четверг, 2 мая 2013 г.

Games

Games

Monkey Boxing - Screenshots

Posted: 02 May 2013 04:15 AM PDT

FEATURES:
High quality 3d Graphics: Fully animated 3D characters with dynamic accurate lighting.
Funny to Play: Ludicrous characters and fast paced, crazy gameplay.
Customization: Create your own Monkey Boxer choosing colors and wearable props up to more than 269 BILLIONS of combinations.
Unlockable Items: Win new wearable props beating loudicrous "famous" monkey boxers.
Addictive Gameplay: Challenge yourself and others to get the best score on infinite game levels.
Training: Train your monkey to get best boxing performances.
Lots of Levels: Win the WMB Cup playing the first 50 levels and then continue fighting for an unlimited number of matches.
2 Players Option: Challenge a friend on the same device.
Gamecenter Leaderboards and lots of Achievements!
4 Languages support: English, Spanish, French, Italian

Guilty Gear XX Accent Core Plus R - Screenshots

Posted: 02 May 2013 03:59 AM PDT

Guilty Gear XX Accent Core Plus R Features:

Numerous Character Balance Changes and Tweaks!
All 25 characters return to the fight, re-tuned and ready for battle.

The Guilty Gear mythology preserved!
All the stories to your favorite characters are portrayed through fully-voiced dialogue.

Many Modes of Play!
Battle through different modes of play MOM, Mission, Survival, and Training.

Remote Sensing, Vol. 5, Pages 2093-2112: Divergent Arctic-Boreal Vegetation Changes between North America and Eurasia over the Past 30 Years

Posted: 02 May 2013 12:00 AM PDT

Arctic-Boreal region—mainly consisting of tundra, shrub lands, and boreal forests—has been experiencing an amplified warming over the past 30 years. As the main driving force of vegetation growth in the north, temperature exhibits tight coupling with the Normalized Difference Vegetation Index (NDVI)—a proxy to photosynthetic activity. However, the comparison between North America (NA) and northern Eurasia (EA) shows a weakened spatial dependency of vegetation growth on temperature changes in NA during the past decade. If this relationship holds over time, it suggests a 2/3 decrease in vegetation growth under the same rate of warming in NA, while the vegetation response in EA stays the same. This divergence accompanies a circumpolar widespread greening trend, but 20 times more browning in the Boreal NA compared to EA, and comparative greening and browning trends in the Arctic. These observed spatial patterns of NDVI are consistent with the temperature record, except in the Arctic NA, where vegetation exhibits a similar long-term trend of greening to EA under less warming. This unusual growth pattern in Arctic NA could be due to a lack of precipitation velocity compared to the temperature velocity, when taking velocity as a measure of northward migration of climatic conditions.

IJERPH, Vol. 10, Pages 1775-1785: Decreased IgA+ B Cells Population and IgA, IgG, IgM Contents of the Cecal Tonsil Induced by Dietary High Fluorine in Broilers

Posted: 02 May 2013 12:00 AM PDT

Fluoride is an environmental and industrial pollutant that affects various organs in humans and animals. The cecal tonsil is an important component of the mucosal immune system and performs important and unique immune functions. In the present study, we investigated the effects of dietary high fluorine on the quantities of IgA+ B cells in the cecal tonsil by immunohistochemistry, and the immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) contents in the cecal tonsil by ELISA. A total of 280 one-day-old avian broilers were divided into four groups and fed on a corn-soybean basal diet as control diet (fluorine 22.6 mg/kg) or the same diet supplemented with 400, 800 and 1,200 mg/kg fluorine (high fluorine groups I, II and III) in the form of sodium fluoride, respectively, throughout a 42-day experimental period. The results showed that the quantities of IgA+ B cells were lower (p < 0.05 or p < 0.01) and the IgA, IgG, and IgM contents were decreased (p < 0.05 or p < 0.01) in high fluorine groups II and III in comparison with those of control group. It was concluded that dietary fluorine, in the 800–1,200 mg/kg range, could reduce the numbers of the IgA+ B cells and immunoglobulin contents in the cecal tonsil, implying the local mucosal immune function was ultimately impacted in broilers.

IJERPH, Vol. 10, Pages 1763-1774: Weight Status, Body Image and Bullying among Adolescents in the Seychelles

Posted: 02 May 2013 12:00 AM PDT

We investigated the relationship between being bullied and measured body weight and perceived body weight among adolescents of a middle-income sub Saharan African country. Our data originated from the Global School-based Health Survey, which targets adolescents aged 13–15 years. Student weights and heights were measured before administrating the questionnaire which included questions about personal data, health behaviors and being bullied. Standard criteria were used to assess thinness, overweight and obesity. Among 1,006 participants who had complete data, 16.5% (95%CI 13.3–20.2) reported being bullied ≥3 days during the past 30 days; 13.4% were thin, 16.8% were overweight and 7.6% were obese. Categories of actual weight and of perceived weight correlated only moderately (Spearman correlation coefficient 0.37 for boys and 0.57 for girls; p < 0.001). In univariate analysis, both actual obesity (OR 1.76; p = 0.051) and perception of high weight (OR 1.63 for "slightly overweight"; OR 2.74 for "very overweight", both p < 0.05) were associated with being bullied. In multivariate analysis, ORs for categories of perceived overweight were virtually unchanged while ORs for actual overweight and obesity were substantially attenuated, suggesting a substantial role of perceived weight in the association with being bullied. Actual underweight and perceived thinness also tended to be associated with being bullied, although not significantly. Our findings suggest that more research attention be given to disentangling the significant association between body image, overweight and bullying among adolescents. Further studies in diverse populations are warranted.

IJERPH, Vol. 10, Pages 1747-1762: A History of Ashes: An 80 Year Comparative Portrait of Smoking Initiation in American Indians and Non-Hispanic Whites—the Strong Heart Study

Posted: 02 May 2013 12:00 AM PDT

The consequences of starting smoking by age 18 are significant. Early smoking initiation is associated with higher tobacco dependence, increased difficulty in smoking cessation and more negative health outcomes. The purpose of this study is to examine how closely smoking initiation in a well-defined population of American Indians (AI) resembles a group of Non-Hispanic white (NHW) populations born over an 80 year period. We obtained data on age of smoking initiation among 7,073 AIs who were members of 13 tribes in Arizona, Oklahoma and North and South Dakota from the 1988 Strong Heart Study (SHS) and the 2001 Strong Heart Family Study (SHFS) and 19,747 NHW participants in the 2003 National Health Interview Survey. The participants were born as early as 1904 and as late as 1985. We classified participants according to birth cohort by decade, sex, and for AIs, according to location. We estimated the cumulative incidence of smoking initiation by age 18 in each sex and birth cohort group in both AIs and NHWs and used Cox regression to estimate hazard ratios for the association of birth cohort, sex and region with the age at smoking initiation. We found that the cumulative incidence of smoking initiation by age 18 was higher in males than females in all SHS regions and in NHWs (p < 0.001). Our results show regional variation of age of initiation significant in the SHS (p < 0.001). Our data showed that not all AIs (in this sample) showed similar trends toward increased earlier smoking. For instance, Oklahoma SHS male participants born in the 1980s initiated smoking before age 18 less often than those born before 1920 by a ratio of 0.7. The results showed significant variation in age of initiation across sex, birth cohort, and location. Our preliminary analyses suggest that AI smoking trends are not uniform across region or gender but are likely shaped by local context. If tobacco prevention and control programs depend in part on addressing the origin of AI smoking it may be helpful to increase the awareness in regional differences.

Sensors, Vol. 13, Pages 5720-5736: Design and Characterization of a Fully Differential MEMS Accelerometer Fabricated Using MetalMUMPs Technology

Posted: 02 May 2013 12:00 AM PDT

This paper presents a fully differential single-axis accelerometer fabricated using the MetalMUMPs process. The unique structural configuration and common-centriod wiring of the metal electrodes enables a fully differential sensing scheme with robust metal sensing structures. CoventorWare is used in structural and electrical design and simulation of the fully differential accelerometer. The MUMPs foundry fabrication process of the sensor allows for high yield, good process consistency and provides 20 μm structural thickness of the sensing element, which makes the capacitive sensing eligible. In device characterization, surface profile of the fabricated device is measured using a Veeco surface profilometer; and mean and gradient residual stress in the nickel structure are calculated as approximately 94.7 MPa and −5.27 MPa/μm, respectively. Dynamic characterization of the sensor is performed using a vibration shaker with a high-end commercial calibrating accelerometer as reference. The sensitivity of the sensor is measured as 0.52 mV/g prior to off-chip amplification. Temperature dependence of the sensing capacitance is also characterized. A −0.021fF/°C is observed. The findings in the presented work will provide useful information for design of sensors and actuators such as accelerometers, gyroscopes and electrothermal actuators that are to be fabricated using MetalMUMPs technology.

Sensors, Vol. 13, Pages 5712-5719: Introduction to the Special Issue on “New Trends towards Automatic Vehicle Control and Perception Systems”

Posted: 02 May 2013 12:00 AM PDT

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Sensors, Vol. 13, Pages 5700-5711: UV/Vis Spectroelectrochemistry as a Tool for Monitoring the Fabrication of Sensors Based on Silver Nanoparticle Modified Electrodes

Posted: 02 May 2013 12:00 AM PDT

A new controlled current multipulse methodology has been developed to modify the screen-printed electrode surface with silver nanoparticles (AgNPs). Spectroelectrochemistry has provided not only information about the type of nanoparticles (NPs) deposited on the electrode surface, but also about the electrosynthesis process. Small NPs without plasmon band are initially generated. Next, these nuclei grow to form bigger NPs in the reduction pulses with a characteristic plasmon band centered at 400 nm. Most of the NPs are generated during the first reduction pulses and a linear growth of the absorbance at a lower reaction rate was obtained in the subsequent pulses. Oxidation pulses do not redissolve completely silver NPs but only partially, meaning that very stable NPs are generated. AgNPs-modified electrodes have been successfully used to determine hydrogen peroxide. Spectroelectrochemistry has also yielded very useful information to understand the voltammetric signal obtained during the reduction of H2O2 on silver modified electrodes.

Sensors, Vol. 13, Pages 5686-5699: Selective Detection and Automated Counting of Fluorescently-Labeled Chrysotile Asbestos Using a Dual-Mode High-Throughput Microscopy (DM-HTM) Method

Posted: 02 May 2013 12:00 AM PDT

Phase contrast microscopy (PCM) is a widely used analytical method for airborne asbestos, but it is unable to distinguish asbestos from non-asbestos fibers and requires time-consuming and laborious manual counting of fibers. Previously, we developed a high-throughput microscopy (HTM) method that could greatly reduce human intervention and analysis time through automated image acquisition and counting of fibers. In this study, we designed a dual-mode HTM (DM-HTM) device for the combined reflection and fluorescence imaging of asbestos, and automated a series of built-in image processing commands of ImageJ software to test its capabilities. We used DksA, a chrysotile-adhesive protein, for selective detection of chrysotile fibers in the mixed dust-free suspension of crysotile and amosite prepared in the laboratory. We demonstrate that fluorescently-stained chrysotile and total fibers can be identified and enumerated automatically in a high-throughput manner by the DM-HTM system. Combined with more advanced software that can correctly identify overlapping and branching fibers and distinguish between fibers and elongated dust particles, the DM-HTM method should enable fully automated counting of airborne asbestos.

Sensors, Vol. 13, Pages 5671-5685: Discrete and Polymeric, Mono- and Dinuclear Silver Complexes of a Macrocyclic Tetraoxime Ligand with AgI–AgI Interactions

Posted: 02 May 2013 12:00 AM PDT

Macrocyclic compounds that can bind cationic species efficiently and selectively with their cyclic cavities have great potential as excellent chemosensors for metal ions. Recently, we have developed a tetraoxime-type tetraazamacrocyclic ligand 1 formed through a facile one-pot cyclization reaction. Aiming to explore and bring out the potential of the tetraoxime macrocycle 1 as a chelating sensor, we report herein the preparation of several kinds of silver complexes of 1 and their unique coordination structures determined by single-crystal X-ray diffraction analyses. As a result, the formation of two kinds of discrete structures, monomeric complexes [Ag(1)X] (X = counter anions) and a dimeric complex [Ag2(1)2]X2, and two kinds of polymeric structures from a mononuclear complex, [Ag(1)]nXn, and from a dinuclear complex, [Ag2(1)X2]n, was demonstrated. In the resulting complexes, the structurally flexible macrocyclic ligand 1 was found to provide several different coordination modes. Notably, in some silver complexes of 1, AgI–AgI interactions were observed with different AgI–AgI distances which depend on the kind of counter anions and the chemical composition.

IJMS, Vol. 14, Pages 9581-9603: Where Do They Come from and Where Do They Go: Candidates for Regulating Extracellular Vesicle Formation in Fungi

Posted: 02 May 2013 12:00 AM PDT

In the past few years, extracellular vesicles (EVs) from at least eight fungal species were characterized. EV proteome in four fungal species indicated putative biogenesis pathways and suggested interesting similarities with mammalian exosomes. Moreover, as observed for mammalian exosomes, fungal EVs were demonstrated to be immunologically active. Here we review the seminal and most recent findings related to the production of EVs by fungi. Based on the current literature about secretion of fungal molecules and biogenesis of EVs in eukaryotes, we focus our discussion on a list of cellular proteins with the potential to regulate vesicle biogenesis in the fungi.

IJMS, Vol. 14, Pages 9556-9580: Antioxidant Systems from Pepper (Capsicum annuum L.): Involvement in the Response to Temperature Changes in Ripe Fruits

Posted: 02 May 2013 12:00 AM PDT

Sweet pepper is susceptible to changes in the environmental conditions, especially temperatures below 15 °C. In this work, two sets of pepper fruits (Capsicum annuum L.) which underwent distinct temperature profiles in planta were investigated. Accordingly, two harvesting times corresponding to each set were established: Harvest 1, whose fruits developed and ripened at 14.9 °C as average temperature; and Harvest 2, with average temperature of 12.4 °C. The oxidative metabolism was analyzed in all fruits. Although total ascorbate content did not vary between Harvests, a shift from the reduced to the oxidized form (dehydroascorbate), accompanied by a higher ascorbate peroxidase activity, was observed in Harvest 2 with respect to Harvest 1. Moreover, a decrease of the ascorbate-generating enzymatic system, the γ-galactono-lactone dehydrogenase, was found at Harvest 2. The activity values of the NADP-dependent dehydrogenases analyzed seem to indicate that a lower NADPH synthesis may occur in fruits which underwent lower temperature conditions. In spite of the important changes observed in the oxidative metabolism in fruits subjected to lower temperature, no oxidative stress appears to occur, as indicated by the lipid peroxidation and protein oxidation profiles. Thus, the antioxidative systems of pepper fruits seem to be involved in the response against temperature changes.

IJMS, Vol. 14, Pages 9536-9555: Targeting Signaling Pathways in Epithelial Ovarian Cancer

Posted: 02 May 2013 12:00 AM PDT

Ovarian carcinoma (OC) is the most lethal gynecological malignancy. Response to platinum-based chemotherapy is poor in some patients and, thus, current research is focusing on new therapy options. The various histological types of OC are characterized by distinctive molecular genetic alterations that are relevant for ovarian tumorigenesis. The understanding of these molecular pathways is essential for the development of novel therapeutic strategies. Purpose: We want to give an overview on the molecular genetic changes of the histopathological types of OC and their role as putative therapeutic targets. In Depth Review of Existing Data: In 2012, the vascular endothelial growth factor (VEGF) inhibitor, bevacizumab, was approved for OC treatment. Bevacizumab has shown promising results as single agent and in combination with conventional chemotherapy, but its target is not distinctive when analyzed before treatment. At present, mammalian target of rapamycin (mTOR) inhibitors, poly-ADP-ribose polymerase (PARP) inhibitors and components of the EGFR pathway are in the focus of clinical research. Interestingly, some phytochemical substances show good synergistic effects when used in combination with chemotherapy. Conclusion: Ongoing studies of targeted agents in conjunction with chemotherapy will show whether there are alternative options to bevacizumab available for OC patients. Novel targets which can be assessed before therapy to predict efficacy are needed. The assessment of therapeutic targets is continuously improved by molecular pathological analyses on tumor tissue. A careful selection of patients for personalized treatment will help to reduce putative side effects and toxicity.

Kiwingu 1.0 - Super-easy access to cloud storage. (Shareware)

Posted: 02 May 2013 02:38 AM PDT

With Kiwingu you will be able to access your cloud storage as simply as you access your USB pen drives. Kiwingu supports multiple protocols to ensure that you can access your cloud storage without bothering with additional software packages. When using Kiwingu, your cloud drive appears in the Finder the same way your USB pen drives would do when you plug them into your computer. Your cloud drives are accessible from every application on your system, and you don't have to make a detour through a Web browser or another piece of software just to upload or download a file to or from the cloud.

  • OS X 10.7 or later


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Rascal Rabbits - Screenshots

Posted: 02 May 2013 03:47 AM PDT

Each level provides a different mathematical challenge and the more efficient you use the food, the better your score will be. Not only are your math skills challenged in a fun way, you also have a limited amount of coins and the less you spend the more stars you'll earn. You learn about efficient grocery shopping and math the same time. Handy right?

inCounter 1.0 - Time-tracking for freelancers. (Commercial)

Posted: 02 May 2013 02:24 AM PDT



inCounter is an OS X application for freelancers (translators, graphic designers, etc.) that helps to keep track of your earnings.

Create a project by adding your timed tasks (inCounter can count the time for you), translation tasks (inCounter can import the translation analysis data from Trados, complete with weighted word count, fuzzy matches, and repetitions), and any other tasks (units prepared, pages written, miles driven etc.).

Project data can be exported in CSV format (to import it into Numbers or Excel) or as inCounter file (to edit later).



OS X 10.6.8 or later

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YourtTrip 1.3.1 - Efficient trip planner. (Commercial)

Posted: 02 May 2013 02:13 AM PDT



YourtTrip is a program committed to satisfying you with easy trip planning and all of the precious memories that come with it. With the powerful share function, the itinerary can be shared via blog or email. With YourtTrip, you'll find making an itinerary has never been so easy or fun.

Get where you and your party want to go by using the itinerary organizer with map-search function! YourtTrip will help you to confirm the specific location. No need to worry about not finding the places that you are looking for, because our integrated map-search function can guide you anywhere. Make a short description before you go there, such as what you are going to do, or not going to do. If you are with somebody else, share your itinerary via email or blog with that person, and get some opinions on this journey. Then you can go on to make the full itinerary in detail.

Don't forget about packing! Fortunately, the usual items are listed in the Packing Folder. For the unusual items, the clever packing system has a function to add the rarely used yet important things you may need for a particular trip. Write down and share cautions and pins on the integrated map.

There is still one important thing to plan, and that's money! The Smart Budget tool can teach you about your own spending habits and help you to make better financial decisions. You'll find planning a budget is almost too easy! After you are back from a trip, the unplanned expenses can be added to the Expense Folder.

Please join our Clear Classification System. You can simply add a collection through the Collection Folder in the main interface. Make a special collection with the Smart Collection Folder. All of the collections are catalogued in a Time Line Bar, from which you can select a particular trip or a period of trips.

The wonderful and precious pictures from your trip can be elegantly put into YourtTrip, making it easy to manage all the pictures without any of the chaos.

YogurtTrip is designed for efficient users. This tiny plan management software is highly recommended for you to make your next trip run smoothly.

We need your advice to perfect YourtTrip in future updates. Don't hesitate to send us your reviews and comments.

Features:

  • Powerful share function that is to share the trip plans with others before you start the trip or back from the trip, via blog and email, or print them out as PDF files.
  • Flexible printing to guide you in making your itinerary.
  • Simple and powerful trip planner.
  • Itinerary with map search function.
  • Clever packing list.
  • Smart budget function.
  • Clear classification system.
  • Movable timeline bar to catalogue trips.
  • Elegant photo management.
  • Last update.


Version 1.3.1:
  • Fix the issue of library upgrade
  • Fix the bug of loading location of the event on map
  • Fix the bug which is caused by dragging an event
  • More stability and bug fixes


OS X 10.6 or later

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aText 2.1.1 - Automatically replaces abbreviations with frequently used phrases. (Demo)

Posted: 02 May 2013 02:06 AM PDT



aText accelerates your typing by replacing abbreviations with frequently used phrases you define: for example, make an abbreviation "myname" to insert your name "First Middle Last" in any application.

With aText you can easily avoid typing the same thing over and over.

aText also makes it easier to type hard-to-insert symbols, images, formatted text.

More Features

  • Insert the current date and time in any format.
  • Embed clipboard content within a snippet, embed one snippet within another, send keys, use editable fields in a snippet.
  • Reposition the cursor in the expanded snippet.
  • Invoke AppleScripts and shell scripts.
  • Built-in snippet groups for correcting misspelled words, HTML, and JavaScript code.
  • Import data from TextExpander, TypeIt4Me.


Version 2.1.1:
  • Fixed: aText sometimes inserts clipboard content instead of snippet content.
  • New option for snippet group.
  • Added multi-item drag-and-drop support.


OS X 10.6 or later

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IJMS, Vol. 14, Pages 9514-9535: HDAC6 and Ovarian Cancer

Posted: 02 May 2013 12:00 AM PDT

The special class IIb histone deacetylase, HDAC6, plays a prominent role in many cellular processes related to cancer, including oncogenesis, the cell stress response, motility, and myriad signaling pathways. Many of the lessons learned from other cancers can be applied to ovarian cancer as well. HDAC6 interacts with diverse proteins such as HSP90, cortactin, tubulin, dynein, p300, Bax, and GRK2 in both the nucleus and cytoplasm to carry out these cancerous functions. Not all pro-cancer interactions of HDAC6 involve deacetylation. The idea of using HDAC6 as a target for cancer treatment continues to expand in recent years, and more potent and specific HDAC6 inhibitors are required to effectively down-regulate the tumor-prone cell signaling pathways responsible for ovarian cancer.
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