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- IJMS, Vol. 14, Pages 9737-9750: Ultrasound Targeted Microbubble Destruction Stimulates Cellular Endocytosis in Facilitation of Adeno-Associated Virus Delivery
- Molecules, Vol. 18, Pages 5235-5250: Simultaneous Determination of Structurally Diverse Compounds in Different Fangchi Species by UHPLC-DAD and UHPLC-ESI-MS/MS
- Molecules, Vol. 18, Pages 5221-5234: Changes in SeMSC, Glucosinolates and Sulforaphane Levels, and in Proteome Profile in Broccoli (Brassica oleracea var. Italica) Fertilized with Sodium Selenate
- Molecules, Vol. 18, Pages 5209-5220: Theoretical Study of H/D Isotope Effects on Nuclear Magnetic Shieldings Using an ab initio Multi-Component Molecular Orbital Method
- Molecules, Vol. 18, Pages 5201-5208: A Facile Asymmetric Synthesis of (S)-14-Methyl-1-Octadecene, the Sex Pheromone of the Peach Leafminer Moth
- Molecules, Vol. 18, Pages 5190-5200: The Short-Term Effects of Soybean Intake on Oxidative and Carbonyl Stress in Men and Women
- Materials, Vol. 6, Pages 1840-1850: Redox Response of Reduced Graphene Oxide-Modified Glassy Carbon Electrodes to Hydrogen Peroxide and Hydrazine
- Bubble Fins - Screenshots
- Dungeon Hunter 4 - Screenshots
- Golf Star - Screenshots
- Fishing Hero - Screenshots
- Bonds of the Skies - Screenshots
- Materials, Vol. 6, Pages 1826-1839: Tensile and Compressive Responses of Ceramic and Metallic Nanoparticle Reinforced Mg Composites
- Materials, Vol. 6, Pages 1803-1825: Engineering Cellular Photocomposite Materials Using Convective Assembly
- Materials, Vol. 6, Pages 1789-1802: Prediction of Microporosity in Complex Thin-Wall Castings with the Dimensionless Niyama Criterion
- Assembots
- Monaco breaking into Xbox Live Arcade on May 10
- Patapon Screens
- Dragon Nest - Dark Summoner Going All Goth On Foes
- Dragon Nest - Soul Eater Cursing Up A Storm
| Posted: 07 May 2013 12:00 AM PDT The generally accepted mechanism for ultrasound targeted microbubble destruction (UTMD) to enhance drug and gene delivery is through sonoporation. However, passive uptake of adeno-associated virus (AAV) into cells following sonoporation does not adequately explain observations of enhanced transduction by UTMD. This study investigated alternative mechanisms of UTMD enhancement in AAV delivery. UTMD significantly enhanced transduction efficiency of AAV in a dose-dependent manner. UTMD stimulated a persistent uptake of AAV into the cytoplasm and nucleus. This phenomenon occurred over several hours, suggesting that some viral particles are endocytosed by cells rather than exclusively passing through pores created by sonoporation. Additionally, UTMD enhanced clathrin expression and accumulation at the plasma membrane suggesting greater clathrin-mediated endocytosis following UTMD. Transmission electron microscopy (TEM) revealed that UTMD stimulated formation of clathrin-coated pits (CPs) and uncoated pits (nCPs). Furthermore, inhibition of clathrin-mediated endocytosis partially blocked the enhancement of AAV uptake following UTMD. The results of this study implicate endocytosis as a mechanism that contributes to UTMD-enhanced AAV delivery. |
| Posted: 07 May 2013 12:00 AM PDT Two bisbenzylisoquinoline alkaloids, two morphine alkaloids, one aporphine alkaloid, syringaresinol and aristolochic acid І were selected as marker compounds and simultaneously analyzed using an ultra-high pressure liquid chromatography-diode array detection (UHPLC-DAD) method. These marker compounds were used for the quality control of Fangchi species of different origins, including Sinomenium acutum, Stephania tetrandra, Cocculus trilobus and Aristolochia fangchi. A reversed-phase UHPLC-DAD method was developed and validated for the simultaneous quantification of structurally diverse markers in different Fangchi species. In addition, an UHPLC-electrospray ionization tandem mass spectrometry (ESI-MS/MS) method was used for marker identification in Fangchi species, which provided diagnostic MS/MS spectral patterns that were dependent upon the marker structures. The UHPLC-MS/MS data were used to confirm and complement the UHPLC-DAD quality evaluation results. Additionally, magnoflorine and syringaresinol were observed for the first time in S. tetrandra and C. trilobus, respectively. Twenty different Fangchi species samples were analyzed for aristolochic acid I, syringaresinol and the alkaloids using the UHPLC-DAD and MS/MS method. Based on the levels of markers and principal component analysis (PCA), this method allowed for the clear classification of the samples into four different groups representing samples originating from the four species. |
| Posted: 07 May 2013 12:00 AM PDT The aim of this work was to analyze the effect of sodium selenate fortification on the content of selenomethyl selenocysteine (SeMSC), total glucosinolates and sulforaphane, as well as the changes in protein profile of the inflorescences of broccoli (Brassica oleracea var. Italica). Two experimental groups were considered: plants treated with 100 mmol/L sodium selenate (final concentration in the pot) and control plants treated with water. Fortification began 2 weeks after transplantation and was repeated once a week during 10 weeks. Broccoli florets were harvested when they reached appropriate size. SeMSC content in broccoli florets increased significantly with sodium selenate fortification; but total glucosinolates and sulforaphane content as well as myrosinase activity were not affected. The protein profile of broccoli florets changed due to fortification with sodium selenate. Some proteins involved in general stress-responses were up-regulated, whereas down-regulated proteins were identified as proteins involved in protection against pathogens. This is the first attempt to evaluate the physiological effect of fortification with sodium selenate on broccoli at protein level. The results of this work will contribute to better understanding the metabolic processes related with selenium uptake and accumulation in broccoli. |
| Posted: 07 May 2013 12:00 AM PDT We have theoretically analyzed the nuclear quantum effect on the nuclear magnetic shieldings for the intramolecular hydrogen-bonded systems of σ-hydroxy acyl aromatic species using the gauge-including atomic orbital technique combined with our multi-component density functional theory. The effect of H/D quantum nature for geometry and nuclear magnetic shielding changes are analyzed. Our study clearly demonstrated that the geometrical changes of hydrogen-bonds induced by H/D isotope effect (called geometrical isotope effect: GIE) is the dominant factor of deuterium isotope effect on 13C chemical shift. |
| Posted: 07 May 2013 12:00 AM PDT An asymmetric synthesis of 14-methyl-1-octadecene, the sex pheromone of the peach leafminer moth has been achieved. The target molecule was synthesized in six linear steps and in 30.3% overall yield from commercially available hexanoyl chloride, (S)-4-benzyloxazolidin-2-one and 1,9-nonanediol. The hexanoyl chloride was connected with (S)-4-benzyloxazolidin-2-one, and with the induction of the chiral oxazolidinone auxiliary, after chiral methylation, LAH reduction and then tosylation gave the chiral key intermediate 5 in high stereoselectivity. 1,9-Nonanediol, was selectively brominated, THP protected and subjected to Li2CuCl4-mediated C-C coupling to afford a C12 intermediate. The target molecule, (S)-14-methyl-1-octadecene, was obtained after the two parts were subjected to a second Li2CuCl4-mediated C-C coupling. Our synthetic approach represents the first time a substrate-control asymmetric synthesis of (S)-14-methyl-1-octadecene has been reported. |
| Posted: 07 May 2013 12:00 AM PDT Beyond other beneficial effects, a soy-rich diet has been shown to reduce the risk of cardiovascular diseases and diabetic complications. Reduction of oxidative and carbonyl stress has been proposed as the underlying mechanism, but the evidence for this is lacking. The aim of our study was to evaluate the effects of short-term increased soy intake on oxidative and carbonyl stress parameters in young volunteers. Young healthy probands (omnivores) of both genders (55 women, 33 men) were given soybeans (2 g/kg bodyweight daily) for one week. Markers of oxidative and carbonyl stress were measured in plasma at the beginning and at the end of one week soybean intake and after another week of a wash-out period. Total antioxidant capacity was increased by soybean intake in both genders. This led to decreased levels of advanced oxidation protein products in women, but not in men. On the contrary, in men, soybean intake increased lipoperoxidation. No effects on carbonyl stress markers (advanced glycation end products-specific fluorescence and fructosamine) were found. Soybean intake has gender-specific effects on oxidative stress in young healthy probands potentially due to divergent action and metabolism of phytoestrogens in men and women. Effects of soybean intake on carbonyl stress should be evaluated in longer studies. |
| Posted: 07 May 2013 12:00 AM PDT The surface of a glassy carbon (GC) electrode was modified with reduced graphene oxide (rGO) to evaluate the electrochemical response of the modified GC electrodes to hydrogen peroxide (H2O2) and hydrazine. The electrode potential of the GC electrode was repeatedly scanned from −1.5 to 0.6 V in an aqueous dispersion of graphene oxide (GO) to deposit rGO on the surface of the GC electrode. The surface morphology of the modified GC electrode was characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). SEM and AFM observations revealed that aggregated rGO was deposited on the GC electrode, forming a rather rough surface. The rGO-modified electrodes exhibited significantly higher responses in redox reactions of H2O2 as compared with the response of an unmodified GC electrode. In addition, the electrocatalytic activity of the rGO-modified electrode to hydrazine oxidation was also higher than that of the unmodified GC electrode. The response of the rGO-modified electrode was rationalized based on the higher catalytic activity of rGO to the redox reactions of H2O2 and hydrazine. The results suggest that rGO-modified electrodes are useful for constructing electrochemical sensors. |
| Posted: 07 May 2013 03:35 AM PDT Aim and charge through bubbles to rescue mermaids. Pop your way to the mermaids by matching your fish's color with two or more bubbles of the same color. Choose between multiple fishes, like rainbow fish or double fish, with different special attacks and effects. Pop higher bubbles to drop lower bubbles from the mass. Blaze through Atlantis, past Sunken Ship island, and party in an enchanted ocean safari with amazing graphics, beautiful music, deluxe special effects, and the cutest fishes around. |
| Dungeon Hunter 4 - Screenshots Posted: 07 May 2013 03:22 AM PDT Venture forth into the most immersive, accomplished, and addictive chapter of the acclaimed action RPG saga! REDISCOVER THE THRILL OF DUNGEON CRAWLING - Progress through an EPIC STORYLINE & stunning environments - SLASH hundreds of enemies and massive bosses - LOOT countless items EXPERIENCE A TRUE RPG - Choose from 4 character Classes with unique combat styles - UPGRADE your battle skills - CUSTOMIZE, craft and charm your gear - Unveil the mysteries around your warrior GO FOR MULTIPLAYER ACTION - Enter COOP arenas for highly intense fights - Show off your battle skills in the PVP modes! |
| Posted: 07 May 2013 03:13 AM PDT Jaw-dropping REAL graphics Golf Star™ proudly features stunning, beautiful graphics unlike anything you've ever seen before. Its perfect retina support and lighting technology surpasses all other Full 3D Golf games. Experience the exhilarating sensation of playing golf as if it were an actual golf course! Realistic Golf Physics Terrain height, ball impact angle, wind, temperature, humidity, and up to 70 other factors implemented to perfectly capture the physics of an actual swing. Go ahead! Take a shot and experience all of the physical elements found in a real-life game of golf! Various Skills and Techniques We've captured the skills and techniques of actual pro golfers. Become a Pro Golfer and choose up to 10 techniques, including draw shots, fade shots, and chip shots. 5 Different Game Modes - Career Mode: Single player mode with quests and competitions with NPCs in tournaments. - Match Mode: Compete against other golfers playing Golf Star™ from all around the world. - Competition Mode: Invite friends to compete in matches anytime, anywhere. - 10 Player Competition Mode: Play against up to 10 players online in a real-time competition. Become the best of all! - Training Mode: Practice makes perfect! Train your golf skills in Training Mode. Weekly Rankings Add friends to challenge them in competitions! Climb to the top rankings and win 1st place! Best of all: Golf Tournaments! Play a new tournament every week and try to win prizes. Aim for the grand slam tourney and become the master of golf! Aim for the Top! Exciting quests and various achievements ... |
| Posted: 07 May 2013 03:09 AM PDT Fishing Hero features over 800 species of fish to catch, numerous fishing gears to use, and different boats to cruise around – just like real offshore fishing. From a modern setting of New York to remote and relaxing beach of Bora Bora, Fishing Hero features over 20 real world locations. |
| Bonds of the Skies - Screenshots Posted: 07 May 2013 02:48 AM PDT |
| Posted: 07 May 2013 12:00 AM PDT In the present study, room temperature mechanical properties of pure magnesium, Mg/ZrO2 and Mg/(ZrO2 + Cu) composites with various compositions are investigated. Results revealed that the use of hybrid (ZrO2 + Cu) reinforcements in Mg led to enhanced mechanical properties when compared to that of single reinforcement (ZrO2). Marginal reduction in mechanical properties of Mg/ZrO2 composites were observed mainly due to clustering of ZrO2 particles in Mg matrix and lack of matrix grain refinement. Addition of hybrid reinforcements led to grain size reduction and uniform distribution of hybrid reinforcements, globally and locally, in the hybrid composites. Macro- and micro- hardness, tensile strengths and compressive strengths were all significantly increased in the hybrid composites. With respect to unreinforced magnesium, failure strain was almost unchanged under tensile loading while it was reduced under compressive loading for both Mg/ZrO2 and Mg/(ZrO2 + Cu) composites. |
| Posted: 07 May 2013 12:00 AM PDT Fabricating industrial-scale photoreactive composite materials containing living cells, requires a deposition strategy that unifies colloid science and cell biology. Convective assembly can rapidly deposit suspended particles, including whole cells and waterborne latex polymer particles into thin (<10 µm thick), organized films with engineered adhesion, composition, thickness, and particle packing. These highly ordered composites can stabilize the diverse functions of photosynthetic cells for use as biophotoabsorbers, as artificial leaves for hydrogen or oxygen evolution, carbon dioxide assimilation, and add self-cleaning capabilities for releasing or digesting surface contaminants. This paper reviews the non-biological convective assembly literature, with an emphasis on how the method can be modified to deposit living cells starting from a batch process to its current state as a continuous process capable of fabricating larger multi-layer biocomposite coatings from diverse particle suspensions. Further development of this method will help solve the challenges of engineering multi-layered cellular photocomposite materials with high reactivity, stability, and robustness by clarifying how process, substrate, and particle parameters affect coating microstructure. We also describe how these methods can be used to selectively immobilize photosynthetic cells to create biomimetic leaves and compare these biocomposite coatings to other cellular encapsulation systems. |
| Posted: 07 May 2013 12:00 AM PDT The dimensionless Niyama criterion was used to predict the formation of microporosity in nickel-based superalloy casting, which extended the model application from a simple plate casting to complex thin-wall superalloy casting. The physical characteristics of the superalloy were calculated by JMatPro software. The relation between the volume percentage of microporosity and the dimensionless Niyama values were constructed. Quantitative metallographic measurements of the microporosity of the practical thin-wall casting were carried out. The prediction agreed well with the experiment in general, except for some thick-wall sites in the casting. |
| Posted: 07 May 2013 01:46 AM PDT A modern take on a classic puzzle game. You must guide you robots from their work place back home to safety after a long shift at work. You must use.. |
| Monaco breaking into Xbox Live Arcade on May 10 Posted: 06 May 2013 11:58 PM PDT Xbox version of heist game initially planned for April 24 release alongside PC version.
Xbox 360 owners wishing to play the already-out heist game Monaco: What's Yours Is Mine on their console can finally do so in a few more days. According to a tweet from the game's official Twitter account, Monaco will be out on Xbox Live Arcade on May 10. The game was supposed to be released alongside the PC version on April 24, but it was delayed due to last-minute technical issues. Creator Andy Schatz said on an Edge Online interview that he would rather not have fans experience a buggy game. Monaco was praised for its diversity of gadgets and character abilities, as well as its cooperative heists. Check out GameSpot for the full review of the game. Read and Post Comments | Get the full article at GameSpot "Monaco breaking into Xbox Live Arcade on May 10" was posted by Jonathan Toyad on Mon, 06 May 2013 23:58:52 -0700 |
| Posted: 06 May 2013 09:25 PM PDT 1 new shots posted.
Get the full article at GameSpot "Patapon Screens" was posted on Mon, 06 May 2013 21:25:02 -0700 |
| Dragon Nest - Dark Summoner Going All Goth On Foes Posted: 06 May 2013 07:51 PM PDT This Kali sub-class is taking her sweet time wandering in the forest, finding new friends to inflict dark magic upon.
Read and Post Comments | Get the full article at GameSpot "Dragon Nest - Dark Summoner Going All Goth On Foes" was posted by rreydebarros on Mon, 06 May 2013 19:51:52 -0700 |
| Dragon Nest - Soul Eater Cursing Up A Storm Posted: 06 May 2013 07:51 PM PDT If you're a fan of debuffing mobs with status ailments, you may want to see this Kali sub-class in action on this gameplay video.
Read and Post Comments | Get the full article at GameSpot "Dragon Nest - Soul Eater Cursing Up A Storm" was posted by rreydebarros on Mon, 06 May 2013 19:51:12 -0700 |
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