Games |
- Bar Magnet 0.435 - Upload torrent files and magnet links to remote servers (beta). (Free)
- Bluenote 1.24 - Easily keep track of notes, tasks, and passwords. (Demo)
- Rdio 2.19 - Unlimited music on desktop and mobile. (Shareware)
- IJMS, Vol. 14, Pages 10090-10106: Vascular Endothelial Growth Factor Induces CXCL1 Chemokine Release via JNK and PI-3K-Dependent Pathways in Human Lung Carcinoma Epithelial Cells
- IJMS, Vol. 14, Pages 10075-10089: The Role of E3 Ubiquitin Ligase Cbl Proteins in β-Elemene Reversing Multi-Drug Resistance of Human Gastric Adenocarcinoma Cells
- IJMS, Vol. 14, Pages 10063-10074: Melatonin Effects on Hard Tissues: Bone and Tooth
- IJMS, Vol. 14, Pages 10042-10062: Genome-Wide Gene Expression Profiles in Antioxidant Pathways and Their Potential Sex Differences and Connections to Vitamin C in Mice
- IJMS, Vol. 14, Pages 10015-10041: Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis
- IJMS, Vol. 14, Pages 9999-10014: A Novel Colorimetric Immunoassay Utilizing the Peroxidase Mimicking Activity of Magnetic Nanoparticles
- IJMS, Vol. 14, Pages 9979-9998: Microarray Analysis of Transcriptional Responses to Abscisic Acid and Salt Stress in Arabidopsis thaliana
- IJMS, Vol. 14, Pages 9963-9978: Posttranslational Modifications of GLUT4 Affect Its Subcellular Localization and Translocation
- Sizzling hot sex after 50 Five ways to make your relationship rage with fire
- IJMS, Vol. 14, Pages 9947-9962: Molecular Dynamics Simulation of Tryptophan Hydroxylase-1: Binding Modes and Free Energy Analysis to Phenylalanine Derivative Inhibitors
- IJMS, Vol. 14, Pages 9906-9946: Cationic Antimicrobial Polymers and Their Assemblies
- IJMS, Vol. 14, Pages 9893-9905: Combining Coarse-Grained Protein Models with Replica-Exchange All-Atom Molecular Dynamics
- IJMS, Vol. 14, Pages 9883-9892: Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and Treatment
- Sensors, Vol. 13, Pages 6054-6088: Sensing Solutions for Collecting Spatio-Temporal Data for Wildlife Monitoring Applications: A Review
- Sensors, Vol. 13, Pages 6032-6053: A Methodology and a Web Platform for the Collaborative Development of Context-Aware Systems
- Sensors, Vol. 13, Pages 6014-6031: An Implantable Neural Sensing Microsystem with Fiber-Optic Data Transmission and Power Delivery
- Sensors, Vol. 13, Pages 5996-6013: Air-Coupled Piezoelectric Transducers with Active Polypropylene Foam Matching Layers
| Bar Magnet 0.435 - Upload torrent files and magnet links to remote servers (beta). (Free) Posted: 10 May 2013 02:38 AM PDT  Bar Magnet allows you to send torrent files and magnet links to remote or local torrent server front-ends just by opening them. This takes all of the hassle out of using a remote server for your torrenting. Currently supported server front-ends:
Version 0.435:
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| Bluenote 1.24 - Easily keep track of notes, tasks, and passwords. (Demo) Posted: 10 May 2013 02:35 AM PDT  Bluenote is one place for jotting down notes, keeping track of your tasks, and accessing your passwords. A beautiful interface separates your info, lets you assign labels and icons, and search with ease. Bluenote automatically encrypts, saves, and syncs on the fly. It's a fantastic app, exclusively for Mac. Features:
Version 1.24:
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| Rdio 2.19 - Unlimited music on desktop and mobile. (Shareware) Posted: 10 May 2013 02:29 AM PDT  Rdio for Mac is a native application that brings all the music and organization of Rdio.com to the Apple desktop. With this new App users can:
Version 2.19:
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| Posted: 10 May 2013 12:00 AM PDT Lung cancer cells express different chemokines and chemokine receptors that modulate leukocyte infiltration within tumor microenvironment. In this study we screened several mediators/growth factors on CXCL1 release in human carcinoma epithelial cells. Of the tested mediators, VEGF was found to have a robust increase in causing CXCL1 release. VEGF stimulated CXCL1 release and mRNA expression in a time- and concentration-dependent manner. The release was inhibited by the VEGF receptor antagonists and the JNK, PI-3K, tyrosine kinase, and transcription inhibitors. In parallel, VEGF induced JNK, PI3K and Akt activation. Strikingly, among these inhibitors only the JNK inhibitor could reduce VEGF-induced CXCL1 mRNA expression, suggesting that JNK participated in VEGF-induced CXCL1 synthesis, whereas PI-3K was responsible for cellular CXCL1 secretory process. In addition, the steroid dexamethasone and TGF-β suppressed CXCL1 release through a transcriptional regulation. We also showed that cells stimulated with VEGF significantly attracted monocyte migration, which could be abolished by CXCL1 B/N Ab, CXC receptor 2 antagonist, TGF-β, and dexamethasone. In summary, we provide here evidence showing JNK activation for VEGF-induced CXCL1 DNA transcription and PI-3K pathway for extracellular CXCL1 release in human carcinoma epithelial cells. The released CXCL1 was functionally linked to recruiting monocytes into lung cancer cell microenvironment. |
| Posted: 10 May 2013 12:00 AM PDT Recent studies indicate that β-elemene, a compound isolated from the Chinese herbal medicine Curcuma wenyujin, is capable of reversing tumor MDR, although the mechanism remains elusive. In this study, β-Elemene treatment markedly increased the intracellular accumulation of doxorubicin (DOX) and rhodamine 123 in both K562/DNR and SGC7901/ADR cells and significantly inhibited the expression of P-gp. Treatment of SGC7901/ADR cells with β-elemene led to downregulation of Akt phosphorylation and significant upregulation of the E3 ubiquitin ligases, c-Cbl and Cbl-b. Importantly, β-elemene significantly enhanced the anti-tumor activity of DOX in nude mice bearing SGC7901/ADR xenografts. Taken together, our results suggest that β-elemene may target P-gp-overexpressing leukemia and gastric cancer cells to enhance the efficacy of DOX treatment. |
| IJMS, Vol. 14, Pages 10063-10074: Melatonin Effects on Hard Tissues: Bone and Tooth Posted: 10 May 2013 12:00 AM PDT Melatonin is an endogenous hormone rhythmically produced in the pineal gland under the control of the suprachiasmatic nucleus (SCN) and the light/dark cycle. This indole plays an important role in many physiological processes including circadian entrainment, blood pressure regulation, seasonal reproduction, ovarian physiology, immune function, etc. Recently, the investigation and applications of melatonin in the hard tissues bone and tooth have received great attention. Melatonin has been investigated relative to bone remolding, osteoporosis, osseointegration of dental implants and dentine formation. In the present review, we discuss the large body of published evidence and review data of melatonin effects on hard tissues, specifically, bone and tooth. |
| Posted: 10 May 2013 12:00 AM PDT Vitamin C (VC) is well known as an antioxidant in humans, primates and guinea pigs. Studies have suggested gender differences in VC requirements in humans, and gender differences in oxidant injury vulnerability in early life may represent a biological mechanism contributing to gender disparity in later life. Using spontaneous bone fracture (sfx) mice, which lack the gene for L-Gulonolactone oxidase (Gulo), we studied the potential sex difference in expression profiles of oxidative genes at the whole-genome level. Then, we analyzed data of gene expressions in a mouse population of recombinant inbred (RI) strains originally derived by crossing C57BL/6J (B6) and DBA/2J (D2) mice. Our data indicated that there were sex differences in the regulation of pre- and pro-oxidative genes in sfx mice. The associations of expression levels among Gulo, its partner genes and oxidative genes in the BXD (B6 × D2) RI strains showed a sex difference. Transcriptome mapping suggests that Gulo was regulated differently between female and male mice in BXD RI strains. Our study indicates the importance of investigating sex differences in Gulo and its oxidative function by using available mouse models. |
| Posted: 10 May 2013 12:00 AM PDT The human embryonic lethal abnormal vision-like protein, HuR, is a member of the Hu family of RNA-binding proteins. Over the past decade, this ubiquitously expressed protein has been extensively investigated in cancer research because it is involved in the regulation of mRNA stability and translation in many cell types. HuR activity and function is associated with its subcellular distribution, transcriptional regulation, translational and post-translational modifications. HuR regulation of target mRNAs is based on the interaction between the three specific domains of HuR protein and one or several U- or AU-rich elements (AREs) in the untranslated region of target mRNAs. A number of cancer-related transcripts containing AREs, including mRNAs for proto-oncogenes, cytokines, growth factors, and invasion factors, have been characterized as HuR targets. It has been proposed that HuR has a central tumorigenic activity by enabling multiple cancer phenotypes. In this review, we comprehensively survey the existing evidence with regard to the diverse functions of HuR in caner development and progression. The current data also suggest that HuR might be a novel and promising therapeutic target and a marker for treatment response and prognostic evaluation. |
| Posted: 10 May 2013 12:00 AM PDT A simple colorimetric immunoassay system, based on the peroxidase mimicking activity of Fe3O4 magnetic nanoparticles (MNPs), has been developed to detect clinically important antigenic molecules. MNPs with ca. 10 nm in diameter were synthesized and conjugated with specific antibodies against target molecules, such as rotaviruses and breast cancer cells. Conjugation of the MNPs with antibodies (MNP-Abs) enabled specific recognition of the corresponding target antigenic molecules through the generation of color signals arising from the colorimetric reaction between the selected peroxidase substrate, 3,3',5,5'-tetramethylbenzidine (TMB) and H2O2. Based on the MNP-promoted colorimetric reaction, the target molecules were detected and quantified by measuring absorbance intensities corresponding to the oxidized form of TMB. Owing to the higher stabilities and economic feasibilities of MNPs as compared to horseradish peroxidase (HRP), the new colorimetric system employing MNP-Abs has the potential of serving as a potent immunoassay that should substitute for conventional HRP-based immunoassays. The strategy employed to develop the new methodology has the potential of being extended to the construction of simple diagnostic systems for a variety of biomolecules related to human cancers and infectious diseases, particularly in the realm of point-of-care applications. |
| Posted: 10 May 2013 12:00 AM PDT Abscisic acid (ABA) plays a crucial role in plant responses to abiotic stress. To investigate differences in plant responses to salt and ABA stimulus, differences in gene expression in Arabidopsis in response to salt and ABA were compared using an Agilent oligo microarray. A total of 144 and 139 genes were significantly up- and downregulated, respectively, under NaCl stress, while 406 and 381 genes were significantly up- and downregulated, respectively, under ABA stress conditions. In addition, 31 genes were upregulated by both NaCl and ABA stresses, and 23 genes were downregulated by these stressors, suggesting that these genes may play similar roles in plant responses to salt and ABA stress. Gene ontology (GO) analysis revealed four subgroups of genes, including genes in the GO categories "Molecular transducer activity", "Growth", "Biological adhesion" and "Pigmentation", which were expressed in response to ABA stress but not NaCl stress. In addition, genes that play specific roles during salt or ABA stress were identified. Our results may help elucidate differences in the response of plants to salt and ABA stress. |
| Posted: 10 May 2013 12:00 AM PDT The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast majority localizing to intracellular organelles. GLUT4 is retained intracellularly by continuous trafficking through two inter-related cycles. GLUT4 passes through recycling endosomes, the trans Golgi network and an insulin-sensitive intracellular compartment, termed GLUT4-storage vesicles or GSVs. It is from GSVs that GLUT4 is mobilized to the cell surface in response to insulin, where it increases the rate of glucose uptake into the cell. As with many physiological responses to external stimuli, this regulated trafficking event involves multiple posttranslational modifications. This review outlines the roles of posttranslational modifications of GLUT4 on its function and insulin-regulated trafficking. |
| Sizzling hot sex after 50 Five ways to make your relationship rage with fire Posted: 10 May 2013 02:30 AM PDT Your lips embrace, and for a moment you feel that spark that long ago would have set your night on fire. |
| Posted: 10 May 2013 12:00 AM PDT Serotonin is a neurotransmitter that modulates many central and peripheral functions. Tryptophan hydroxylase-1 (TPH1) is a key enzyme of serotonin synthesis. In the current study, the interaction mechanism of phenylalanine derivative TPH1 inhibitors was investigated using molecular dynamics (MD) simulations, free energy calculations, free energy decomposition analysis and computational alanine scanning. The predicted binding free energies of these complexes are consistent with the experimental data. The analysis of the individual energy terms indicates that although the van der Waals and electrostatics interaction contributions are important in distinguishing the binding affinities of these inhibitors, the electrostatic contribution plays a more crucial role in that. Moreover, it is observed that different configurations of the naphthalene substituent could form different binding patterns with protein, yet lead to similar inhibitory potency. The combination of different molecular modeling techniques is an efficient way to interpret the interaction mechanism of inhibitors and our work could provide valuable information for the TPH1 inhibitor design in the future. |
| IJMS, Vol. 14, Pages 9906-9946: Cationic Antimicrobial Polymers and Their Assemblies Posted: 10 May 2013 12:00 AM PDT Cationic compounds are promising candidates for development of antimicrobial agents. Positive charges attached to surfaces, particles, polymers, peptides or bilayers have been used as antimicrobial agents by themselves or in sophisticated formulations. The main positively charged moieties in these natural or synthetic structures are quaternary ammonium groups, resulting in quaternary ammonium compounds (QACs). The advantage of amphiphilic cationic polymers when compared to small amphiphilic molecules is their enhanced microbicidal activity. Besides, many of these polymeric structures also show low toxicity to human cells; a major requirement for biomedical applications. Determination of the specific elements in polymers, which affect their antimicrobial activity, has been previously difficult due to broad molecular weight distributions and random sequences characteristic of radical polymerization. With the advances in polymerization control, selection of well defined polymers and structures are allowing greater insight into their structure-antimicrobial activity relationship. On the other hand, antimicrobial polymers grafted or self-assembled to inert or non inert vehicles can yield hybrid antimicrobial nanostructures or films, which can act as antimicrobials by themselves or deliver bioactive molecules for a variety of applications, such as wound dressing, photodynamic antimicrobial therapy, food packing and preservation and antifouling applications. |
| Posted: 10 May 2013 12:00 AM PDT We describe a combination of all-atom simulations with CABS, a well-established coarse-grained protein modeling tool, into a single multiscale protocol. The simulation method has been tested on the C-terminal beta hairpin of protein G, a model system of protein folding. After reconstructing atomistic details, conformations derived from the CABS simulation were subjected to replica-exchange molecular dynamics simulations with OPLS-AA and AMBER99sb force fields in explicit solvent. Such a combination accelerates system convergence several times in comparison with all-atom simulations starting from the extended chain conformation, demonstrated by the analysis of melting curves, the number of native-like conformations as a function of time and secondary structure propagation. The results strongly suggest that the proposed multiscale method could be an efficient and accurate tool for high-resolution studies of protein folding dynamics in larger systems. |
| Posted: 10 May 2013 12:00 AM PDT The Rab27 family of small GTPases regulates exocytosis of distinct vesicle types including multivesicular endosomes, which results in the release of exosomes. Exosomes are nanometer-sized membrane vesicles that enclose soluble factors such as proteins and nucleic acids within a lipid bilayer and can travel toward distant tissues to influence multiple aspects of cell behavior. In our view that tumors are endocrine organs producing exosomes, Rab27 GTPases and their effector proteins are critical determinants for invasive growth and metastasis. Rab27 proteins and their effectors may serve as prognostic biomarkers or as targets for patient-tailored therapy. |
| Posted: 10 May 2013 12:00 AM PDT Movement ecology is a field which places movement as a basis for understanding animal behavior. To realize this concept, ecologists rely on data collection technologies providing spatio-temporal data in order to analyze movement. Recently, wireless sensor networks have offered new opportunities for data collection from remote places through multi-hop communication and collaborative capability of the nodes. Several technologies can be used in such networks for sensing purposes and for collecting spatio-temporal data from animals. In this paper, we investigate and review technological solutions which can be used for collecting data for wildlife monitoring. Our aim is to provide an overview of different sensing technologies used for wildlife monitoring and to review their capabilities in terms of data they provide for modeling movement behavior of animals. |
| Posted: 10 May 2013 12:00 AM PDT Information and services personalization is essential for an optimal user experience. Systems have to be able to acquire data about the user's context, process them in order to identify the user's situation and finally, adapt the functionality of the system to that situation, but the development of context-aware systems is complex. Data coming from distributed and heterogeneous sources have to be acquired, processed and managed. Several programming frameworks have been proposed in order to simplify the development of context-aware systems. These frameworks offer high-level application programming interfaces for programmers that complicate the involvement of domain experts in the development life-cycle. The participation of users that do not have programming skills but are experts in the application domain can speed up and improve the development process of these kinds of systems. Apart from that, there is a lack of methodologies to guide the development process. This article presents as main contributions, the implementation and evaluation of a web platform and a methodology to collaboratively develop context-aware systems by programmers and domain experts. |
| Posted: 10 May 2013 12:00 AM PDT We have developed a prototype cortical neural sensing microsystem for brain implantable neuroengineering applications. Its key feature is that both the transmission of broadband, multichannel neural data and power required for the embedded microelectronics are provided by optical fiber access. The fiber-optic system is aimed at enabling neural recording from rodents and primates by converting cortical signals to a digital stream of infrared light pulses. In the full microsystem whose performance is summarized in this paper, an analog-to-digital converter and a low power digital controller IC have been integrated with a low threshold, semiconductor laser to extract the digitized neural signals optically from the implantable unit. The microsystem also acquires electrical power and synchronization clocks via optical fibers from an external laser by using a highly efficient photovoltaic cell on board. The implantable unit employs a flexible polymer substrate to integrate analog and digital microelectronics and on-chip optoelectronic components, while adapting to the anatomical and physiological constraints of the environment. A low power analog CMOS chip, which includes preamplifier and multiplexing circuitry, is directly flip-chip bonded to the microelectrode array to form the cortical neurosensor device. |
| Posted: 10 May 2013 12:00 AM PDT This work presents the design, construction and characterization of air-coupled piezoelectric transducers using 1–3 connectivity piezocomposite disks with a stack of matching layers being the outer one an active quarter wavelength layer made of polypropylene foam ferroelectret film. This kind of material has shown a stable piezoelectric response together with a very low acoustic impedance (<0.1 MRayl). These features make them a suitable candidate for the dual use or function proposed here: impedance matching layer and active material for air-coupled transduction. The transducer centre frequency is determined by the l/4 resonance of the polypropylene foam ferroelectret film (0.35 MHz), then, the rest of the transducer components (piezocomposite disk and passive intermediate matching layers) are all tuned to this frequency. The transducer has been tested in several working modes including pulse-echo and pitch-catch as well as wide and narrow band excitation. The performance of the proposed novel transducer is compared with that of a conventional air-coupled transducers operating in a similar frequency range. |
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