antimicrobial activity, while high-performance liquid chromatography (HPLC) was employed to identify the saponins produced by representative strains. Alternaria, Botryosphaeria, Camarosporium, Cryptosporiopsis, Diaporthe, Dictyochaeta, Penicillium, Fusarium, Nectria, Peniophora, Schizophyllum, Cladosporium and Trichoderma species were isolated in this study. Overall, 25% of the isolates belonged to Diaporthe (Diaporthe eres), and 12.5% belonged to Alternaria. The highest concentration of saponins was produced by G22 (2.049 mg/mL). According to the results of the phylogenetic analysis, G22 belonged to the genus Penicillium. The culture filtrate of G22 exhibited antibacterial activity against Staphylococcus aureus, and ginsenosides Re and Rb2 were detected in G22 culture filtrates by HPLC.

IJMS, Vol. 13, Pages 16241-16254: Alterations in Glutathione Redox Metabolism, Oxidative Stress, and Mitochondrial Function in the Left Ventricle of Elderly Zucker Diabetic Fatty Rat Heart

Posted: 30 Nov 2012 12:00 AM PST

The Zucker diabetic fatty (ZDF) rat is a genetic model in which the homozygous (FA/FA) male animals develop obesity and type 2 diabetes. Morbidity and mortality from cardiovascular complications, due to increased oxidative stress and inflammatory signals, are the hallmarks of type 2 diabetes. The precise molecular mechanism of contractile dysfunction and disease progression remains to be clarified. Therefore, we have investigated molecular and metabolic targets in male ZDF (30–34 weeks old) rat heart compared to age matched Zucker lean (ZL) controls. Hyperglycemia was confirmed by a 4-fold elevation in non-fasting blood glucose (478.43 ± 29.22 mg/dL in ZDF vs. 108.22 ± 2.52 mg/dL in ZL rats). An increase in reactive oxygen species production, lipid peroxidation and oxidative protein carbonylation was observed in ZDF rats. A significant increase in CYP4502E1 activity accompanied by increased protein expression was also observed in diabetic rat heart. Increased expression of other oxidative stress marker proteins, HO-1 and iNOS was also observed. GSH concentration and activities of GSH-dependent enzymes, glutathione S-transferase and GSH reductase, were, however, significantly increased in ZDF heart tissue suggesting a compensatory defense mechanism. The activities of mitochondrial respiratory enzymes, Complex I and Complex IV were significantly reduced in the heart ventricle of ZDF rats in comparison to ZL rats. Western blot analysis has also suggested a decreased expression of IκB-α and phosphorylated-JNK in diabetic heart tissue. Our results have suggested that mitochondrial dysfunction and increased oxidative stress in ZDF rats might be associated, at least in part, with altered NF-κB/JNK dependent redox cell signaling. These results might have implications in the elucidation of the mechanism of disease progression and designing strategies for diabetes prevention.

IJMS, Vol. 13, Pages 16223-16240: Modelling Translation Initiation under the Influence of sRNA

Posted: 30 Nov 2012 12:00 AM PST

Bacterial small non-coding RNA (sRNA) plays an important role in post-transcriptional gene regulation. Although the number of annotated sRNA is steadily increasing, their functional characterization is still lagging behind. Various computational strategies for finding sRNA–mRNA interactions, and thus putative sRNA targets, were developed. Most of them suffer from a high false positive rate. Here, we present a qualitative model to simulate the effect of an sRNA on the translation initiation of a potential target. Information about the ribosome–mRNA interaction, sRNA–mRNA interaction and expression information from deep sequencing experiments is integrated to calculate the change in translation initiation complex formation, as a proxy for translational activity. This model can be used to post-evaluate predicted targets, hence condensing the list of potential targets. We show that our translation initiation model, under the influence of an sRNA, can successfully simulate thirteen out of fifteen tested sRNA–mRNA interactions in a qualitative manner. To show the gain in specificity, we applied our method to a target search for the Escherichia coli sRNA RyhB. Compared with simple target prediction without post-evaluation, we reduce the number of targets to less than one fourth potential targets, considerably reducing the burden of experimental validation.

Stephano talks about his Day 1 Run at IPL 5, fatigue and more

Posted: 30 Nov 2012 01:16 AM PST

Slasher catches up with Stephano to find out if HerO really had special tactics, his fatigue level, overcoming drama and more.

 

Read and Post Comments | Get the full article at GameSpot

"Stephano talks about his Day 1 Run at IPL 5, fatigue and more" was posted by DanM on Fri, 30 Nov 2012 01:16:23 -0800
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