Games |
- Tug of Gore - Screenshots
- Witness plea follows hi-tech home raid
- Pharmaceuticals, Vol. 6, Pages 681-688: Evolution of Biologics Screening Technologies
- Sustainability, Vol. 5, Pages 2210-2232: ¨ A Dilemma of Abundance: Governance Challenges of Reconciling Shale Gas Development and Climate Change Mitigation
- Sustainability, Vol. 5, Pages 2191-2209: Coping with Climate Change among Adolescents: Implications for Subjective Well-Being and Environmental Engagement
- Viruses, Vol. 5, Pages 1231-1249: Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins
- Molecules, Vol. 18, Pages 5568-5579: Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds
- Molecules, Vol. 18, Pages 5543-5567: Isotope Effects as Probes for Enzyme Catalyzed Hydrogen-Transfer Reactions
- Molecules, Vol. 18, Pages 5531-5542: Water Extractable Arabinoxylan Aerogels Prepared by Supercritical CO2 Drying
- Remote Sensing, Vol. 5, Pages 2368-2388: Quantifying Dynamics in Tropical Peat Swamp Forest Biomass with Multi-Temporal LiDAR Datasets
- Remote Sensing, Vol. 5, Pages 2348-2367: Comparison of Satellite-Derived Land Surface Temperature and Air Temperature from Meteorological Stations on the Pan-Arctic Scale
- Remote Sensing, Vol. 5, Pages 2327-2347: Optical and Thermal Remote Sensing of Turfgrass Quality, Water Stress, and Water Use under Different Soil and Irrigation Treatments
- Set for iWork 1.2 - Pages, Numbers, and Keynote templates. (Commercial)
- AdmitOne 1.1.4 - Find top-rated movies. (Free)
- Invisible 1.1 - Easily hide your personal files. (Commercial)
- Portfolio mobile 1.8.7 - Stock portfolio solution. (Demo)
- Mac Game Store 2.2.3 - Download, purchase, and manage Mac games. (Free)
- MacX Video Converter Pro 3.6.0 - Convert and share videos. (Shareware)
- Music Tag Editor 2.1.1 - Easily edit music tags. (Commercial)
- Remote Sensing, Vol. 5, Pages 2308-2326: Modeling Stand Height, Volume, and Biomass from Very High Spatial Resolution Satellite Imagery and Samples of Airborne LiDAR
| Posted: 14 May 2013 04:16 AM PDT Players can tap their DuDu to temporarily increase tugging power. But beware - other players can steal this power too! Players are only allowed to touch the iPad with just one hand. The other hand may be used in whatever way the players see fit. |
| Witness plea follows hi-tech home raid Posted: 14 May 2013 03:06 AM PDT They kicked in the front door of a home in Peartree Avenue, Bitterne , between 3pm and 11.30pm on Sunday, May 5, while the 68-year-old man and 70-year-old woman living there were out. This posting includes an audio/video/photo media file: Download Now |
| Pharmaceuticals, Vol. 6, Pages 681-688: Evolution of Biologics Screening Technologies Posted: 14 May 2013 12:00 AM PDT Screening for biologics, in particular antibody drugs, has evolved significantly over the last 20 years. Initially, the screening processes and technologies from many years experience with small molecules were adopted and modified to suit the needs of biologics discovery. Since then, antibody drug discovery has matured significantly and is today investing earlier in new technologies that commercial suppliers are now developing specifically to meet the growing needs of large molecule screening. Here, we review the evolution of screening and automation technologies employed in antibody discovery and highlight the benefits that these changes have brought. |
| Posted: 14 May 2013 12:00 AM PDT Shale gas proponents argue this unconventional fossil fuel offers a "bridge" towards a cleaner energy system by offsetting higher-carbon fuels such as coal. The technical feasibility of reconciling shale gas development with climate action remains contested. However, we here argue that governance challenges are both more pressing and more profound. Reconciling shale gas and climate action requires institutions capable of responding effectively to uncertainty; intervening to mandate emissions reductions and internalize costs to industry; and managing the energy system strategically towards a lower carbon future. Such policy measures prove challenging, particularly in jurisdictions that stand to benefit economically from unconventional fuels. We illustrate this dilemma through a case study of shale gas development in British Columbia, Canada, a global leader on climate policy that is nonetheless struggling to manage gas development for mitigation. The BC case is indicative of the constraints jurisdictions face both to reconcile gas development and climate action, and to manage the industry adequately to achieve social licence and minimize resistance. More broadly, the case attests to the magnitude of change required to transform our energy systems to mitigate climate change. |
| Posted: 14 May 2013 12:00 AM PDT The objective of this questionnaire study was to investigate how Swedish adolescents (n = 321) cope with climate change and how different coping strategies are associated with environmental efficacy, pro-environmental behavior, and subjective well-being. The results were compared to an earlier study on 12-year-olds, and the same coping strategies, problem-focused coping, de-emphasizing the seriousness of the threat, and meaning-focused coping, were identified. As in the study on children, problem-focused and meaning-focused coping were positively related to felt efficacy and environmental behavior, while de-emphasizing the threat was negatively related to these measures. As expected, the more problem-focused coping the adolescents used, the more likely it was that they experienced negative affect in everyday life. This association was explained by the tendency for highly problem-focused adolescents to worry more about climate change. In contrast, meaning-focused coping was positively related to both well-being and optimism. When controlling for well-known predictors such as values and gender, meaning-focused and problem-focused coping were independent positive predictors of environmental efficacy and pro-environmental behavior, while de-emphasizing the threat was a negative predictor of pro-environmental behavior. The results are discussed in relation to coping theories and earlier studies on coping with climate change. |
| Posted: 14 May 2013 12:00 AM PDT The role of enzymes involved in polycomb repression of gene transcription has been studied extensively in human cancer. Polycomb repressive complexes mediate oncogene-induced senescence, a principal innate cell-intrinsic tumor suppressor pathway that thwarts expansion of cells that have suffered oncogenic hits. Infections with human cancer viruses including human papillomaviruses (HPVs) and Epstein-Barr virus can trigger oncogene-induced senescence, and the viruses have evolved strategies to abrogate this response in order to establish an infection and reprogram their host cells to establish a long-term persistent infection. As a consequence of inhibiting polycomb repression and evading oncogene induced-senescence, HPV infected cells have an altered epigenetic program as evidenced by aberrant homeobox gene expression. Similar alterations are frequently observed in non-virus associated human cancers and may be harnessed for diagnosis and therapy. |
| Posted: 14 May 2013 12:00 AM PDT Three new multiflorane-type triterpenes; 7a-methoxymultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3a,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11)-diene-3a-29-diol 3-benzoate (5) exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells. |
| Posted: 14 May 2013 12:00 AM PDT Kinetic Isotope effects (KIEs) have long served as a probe for the mechanisms of both enzymatic and solution reactions. Here, we discuss various models for the physical sources of KIEs, how experimentalists can use those models to interpret their data, and how the focus of traditional models has grown to a model that includes motion of the enzyme and quantum mechanical nuclear tunneling. We then present two case studies of enzymes, thymidylate synthase and alcohol dehydrogenase, and discuss how KIEs have shed light on the C-H bond cleavages those enzymes catalyze. We will show how the combination of both experimental and computational studies has changed our notion of how these enzymes exert their catalytic powers. |
| Posted: 14 May 2013 12:00 AM PDT Water extractable arabinoxylan (WEAX) aerogels were prepared by extracting the solvent from the alcogels (WEAX hydrogels with an alcohol as the solvent) with carbon dioxide under supercritical conditions. WEAX aerogels were characterized using scanning electron microscopy and adsorption and desorption nitrogen isotherms. The micrographs indicate a heterogeneous porous network structure in WEAX aerogel. Adsorption/desorption nitrogen isotherms of this material were type IV, which confirm that this material possess a mesoporous structure. WEAX aerogels rehydration capability was evaluated and the water absorption mechanism was determined. The WEAX aerogels water absorption mechanism was non-Fickian (n = 0.54). |
| Posted: 14 May 2013 12:00 AM PDT Tropical peat swamp forests in Indonesia store huge amounts of carbon and are responsible for enormous carbon emissions every year due to forest degradation and deforestation. These forest areas are in the focus of REDD+ (reducing emissions from deforestation, forest degradation, and the role of conservation, sustainable management of forests and enhancement of forest carbon stocks) projects, which require an accurate monitoring of their carbon stocks or aboveground biomass (AGB). Our study objective was to evaluate multi-temporal LiDAR measurements of a tropical forested peatland area in Central Kalimantan on Borneo. Canopy height and AGB dynamics were quantified with a special focus on unaffected, selective logged and burned forests. More than 11,000 ha were surveyed with airborne LiDAR in 2007 and 2011. In a first step, the comparability of these datasets was examined and canopy height models were created. Novel AGB regression models were developed on the basis of field inventory measurements and LiDAR derived height histograms for 2007 (r2 = 0.77, n = 79) and 2011 (r2 = 0.81, n = 53), taking the different point densities into account. Changes in peat swamp forests were identified by analyzing multispectral imagery. Unaffected forests accumulated on average 20 t/ha AGB with a canopy height increase of 2.3 m over the four year time period. Selective logged forests experienced an average AGB loss of 55 t/ha within 30 m and 42 t/ha within 50 m of detected logging trails, although the mean canopy height increased by 0.5 m and 1.0 m, respectively. Burned forests lost 92% of the initial biomass. These results demonstrate the great potential of repetitive airborne LiDAR surveys to precisely quantify even small scale AGB and canopy height dynamics in remote tropical forests, thereby featuring the needs of REDD+. |
| Posted: 14 May 2013 12:00 AM PDT Satellite-based temperature measurements are an important indicator for global climate change studies over large areas. Records from Moderate Resolution Imaging Spectroradiometer (MODIS), Advanced Very High Resolution Radiometer (AVHRR) and (Advanced) Along Track Scanning Radiometer ((A)ATSR) are providing long-term time series information. Assessing the quality of remote sensing-based temperature measurements provides feedback to the climate modeling community and other users by identifying agreements and discrepancies when compared to temperature records from meteorological stations. This paper presents a comparison of state-of-the-art remote sensing-based land surface temperature data with air temperature measurements from meteorological stations on a pan-arctic scale (north of 60° latitude). Within this study, we compared land surface temperature products from (A)ATSR, MODIS and AVHRR with an in situ air temperature (Tair) database provided by the National Climate Data Center (NCDC). Despite analyzing the whole acquisition time period of each land surface temperature product, we focused on the inter-annual variability comparing land surface temperature (LST) and air temperature for the overlapping time period of the remote sensing data (2000–2005). In addition, land cover information was included in the evaluation approach by using GLC2000. MODIS has been identified as having the highest agreement in comparison to air temperature records. The time series of (A)ATSR is highly variable, whereas inconsistencies in land surface temperature data from AVHRR have been found. |
| Posted: 14 May 2013 12:00 AM PDT Optical and thermal remote sensing data were acquired at ground level over several turfgrass species under different soil and irrigation treatments in northern Colorado, USA. Three vegetation indices (VIs), estimated based on surface spectral reflectance, were sensitive to the effect of reduced water application on turfgrass quality. The temperature-based Grass Water Stress Index (GWSI) was also estimated by developing non-transpiring and non-water-stressed baselines. The VIs and the GWSI were all consistent in (i) having a non-linear relationship with the water application depth; and, (ii) revealing that the sensitivity of studied species to water availability increased in order from warm season mix to Poa pratensis L. and then Festuca spp.. Implemented soil preparation treatments had no significant effect on turfgrass quality and water stress. The differences between GWSI-based estimates of water use and the results of a complex surface energy balance model (METRIC) were not statistically significant, suggesting that the empirical GWSI method could provide similar results if the baselines are accurately developed under the local conditions of the study area. |
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| AdmitOne 1.1.4 - Find top-rated movies. (Free) Posted: 14 May 2013 02:38 AM PDT  AdmitOne shows you all top-charts DVDs. When selecting a DVD for download, AdmitOne will search and find the best torrent for you from some of the best torrent sites out there. Then, if you choose to download a movie, your download will automatically start, and your movie will be ready to watch in a short time. Version 1.1.4:
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| Portfolio mobile 1.8.7 - Stock portfolio solution. (Demo) Posted: 14 May 2013 02:27 AM PDT  Portfolio mobile for Mac has all the features you're looking for. Portfolio tracking, technical analysis, foreign trading, and more.
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| Mac Game Store 2.2.3 - Download, purchase, and manage Mac games. (Free) Posted: 14 May 2013 02:19 AM PDT  Mac Game Store provides a better and easier shopping experience to get the latest Mac games. Mac Game Store has an extensive library of Mac Games with new games being added daily. This new app provides game screenshots, game trailers, community reviews, and game ratings. The app utilizes the cloud so games are downloaded extremely quickly and allows customers to store their games in the cloud. Version 2.2.3:
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| MacX Video Converter Pro 3.6.0 - Convert and share videos. (Shareware) Posted: 14 May 2013 02:13 AM PDT  MacX Video Converter Pro all-in-one video converter converts MKV,TS, M2TS, MTS, AVCHD, AVC, AVI, MPEG, MP4, H.264, MOV, FLV, F4V, RM, RMVB, WebM, Google TV, etc., to your Mac, iMovie, iTunes, iPhone, iPad, iPod, PSP, mobile phone, etc. With multi-track HD video supported, it can also convert videos to VOB files that can be burned to DVD. Works as a YouTube video downloader which will then convert the video to any format. Features:
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| Music Tag Editor 2.1.1 - Easily edit music tags. (Commercial) Posted: 14 May 2013 02:03 AM PDT  Music Tag Editor can help you edit your music-tag info easily and effectively. You can also use it to convert the text encoding of music tags. It can repair the messy code in music tags. You also can download the album image for MP3 files. Supported music formats: MP3, M4A (Apple lossless), FLAC, MP4. Features:
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| Posted: 14 May 2013 12:00 AM PDT Plot-based sampling with ground measurements or photography is typically used to establish and maintain National Forest Inventories (NFI). The re-measurement phase of the Canadian NFI is an opportunity to develop novel methods for the estimation of forest attributes such as stand height, crown closure, volume, and aboveground biomass (AGB) from satellite, rather than, airborne imagery. Based on panchromatic Very High Spatial Resolution (VHSR) images and Light Detection and Ranging (LiDAR) data acquired in the Yukon Territory, Canada, we propose an approach for boreal forest stand attribute characterization. Stand and tree objects are delineated, followed by modeling of stand height, volume, and AGB using metrics derived from the stand and tree crown objects. The calibration and validation of the models are based on co-located LiDAR-derived estimates. A k-nearest neighbor approach provided the best accuracy for stand height estimation (R2 = 0.76, RMSE = 1.95 m). Linear regression models were the most efficient for estimating stand volume (R2 = 0.94, RMSE = 9.6 m3/ha) and AGB (R2 = 0.92, RMSE = 22.2 t/ha). This study was implemented for one Canadian ecozone and demonstrated the capacity of a methodology to produce forest inventory attributes with acceptable accuracies offering potential to be applied to other boreal regions. |
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