четверг, 30 мая 2013 г.

Games

Games

Snail 1.0.3 - Fast and simple time management utility. ()

Posted: 30 May 2013 03:00 AM PDT



Snail is time and task management made fast and simple, perfect for mastering your daily workflow. Created with love and care, Snail combines a beautiful interface with precision execution. Intuitive to use, it's always at hand, ready to help.

Version 1.0.3:
  • iCloud synchronisation (OS X 10.8 only)
  • Some bug fixes


  • OS X 10.7 or later



More information

popCalendar 1.0.2 - Calendar for the menu bar. ()

Posted: 30 May 2013 02:42 AM PDT



popCalendar is a tiny calendar that fits in your menu bar, giving you faster access to your timetable. A month-view lets you find the day or the date you need, while a click on a day lets you see all of its events. All of that without having to launch iCal!

Version 1.0.2:
  • Bug fixes in OS X 10.7


  • OS X 10.7 or later



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Producteev 2.0.1 - Manage to-do's from your Desktop. (Free)

Posted: 30 May 2013 02:36 AM PDT



Producteev is the latest app from the Producteev platform, that will let you manage your to-dos right from your desktop. Either as an individual, or as part of a team, we're here to help you get things done from anywhere.

Multi-Platform - Producteev is a task-management application for individuals and teams that syncs with a lot of tools and devices that you're using everyday : IM, E-mail (send tasks to task@producteev.com to install our email plugins), iPhone, and other mobile platforms, Web (www.producteev.com), mobile Web app, and other third party clients.

Features: The Mac application works offline and syncs with all of our other apps in real time. It works with Growl notifications and integrates all of our major Web features: deadlines and reminders, assignation, labels, repetitions, notes and file preview, collaboration, starring, filters, search, multiple workspaces, etc.

User Interface - All of this with the best interface you can imagine, from a simple to-do list app.

Coming soon: Invite colleagues right from the desktop + more settings / preferences options.



Version 2.0.1:

Minor bug fixes:
  • Some of you couldn't use the subtasks, now everyone can!
  • Other improvements


  • OS X 10.7 or later



More information

Participants 1.2 - Quickly and easily take attendance. (Commercial)

Posted: 30 May 2013 02:23 AM PDT



Participants is perfect for teachers, business people, group organizers, or anyone who needs to take attendance. Import people from your address book, assign them to groups, and add them as participants in your next event. Easily take attendance at your event by checking off the participants that attend.

Features:

  • Use the groups feature to quickly add a large or small group of participants to your event.
  • Easily print an attendance or contact list.
  • Easily e-mail event participants.
  • Full address book and calendar integration.
  • iCloud syncing between iOS and Mac ensures that you always have access to your participants data, whether at work, school, or home.
Wirelessly sync between your iOS devices and Mac computers with iCloud. Visit our Web site to see Participants in action!

Version 1.2:
  • Events can be duplicated, making it easy to populate a new event from an existing event.
  • All your contacts can be imported using a new mass-import feature.
  • Attendance lists, contact lists, and participant history can now be exported to a CSV spreadsheet.


  • OS X 10.7 or later



More information

Genes, Vol. 4, Pages 264-274: Molecular Expression of the Scribble Complex Genes, Dlg, Scrib and Lgl, in Silkworm, Bombyx mori

Posted: 30 May 2013 12:00 AM PDT

The Scribble protein complex genes, consisting of lethal giant larvae (Lgl), discs large (Dlg) and scribble (Scrib) genes, are components of an evolutionarily conserved genetic pathway that links the cell polarity in cells of humans and Drosophila. The tissue expression and developmental changes of the Scribble protein complex genes were documented using qRT-RCR method. The Lgl and Scrib genes could be detected in all the experimental tissues, including fat body, midgut, testis/ovary, wingdisc, trachea, malpighian tubule, hemolymph, prothoracic gland and silk gland. The Dlg gene, mainly expressed only in testis/ovary, could not be detected in prothoracic gland and hemolymph. In fat body, there were two higher expression stages of the three genes. The highest peak of the expression of the Lgl and Scrib genes in wingdisc lay at the 1st day of the 5th instar, but the Dlg gene was at 3rd day of 5th instar. The above results indicate that Scribble complex genes are involved in the process of molting and development of the wingdisc in the silkworm. This will be useful in the future for the elucidation of the detailed biological function of the three genes Scrib, Dlg and Lgl in B. mori.

Insects, Vol. 4, Pages 217-229: Laboratory and Simulated Field Bioassays to Evaluate Larvicidal Activity of Pinus densiflora Hydrodistillate, Its Constituents and Structurally Related Compounds against Aedes albopictus, Aedes aegypti and Culex pipiens pallens in Relation to Their Inhibitory Effects on Acetylcholinesterase Activity

Posted: 30 May 2013 12:00 AM PDT

The toxicity of Pinus densiflora (red pine) hydrodistillate, its 19 constituents and 28 structurally related compounds against early third-instar larvae of Aedes albopictus (Ae. albopictus), Aedes aegypti (Ae. aegypti) and Culex pipiens palles (Cx. p. pallens) was examined using direct-contact bioassays. The efficacy of active compounds was further evaluated in semi-field bioassays using field-collected larval Cx. p. pallens. Results were compared with those of two synthetic larvicides, temephos and fenthion. In laboratory bioassays, Pinus densiflora hydrodistillate was found to have 24 h LC50 values of 20.33, 21.01 and 22.36 mg/L against larval Ae. albopictus, Ae. aegypti and Cx. p. pallens respectively. Among the identified compounds, thymol, δ-3-carene and (+)-limonene exhibited the highest toxicity against all three mosquito species. These active compounds were found to be nearly equally effective in field trials as well. In vitro bioassays were conducted to examine the acetylcholinesterase (AChE) inhibitory activity of 10 selected compounds. Results showed that there is a noticeable correlation between larvicidal activity and AChE inhibitory activity. In light of global efforts to find alternatives for currently used insecticides against disease vector mosquitoes, Pinus densiflora hydrodistillate and its constituents merit further research as potential mosquito larvicides.

Viruses, Vol. 5, Pages 1374-1394: Current Understanding of the Role of the Brd4 Protein in the Papillomavirus Lifecycle

Posted: 30 May 2013 12:00 AM PDT

The Brd4 protein is an epigenetic reader that is central to regulation of cellular transcription and mitotic bookmarking. The transcription and replication proteins of many viruses interact with Brd4. We describe the multiple roles of Brd4 in the papillomavirus lifecycle.

Cells, Vol. 2, Pages 361-392: Monte Carlo Study Elucidates the Type 1/Type 2 Choice in Apoptotic Death Signaling in Healthy and Cancer Cells

Posted: 30 May 2013 12:00 AM PDT

Apoptotic cell death is coordinated through two distinct (type 1 and type 2) intracellular signaling pathways. How the type 1/type 2 choice is made remains a central problem in the biology of apoptosis and has implications for apoptosis related diseases and therapy. We study the problem of type 1/type 2 choice in silico utilizing a kinetic Monte Carlo model of cell death signaling. Our results show that the type 1/type 2 choice is linked to deterministic versus stochastic cell death activation, elucidating a unique regulatory control of the apoptotic pathways. Consistent with previous findings, our results indicate that caspase 8 activation level is a key regulator of the choice between deterministic type 1 and stochastic type 2 pathways, irrespective of cell types. Expression levels of signaling molecules downstream also regulate the type 1/type 2 choice. A simplified model of DISC clustering elucidates the mechanism of increased active caspase 8 generation and type 1 activation in cancer cells having increased sensitivity to death receptor activation. We demonstrate that rapid deterministic activation of the type 1 pathway can selectively target such cancer cells, especially if XIAP is also inhibited; while inherent cell-to-cell variability would allow normal cells stay protected.

Biology, Vol. 2, Pages 798-809: Fungal Diversity in a Dark Oligotrophic Volcanic Ecosystem (DOVE) on Mount Erebus, Antarctica

Posted: 30 May 2013 12:00 AM PDT

Fumarolic Ice caves on Antarctica's Mt. Erebus contain a dark oligotrophic volcanic ecosystem (DOVE) and represent a deep biosphere habitat that can provide insight into microbial communities that utilize energy sources other than photosynthesis. The community assembly and role of fungi in these environments remains largely unknown. However, these habitats could be relatively easily contaminated during human visits. Sixty-one species of fungi were identified from soil clone libraries originating from Warren Cave, a DOVE on Mt. Erebus. The species diversity was greater than has been found in the nearby McMurdo Dry Valleys oligotrophic soil. A relatively large proportion of the clones represented Malassezia species (37% of Basidomycota identified). These fungi are associated with skin surfaces of animals and require high lipid content for growth, indicating that contamination may have occurred through the few and episodic human visits in this particular cave. These findings highlight the importance of fungi to DOVE environments as well as their potential use for identifying contamination by humans. The latter offers compelling evidence suggesting more strict management of these valuable research areas.

Metabolites, Vol. 3, Pages 463-483: Multiple Roles of Photosynthetic and Sunscreen Pigments in Cyanobacteria Focusing on the Oxidative Stress

Posted: 30 May 2013 12:00 AM PDT

Cyanobacteria have two types of sunscreen pigments, scytonemin and mycosporine-like amino acids (MAAs). These secondary metabolites are thought to play multiple roles against several environmental stresses such as UV radiation and desiccation. Not only the large molar absorption coefficients of these sunscreen pigments, but also their antioxidative properties may be necessary for the protection of biological molecules against the oxidative damages induced by UV radiation. The antioxidant activity and vitrification property of these pigments are thought to be requisite for the desiccation and rehydration processes in anhydrobiotes. In this review, the multiple roles of photosynthetic pigments and sunscreen pigments on stress resistance, especially from the viewpoint of their structures, biosynthetic pathway, and in vitro studies of their antioxidant activity, will be discussed.

JDB, Vol. 1, Pages 3-19: Evolutionary Origin of the Proepicardium

Posted: 30 May 2013 12:00 AM PDT

The embryonic epicardium and the cardiac mesenchyme derived from it are critical to heart development. The embryonic epicardium arises from an extracardiac progenitor tissue called the proepicardium, a proliferation of coelomic cells located at the limit between the liver and the sinus venosus. A proepicardium has not been described in invertebrates, and the evolutionary origin of this structure in vertebrates is unknown. We herein suggest that the proepicardium might be regarded as an evolutionary derivative from an ancient pronephric external glomerulus that has lost its excretory role. In fact, we previously described that the epicardium arises by cell migration from the primordia of the right pronephric external glomerulus in a representative of the most primitive vertebrate lineage, the lamprey Petromyzon marinus. In this review, we emphasize the striking similarities between the gene expression profiles of the proepicardium and the developing kidneys, as well as the parallelisms in the signaling mechanisms involved in both cases. We show some preliminary evidence about the existence of an inhibitory mechanism blocking glomerular differentiation in the proepicardium. We speculate as to the possibility that this developmental link between heart and kidney can be revealing a phylogenetically deeper association, supported by the existence of a heart-kidney complex in Hemichordates. Finally, we suggest that primitive hematopoiesis could be related with this heart-kidney complex, thus accounting for the current anatomical association of the hematopoietic stem cells with an aorta-gonad-mesonephros area. In summary, we think that our hypothesis can provide new perspectives on the evolutionary origin of the vertebrate heart.

Information, Vol. 4, Pages 240-261: Emergence and Evolution of Meaning: The General Definition of Information (GDI) Revisiting Program—Part 2: The Regressive Perspective: Bottom-up

Posted: 30 May 2013 12:00 AM PDT

In this second part of our inquiry into the emergence and evolution of meaning, the category of meaning is explored from the manifestation of reality in its corresponding level of interaction towards the interpretation of such reality (the first part deals correspondingly with an appropriate top-down approach). Based on the physical constraints of manifestation through electromagnetic waves, which constitutes the base of animal vision, we analyze the limits of the meaning-offer of such a manifestation, which allows us, on the one hand, to compare the efficiency of natural evolution in the reception of such meaning-offers; on the other hand, to analyze the conditions of developing agency able to acknowledge the reality underlying its manifestation. Regarding the complexity of such an agency and its related pragmatic response, we distinguish different levels, which allow the development of the General Definition of Information (GDI) properly, with respect to interpretation, as advanced in the first part, throughout nature. As we show at the end, our approach provides new grounds for the Unified Theory of Information (UTI) Program, as well as the possibility for bridging other approaches in the converging fields of information, meaning, computation, and communication.

OpenDrive 1.0.25 - Finder-accessible remote storage; free 5GB account. (Free)

Posted: 30 May 2013 02:16 AM PDT



OpenDrive links you directly to the cloud by creating a virtual drive accessible through the Finder. It allows you to open, modify, and save files just like a traditional drive. Keep your most important files backed up to OpenDrive for access anywhere, at anytime, from any Internet connection. Share your memories with family and friends, or stay in sync with clients and colleagues. OpenDrive integrates seamlessly and gives you instant access to the cloud for sharing, backup, and online storage.

Note: You must first sign up to use OpenDrive.

OpenDrive is available at various pricing plans. The Basic Plan is free for one user and you get 5 GB storage, 1 GB/day bandwidth, 200 KB/s speed. For premium users OpenDrive creates a zero-knowledge encryption folder, "Secure Files", where uploaded files are encrypted with strong AES-256 encryption on-the-fly. The encryption key never leaves your computer and files are encrypted before they are sent to OpenDrive servers.



Version 1.0.25:
  • Sync and backup task notifications
  • Task-bar icon crash fix


OS X 10.5 or later


More information

Quick3DPlan 2.7.7 - Design kitchen layouts easily. (Commercial)

Posted: 30 May 2013 02:08 AM PDT



Quick3DPlan is the easiest kitchen design software for professional designers. Includes two universal cabinet catalogs, one in inches and another in centimeters. More than four hundred units, appliances, and accessories. More than a hundred materials and colors.
  • Easy to use and easy to learn.
  • Design in inches with a frameless cabinet catalog.
  • The catalogs include thousands of cabinets with customizable dimensions and different models of doors, knobs, handles, and finishes. There are dozens of accessories (tables, chairs, stools, etc.) and appliances.
  • Modify the design directly on the screen by moving the cabinets with the mouse. You can also double-click on a cabinet, accessory, or appliance and change its dimensions or replace it with a different model.
  • You can use two windows to design. One with the 2D floor plan and the other with a 3D image with lights and textures. You can insert, move, and modify items in either of them.
  • Generate a list of cabinets, appliances, and accessories that can be printed or exported to Excel.


Version 2.7.7:
  • Cabinets can't be inserted by mistake over doors or windows.
  • New option to center doors and windows on walls.
  • Pillars can be moved a specific distance.
  • Dialog windows open where they were when you closed them.


  • OS X 10.6.6 or later



More information

The Flock - Screenshots

Posted: 30 May 2013 02:49 AM PDT

As the Carrier, you need to survive as long as possible and try to hold the artifact for a set amount of time in order to win the game. However hunting Flock might be lurking around the corner and kill you in an instant and steal the light artifact for themselves, in their turn becoming the new Carrier.

Flock are bigger, faster and can reach far higher places than the Carrier. But the Carrier is not helpless. It can use the solar capsule to spot moving players which will be burned to their death in an instant as a result. In their defence, Flock players can decide not to move and be safe from the light!

The dark atmosphere will help making it an engaging, sometimes even scary game. Players will switch roles from hunter and being hunted. This will make it a psychological experience in which players must deal with their weaknesses very carefully and play to their strengths or be outsmarted by other players.

Features:
- Asymmetrical online multiplayer
- Exciting and unique gameplay
- Engaging and simple mechanics
- Non-linear dynamic audio system
- Hunt and be hunted

20th century Cornish life is captured in early film clips

Posted: 30 May 2013 12:48 AM PDT

We are all used to viewing the most memorable events of the 20th century on archive film but how often do we get a chance to see the everyday lives of those who inhabited our own localities in previous generations? From the earliest days of moving pictures, enthusiasts across the country armed themselves with crude cine cameras, setting out to ... (more)

This posting includes an audio/video/photo media file: Download Now

Antibiotics, Vol. 2, Pages 274-287: Assessment of the Presence of Pharmaceutical Compounds in Seawater Samples from Coastal Area of Gran Canaria Island (Spain)

Posted: 30 May 2013 12:00 AM PDT

This study presents the evaluation of seven pharmaceutical compounds belonging to different commonly used therapeutic classes in seawater samples from coastal areas of Gran Canaria Island. The target compounds include atenolol (antihypertensive), acetaminophen (analgesic), norfloxacin and ciprofloxacin (antibiotics), carbamazepine (antiepileptic) and ketoprofen and diclofenac (anti-inflammatory). Solid phase extraction (SPE) was used for the extraction and preconcentration of the samples, and liquid chromatography tandem mass spectrometry (LC-MS/MS) was used for the determination of the compounds. Under optimal conditions, the recoveries obtained were in the range of 78.3% to 98.2%, and the relative standard deviations were less than 11.8%. The detection and quantification limits of the method were in the ranges of 0.1–2.8 and 0.3–9.3 ng·L−1, respectively. The developed method was applied to evaluate the presence of these pharmaceutical compounds in seawater from four outfalls in Gran Canaria Island (Spain) during one year. Ciprofloxacin and norfloxacin were found in a large number of samples in a concentration range of 9.0–3551.7 ng·L−1. Low levels of diclofenac, acetaminophen and ketoprofen were found sporadically.

Sensors, Vol. 13, Pages 7121-7139: A New Hybrid Gyroscope with Electrostatic Negative Stiffness Tuning

Posted: 30 May 2013 12:00 AM PDT

A variety of gyroscopes have been extensively studied due to their capability of precision detection of rotation rates and extensive applications in navigation, guidance and motion control. In this work, a new Hybrid Gyroscope (HG) which combines the traditional Dynamically Tuned Gyroscope (DTG) with silicon micromachined technology is investigated. The HG not only has the potentiality of achieving the same high precision as the traditional DTG, but also features a small size and low cost. The theoretical mechanism of the HG with a capacitance transducer and an electrostatic torquer is derived and the influence of the installation errors from the capacitance plate and the disc rotor module is investigated. A new tuning mechanism based on negative stiffness rather than the traditional dynamic tuning is proposed. The experimental results prove that the negative stiffness tuning is practicable and a tuning voltage of as high as 63 V is demonstrated. Due to the decreased installation error, the non-linearity of the scale factor is reduced significantly from 11.78% to 0.64%, as well as the asymmetry from 93.3% to 1.56% in the open loop condition. The rebalancing close-loop control is simulated and achieved experimentally, which proves that the fundamental principle of the HG is feasible.

Sensors, Vol. 13, Pages 7104-7120: A New Self-Calibrated Procedure for Impact Detection and Location on Flat Surfaces

Posted: 30 May 2013 12:00 AM PDT

Many analyses of acoustic signals processing have been proposed for different applications over the last few years. When considering a bar-based structure, if the material through which the sound waves propagate is considered to be acoustically homogeneous and the sound speed is well known, then it is possible to determine the position and time of impact by a simple observation of the arrival times of the signals of all the transducers that are strategically disposed on the structure. This paper presents a generalized method for impact detection and location on a flat plate, together with a calibration procedure with which to obtain the sound speed from only one set of measurements. This propagation speed is not well known as a result of either imprecise material properties or the overlapping of longitudinal and transversal waves with different propagation velocities. The use of only three piezoelectric sensors allows the position and time of impact on the flat plate to be obtained when the sound speed is well known, while the use of additional sensors permits a larger detection area to be covered, helps to estimate the sound speed and/or avoids the wrong timing of difference measurements. Experimental results are presented using a robot with a specially designed knocking tool that produces impacts on a metallic flat plate.

Molecules, Vol. 18, Pages 6425-6438: Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging

Posted: 30 May 2013 12:00 AM PDT

d-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter (111In). The resultant nano-scale tumor-targeting imaging tracer, 111In-DG-NIRF-CCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 ± 0.80 % of the injected dose per gram of tissue (%ID/g). Tumors were clearly delineated in both single-photon emission computed tomography (SPECT) and optical imaging. The results suggest that the prepared imaging tracer is a promising agent for tumor diagnosis.
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