среда, 8 мая 2013 г.

Games

Games

Designs for Students 1.1 - Templates for Pages, Numbers, Keynote, and iBooks Author. (Commercial)

Posted: 08 May 2013 03:10 AM PDT



Designs for Students is the ideal productivity tool for those at school or college, providing 80 unique designs for Pages, 10 spreadsheet templates for Numbers, 35 first-class slideshow themes for Keynote, and 15 book templates for iBooks Author. Focus on your classwork and leave the design and layout stuff to us!

Choose among the 80 templates for Pages to create a beautiful timetable, to-do list, or even business cards for your own garage-based business. All templates are fully customizable and available in US and international paper sizes.

The 35 stylish themes for Keynote will help you present your class projects with maximum results. Each theme contains 20 master slides and is available in the 5 most popular sizes.

If you need to draw up a budget or a cost comparison among several colleges, look no further than the 10 templates for Numbers included in the Designs for Students set. Customize the templates to your requirements: create tables, make calculations, draw diagrams, or insert images.

Last but not least, the set provides 15 templates for iBooks Author for creating your own awesome yearbook, cookbook, or a project portfolio for that garage-based business.

Use Designs for Students and have more time left for partying!



Version 1.1:
  • 5 new iBooks Author templates;
  • 5 new Keynote templates;
  • 30 new Pages templates.


  • OS X 10.4.4 or later
  • iWork
  • iBooks Author


Download Now

Templates for Pages 2.0 - Templates for Apple Pages (was Pages Templates). (Commercial)

Posted: 08 May 2013 03:04 AM PDT



Templates for Pages offers 1050 premium quality, beautiful yet functional templates for Apple's Pages. The set includes various templates, from business cards and brochures to posters and invitations. The Templates for Pages pack features an engrossing combination of a modern and professional print layout and an exciting air of imagination, adding a note of sophistication to your content. Available in US and international paper sizes.

Version 2.0:
  • 50 new templates.


  • OS X 10.4.10 or later
  • iWork '08 or later


Download Now

IJMS, Vol. 14, Pages 9803-9819: Two Volatile Organic Compounds Trigger Plant Self-Defense against a Bacterial Pathogen and a Sucking Insect in Cucumber under Open Field Conditions

Posted: 08 May 2013 12:00 AM PDT

Systemic acquired resistance (SAR) is a plant self-defense mechanism against a broad-range of pathogens and insect pests. Among chemical SAR triggers, plant and bacterial volatiles are promising candidates for use in pest management, as these volatiles are highly effective, inexpensive, and can be employed at relatively low concentrations compared with agrochemicals. However, such volatiles have some drawbacks, including the high evaporation rate of these compounds after application in the open field, their negative effects on plant growth, and their inconsistent levels of effectiveness. Here, we demonstrate the effectiveness of volatile organic compound (VOC)-mediated induced resistance against both the bacterial angular leaf spot pathogen, Pseudononas syringae pv. lachrymans, and the sucking insect aphid, Myzus persicae, in the open field. Using the VOCs 3-pentanol and 2-butanone where fruit yields increased gave unexpectedly, a significant increase in the number of ladybird beetles, Coccinella septempunctata, a natural enemy of aphids. The defense-related gene CsLOX was induced by VOC treatment, indicating that triggering the oxylipin pathway in response to the emission of green leaf volatiles can recruit the natural enemy of aphids. These results demonstrate that VOCs may help prevent plant disease and insect damage by eliciting induced resistance, even in open fields

IJMS, Vol. 14, Pages 9790-9802: D-pinitol Inhibits Prostate Cancer Metastasis through Inhibition of αVβ3 Integrin by Modulating FAK, c-Src and NF-κB Pathways

Posted: 08 May 2013 12:00 AM PDT

Prostate cancer is the most commonly diagnosed malignancy in men and shows a predilection for metastasis to the bone. D-pinitol, a 3-methoxy analogue of d-chiro-inositol, was identified as an active principle in soy foods and legumes, and it has been proven to induce tumor apoptosis and metastasis of cancer cells. In this study, we investigated the anti-metastasis effects of D-pinitol in human prostate cancer cells. We found that D-pinitol reduced the migration and the invasion of prostate cancer cells (PC3 and DU145) at noncytotoxic concentrations. Integrins are the major adhesive molecules in mammalian cells and have been associated with the metastasis of cancer cells. Treatment of prostate cancer cells with D-pinitol reduced mRNA and cell surface expression of αvβ3 integrin. In addition, D-pinitol exerted its inhibitory effects by reducing focal adhesion kinase (FAK) phosphorylation, c-Src kinase activity and NF-kB activation. Thus, D-pinitol may be a novel anti-metastasis agent for the treatment of prostate cancer metastasis.

Religions, Vol. 4, Pages 288-289: Lady Saints

Posted: 08 May 2013 12:00 AM PDT

A meditation on the death of the author's Sicilian grandmother that explores how a child copes with loss by transforming the grandmother's vast collection of plastic and porcelain female saints into imaginary friends.

Molecules, Vol. 18, Pages 5317-5325: Characterization of Volatile Components in Makgeolli, a Traditional Korean Rice Wine, with or without Pasteurization, During Storage

Posted: 08 May 2013 12:00 AM PDT

Changes in the volatile components of unpasteurized and pasteurized makgeolli during 30 days of storage were investigated by gas chromatography-mass spectrometry (GC-MS) and GC-olfactometry (GC-O). A total of 11 odor-active compounds such as 3-methyl-1-butanol (isoamyl alcohol), 2-methyl-1-butanol, 2,3-butanediol, butanoic acid, 3-methylbutanoic acid (isovaleric acid), 2-methylbutanoic acid, 3-(methylthio)-1-propanol (methionol), 2-phenylethanol, ethyl decanoate, ethyl dodecanoate, and ethyl tetradecanoate were determined in both the pasteurized and unpasteurized makgeolli during 30 days of storage. Although there were no significant differences in the concentrations of odor-active compounds at the initial storage time, most of odor-active compounds were more significantly increased in unpasteurized makgeolli compared to the pasteurized one during the storage period.

Molecules, Vol. 18, Pages 5306-5316: Isolation of Nematicidal Triterpenoid Saponins from Pulsatilla koreana Root and Their Activities against Meloidogyne incognita

Posted: 08 May 2013 12:00 AM PDT

Pulsatilla koreana, a species endemic to Korea, is an important herb used in traditional medicine to treat amoebic dysentery and malaria. In the present study, 23 oleanane-type triterpenoid saponins 1–23 and eight lupane-type triterpenoid saponins 24–31 were isolated from the roots of P. koreana. Their structures were elucidated on the basis of spectroscopic data. The methanol extract and isolated compounds were next assessed for nematicidal activity against the root-knot nematode (Meloidogyne incognita). The methanol extract showed strong nematicidal activity after 48 h, with a LC50 value of 92.8 μg/mL. Compounds 2, 5, 9, 20, and 21 showed significant effects, with LC50 values ranging from 70.1 to 94.7 μg/mL after 48 h. These results suggest that triterpenoid saponins from P. koreana should be explored as potential natural nematicides for developing new agents to control root-knot nematode disease

Vaccines, Vol. 1, Pages 167-173: Hepatitis B Vaccination in Pregnancy in the United States

Posted: 08 May 2013 12:00 AM PDT

Hepatitis B remains a significant health issue worldwide, and contributes significantly to the incidence of cirrhosis and hepatocellular carcinoma. Widespread adoption of hepatitis B vaccination strategies has lead to significant declines in acute hepatitis B infections. Current recommendations for vaccination in the non-pregnant population include vaccinating all persons found to have risk-factors for disease acquisition. Hepatitis B virus is known to occur through vertical transmission or early childhood transmission, and strategies to decrease transmission include avoidance of exposure, avoidance of high-risk behaviors, universal screening of women during pregnancy, and active and passive immunization. It is currently recommended that all pregnant women undergo screening for hepatitis B virus at presentation for prenatal care. Those who engage in high-risk behavior should be re-screened at presentation for delivery. Studies have demonstrated the safety and efficacy of the hepatitis B vaccine in pregnancy, and its use is an important component in prevention of disease acquisition. Pregnant women in the United States who are found to be at risk for disease acquisition should be specifically targeted for vaccination.

Energies, Vol. 6, Pages 2446-2467: Analysis and Assessments of Combined Cooling, Heating and Power Systems in Various Operation Modes for a Building in China, Dalian

Posted: 08 May 2013 12:00 AM PDT

Combined Cooling, Heating and Power (CCHP) systems have been widely used in different kinds of buildings to make better use of fuels because of their high overall efficiency. This paper presents a mathematical analysis of a CCHP system in comparison to a Heating, Ventilation and Air Conditioning (HVAC) system. The operation strategies following electric load (FEL), thermal load (FTL) and a hybrid electric-thermal load (FHL) are proposed and investigated in this study. Criteria, namely primary energy saving (PES), exergy efficiency (ηexergy), and CO2 emission reduction (CER) are defined to evaluate the performances of CCHP systems for a hypothetical building located in Dalian (China). The results indicate that: (1) a new mathematical foundation is established to find whether the recovered thermal energy and the amount of electricity generated by the power generation unit (PGU) are enough to provide the energy required; (2) the CCHP system does not always perform better than a HVAC system from an instantaneous perspective, especially in FTL mode; (3) the CCHP system in FEL operation mode can be seen as a suitable energy system in Dalian from the annual performance perspective. Furthermore, a sensitivity analysis is presented in order to show how the performances vary due to the changes of various technical variables.

Artifact Red-X - Screenshots

Posted: 08 May 2013 03:49 AM PDT

Humans & Aliens have been locked in a millennia-long war which began when a group of explorers discovered an artifact in the center of the milky way galaxy. This artifact was found to be as old as the universe itself.  When touched by an ungloved hand the artifact cracked,  revealing a power source with such tremendous energy no one could resist removing it for study. As the scientist attempted to remove the element, it released an energy wave which rippled throughout the galaxy. The energy wave had a strange effect on all organic life causing the cells in the vertebrae to mutate in what scientists are calling "Freeform Evolution". These mutations transform the individual's physiology based on emotion, self thought and environmental interaction. The 'energy' somehow absorbs the bombardment of stimuli, combined with the individual's own self projection,  undergoes molecular and cellular metamorphosis.

In addition to aesthetic changes, whoever the individual interacts with can also influence these physical changes. It was found that by associating with unsavory individuals, the group of individuals all appear to produce particular pheromones in a way to identify with one another.  This indicated that "Freeform Evolution" is somehow interconnected with every molecule. These changes have changed the social dynamics of all the known species in this region of space.
 
Despite the hazardous nature of Element Red-X on organic matter, the use of this element as a power source has drastically advanced human civilization. The energy produced by a micron of Red-X powers faster than light space travel, which has allowed humanity to expand rapidly into the universe.  As humanity's insatiable demand of element Red-X grows, so to do the squabbles over the control of the rare element.  ...

Dragon Swarm - Screenshots

Posted: 08 May 2013 03:35 AM PDT

The goal of the game is to win each battle by eliminating other players in order to control the map. Players send forth dragons from their lairs to attack, and there are 3 upgradable lair types, each with different abilities.

Players must decide how to use these unique lairs and dragons to their best advantage to win. The arcade style gameplay makes this real-time strategy game highly accessible, even to players new to the genre.

There are 3 primary game modes:
•  Online via Game Center: 2v2 team or PvP matches with up to 4 friends or random players online.
•  Nearby via LAN: Up to 6 can play in fully configurable skirmishes on a local network or Wi-Fi.
•  Single Player: Skirmish against computer controlled bots while offline.

Entropy, Vol. 15, Pages 1690-1704: An Estimate of Mutual Information that Permits Closed-Form Optimisation

Posted: 08 May 2013 12:00 AM PDT

We introduce a new estimate of mutual information between a dataset and a target variable that can be maximised analytically and has broad applicability in the field of machine learning and statistical pattern recognition. This estimate has previously been employed implicitly as an approximation to quadratic mutual information. In this paper we will study the properties of these estimates of mutual information in more detail, and provide a derivation from a perspective of pairwise interactions. From this perspective, we will show a connection between our proposed estimate and Laplacian eigenmaps, which so far has not been shown to be related to mutual information. Compared with other popular measures of mutual information, which can only be maximised through an iterative process, ours can be maximised much more efficiently and reliably via closed-form eigendecomposition.

Sensors, Vol. 13, Pages 5881-5896: A Mobile Acoustic Subsurface Sensing (MASS) System for Rapid Roadway Assessment

Posted: 08 May 2013 12:00 AM PDT

Surface waves are commonly used for vibration-based nondestructive testing for infrastructure. Spectral Analysis of Surface Waves (SASW) has been used to detect subsurface properties for geologic inspections. Recently, efforts were made to scale down these subsurface detection approaches to see how they perform on small-scale structures such as concrete slabs and pavements. Additional efforts have been made to replace the traditional surface-mounted transducers with non-contact acoustic transducers. Though some success has been achieved, most of these new approaches are inefficient because they require point-to-point measurements or off-line signal analysis. This article introduces a Mobile Acoustic Subsurface Sensing system as MASS, which is an improved surface wave based implementation for measuring the subsurface profile of roadways. The compact MASS system is a 3-wheeled cart outfitted with an electromagnetic impact source, distance register, non-contact acoustic sensors and data acquisition/ processing equipment. The key advantage of the MASS system is the capability to collect measurements continuously at walking speed in an automatic way. The fast scan and real-time analysis advantages are based upon the non-contact acoustic sensing and fast air-coupled surface wave analysis program. This integration of hardware and software makes the MASS system an efficient mobile prototype for the field test.

Nutrients, Vol. 5, Pages 1531-1543: Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia

Posted: 08 May 2013 12:00 AM PDT

To compare the efficacy of a diet rich in natural folate and of two different folic acid supplementation protocols in subjects with "moderate" hyperhomocysteinemia, also taking into account C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. Subjects/Methods: We performed a 13 week open, randomized, double blind clinical trial on 149 free living persons with mild hyperhomocyteinemia, with daily 200 μg from a natural folate-rich diet, 200 μg [6S]5-methyltetrahydrofolate (5-MTHF), 200 μg folic acid or placebo. Participants were stratified according to their MTHFR genotype. Results: Homocysteine (Hcy) levels were reduced after folate enriched diet, 5-MTHF or folic acid supplementation respectively by 20.1% (p < 0.002), 19.4% (p < 0.001) and 21.9% (p < 0.001), as compared to baseline levels and significantly as compared to placebo (p < 0.001, p < 0.002 and p < 0.001, respectively for enriched diet, 5-MTHF and folic acid). After this enriched diet and the folic acid supplementation, Hcy in both genotype groups decreased approximately to the same level, with higher percentage decreases observed for the TT group because of their higher pre-treatment value. Similar results were not seen by genotype for 5-MTHF. A significant increase in RBC folate concentration was observed after folic acid and natural folate-rich food supplementations, as compared to placebo. Conclusions: Supplementation with natural folate-rich foods, folic acid and 5-MTHF reached a similar reduction in Hcy concentrations.

IJERPH, Vol. 10, Pages 1916-1926: Canadian Lung Cancer Relative Risk from Radon Exposure for Short Periods in Childhood Compared to a Lifetime

Posted: 08 May 2013 12:00 AM PDT

Long-term exposure to elevated indoor radon concentrations has been determined to be the second leading cause of lung cancer in adults after tobacco smoking. With the establishment of a National Radon Program in Canada in 2007 thousands of homes across the country have been tested for radon. Although the vast majority of people are exposed to low or moderate radon concentrations; from time to time; there are homes found with very high concentrations of radon. Among those living in homes with very high radon concentrations, it is typically parents of young children that demonstrate a great deal of concern. They want to know the equivalent risk in terms of the lifetime relative risk of developing lung cancer when a child has lived in a home with high radon for a few years. An answer to this question of risk equivalency is proposed in this paper. The results demonstrate clearly that the higher the radon concentration; the sooner remedial measures should be undertaken; as recommended by Health Canada in the Canadian radon guideline.

Brain Sciences, Vol. 3, Pages 781-789: Neurovascular Coupling of the Posterior Cerebral Artery in Spinal Cord Injury: A Pilot Study

Posted: 08 May 2013 12:00 AM PDT

Purpose: To compare neurovascular coupling in the posterior cerebral artery (PCA) between those with spinal cord injury (SCI) and able bodied (AB) individuals. Methods: A total of seven SCI and seven AB were matched for age and sex. Measures included PCA velocity (PCAv), beat-by-beat blood pressure and end-tidal carbon dioxide. Posterior cerebral cortex activation was achieved by 10 cycles of (1) 30 s eyes closed (pre-stimulation), (2) 30 s reading (stimulation). Results: Blood pressure was significantly reduced in those with SCI (SBP: 100 ± 13 mmHg; DBP: 58 ± 13 mmHg) vs. AB (SBP: 121 ± 12 mmHg; DBP: 74 ± 9 mmHg) during both pre-stimulation and stimulation, but the relative increase was similar during the stimulation period. Changes in PCAv during stimulation were mitigated in the SCI group (6% ± 6%) vs. AB (29% ± 12%, P < 0.001). Heart rate and end-tidal carbon dioxide responded similarly between groups. Conclusions: Clearly, NVC is impaired in those with SCI. This study may provide a link between poor perfusion of the posterior cerebral region (containing the medullary autonomic centres) and autonomic dysfunction after SCI.

Cells, Vol. 2, Pages 294-305: Morphological Features of Organelles during Apoptosis: An Overview

Posted: 08 May 2013 12:00 AM PDT

An apoptotic program leading to controlled cell dismantling implies perturbations of nuclear dynamics, as well as changes affecting the organelle structure and distribution. In human cancer cells driven to apoptosis by different stimuli, we have recently investigated the morphological properties of several organelles, including mitochondria, lysosomes, endoplasmic reticulum and Golgi apparatus. In this review, we will discuss the body of evidence in the literature suggesting that organelles are generally relocated and/or degraded during apoptosis, irrespectively of the apoptogenic stimulus and cell type.

Cancers, Vol. 5, Pages 519-528: Lost in Translation: Ambiguity in Nerve Sheath Tumor Nomenclature and Its Resultant Treatment Effect

Posted: 08 May 2013 12:00 AM PDT

There is much ambiguity surrounding the diagnosis of nerve sheath tumors, including atypical neurofibroma and low-grade MPNST, and yet, the distinction between these entities designates either benign or malignant behavior and thus carries presumed profound prognostic importance that often guides treatment. This study reviews the diagnostic criteria used to designate atypical neurofibroma from low-grade MPNSTs and reviews existing literature the natural history of each of these tumors to see if the distinction is, in fact, of importance.

Societies, Vol. 3, Pages 204-216: Improving Early Detection of Refugee-Related Stress Symptoms: Evaluation of an Inter-Professional and Inter-Cultural Skills Training Course in Sweden

Posted: 08 May 2013 12:00 AM PDT

Twenty-three of 26 participants, mainly women from six local agencies involved in the reception of refugees, completed a university course titled "Refugee-related stress and mental health—local cooperation", which was spread over seven days in 2011. The course was based on evidence and clinical experience and was commissioned to serve as competency training by Stockholm County Council and Södertälje Municipality. It received funding from the Swedish National Board of Health and Welfare. It was a continuation of an earlier one-week full-time university course from 2010 with the same title. As a result of a new law relating to refugee reception, which led to organizational change, the participants requested a continuation of the original course. The learning objectives were met (5.4 on a 6-point scale; 1 = strongly disagree, 6 = strongly agree). The general assessment of the course as a whole by the participants was 5.7 (on a 6-point scale, 1 = very unsatisfied, 6 = very satisfied). The participants thought that their skills had increased, and their perception was that they had significantly better control of their work situation following completion of the course. The most important findings were that participants from different agencies at the local level: (1) perceived that they had developed the sense that there was a local inter-cultural and inter-professional inter-agency collaboration in the reception of newly arrived refugees and (2) will continue efforts to stabilize and develop this together. This method of teaching, in terms of skills training, is not a "quick fix." It is a process, and it needs support from those in power in order to continue.

The hidden secret of women and gambling

Posted: 08 May 2013 01:04 AM PDT

While men are considered "action" gamblers, it's estimated that 95 percent of women prefer solitary options like playing slots and video poker for one main purpose.

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