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- Sensors, Vol. 13, Pages 6492-6523: An Easy to Deploy Street Light Control System Based on Wireless Communication and LED Technology
- Sensors, Vol. 13, Pages 6477-6491: 3D Preoperative Planning in the ER with OsiriX®: When There is No Time for Neuronavigation
- IJMS, Vol. 14, Pages 10332-10342: Peripheral Blood miR-328 Expression as a Potential Biomarker for the Early Diagnosis of NSCLC
- IJMS, Vol. 14, Pages 10307-10331: Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection
- IJMS, Vol. 14, Pages 10298-10306: An Exonuclease III Protection-Based Electrochemical Method for Estrogen Receptor Assay
- IJMS, Vol. 14, Pages 10242-10297: Plant Defense against Insect Herbivores
- Molecules, Vol. 18, Pages 5736-5748: Production of Flavours and Fragrances via Bioreduction of (4R)-(-)-Carvone and (1R)-(-)-Myrtenal by Non-Conventional Yeast Whole-Cells
- Molecules, Vol. 18, Pages 5723-5735: Four New Citrinin Derivatives from a Marine-Derived Penicillium sp. Fungal Strain
- Molecules, Vol. 18, Pages 5706-5722: Virtual Screening and Structure-Based Discovery of Indole Acylguanidines as Potent β-secretase (BACE1) Inhibitors
- Molecules, Vol. 18, Pages 5697-5705: A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines
- Entropy, Vol. 15, Pages 1847-1874: Entanglement Structure in Expanding Universes
- Bridge
- Entropy, Vol. 15, Pages 1821-1846: A Unification between Dynamical System Theory and Thermodynamics Involving an Energy, Mass, and Entropy State Space Formalism
- Entropy, Vol. 15, Pages 1776-1820: Quantum Entanglement Concentration Based on Nonlinear Optics for Quantum Communications
- Anno Online now in open beta
- EA Dropping Online Passes - Report
- GS News - EA Dropping Online Pass
- The Next Generation of Game Developers
- StatsBar 1.4 - Monitor system processes from the menu bar. (Commercial)
- Thunderbird 17.0.6 - Email client from Mozilla. (Free)
| Posted: 16 May 2013 12:00 AM PDT This paper presents an intelligent streetlight management system based on LED lamps, designed to facilitate its deployment in existing facilities. The proposed approach, which is based on wireless communication technologies, will minimize the cost of investment of traditional wired systems, which always need civil engineering for burying of cable underground and consequently are more expensive than if the connection of the different nodes is made over the air. The deployed solution will be aware of their surrounding's environmental conditions, a fact that will be approached for the system intelligence in order to learn, and later, apply dynamic rules. The knowledge of real time illumination needs, in terms of instant use of the street in which it is installed, will also feed our system, with the objective of providing tangible solutions to reduce energy consumption according to the contextual needs, an exact calculation of energy consumption and reliable mechanisms for preventive maintenance of facilities. |
| Posted: 16 May 2013 12:00 AM PDT The evaluation of patients in the emergency room department (ER) through more accurate imaging methods such as computed tomography (CT) has revolutionized their assistance in the early 80s. However, despite technical improvements seen during the last decade, surgical planning in the ER has not followed the development of image acquisition methods. The authors present their experience with DICOM image processing as a navigation method in the ER. The authors present 18 patients treated in the Emergency Department of the Hospital das Clínicas of the University of Sao Paulo. All patients were submitted to volumetric CT. We present patients with epidural hematomas, acute/subacute subdural hematomas and contusional hematomas. Using a specific program to analyze images in DICOM format (OsiriX®), the authors performed the appropriate surgical planning. The use of 3D surgical planning made it possible to perform procedures more accurately and less invasively, enabling better postoperative outcomes. All sorts of neurosurgical emergency pathologies can be treated appropriately with no waste of time. The three-dimensional processing of images in the preoperative evaluation is easy and possible even within the emergency care. It should be used as a tool to reduce the surgical trauma and it may dispense methods of navigation in many cases. |
| Posted: 16 May 2013 12:00 AM PDT Lung cancer is often diagnosed at an advanced stage, with subsequently poor prognosis. There are no biomarkers available to facilitate early diagnosis or to discriminate between benign and malignant nodules. MicroRNAs (miRNAs) are stable molecules that can be found and measured in peripheral blood, thus representing potential diagnostic biomarkers. We evaluated 100 individuals comprising 86 patients with predominantly early-stage non-small cell lung cancer (NSCLC) and 24 healthy donors. RNA was extracted from peripheral blood samples and the expression of a panel of miRNAs was analyzed by Real-Time PCR method. Expression levels of miR-328, miR-18a, miR-339 and miR-140 were significantly higher in NSCLC patients than in healthy donors (p < 0.05). In particular, miR-328 showed good diagnostic accuracy in discriminating between patients with early NSCLC and healthy donors (AUC ROC 0.82, 95% CI 0.72–0.92), with 70% sensitivity and 83% specificity at the best relative expression cut-off of 300. Moreover, miR-339 was a good discriminant between healthy donors and late-stage NSCLC patients (AUC ROC 0.79, 95% CI 0.68–0.91). In conclusion, miR-328 represents a potential diagnostic biomarker of NSCLC, especially for the identification of early-stage tumors. Its role in discriminating between benign and malignant nodules detected by spiral CT warrants further investigation. |
| Posted: 16 May 2013 12:00 AM PDT Epigenetic alterations including DNA methylation and microRNAs (miRNAs) play important roles in the initiation and progression of human cancers. As the extensively studied epigenetic changes in tumors, DNA methylation and miRNAs are the most potential epigenetic biomarkers for cancer diagnosis. After the identification of circulating cell-free nuclear acids, increasing evidence demonstrated great potential of cell-free epigenetic biomarkers in the blood or other body fluids for cancer detection. |
| Posted: 16 May 2013 12:00 AM PDT Estrogen receptor (ER), expressed in approximately 80% of primary breast cancer cells, has proven to be a valuable predictive factor of the disease. Herein, by making use of the specific binding of ER to its DNA response elements, we propose an Exonuclease III (Exo III) protection-based electrochemical method for detecting ER proteins. In this assay, the presence of ER can protect the duplex DNA molecules immobilized on an electrode surface from Exo III-catalyzed digestion, resulting in an increased electrochemical signal. Experimental results have revealed that the proposed method can allow the quantification of ER in the range of 0.5 to 100 nM with a satisfactory detection limit of 0.38 nM. Furthermore, since this approach can also be employed to detect ER directly in nuclear extracts, it may be of great use in biomedical applications in the future. |
| IJMS, Vol. 14, Pages 10242-10297: Plant Defense against Insect Herbivores Posted: 16 May 2013 12:00 AM PDT Plants have been interacting with insects for several hundred million years, leading to complex defense approaches against various insect feeding strategies. Some defenses are constitutive while others are induced, although the insecticidal defense compound or protein classes are often similar. Insect herbivory induce several internal signals from the wounded tissues, including calcium ion fluxes, phosphorylation cascades and systemic- and jasmonate signaling. These are perceived in undamaged tissues, which thereafter reinforce their defense by producing different, mostly low molecular weight, defense compounds. These bioactive specialized plant defense compounds may repel or intoxicate insects, while defense proteins often interfere with their digestion. Volatiles are released upon herbivory to repel herbivores, attract predators or for communication between leaves or plants, and to induce defense responses. Plants also apply morphological features like waxes, trichomes and latices to make the feeding more difficult for the insects. Extrafloral nectar, food bodies and nesting or refuge sites are produced to accommodate and feed the predators of the herbivores. Meanwhile, herbivorous insects have adapted to resist plant defenses, and in some cases even sequester the compounds and reuse them in their own defense. Both plant defense and insect adaptation involve metabolic costs, so most plant-insect interactions reach a stand-off, where both host and herbivore survive although their development is suboptimal. |
| Posted: 16 May 2013 12:00 AM PDT As part of a program aiming at the selection of yeast strains which might be of interest as sources of natural flavours and fragrances, the bioreduction of (4R)-(−)-carvone and (1R)-(−)-myrtenal by whole-cells of non-conventional yeasts (NCYs) belonging to the genera Candida, Cryptococcus, Debaryomyces, Hanseniaspora, Kazachstania, Kluyveromyces, Lindnera, Nakaseomyces, Vanderwaltozyma and Wickerhamomyces was studied. Volatiles produced were sampled by means of headspace solid-phase microextraction (SPME) and the compounds were analysed and identified by gas chromatography–mass spectroscopy (GC-MS). Yields (expressed as % of biotransformation) varied in dependence of the strain. The reduction of both (4R)-(−)-carvone and (1R)-(−)-myrtenal were catalyzed by some ene-reductases (ERs) and/or carbonyl reductases (CRs), which determined the formation of (1R,4R)-dihydrocarvone and (1R)-myrtenol respectively, as main flavouring products. The potential of NCYs as novel whole-cell biocatalysts for selective biotransformation of electron-poor alkenes for producing flavours and fragrances of industrial interest is discussed. |
| Posted: 16 May 2013 12:00 AM PDT Four new citrinin derivatives, including two citrinin dimers and two citrinin monomer derivatives, were isolated and identified from a marine-derived fungal strain Penicillium sp. ML226 along with six known related compounds. Their structures were elucidated by spectroscopic and chemical methods. The new compounds showed modest cytotoxic activity against HepG-2 cell line and weak antimicrobial activity against Staphylococcus aureus. |
| Posted: 16 May 2013 12:00 AM PDT Proteolytic cleavage of amyloid precursor protein by β-secretase (BACE1) is a key step in generating the N-terminal of β-amyloid (Aβ), which further forms into amyloid plaques that are considered as the hallmark of Alzheimer's disease. Inhibitors of BACE1 can reduce the levels of Aβ and thus have a therapeutic potential for treating the disease. We report here the identification of a series of small molecules bearing an indole acylguanidine core structure as potent BACE1 inhibitors. The initial weak fragment was discovered by virtual screening, and followed with a hit-to-lead optimization. With the aid of co-crystal structures of two discovered inhibitors (compounds 19 and 25) with BACE1, we explored the SAR around the indole and aryl groups, and obtained several BACE1 inhibitors about 1,000-fold more potent than the initial fragment hit. Accompanying the lead optimization, a previously under-explored sub-site opposite the flap loop was redefined as a potential binding site for later BACE1 inhibitor design. |
| Molecules, Vol. 18, Pages 5697-5705: A Novel Multi-Component Reaction to Imidazo[4,5-g]-quinazolines Posted: 16 May 2013 12:00 AM PDT The trace impurities discovered after extended storage of a 5-amino- benzimidazole library were determined as imidazo[4,5-g]quinazoline derivatives by extensive spectroscopic data analysis. The formation of this highly aromatic heterocyclic ring involved a novel multi-component reaction, using which several novel compounds were prepared. Its mechanism was deduced as a cascade of chemical transformations, including the formation of a Schiff's base, intramolecular hetero-Diels-Alder reaction, defluorination and dehydrogenation. |
| Entropy, Vol. 15, Pages 1847-1874: Entanglement Structure in Expanding Universes Posted: 16 May 2013 12:00 AM PDT We investigate entanglement of a quantum field in de Sitter spacetime using a particle detector model. By considering the entanglement between two comoving detectors interacting with a scalar field, it is possible to detect the entanglement of the scalar field by swapping it to detectors. For the massless minimal scalar field, we find that the entanglement between the detectors cannot be detected when their physical separation exceeds the Hubble horizon scale. This behavior supports the appearance of the classical nature of quantum fluctuations generated during the inflationary era. |
| Posted: 16 May 2013 01:51 AM PDT This week we are looking at various aspects of the Stayman convention. What is the fewest number of points you need to use Stayman? Normally, responder will have at least enough points to invite game. |
| Posted: 16 May 2013 12:00 AM PDT In this paper, we combine the two universalisms of thermodynamics and dynamical systems theory to develop a dynamical system formalism for classical thermodynamics. Specifically, using a compartmental dynamical system energy flow model involving heat flow, work energy, and chemical reactions, we develop a state-space dynamical system model that captures the key aspects of thermodynamics, including its fundamental laws. In addition, we show that our thermodynamically consistent dynamical system model is globally semistable with system states converging to a state of temperature equipartition. Furthermore, in the presence of chemical reactions, we use the law of mass-action and the notion of chemical potential to show that the dynamic system states converge to a state of temperature equipartition and zero affinity corresponding to a state of chemical equilibrium. |
| Posted: 16 May 2013 12:00 AM PDT Entanglement concentration is of most importance in long distance quantum communication and quantum computation. It is to distill maximally entangled states from pure partially entangled states based on the local operation and classical communication. In this review, we will mainly describe two kinds of entanglement concentration protocols. One is to concentrate the partially entangled Bell-state, and the other is to concentrate the partially entangled W state. Some protocols are feasible in current experimental conditions and suitable for the optical, electric and quantum-dot and optical microcavity systems. |
| Posted: 15 May 2013 10:19 PM PDT Strategy simulation title is playable within browser; closed beta accounts will not get an account wipe.
City-builder fans can now get their hands on the public beta version of Anno Online, according to Ubisoft. Players can check out the open beta version of the simulation on the official site and play it through their internet browser. Furthermore, players who participated in the game's closed beta will not have their accounts wiped and will receive a decorative statue as a gift. Gamers who have started on the open beta on the first week will get a premium ship that can carry more freight and has increased speed. Anno Online's closed beta started on April 23. The game is a sequel to Anno 1404. Read and Post Comments | Get the full article at GameSpot "Anno Online now in open beta" was posted by Jonathan Toyad on Wed, 15 May 2013 22:19:08 -0700 |
| EA Dropping Online Passes - Report Posted: 15 May 2013 08:28 PM PDT Future EA games won't require Online Passes; the service is being scrapped after tepid player response.
EA will be dropping Online Passes from all of its future games, citing lacklustre player support, according to a report by Venture Beat.
EA senior director of corporate communications John Reseburg revealed the news. "Yes, we"re discontinuing Online Pass," he said "None of our new EA titles will include that feature." EA is not the only game publisher that elects to bundle an Online Pass with new copies of its games. The one-time codes are designed to restrict access to key features, such as online multiplayer. Players who buy a second-hand version of the game are given the option to purchase an Online Pass for a fee, prior to being able to play with others.
 "Initially launched as an effort to package a full menu of online content and services, many players didn"t respond to the format," Reseburg said. "We"ve listened to the feedback and decided to do away with it, moving forward." "We"re still committed to creating content and services that enhance the game experience well beyond the day you first start playing," Reseburg said. Online Passes have often been viewed as ways for developers and publishers to offset the financial shortfall of not seeing revenue when games are traded in and resold through retailers. Last November, Square Enix revealed that it would make the Contracts mode in Hitman: Absolution accessible to all players. The trend continued in March with the Tomb Raider reboot providing unfettered access to online play without a key, while Insomniac Games" upcoming shooter Fuse--which is published through the EA Partners program, and built around four-player cooperative play--will also ship without the need for an Online Pass. Read and Post Comments | Get the full article at GameSpot "EA Dropping Online Passes - Report" was posted by Dan Chiappini on Wed, 15 May 2013 20:28:37 -0700 |
| GS News - EA Dropping Online Pass Posted: 15 May 2013 08:21 PM PDT Future EA games won"t require Online Passes; service being scrapped because of tepid player response
Read and Post Comments | Get the full article at GameSpot "GS News - EA Dropping Online Pass" was posted by Edmond Tran and Jessica McDonell on Wed, 15 May 2013 20:21:07 -0700 |
| The Next Generation of Game Developers Posted: 15 May 2013 07:36 PM PDT We speak to game design students from universities and colleges around Sydney about their perception of the challenges and opportunities regarding video game development and how they hope to put their stamp on the industry! Are you a game design student? Let us know your opinions! Read and Post Comments | Get the full article at GameSpot "The Next Generation of Game Developers" was posted by Dan Chiappini, Edmond Tran and Jessica McDonell on Wed, 15 May 2013 19:36:59 -0700 |
| StatsBar 1.4 - Monitor system processes from the menu bar. (Commercial) Posted: 15 May 2013 08:59 PM PDT  StatsBar gives you a comprehensive and detailed analysis of the following areas of your Mac:
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| Thunderbird 17.0.6 - Email client from Mozilla. (Free) Posted: 15 May 2013 08:59 PM PDT  As of July 2012, Thunderbird is no longer being actively developed, although security improvements will continue to be released as needed. Thunderbird is a free, open-source, cross-platform e-mail and news client developed by the Mozilla Foundation. The project strategy is modeled after Mozilla Firefox, a project aimed at creating a Web browser. Version 17.0.6: Fixed:
OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
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