Games |
- Fuse - GR Review
- Gaming parlors laud casino defeat
- AOL Desktop 1.7.763 - Complete AOL Internet package (beta). (Free)
- Handheld Designer 1.4.2 - Create HTML5 mobile Web applications for iOS devices. (Demo)
- Marine Drugs, Vol. 11, Pages 1836-1852: Anti-Microbial, Anti-Biofilm Activities and Cell Selectivity of the NRC-16 Peptide Derived from Witch Flounder, Glyptocephalus cynoglossus
- Marine Drugs, Vol. 11, Pages 1815-1835: Diarrhetic Shellfish Toxins and Other Lipophilic Toxins of Human Health Concern in Washington State
- IJERPH, Vol. 10, Pages 2150-2163: Fish Consumption during Pregnancy, Mercury Transfer, and Birth Weight along the Madeira River Basin in Amazonia
- Antibodies, Vol. 2, Pages 371-391: Role and Redirection of IgE against Cancer
- Molecules, Vol. 18, Pages 6269-6280: Synthesis, Antibacterial and Thermal Studies of Cellulose Nanocrystal Stabilized ZnO-Ag Heterostructure Nanoparticles
- Nutrients, Vol. 5, Pages 1840-1855: Sodium Intakes of US Children and Adults from Foods and Beverages by Location of Origin and by Specific Food Source
- Entropy, Vol. 15, Pages 2081-2099: Analysis of Entropy Generation Rate in an Unsteady Porous Channel Flow with Navier Slip and Convective Cooling
- CUP: Charlotte Power Rankings
- Metabolites, Vol. 3, Pages 440-462: Small Molecule Identification with MOLGEN and Mass Spectrometry
- Micromachines, Vol. 4, Pages 206-214: Photomasks Fabrication Based on Optical Reduction for Microfluidic Applications
- Religions, Vol. 4, Pages 290-305: Bare Rocks and Fallen Angels: Environmental Change, Climate Perceptions and Ritual Practice in the Peruvian Andes
- Pathogens, Vol. 2, Pages 402-421: Animal Models of Tick-Borne Hemorrhagic Fever Viruses
- Fuse review
- Washington Bridge Creaks as U.S. Repair Costs Increase
- PS4 may include DRM for used games - Report
- Microsoft files patent for television achievements
| Posted: 26 May 2013 07:44 AM PDT A short Fuse. Fuse is a victim of its delayed development cycle. Back in 2010, Insomniac Games hinted at the development of this title and revealed the game in 2011 under a different name, Overstrike, but then reworked the branding for several years before deciding on its current form. Unfortunately, the standard of video games has risen, so while most of the title's features still hold up, several parts do not. |
| Gaming parlors laud casino defeat Posted: 28 May 2013 02:12 AM PDT Some charity gaming owners breathed a sigh of relief Wednesday, when the state House of Representatives rejected a bill that would have allowed a casino in New Hampshire, while others are still concerned about the effect that Massachusetts casinos might have on the Granite State. |
| AOL Desktop 1.7.763 - Complete AOL Internet package (beta). (Free) Posted: 28 May 2013 02:47 AM PDT  AOL Desktop is a complete AOL Internet package for your Mac. AOL is back for Mac. AOL is reaffirming its commitment to Mac users with the first beta release of a brand new, all-in-one Web software, now available for download: AOL Desktop for Mac. The best part, this free new software was developed by Mac users, for Mac users, from the ground up. Your Mac makes your life easy. Make it even easier with the new AOL Desktop for Mac. Highlights include:
Version 1.7.763: Release notes were unavailable when this listing was updated. OS X 10.4.11 or later More information |
| Handheld Designer 1.4.2 - Create HTML5 mobile Web applications for iOS devices. (Demo) Posted: 28 May 2013 02:03 AM PDT  Handheld Designer makes it easy and fun for anyone to create HTML5 mobile Web applications for the iPhone, iPad, and iPod touch without learning HTML or CSS. Build games, productivity, and to-do list apps, and more. When you're done, share your app with the world with a single click using the free built-in Web app hosting. Handheld Designer features:
Version 1.4.2:
More information |
| Posted: 28 May 2013 12:00 AM PDT Previous studies had identified novel antimicrobial peptides derived from witch flounder. In this work, we extended the search for the activity of peptide that showed antibacterial activity on clinically isolated bacterial cells and bacterial biofilm. Pseudomonas aeruginosa was obtained from otitis media and cholelithiasis patients, while Staphylococcus aureus was isolated from otitis media patients. We found that synthetic peptide NRC-16 displays antimicrobial activity and is not sensitive to salt during its bactericidal activity. Interestingly, this peptide also led to significant inhibition of biofilm formation at a concentration of 4–16 μM. NRC-16 peptide is able to block biofilm formation at concentrations just above its minimum inhibitory concentration while conventional antibiotics did not inhibit the biofilm formation except ciprofloxacin and piperacillin. It did not cause significant lysis of human RBC, and is not cytotoxic to HaCaT cells and RAW264.7 cells, thereby indicating its selective antimicrobial activity. In addition, the peptide's binding and permeation activities were assessed by tryptophan fluorescence, calcein leakage and circular dichroism using model mammalian membranes composed of phosphatidylcholine (PC), PC/cholesterol (CH) and PC/sphingomyelin (SM). These experiments confirmed that NRC-16 does not interact with any of the liposomes but the control peptide melittin did. Taken together, we found that NRC-16 has potent antimicrobial and antibiofilm activities with less cytotoxicity, and thus can be considered for treatment of microbial infection in the future. |
| Posted: 28 May 2013 12:00 AM PDT The illness of three people in 2011 after their ingestion of mussels collected from Sequim Bay State Park, Washington State, USA, demonstrated the need to monitor diarrhetic shellfish toxins (DSTs) in Washington State for the protection of human health. Following these cases of diarrhetic shellfish poisoning, monitoring for DSTs in Washington State became formalized in 2012, guided by routine monitoring of Dinophysis species by the SoundToxins program in Puget Sound and the Olympic Region Harmful Algal Bloom (ORHAB) partnership on the outer Washington State coast. Here we show that the DSTs at concentrations above the guidance level of 16 μg okadaic acid (OA) + dinophysistoxins (DTXs)/100 g shellfish tissue were widespread in sentinel mussels throughout Puget Sound in summer 2012 and included harvest closures of California mussel, varnish clam, manila clam and Pacific oyster. Concentrations of toxins in Pacific oyster and manila clam were often at least half those measured in blue mussels at the same site. The primary toxin isomer in shellfish and plankton samples was dinophysistoxin-1 (DTX-1) with D. acuminata as the primary Dinophysis species. Other lipophilic toxins in shellfish were pectenotoxin-2 (PTX-2) and yessotoxin (YTX) with azaspiracid-2 (AZA-2) also measured in phytoplankton samples. Okadaic acid, azaspiracid-1 (AZA-1) and azaspiracid-3 (AZA-3) were all below the levels of detection by liquid chromatography tandem mass spectrometry (LC-MS/MS). A shellfish closure at Ruby Beach, Washington, was the first ever noted on the Washington State Pacific coast due to DSTs. The greater than average Fraser River flow during the summers of 2011 and 2012 may have provided an environment conducive to dinoflagellates and played a role in the prevalence of toxigenic Dinophysis in Puget Sound. |
| Posted: 28 May 2013 12:00 AM PDT Birth weight can be a predictor of maternal health issues related to nutrition and environmental contaminants. Total hair mercury (HHg) concentration was studied as an indicator of both fish consumption and methylmercury exposure in mothers (and newborns) living in selected low income areas of the Madeira River basin, Amazonia, Brazil. This cohort study (n = 1,433) consisted of traditional riverines (n = 396), riverines who had moved to urban (n = 676) and rural (n = 67) settings, and tin miner settlers (n = 294). Median maternal HHg was significantly different (p = 0.00001) between riverine (12.1 µg·g−1), rural (7.82 µg·g−1), urban (5.4 µg·g−1), and tin miner (4.5 µg·g−1) groups studied. The same trend (of medians) was observed for newborns' HHg which also showed significant differences between riverine (3.0 µg·g−1), rural (2.0 µg·g−1), urban (1.5 µg·g−1), and tin miner (0.8 µg·g−1) groups. The correlation between maternal and newborn HHg was statistically significant in the riverine (r = 0.8952; p = 0.0001), urban (r = 0.6744; p = 0.0001), and rural (r = 0.8416; p = 0.0001) groups but not in the mother-infant pairs in the tin miner group (r = 0.0638; p = 0.2752). Birth weight was significantly different among groups but did not show a pattern consistent with that of fish consumption (and HHg). A multiple regression analysis showed that only family income and gestational age had a significant impact on birth weight. Conclusions: Maternal HHg is an important biomarker of maternal fish consumption and of methylmercury exposure during pregnancy. However, in these Amazonian groups, only maternal education and gestational age seemed to affect birth weight positively. |
| Antibodies, Vol. 2, Pages 371-391: Role and Redirection of IgE against Cancer Posted: 28 May 2013 12:00 AM PDT IgE is a highly elusive antibody class, yet a tremendously powerful elicitor of immune reactions. Despite huge efforts spent on the characterization and understanding of the IgE system many questions remain either unanswered or only marginally addressed. One above all relates to the role of IgE. A common doubt is based on whether IgE mode of action should only be relegated to anti-parasite immunity and allergic manifestations. In search for a hidden role of IgE, reports from several laboratories are described herein in which a natural IgE link to cancer or the experimental redirection of IgE against cancer have been investigated. Epidemiological and investigational studies are trying to elucidate a possible direct intervention of endogenous IgE against cancer, raising thus far no definitive evidence. Conversely, experimental approaches implementing several strategies and engineered IgE formats built up a series of convincing results indicating that cancer might be tackled by the effector functions of this immunoglobulin class. Because of its peculiar immune features, IgE may present a superior anti-tumor performance as compared to IgG. However, extreme care should be taken on how IgE-based anti-tumor approaches should be devised. Overall, IgE appears as a promising resource, likely destined to enrich the anti-cancer arsenal |
| Posted: 28 May 2013 12:00 AM PDT Synthesis of ZnO-Ag heterostructure nanoparticles was carried out by a precipitation method with cellulose nanocrystals (CNCs) as a stabilizer for antimicrobial and thermal studies. ZnO-Ag nanoparticles were obtained from various weight percentages of added AgNO3 relative to Zn precursors for evaluating the best composition with enhanced functional properties. The ZnO-Ag/CNCs samples were characterized systematically by TEM, XRD, UV, TGA and DTG. From the TEM studies we observed that ZnO-Ag heterostructure nanoparticles have spherical shapes with size diameters in a 9–35 nm range. The antibacterial activities of samples were assessed against the bacterial species Salmonella choleraesuis and Staphylococcus aureus. The CNC-stabilized ZnO-Ag exhibited greater bactericidal activity compared to cellulose-free ZnO-Ag heterostructure nanoparticles of the same particle size. The incorporation of ZnO-Ag hetreostructure nanoparticles significantly increased the thermal stability of cellulose nanocrystals. |
| Posted: 28 May 2013 12:00 AM PDT Sodium intakes, from foods and beverages, of 22,852 persons in the National Health and Nutrition Examination Surveys (NHANES 2003–2008) were examined by specific food source and by food location of origin. Analyses were based on a single 24-h recall. Separate analyses were conducted for children (6–11 years of age), adolescents (12–19), and adults (20–50 and ≥51 years). Grouping of like foods (e.g., food sources) used a scheme proposed by the National Cancer Institute, which divides foods/beverages into 96 food subgroups (e.g., pizza, yeast breads or cold cuts). Food locations of origin were stores (e.g., grocery, convenience and specialty stores), quick-service restaurant/pizza (QSR), full-service restaurant (FSR), school, or other. Food locations of sodium were also evaluated by race/ethnicity amongst adults. Stores provided between 58.1% and 65.2% of dietary sodium, whereas QSR and FSR together provided between 18.9% and 31.8% depending on age. The proportion of sodium from QSR varied from 10.1% to 19.9%, whereas that from FSR varied from 3.4% to 13.3%. School meals provided 10.4% of sodium for 6–11 year olds and 6.0% for 12–19 year olds. Pizza from QSR, the top away from home food item, provided 5.4% of sodium in adolescents. QSR pizza, chicken, burgers and Mexican dishes combined provided 7.8% of total sodium in adult diets. Most sodium came from foods purchased in stores. Food manufacturers, restaurants, and grocery stores all have a role to play in reducing the amount of sodium in the American diet. |
| Posted: 28 May 2013 12:00 AM PDT This study deals with the combined effects of Navier Slip, Convective cooling, variable viscosity, and suction/injection on the entropy generation rate in an unsteady flow of an incompressible viscous fluid flowing through a channel with permeable walls. The model equations for momentum and energy balance are solved numerically using semi-discretization finite difference techniques. Both the velocity and temperature profiles are obtained and utilized to compute the entropy generation number. The effects of key parameters on the fluid velocity, temperature, entropy generation rate and Bejan number are depicted graphically and analyzed in detail. |
| Posted: 27 May 2013 12:00 AM PDT  Jimmie Johnson stays on top of the FOXSports.com/SPEED.com Power Rankings this week… |
| Metabolites, Vol. 3, Pages 440-462: Small Molecule Identification with MOLGEN and Mass Spectrometry Posted: 28 May 2013 12:00 AM PDT This paper details the MOLGEN entries for the 2012 CASMI contest for small molecule identification to demonstrate structure elucidation using structure generation approaches. Different MOLGEN programs were used for different categories, including MOLGEN–MS/MS for Category 1, MOLGEN 3.5 and 5.0 for Category 2 and MOLGEN–MS for Categories 3 and 4. A greater focus is given to Categories 1 and 2, as most CASMI participants entered these categories. The settings used and the reasons behind them are described in detail, while various evaluations are used to put these results into perspective. As one author was also an organiser of CASMI, these submissions were not part of the official CASMI competition, but this paper provides an insight into how unknown identification could be performed using structure generation approaches. The approaches are semi-automated (category dependent) and benefit greatly from user experience. Thus, the results presented and discussed here may be better than those an inexperienced user could obtain with MOLGEN programs. |
| Posted: 28 May 2013 12:00 AM PDT A procedure for fabrication of photomasks on photographic films with minimum feature achievable of about 20 μm, which are particularly suitable for the fast prototyping of microfluidic devices, has been improved. We used a commercial photographic enlarger in reverse mode obtaining 10:1 reduction factor with error less than 1%. Masks have been characterized by optical transmission measurement and contact profilometry: the exposed region completely absorbs light in the wavelength region explored, while the non-exposed region is transparent from 350 nm on; the average film thickness is of 410 nm and its roughness is about 120 nm. A PDMS microfluidic device has been realized and tested in order to prove the effectiveness of designed photomasks used with the common UV light box. |
| Posted: 28 May 2013 12:00 AM PDT One of the many dimensions of globalization is climate change that in recent years has caused much concern in the developed world. The aim of this article is to explore how people living on the margins of the global world conceive climate change. Drawing on ethnographic field data from the 1980s and today it examines how the ritual practice and the religious belief of a rural community in the Peruvian Andes has changed during the last 27 years and how the villagers perceive this change. It argues that the villagers traditionally conceive the environment as co-habited by humans and non-humans but that recent environmental change in the Andes has caused a shift in this world-view. Today, many villagers have adopted the global vocabulary on climate change and are concerned with their own impact in the environment. However, the villagers reject the idea that it is human activities in other parts of the world that cause environmental problems in their community and claim that these must be addressed locally. It suggests that even though the villagers' reluctance to subscribe to the global discourse of climate change makes them look like the companions of climate skeptics in the developed world, their reasons are very different. |
| Pathogens, Vol. 2, Pages 402-421: Animal Models of Tick-Borne Hemorrhagic Fever Viruses Posted: 28 May 2013 12:00 AM PDT Tick-borne hemorrhagic fever viruses (TBHFV) are detected throughout the African and Eurasian continents and are an emerging or re-emerging threat to many nations. Due to the largely sporadic incidences of these severe diseases, information on human cases and research activities in general have been limited. In the past decade, however, novel TBHFVs have emerged and areas of endemicity have expanded. Therefore, the development of countermeasures is of utmost importance in combating TBHFV as elimination of vectors and interrupting enzootic cycles is all but impossible and ecologically questionable. As in vivo models are the only way to test efficacy and safety of countermeasures, understanding of the available animal models and the development and refinement of animal models is critical in negating the detrimental impact of TBHFVs on public and animal health. |
| Posted: 28 May 2013 12:32 AM PDT Here's what we thought about Insomniac Games' multiplatform third-person |
| Washington Bridge Creaks as U.S. Repair Costs Increase Posted: 27 May 2013 10:03 PM PDT The vintage-1925 Meridian Street bridge in Puyallup, Washington , creaks and shakes as 15,000 vehicles a day rumble over it, striking fear into the hearts of commuters like Robert Elkins. This posting includes an audio/video/photo media file: Download Now |
| PS4 may include DRM for used games - Report Posted: 27 May 2013 09:40 PM PDT Sony may be considering DRM for used games; Twitter protest calls for change.
While Sony has already confirmed that the PlayStation 4 will allow consumers to play used games, to date the company has not detailed specifics of how second-hand software or any associated digital rights management (DRM) will be handled. Still unanswered is the question of whether or not players will be required to pay additional fees to activate a previously owned game. GameTrailers TV host Geoff Keighley believes that Sony may be looking to follow Microsoft's lead by considering DRM for used games in the upcoming generation.
 "Sony I think has been seen as this kind of white knight so far that's not going to restrict used games. Based on some of the things I'm hearing, I don't think that's entirely true. I can't see publishers allowing one system to do one thing more than another," he said during a dissection of the Microsoft press conference. Keighley's comments, which can be heard at the 17 minute mark, suggest that while Sony has not yet officially unveiled details of used games on the device, he doesn't anticipate it being drastically different to the approach taken by its biggest competitor, Microsoft's Xbox One. In February this year Sony vice president of Worldwide Studios, Michael Denny said the company would "do the right thing" by consumers with used games on the PlayStation 4. "It's not something that I feel I have any further announcement or comment to make on other than to acknowledge with you that it's a massively important issue, and of course we are going to do the right thing," he said at the time. User famousmortimer on the NeoGAF forum has called for displeased gamers to respectfully tweet at key Sony employees and third-party publishers asking them to (re)consider the move prior to the new console going on sale this holiday season. Head of Sony Hardware Marketing, John Koller responded to the outreach by gamers, tweeting: "This is why I love PlayStation fans--the passion bucket overflows". SCEA producer, Nick Accordino also replied, saying he was: "Humbled by the outpouring of passionate PlayStation fans and their willingness to talk to us directly. Please know that we hear you." GameSpot contacted Sony seeking clarification regarding DRM for used games on the PlayStation 4. A spokesperson declined, saying "we don't comment on rumour and speculation."
Read and Post Comments | Get the full article at GameSpot "PS4 may include DRM for used games - Report" was posted by Dan Chiappini on Mon, 27 May 2013 21:40:30 -0700 |
| Microsoft files patent for television achievements Posted: 27 May 2013 07:52 PM PDT Encourages players to watch nominated events or whole series; may include Gamerscore-style points, avatar items, or physical goods as rewards. A patent filed in November 2011 (and made available to the public this month) for an achievement system when watching television and video programming hints that Microsoft may be considering plans to woo users with virtual and physical rewards, according to a report by GamesIndustry International. "Television viewing tends to be a passive experience for a viewer without many opportunities for the viewer to engage or have interactive experiences with the presented content," reads the application. "To increase interactive viewing and encourage a user to watch one or more particular items of video content, awards and achievements may be tied to those items of video content." Dubbed 'Awards and Achievements Across TV Ecosystems', the listing can be found on the US Patent and Trademark Office website. It includes potential scenarios to compensate users for viewing specific programming, watching commercials, or interacting with on-screen events as tracked by the Kinect. The latter may include tracking your lounge room to check you're there, or asking you to "display a product that is imaged by a camera, and the computing system may identify the product". According to the application, spectators who view a single event, such as the Super Bowl, or watch an entire season of video content may be rewarded. "Additionally, by tying the awards and achievements to particular items of video or advertising content, viewers may be encouraged to increase their viewership of the content, thus increasing advertising opportunities," the patent reads. Rewards for viewers could include an increase in an Xbox Gamerscore-style point system, Xbox Live avatar clothing and items, physical goods, or unlocks of previously inaccessible content, though no specifics were provided. GameSpot contacted Microsoft to confirm whether any of the features listed in the patent application will be supported by the company's upcoming Xbox One console. A spokesperson was unavailable for comment at time of publication. This latest filing by Microsoft shares similarities with a previous patent that describes monitoring viewers watching content.
Read and Post Comments | Get the full article at GameSpot "Microsoft files patent for television achievements" was posted by Dan Chiappini on Mon, 27 May 2013 19:52:08 -0700 |
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