Games |
- DesktopShelves 1.4 - Display any folder as a shelf on your desktop.. (Demo)
- HueGo! Lite 2.0.0 - Simple on-screen color picker.. (Free)
- Hue Go! 2.0.0 - Color picker selects colors from anywhere on screen.. (Commercial)
- TransformMovie 1.2.8 - Batch rotate & resize movies.. (Demo)
- SEO SpyGlass 4.6.2 - Detailed information on competitors search engine postions.. (Free)
- Microarrays, Vol. 1, Pages 3-24: Microbial Diagnostic Microarrays for the Detection and Typing of Food- and Water-Borne (Bacterial) Pathogens
- IJMS, Vol. 12, Pages 6796-6809: Nuclear Markers of Danube Sturgeons Hybridization
- Microarrays, Vol. 1, Pages 1-2: The Journal Microarrays
- IJMS, Vol. 12, Pages 6781-6795: The Stimulation of IGF-1R Expression by Lewis(y) Antigen Provides a Powerful Development Mechanism of Epithelial Ovarian Carcinoma
- Marine Drugs, Vol. 9, Pages 1914-1954: The Structural Diversity of Carbohydrate Antigens of Selected Gram-Negative Marine Bacteria
- Molbank, Vol. 2011, Pages M740: N-(4-Methylsulfonamido-3-phenoxyphenyl)-9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboximide
- Molecules, Vol. 16, Pages 8670-8683: Synthesis, Metal Ion Complexation and Computational Studies of Thio Oxocrown Ethers
- Land-a Panda - Videos and Trailers
- Gravinaytor - Videos and Trailers
- Azkend 2 - Videos and Trailers
- Get Up And Dance - Videos and Trailers
- Max and the Magic Marker - Videos and Trailers
- Pocket God - Videos and Trailers
- France arrests over 'casino scam'
- Activity Audit 1.1.1 - Gain insight into the way you work with your Mac.. (Demo)
DesktopShelves 1.4 - Display any folder as a shelf on your desktop.. (Demo) Posted: 14 Oct 2011 03:19 AM PDT DesktopShelves can help clean up a desktop cluttered by dozens of different files. You can display any folder as a shelf on your Desktop. On a shelf the size of 5 normal Desktop items you can fit 20 files, because items on a shelf are slightly rotated like books on a real-world shelf. That saves a lot of screen real estate. If you mouse-over your shelves, you can see a larger preview of the file. A double-click opens it. You can use DesktopShelves in many different ways: to organize files by project, quickly access frequently used files, or to collect text snippets and templates. Other features include:
Version 1.4:
Mac OS X 10.6 or later. Download Now This posting includes an audio/video/photo media file: Download Now |
HueGo! Lite 2.0.0 - Simple on-screen color picker.. (Free) Posted: 14 Oct 2011 03:31 AM PDT HueGo! Lite allows users to sample colors from their display or from a color prism. Features:
Version 2.0.0: Release notes were unavailable when this listing was updated. Max OS X 10.4 or later. Download Now |
Hue Go! 2.0.0 - Color picker selects colors from anywhere on screen.. (Commercial) Posted: 14 Oct 2011 03:37 AM PDT Hue Go! lets you select colors from anywhere on your screen and copy the html HEX code with ease. Easy to use, just open Hue GO! and press the escape key to begin sampling. Point to the color you want to sample and press escape again. Press Command-C to copy the code. Free version (HueGo! Lite) also available. Version 2.0.0: Release notes were unavailable when this listing was updated. Mac OS X 10.4 or later. Download Now |
TransformMovie 1.2.8 - Batch rotate & resize movies.. (Demo) Posted: 14 Oct 2011 03:13 AM PDT TransformMovie is an application for rotating, filtering, flipping and sizing movies in batch, changing their rate of play and other movie properties. TransformMovie is also part of the Limit Point Software Utilities Bundle: purchase a Utilities password to activate all the utilities, including TransformMovie. Updates are free, new products included. TransformMovie is also available on the Mac App Store. Version 1.2.8:
Mac OS X 10.4.11 or later. Download Now This posting includes an audio/video/photo media file: Download Now |
SEO SpyGlass 4.6.2 - Detailed information on competitors search engine postions.. (Free) Posted: 14 Oct 2011 03:08 AM PDT SEO SpyGlass is a powerful competition analysis tool designed for webmasters and SEO professionals seeking ways to skyrocket their websites to the top of Google and all major search engines. SEO SpyGlass lets you ethically and effectively spy on your top performing Internet rivals. Armed with this cutting-edge SEO software you'll be able to decipher what exactly your Web competitors did to gain top search engine placement for your most targeted keywords. There are three editions of SEO Spyglass: Free, Pro ($99.75), and Enterprise ($249.75). For a feature comparison, see this page. To name but a few, here're important SEO factors that SEO SpyGlass lets you know:
Version 4.6.2:
Download Now This posting includes an audio/video/photo media file: Download Now |
Posted: 14 Oct 2011 12:00 AM PDT Reliable and sensitive pathogen detection in clinical and environmental (including food and water) samples is of greatest importance for public health. Standard microbiological methods have several limitations and improved alternatives are needed. Most important requirements for reliable analysis include: (i) specificity; (ii) sensitivity; (iii) multiplexing potential; (iv) robustness; (v) speed; (vi) automation potential; and (vii) low cost. Microarray technology can, through its very nature, fulfill many of these requirements directly and the remaining challenges have been tackled. In this review, we attempt to compare performance characteristics of the microbial diagnostic microarrays developed for the detection and typing of food and water pathogens, and discuss limitations, points still to be addressed and issues specific for the analysis of food, water and environmental samples. |
IJMS, Vol. 12, Pages 6796-6809: Nuclear Markers of Danube Sturgeons Hybridization Posted: 14 Oct 2011 12:00 AM PDT Acipenseriformes are composed of 25 sturgeon species and two paddlefish species distributed exclusively in the northern hemisphere. The Danube River and the Black Sea were originally inhabited by six sturgeon species but two are extinct and only four are still reproducing currently in the Lower Danube: Huso huso, Acipenser stellatus, A. gueldenstaedtii and A. ruthenus. Sturgeon species hybridize more easily than other fish and the determination of pure species or hybrid status is important for conservation and for breeding in fish farms. This survey demonstrated that morphological determination of this status is not reliable and a molecular tool, based on eight microsatellites genotypes is proposed. This method, based on three successive statistical analyses including Factorial Correspondence Analysis (FCA), Structure assignation and NewHybrids status determination, showed a high efficiency in discriminating pure species specimens from F1, F2 and two kinds of backcross individuals involving three of the four reproducing Lower Danube sturgeon species. |
Microarrays, Vol. 1, Pages 1-2: The Journal Microarrays Posted: 14 Oct 2011 12:00 AM PDT Our publishing company MDPI AG has its headquarters in Basel, Switzerland where there are thousands of scientists working in the laboratories of pharmaceutical companies and institutes including Novartis [1], F. Hoffmann-La Roche [2] and institutes affiliated with University of Basel [3]. In 1996, the first annual microplate conference MipTec was held in Basel, and the MipTec 2011 was held a few days ago in Basel [4]. I published a paper on microplate standardization presented at MipTec 1996 in MDPI's longest-running journal Molecules [5-7]. [....] |
Posted: 14 Oct 2011 12:00 AM PDT Objective: This study aimed to measure and correlate the expression of insulin-like growth factor receptor-1 (IGF-1R) and the Lewis(y) antigen in ovarian cancer cell lines and tissue samples. Methods: Reverse transcriptase PCR (RT-PCR), Western blotting, immunoprecipitation, immunohistochemistry, and immunofluorescence double-labeling techniques were applied to detect and measure the expression of Lewis(y) and IGF-1R. Results: In α1,2-fucosyltransferase (α1,2-FT)-transfected cells, IGF-1R expression was significantly upregulated compared with cells that do not overexpress α1,2-FT (P < 0.05). The amount of Lewis(y) expressed on IGF-1R increased 1.81-fold in α1,2-FT-overexpressing cells (P < 0.05), but the ratio of Lewis(y) expressed on IGF-1R to total IGF-1R was unaltered between two cells (P > 0.05). In malignant epithelial ovarian tumors, the positivity rates of Lewis(y) and IGF-1R detection were 88.3% and 93.33%, respectively, which is higher than the positivity rates in marginal (60.00% and 63.33%, all P < 0.05), benign (33.00% and 53.33%, all P < 0.01), and normal (0% and 40%, all P 0.05). Both IGF-1R and Lewis(y) were highly expressed in ovarian cancer tissues, and their expression levels were positively correlated (P < 0.05). Conclusion: Overexpression of Lewis(y) results in overexpression of IGF-1R. Both IGF-1R and Lewis(y) are associated with the occurrence and development of ovarian cancers. |
Posted: 14 Oct 2011 12:00 AM PDT Marine microorganisms have evolved for millions of years to survive in the environments characterized by one or more extreme physical or chemical parameters, e.g., high pressure, low temperature or high salinity. Marine bacteria have the ability to produce a range of biologically active molecules, such as antibiotics, toxins and antitoxins, antitumor and antimicrobial agents, and as a result, they have been a topic of research interest for many years. Among these biologically active molecules, the carbohydrate antigens, lipopolysaccharides (LPSs, O-antigens) found in cell walls of Gram-negative marine bacteria, show great potential as candidates in the development of drugs to prevent septic shock due to their low virulence. The structural diversity of LPSs is thought to be a reflection of the ability for these bacteria to adapt to an array of habitats, protecting the cell from being compromised by exposure to harsh environmental stress factors. Over the last few years, the variety of structures of core oligosaccharides and O-specific polysaccharides from LPSs of marine microrganisms has been discovered. In this review, we discuss the most recently encountered structures that have been identified from bacteria belonging to the genera Aeromonas, Alteromonas, Idiomarina, Microbulbifer, Pseudoalteromonas, Plesiomonas and Shewanella of the Gammaproteobacteria phylum; Sulfitobacter and Loktanella of the Alphaproteobactera phylum and to the genera Arenibacter, Cellulophaga, Chryseobacterium, Flavobacterium, Flexibacter of the Cytophaga-Flavobacterium-Bacteroides phylum. Particular attention is paid to the particular chemical features of the LPSs, such as the monosaccharide type, non-sugar substituents and phosphate groups, together with some of the typifying traits of LPSs obtained from marine bacteria. A possible correlation is then made between such features and the environmental adaptations undertaken by marine bacteria. |
Posted: 14 Oct 2011 12:00 AM PDT The title compound, N-(4-methylsulfonamido-3-phenoxyphenyl)-9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboximide was synthesized in high yield by reaction of N-(4-amino-2-phenoxyphenyl)methanesulfonamide and 9,10-dihydroanthracene-9,10-endo-α,β-succinic anhydride in glacial acetic acid. The structure of the compound was fully characterized by IR, 1H and 13C NMR, mass spectral analysis and elemental analysis. |
Posted: 14 Oct 2011 12:00 AM PDT The synthesis of some thio-oxocrown ether ligands, B1 (1,4-dithio-12-crown-4), B2 (1,7-dithio-12-crown-4), B3 (1,7-dithio-15-Crown-5), B4 (1,7-dithio-18-crown-6), B5 (1,10-dithio-18-crown-6), B6 (1,10-dithio-21-crown-7), under mild conditions, were reported. The ligands were characterized by FT-IR, 1H NMR and GC-MS spectroscopy. The formation of 1:1 ligand complexes with a variety of metal salts (Ag+, Ca+2, K+, Na+, Mg+2, Zn+2 and Fe+2) were investigated by a conductometric method in a 1:1 dioxane–water system at 25 °C, and the complexation constants (Ke = (ΛMAm -Λ) / ((Λ-ΛMaΛbAm) [L]) and free energy (∆Go= - RT lnKe) values are calculated. Details of the specific molecular interactions between the ligands and metals were proposed. We also performed DFT calculations to explain their geometrical properties, charges and frontier molecular orbitals. |
Land-a Panda - Videos and Trailers Posted: 14 Oct 2011 02:41 AM PDT Land-a Panda gameplay trailer. |
Gravinaytor - Videos and Trailers Posted: 14 Oct 2011 02:28 AM PDT iPhone game trailer. |
Azkend 2 - Videos and Trailers Posted: 14 Oct 2011 02:48 AM PDT Azkend 2 teaser trailer. |
Get Up And Dance - Videos and Trailers Posted: 14 Oct 2011 02:32 AM PDT Get Up And Dance launch trailer. |
Max and the Magic Marker - Videos and Trailers Posted: 14 Oct 2011 02:36 AM PDT DS only trailer. |
Pocket God - Videos and Trailers Posted: 14 Oct 2011 02:59 AM PDT Pocket God Episode 41 - I Sting The Body Electric trailer. |
France arrests over 'casino scam' Posted: 14 Oct 2011 02:58 AM PDT The Frenchman is accused of marking a deck of cards with invisible ink and ensuring the three Italians played from that deck, reports say. This posting includes an audio/video/photo media file: Download Now |
Activity Audit 1.1.1 - Gain insight into the way you work with your Mac.. (Demo) Posted: 14 Oct 2011 02:59 AM PDT Activity Audit creates a journal of the applications you use on your Mac. The journal acts as an audit trail, documenting which applications you use and how long you use each one. After just an hour, you will be amazed the information revealed by Activity Audit. After a day, you will gain new insights into your working pattern and how you spend your time on your Mac. Activity Audit works seamlessly with Mac OS X's iCal to bring you a calendar of your activity. Each time you open an application, a calendar event is created. The event is automatically extended as the application continues to run. When you quit the application, the event is completed. Activity Audit is quiet and unobtrusive. Once started, Activity Audit runs invisibly in the background. Designed to be started and left running, Activity Audit does not demand attention or alter your workflow. Start auditing, quit Activity Audit, and get on your with day. Version 1.1.1:
Mac OS X 10.6.7 or later Download Now This posting includes an audio/video/photo media file: Download Now |
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