четверг, 13 октября 2011 г.

Games

Games

Water, Vol. 3, Pages 976-987: Framework for Enhancing the Supply-Demand Balance of a Tri-Supply Urban Water Scheme in Australia

Posted: 13 Oct 2011 12:00 AM PDT

Fit-for-purpose potable source substitution of appropriate water end uses with rainwater or recycled water is often essential to maintain water security in growing urban regions. This paper provides the results of a detailed supply-demand forecasting review of a unique tri-supply (i.e., potable, A+ recycled and rain water sources reticulated to household) urban water scheme located in Queensland, Australia. Despite the numerous benefits of this scheme, system efficiency (e.g., reduced demand levels, water treatment, low chemical and energy use) and economic viability (i.e., capital and operating costs per kL of supply) aspects need to be considered against derived potable water savings. The review underpinned the design of a framework to enhance the schemes supply-demand balance and reduce the unit cost of alternative source supplies. Detailed scenario and sensitivity analysis identified the possibility of a refined scheme design, whereby the A+ recycled water supply would be reticulated to the cold water input tap to the washing machine, and the rain tank that originally supplied this end use be removed from future constructed households. The refined scheme design enhances the present recycled plant utilisation rate and reduces the cost to home owners when building their dwelling due to the removed requirement to install a rain tank to indoor end uses; such actions reduce the overall unit cost of the scheme.

Molbank, Vol. 2011, Pages M739: 4-Amino-N-(2-hydroxy-4-pentadecylbenzylidene)benzenesulfonamide

Posted: 13 Oct 2011 12:00 AM PDT

4-Amino-N-(2-hydroxy-4-pentadecylbenzylidene)benzenesulfonamide has been synthesized by reaction of 2-hydroxy-4-pentadecylbenzaldehyde with 4-aminobenzenesulfonamide in the presence of acetic acid in ethanol. The structure of this new compound was confirmed by elemental analysis, IR, 1H-NMR, 13C-NMR and mass spectral analysis.

IJMS, Vol. 12, Pages 6765-6780: A Novel Cold-Adapted Lipase from Sorangium cellulosum Strain So0157-2: Gene Cloning, Expression, and Enzymatic Characterization

Posted: 13 Oct 2011 12:00 AM PDT

Genome sequencing of cellulolytic myxobacterium Sorangium cellulosum reveals many open-reading frames (ORFs) encoding various degradation enzymes with low sequence similarity to those reported, but none of them has been characterized. In this paper, a predicted lipase gene (lipA) was cloned from S. cellulosum strain So0157-2 and characterized. lipA is 981-bp in size, encoding a polypeptide of 326 amino acids that contains the pentapeptide (GHSMG) and catalytic triad residues (Ser114, Asp250 and His284). Searching in the GenBank database shows that the LipA protein has only the 30% maximal identity to a human monoglyceride lipase. The novel lipA gene was expressed in Escherichia coli BL21 and the recombinant protein (r-LipA) was purified using Ni-NTA affinity chromatography. The enzyme hydrolyzed the p-nitrophenyl (pNP) esters of short or medium chain fatty acids (≤C10), and the maximal activity was on pNP acetate.The r-LipA is a cold-adapted lipase, with high enzymatic activity in a wide range of temperature and pH values. At 4 °C and 30 °C, the Km values of r-LipA on pNP acetate are 0.037 ± 0.001 and 0.174 ± 0.006 mM, respectively. Higher pH and temperature conditions promoted hydrolytic activity toward the pNP esters with longer chain fatty acids. Remarkably, this lipase retained much of its activity in the presence of commercial detergents and organic solvents. The results suggest that the r-LipA protein has some new characteristics potentially promising for industrial applications and S. cellulosum is an intriguing resource for lipase screening.

0xED 1.0.8 - Native OS X hex editor based on the Cocoa framework.. (Free)

Posted: 13 Oct 2011 02:51 AM PDT



0xED is a native OS X hex editor based on the Cocoa framework.

Features:

  • Fast editing of large files
  • Unlimited file size (limited by what the actual file system supports)
  • Small memory footprint
  • Instant opening of files of any size
  • Supports all normal text editor keyboard shortcuts
  • HFS+ compatible
  • Full hex/text search/replace
  • Binary/text Cut/copy/paste support
  • Main window is sizable
  • Plug-in system to display your custom data types
  • Universal 32/64 bit binary
  • Free of charge



Version 1.0.8:
  • Bug fixes.
  • Dead key support for text column.
  • French localization.
  • Dropped support for Mac OS X 10.3 and 10.4.
  • 64 bit support (will require plugins be recompiled when running 64 bit).
  • Updated sample project.
  • Speed improvements on large number of edits and when searching.
  • EBCDIC 037, GSM 03.38 text column support.


Mac OS X 10.5.8 or later.

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Sensors, Vol. 11, Pages 9717-9731: Authenticity Preservation with Histogram-Based Reversible Data Hiding and Quadtree Concepts

Posted: 13 Oct 2011 12:00 AM PDT

With the widespread use of identification systems, establishing authenticity with sensors has become an important research issue. Among the schemes for making authenticity verification based on information security possible, reversible data hiding has attracted much attention during the past few years. With its characteristics of reversibility, the scheme is required to fulfill the goals from two aspects. On the one hand, at the encoder, the secret information needs to be embedded into the original image by some algorithms, such that the output image will resemble the input one as much as possible. On the other hand, at the decoder, both the secret information and the original image must be correctly extracted and recovered, and they should be identical to their embedding counterparts. Under the requirement of reversibility, for evaluating the performance of the data hiding algorithm, the output image quality, named imperceptibility, and the number of bits for embedding, called capacity, are the two key factors to access the effectiveness of the algorithm. Besides, the size of side information for making decoding possible should also be evaluated. Here we consider using the characteristics of original images for developing our method with better performance. In this paper, we propose an algorithm that has the ability to provide more capacity than conventional algorithms, with similar output image quality after embedding, and comparable side information produced. Simulation results demonstrate the applicability and better performance of our algorithm.

Sensors, Vol. 11, Pages 9700-9716: Coexistence of WiFi and WiMAX Systems Based on PS-Request Protocols

Posted: 13 Oct 2011 12:00 AM PDT

We introduce both the coexistence zone within the WiMAX frame structure and a PS-Request protocol for the coexistence of WiFi and WiMAX systems sharing a frequency band. Because we know that the PS-Request protocol has drawbacks, we propose a revised PS-Request protocol to improve the performance. Two PS-Request protocols are based on the time division operation (TDO) of WiFi system and WiMAX system to avoid the mutual interference, and use the vestigial power management (PwrMgt) bit within the Frame Control field of the frames transmitted by a WiFi AP. The performance of the revised PS-Request protocol is evaluated by computer simulation, and compared to those of the cases without a coexistence protocol and to the original PS-Request protocol.

Polymers, Vol. 3, Pages 1794-1804: Dependence of Optical and Microstructure Properties of Thiol-Capped Silver Nanoparticles Embedded in Polymeric Matrix

Posted: 13 Oct 2011 12:00 AM PDT

Thiol-capped silver nanoparticles were prepared by in situ thermal decomposition of different silver(I)-thiolates precursors in a polymeric matrix. Depending on the structure of the organic coating, contact-free distribution of metal nanoparticles or nanoparticles aggregates were achieved. The structure and morphology of nanocomposites was analyzed by Transmission Electron Microscopy (TEM), and X-Ray Diffraction (XRD). Nanoparticles' interaction was investigated by differential scanning calorimetry (DSC), and UV-Visible spectroscopy. In particular, only silver nanoparticles coated by n-alkyl thiols aggregated, while a contact-free dispersion was obtained by cyclohexyl thiol-capped silver nanoparticles.

Membranes, Vol. 1, Pages 299-313: Liquid Phase Micro-Extraction of Linear Alkylbenzene Sulfonate Anionic Surfactants in Aqueous Samples

Posted: 13 Oct 2011 12:00 AM PDT

Hollow fiber liquid phase micro-extraction (LPME) of linear alkylbenzene sulfonates (LAS) from aqueous samples was studied. Ion pair extraction of C10, C11, C12 and C13 homologues was facilitated with trihexylamine as ion-pairing agent, using di-n-hexylether as solvent for the supported liquid membrane (SLM). Effects of extraction time, acceptor buffer concentration, stirring speed, sample volume, NaCl and humic acids were studied. At 10–50 µg L−1 linear R2-coefficients were 0.99 for C10 and C11 and 0.96 for C12. RSD was typically ~15%. Three observations were especially made. Firstly, LPME for these analytes was unusually slow with maximum enrichment observed after 15–24 h (depending on sample volume). Secondly, the enrichment depended on LAS sample concentration with 35–150 times enrichment below ~150 µg L−1 and 1850–4400 times enrichment at 1 mg L−1. Thirdly, lower homologues were enriched more than higher homologues at low sample concentrations, with reversed conditions at higher concentrations. These observations may be due to the fact that LAS and the amine counter ion themselves influence the mass transfer at the water-SLM interface. The observations on LPME of LAS may aid in LPME application to other compounds with surfactant properties or in surfactant enhanced membrane extraction of other compounds.

Genes, Vol. 2, Pages 689-705: RNA-Seq for Plant Pathogenic Bacteria

Posted: 13 Oct 2011 12:00 AM PDT

The throughput and single-base resolution of RNA-Sequencing (RNA-Seq) have contributed to a dramatic change in transcriptomic-based inquiries and resulted in many new insights into the complexities of bacterial transcriptomes. RNA-Seq could contribute to similar advances in our understanding of plant pathogenic bacteria but it is still a technology under development with limitations and unknowns that need to be considered. Here, we review some new developments for RNA-Seq and highlight recent findings for host-associated bacteria. We also discuss the technical and statistical challenges in the practical application of RNA-Seq for studying bacterial transcriptomes and describe some of the currently available solutions.

Cancers, Vol. 3, Pages 3856-3893: Cytokines in Cancer Immunotherapy

Posted: 13 Oct 2011 12:00 AM PDT

Cytokines are molecular messengers that allow the cells of the immune system to communicate with one another to generate a coordinated, robust, but self-limited response to a target antigen. The growing interest over the past two decades in harnessing the immune system to eradicate cancer has been accompanied by heightened efforts to characterize cytokines and exploit their vast signaling networks to develop cancer treatments. The goal of this paper is to review the major cytokines involved in cancer immunotherapy and discuss their basic biology and clinical applications. The paper will also describe new cytokines in pre-clinical development, combinations of biological agents, novel delivery mechanisms, and potential directions for future investigation using cytokines.

Toxins, Vol. 3, Pages 1233-1248: Structure-Based Design of Ricin Inhibitors

Posted: 13 Oct 2011 12:00 AM PDT

Ricin is a potent cytotoxin easily purified in large quantities. It presents a significant public health concern due to its potential use as a bioterrorism agent. For this reason, extensive efforts have been underway to develop antidotes against this deadly poison. The catalytic A subunit of the heterodimeric toxin has been biochemically and structurally well characterized, and is an attractive target for structure-based drug design. Aided by computer docking simulations, several ricin toxin A chain (RTA) inhibitors have been identified; the most promising leads belonging to the pterin family. Development of these lead compounds into potent drug candidates is a challenging prospect for numerous reasons, including poor solubility of pterins, the large and highly polar secondary binding pocket of RTA, as well as the enzyme's near perfect catalytic efficiency and tight binding affinity for its natural substrate, the eukaryotic ribosome. To date, the most potent RTA inhibitors developed using this approach are only modest inhibitors with apparent IC50 values in the 10−4 M range, leaving significant room for improvement. This review highlights the variety of techniques routinely employed in structure-based drug design projects, as well as the challenges faced in the design of RTA inhibitors.

Pharmaceutics, Vol. 3, Pages 706-722: Investigation of the Formation Process of Two Piracetam Cocrystals during Grinding

Posted: 12 Oct 2011 12:00 AM PDT

Cocrystal formation rates during dry grinding and liquid-assisted grinding were investigated by X-ray powder diffractometry and Raman spectroscopy. Two polymorphic forms of piracetam were used to prepare known piracetam cocrystals as model substances, i.e.,piracetam-citric acid and piracetam-tartaric acid cocrystals. Raman spectroscopy in combination with principal component analysis was used to visualize the cocrystal formation pathways. During dry grinding, cocrystal formation appeared to progress via an amorphous intermediate stage, which was more evident for the piracetam-citric acid than for the piracetam-tartaric acid cocrystal. It was shown that liquid-assisted grinding led to faster cocrystal formation than dry grinding, which may be explained by the higher transformation rate due to the presence of liquid. The cocrystal formation rate did not depend on the applied polymorphic form of the piracetam and no polymorphic cocrystals were obtained.

Rugby Challenge All Blacks Haka Gameplay Movie

Posted: 13 Oct 2011 12:13 AM PDT

The All Blacks intimidate the Irish with the infamous haka in Rugby Challenge

Read and Post Comments | Get the full article at GameSpot

"Rugby Challenge All Blacks Haka Gameplay Movie" was posted by edmondt on Thu, 13 Oct 2011 00:13:25 -0700

Rugby Challenge England vs France Gameplay Movie

Posted: 13 Oct 2011 12:11 AM PDT

England and France duke it out on the field in Rugby Challenge

Read and Post Comments | Get the full article at GameSpot

"Rugby Challenge England vs France Gameplay Movie" was posted by edmondt on Thu, 13 Oct 2011 00:11:42 -0700

Rugby Challenge South Africa Vs. Japan Gameplay Movie

Posted: 13 Oct 2011 12:10 AM PDT

South Africa takes on Japan in Rugby Challenge

Read and Post Comments | Get the full article at GameSpot

"Rugby Challenge South Africa Vs. Japan Gameplay Movie" was posted by edmondt on Thu, 13 Oct 2011 00:10:57 -0700

SOE president says attempted hacks hit dormant accounts

Posted: 12 Oct 2011 08:36 PM PDT

John Smedley confident log-in and password information used in recent attack wasn't obtained from Sony, says attackers had "small percentage" of success in gaining access.

 

Yesterday, Sony revealed a new attack on its networks, this one resulting in the electronics giant temporarily locking down some 93,000 PlayStation Network, Sony Entertainment Network, and Sony Online Entertainment accounts. In an official statement, Sony chief information security officer Philip Reitinger said, "it is likely the data came from another source and not from our networks."

Speaking with GameSpot tonight after Game Developers Conference Online Awards, Sony Online Entertainment president John Smedley shed a little more light on what led the company to believe its system was not the ultimate source for the log in info used in the attack.

"It's just simple math," Smedley said. "There was such a small percentage of successes. They were attacking with a large number. Because of that, the math tells us it wasn't [Sony's information]. We've said publicly when we were compromised before that the information is out there and could have been used. That was obviously the first thing we looked at. Then we did the mathematical analysis and said, 'Obviously that's not what happened.' I'm not going to say it's impossible [the info came from Sony]. We just think that's not the most likely case."

As for the accounts that were targeted, Smedley said many of them had never been accessed since the PlayStation Network was restored after an extended outage earlier this year. That outage was precipitated by a security breach that exposed exposed some 77 million PSN accounts, not to mention an additional 24.6 million Sony Online Entertainment accounts. Upon logging back into the service after the restoration, users were prompted to change their passwords.

"We really strongly encourage users to change their passwords," Smedley said. "We can't force them to log in and do that. A great number of these accounts they were going after were dormant accounts. Those people in many cases had not yet done their password change. It takes some work to get them to focus on that."

Read and Post Comments | Get the full article at GameSpot

"SOE president says attempted hacks hit dormant accounts" was posted by Brendan Sinclair on Wed, 12 Oct 2011 20:36:54 -0700

Top Truck 3

Posted: 13 Oct 2011 02:31 AM PDT

Top Truck is back for another episode of car crushing madness!

Author W.P. Kinsella, 76, enjoys nostalgic visit to Edmonton

Posted: 13 Oct 2011 12:00 AM PDT

W.P. Kinsella doesn't like dogs. He doesn't like overpriced cafA©s. And he doesn't like public transportation.

This posting includes an audio/video/photo media file: Download Now

Apple OS X Lion Server 10.7.2 - Server add-on for OS X Lion users.. (Updater)

Posted: 12 Oct 2011 08:59 PM PDT



Lion Server is the next generation of Apple's award-winning server software. Designed for OS X and iOS devices, Lion Server makes it easy to share files, schedule meetings, synchronize contacts, host your own website, publish wikis, distribute podcasts, remotely access your network, and more.

Mac OS X Server is now a set of applications you can purchase right from the Mac App Store. Anyone can quickly and easily turn a Mac running Lion into a server that's perfect for home offices, businesses, schools, and hobbyists alike.

File Sharing

  • File sharing for Mac, PC, and iPad
  • Standards-based AFP, SMB, and WebDAV file services
  • Flexible file permissions
  • Spotlight searching
Mail Services
  • Standards-based SMTP, IMAP, and POP server
  • Push notifications
  • SSL encryption
  • Adaptive junk mail filtering
  • Virus detection and quarantine
  • Webmail with email rules and vacation messages
iCal Server
  • Share calendars, schedule meetings and events, and book conference rooms
  • Standards-based CalDAV server for access from Mac, iPad, iPhone, and PC
  • View availability with free/busy lookups
  • Email invitations and notifications
  • Push notifications
Address Book Server
  • Synchronize contacts with Mac, iPad, and iPhone
  • Allow multiple users to access and update contacts
  • Standards-based CardDAV server
  • Push notifications
Profile Manager
  • Configuration and management for OS X Lion and iOS
  • Over-the-air enrollment
  • Mobile device management
  • Web-based administration console
  • Self-service user portal for clearing passcodes, remote lock and wipe
iChat Server
  • Secure encrypted instant messaging for your organization
  • Persistent chat rooms
  • Store-and-forward for sending messages to buddies who are offline
  • Server-to-server federation
  • Works with iChat audio and video conferencing
Wiki Server
  • Point-and-click page editor to change formatting and insert images, movies, and attachments
  • Access controls
  • Tags and comments
  • Revision history
  • Document sharing
  • Quick Look previews
  • Email notifications
Podcasting
  • Capture audio and video, record onscreen actions, and publish content
  • Publish QuickTime audio and video formats, PDFs, and ePub documents
  • Automatic RSS feed generation
  • Media library and file management using Podcast Publisher
Virtual Private Network
  • Highly secure remote access for your network services
  • Encrypted VPN connections for Mac, iPad, iPhone, and PC
Time Machine
  • Provide a backup destination for Mac computers on your network
  • Deliver backup support for OS X Lion and Snow Leopard systems
Xsan
  • Block-level SAN file sharing with concurrent read/write access
  • Xsan volume hosting and configuration
  • Volume management, storage pools, striping, and volume mapping
  • Real-time monitoring, graphs, and event notifications
  • Metadata controller failover and file system journaling
Server App
  • Local or remote setup
  • User and groups settings
  • Real-time graphs of server usage and activity


Version 10.7.2:

The 10.7.2 update is recommended for all servers currently running Lion Server. This update includes general operating system fixes that enhance the stability, compatibility and security of your server and improved reliability of the following services and applications:

  • Calendar Server
  • Directory integration
  • Mail Server
  • Open Directory Server
  • Podcast Producer Library and Publisher
  • PostgreSQL database
  • Profile Manager
  • Server.app
  • Software Update Server
  • Wiki Server
The update also includes specific fixes for:
  • viewing logs from within Server.app
  • resetting passwords for multiple users in Server.app
  • improved support for editing multiple groups in Server.app
  • support for new iOS 5 Mobile Device Management features in Profile Manager
  • support for creating a Recovery Partition in images created with Server Image Utility
  • improved support for specifying web server Virtual Host configurations using Server.app
  • specifying where service data is located
  • improved reliability when migrating servers


Mac OX 10.7 or later.

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Apple Aperture 3.2 - Post-production photography solution.. (Updater)

Posted: 12 Oct 2011 08:59 PM PDT



Apple Aperture is designed from the ground up for professional photographers, Aperture provides everything you need for after the shoot, delivering the first all-in-one post-production tool for photographers.

Featuring a RAW-focused workflow, Aperture makes RAW as easy as JPEG, letting you import, edit, catalog, organize, retouch, publish, and archive your images more effectively and efficiently than ever before. From capture to output, you work directly with your RAW files, never having to first convert them into another format before viewing, adjusting, organizing, or printing them.

And with the most powerful image processing in the world, Aperture is fast - whether you're working with RAW, JPEG, or TIFF images. It supports the RAW formats from all leading digital camera manufacturers (including Canon and Nikon) and provides optimized support for such market leading cameras as the Canon EOS 1Ds Mark II, Canon EOS 20D, and Nikon D2x as well as the highly popular Canon Digital Rebel and Nikon D50. It also supports the Adobe DNG format.

Version 3.2:

Supports compatibility with iCloud and iOS 5. This update also addresses minor stability, performance and compatibility issues, including:

  • Resolves an issue that could cause the "Loading" indicator to reappear in the Viewer when cropping a photo
  • Aperture now automatically relaunches into Full Screen mode if the application was in Full Screen mode when last quit
  • Pinch-to-zoom gesture now automatically activates Zoom mode in the Viewer
  • Left and right swipe gestures can now be used to navigate between photos in the Viewer
  • Microsoft Outlook can now be chosen in Preferences as the application used by Aperture for emailing photos
  • Fixes a problem that could cause Aperture, running on OS X Lion, to quit unexpectedly when using brushes to apply adjustments
  • Loupe now correctly displays magnification levels between 50-100%.
  • Fixes an issue that could cause Aperture, running on OS X Lion, to display the incorrect color profile on externally edited images
  • Import window now includes an option to delete photos from iPhone and iPad after they have been imported into Aperture
  • The Lift & Stamp tool now displays the correct cursor icons when being used in Split View and Viewer only modes



  • Mac OS X 10.6 or later.
  • 1GB RAM (2GB or more recommended).


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