понедельник, 9 июля 2012 г.

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Energies, Vol. 5, Pages 2331-2350: Energy Storage System with Voltage Equalization Strategy for Wind Energy Conversion

Posted: 09 Jul 2012 12:00 AM PDT

In this paper, an energy storage system with voltage equalization strategy for wind energy conversion is presented. The proposed energy storage system provides a voltage equalization strategy for series-connected lead-acid batteries to increase their total storage capacity and lifecycle. In order to draw the maximum power from the wind energy, a perturbation-and-observation method and digital signal processor (DSP) are incorporated to implement maximum power point tracking (MPPT) algorithm and power regulating scheme. In the proposed energy storage system, all power switches have zero-voltage-switching (ZVS) feature at turn-on transition. Therefore, the conversion efficiency can be increased. Finally, a prototype energy storage system for wind energy conversion is built and implemented. Experimental results have verified the performance and feasibility of the proposed energy storage system for wind energy conversion.

Energies, Vol. 5, Pages 2310-2330: Sliding Mode Control Strategy for Wind Turbine Power Maximization

Posted: 09 Jul 2012 12:00 AM PDT

The efficiency of the wind power conversions systems can be greatly improved using an appropriate control algorithm. In this work, a sliding mode control for variable speed wind turbine that incorporates a doubly fed induction generator is described. The electrical system incorporates a wound rotor induction machine with back-to-back three phase power converter bridges between its rotor and the grid. In the presented design the so-called vector control theory is applied, in order to simplify the electrical equations. The proposed control scheme uses stator flux-oriented vector control for the rotor side converter bridge control and grid voltage vector control for the grid side converter bridge control. The stability analysis of the proposed sliding mode controller under disturbances and parameter uncertainties is provided using the Lyapunov stability theory. Finally simulated results show, on the one hand, that the proposed controller provides high-performance dynamic characteristics, and on the other hand, that this scheme is robust with respect to the uncertainties that usually appear in the real systems.

Keyboard Maestro 5.3.1 - Hot key tasking solution.. (Shareware)

Posted: 09 Jul 2012 02:07 AM PDT



Keyboard Maestro is your hot key solution that allows you to perform a multitude of tasks simply by pressing a keystroke! Keyboard Maestro also incorporates the wildly popular MacOS Classic utility Program Switcher, which allows you to launch, switch, and quit applications with a simple keystroke.

Features:

  • Macro
  • Program and Window Switcher
  • Clipboard Switcher
  • Clipboard History Switcher



Version 5.3.1:
  • Resolved an issue with executing Automator Workflows in OS X 10.8.
  • Resolved a performance issue with the Button Condition.
  • Notify via Growl when a timeout cancels a macro.
  • Fixed some memory leaks.
  • Fixed the SECONDS() function.
  • Fixed a performance issue with getting the Finder's selection.
  • Fixed the YEAR/MONTH/DAY/DOW/HOUR/MINUTE/SECOND to be in local timezone.
  • Fixed some edge cases in the Hard Wrap filter.
  • Allow "APPLICATION" in the menu condition.
  • Avoid "no autorelease pool" warnings on launch of engine in Mac App Store version.
  • Removed "move to" logging.
  • Fixed Edit with TextEdit macro library entry.
  • Fixed short form variables with spaces or underscores in their names.
  • Fixed triple click action editor to actually triple click.
  • Fixed a case where the editor get confused when switching macros.


Mac OS X 10.6 or later

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B.B. King Blues Club & Grill Announces Shows, Now thru 7/23

Posted: 09 Jul 2012 01:30 AM PDT

The following are the complete and current upcoming event listings for today, July 9 July 23, 2012 at B. B. King Blues Club and Grill, NYC.

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Molecules, Vol. 17, Pages 8241-8254: The “Funny” Current (If) Inhibition by Ivabradine at Membrane Potentials Encompassing Spontaneous Depolarization in Pacemaker Cells

Posted: 09 Jul 2012 12:00 AM PDT

Recent clinical trials have shown that ivabradine (IVA), a drug that inhibits the funny current (If) in isolated sinoatrial nodal cells (SANC), decreases heart rate and reduces morbidity and mortality in patients with cardiovascular diseases. While IVA inhibits If, this effect has been reported at essentially unphysiological voltages, i.e., those more negative than the spontaneous diastolic depolarization (DD) between action potentials (APs). We tested the relative potency of IVA to block If over a wide range of membrane potentials, including those that encompass DD governing to the SANC spontaneous firing rate. A clinically relevant IVA concentration of 3 μM to single, isolated rabbit SANC slowed the spontaneous AP firing rate by 15%. During voltage clamp the maximal If was 18 ± 3 pA/pF (at −120 mV) and the maximal If reduction by IVA was 60 ± 8% observed at −92 ± 4 mV. At the maximal diastolic depolarization (~−60 mV) If amplitude was only −2.9 ± 0.4 pA/pF, and was reduced by only 41 ± 6% by IVA. Thus, If amplitude and its inhibition by IVA at physiologically relevant membrane potentials are substantially less than that at unphysiological (hyperpolarized) membrane potentials. This novel finding more accurately describes how IVA affects SANC function and is of direct relevance to numerical modeling of SANC automaticity.

Molecules, Vol. 17, Pages 8217-8240: Synthesis and Antibacterial Evaluation of a New Series of N-Alkyl-2-alkynyl/(E)-alkenyl-4-(1H)-quinolones

Posted: 09 Jul 2012 12:00 AM PDT

To gain further insight into the structural requirements of the aliphatic group at position 2 for their antimycobacterial activity, some N-alkyl-4-(1H)-quinolones bearing position 2 alkynyls with various chain length and triple bond positions were prepared and tested for in vitro antibacterial activity against rapidly-growing strains of mycobacteria, the vaccine strain Mycobacterium bovis BCG, and methicillin-resistant Staphylococcus aureus strains, EMRSA-15 and -16. The compounds were also evaluated for inhibition of ATP-dependent MurE ligase of Mycobacterium tuberculosis. The lowest MIC value of 0.5 mg/L (1.2–1.5 µM) was found against M. fortuitum and M. smegmatis. These compounds displayed no or only weak toxicity to the human lung fibroblast cell line MRC-5 at 100 µM concentration. The quinolone derivatives exhibited pronounced activity against the epidemic MRSA strains (EMRSA-15 and -16) with MIC values of 2–128 mg/L (5.3–364.7 µM), and M. bovis BCG with an MIC value of 25 mg/L (66.0–77.4 µM). In addition, the compounds inhibited the MurE ligase of M. tuberculosis with moderate to weak activity showing IC50 values of 200–774 µM. The increased selectivity towards mycobacterial bacilli with reference to MRC-5 cells observed for 2-alkynyl quinolones compared to their corresponding 2-alkenyl analogues serves to highlight the mycobacterial specific effect of the triple bond. Exploration of a terminal bromine atom at the side chain of N-alkyl-2-(E)-alkenyl-4-(1H)-quinolones showed improved antimycobacterial activity whereas a cyclopropyl residue at N-1 was suggested to be detrimental to antibacterial activity.

Molecules, Vol. 17, Pages 8206-8216: An Alternative Synthesis of 3′,4′-Diaminoflavones to Evaluate Their Antioxidant Ability and Cell Apoptosis of Zebrafish Larvae

Posted: 09 Jul 2012 12:00 AM PDT

We described herein a concise synthesis of 3′,4′-diaminoflavone 10. This new, three-step synthetic approach is more efficient than the conventional seven-step synthetic method. The route is shortened significantly by introducing the amino moieties early and eliminating the need for nitro group reduction. The other two analogues, 5,7-dihydroxy-3′,4′-diaminoflavone 11 and 5,7-dimethoxy-3′,4′-diaminoflavone 12, were also synthesized similarly. The above three compounds, along with flavone, were evaluated for their antioxidant and UVB-protection abilities on zebrafish larvae. The data showed that compound 10 exhibited the best result, with −102.3% of ROS-scavenging rate.

Molecules, Vol. 17, Pages 8196-8205: Terpenes as Green Solvents for Extraction of Oil from Microalgae

Posted: 09 Jul 2012 12:00 AM PDT

Herein is described a green and original alternative procedure for the extraction of oil from microalgae. Extractions were carried out using terpenes obtained from renewable feedstocks as alternative solvents instead of hazardous petroleum solvents such as n-hexane. The described method is achieved in two steps using Soxhlet extraction followed by the elimination of the solvent from the medium using Clevenger distillation in the second step. Oils extracted from microalgae were compared in terms of qualitative and quantitative determination. No significant difference was obtained between each extract, allowing us to conclude that the proposed method is green, clean and efficient.

ePub DRM Removal 1.7.3 - Remove DRM from ePub.. (Shareware)

Posted: 09 Jul 2012 01:29 AM PDT



ePUB DRM Removal is powerfull software to remove DRM protections from Adobe digital editions with no quality loss. Just remove the ePUB files DRM header, with no change to the files. Read the ePUB on iPad, iPhone, iTouch, Sony Reader, Android, Nook etc.

Features :

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Version 1.7.3:
  • Remove DRM from ePub in batch conversion.
  • New interface, easier to use. Bug fixed, more powerful.


Mac OS X 10.5 or later

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Zomboz 2

Posted: 09 Jul 2012 01:04 AM PDT

Shoot the zombies by considering the gravitation limitations on all levels!

Molecules, Vol. 17, Pages 8186-8195: Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum

Posted: 09 Jul 2012 12:00 AM PDT

A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549 (human lung carcinoma epithelial-like) and V79379A (Chinese hamster lung fibroblast-like) cells using the tetrazolium salt reduction (MTT) assay. All of tested compounds induced high time- and concentration-dependent cytotoxic effects.

Sensors, Vol. 12, Pages 9448-9466: An Enhanced MEMS Error Modeling Approach Based on Nu-Support Vector Regression

Posted: 09 Jul 2012 12:00 AM PDT

Micro Electro Mechanical System (MEMS)-based inertial sensors have made possible the development of a civilian land vehicle navigation system by offering a low-cost solution. However, the accurate modeling of the MEMS sensor errors is one of the most challenging tasks in the design of low-cost navigation systems. These sensors exhibit significant errors like biases, drift, noises; which are negligible for higher grade units. Different conventional techniques utilizing the Gauss Markov model and neural network method have been previously utilized to model the errors. However, Gauss Markov model works unsatisfactorily in the case of MEMS units due to the presence of high inherent sensor errors. On the other hand, modeling the random drift utilizing Neural Network (NN) is time consuming, thereby affecting its real-time implementation. We overcome these existing drawbacks by developing an enhanced Support Vector Machine (SVM) based error model. Unlike NN, SVMs do not suffer from local minimisation or over-fitting problems and delivers a reliable global solution. Experimental results proved that the proposed SVM approach reduced the noise standard deviation by 10–35% for gyroscopes and 61–76% for accelerometers. Further, positional error drifts under static conditions improved by 41% and 80% in comparison to NN and GM approaches.

Sensors, Vol. 12, Pages 9423-9447: A Fully Sensorized Cooperative Robotic System for Surgical Interventions

Posted: 09 Jul 2012 12:00 AM PDT

In this research a fully sensorized cooperative robot system for manipulation of needles is presented. The setup consists of a DLR/KUKA Light Weight Robot III especially designed for safe human/robot interaction, a FD-CT robot-driven angiographic C-arm system, and a navigation camera. Also, new control strategies for robot manipulation in the clinical environment are introduced. A method for fast calibration of the involved components and the preliminary accuracy tests of the whole possible errors chain are presented. Calibration of the robot with the navigation system has a residual error of 0.81 mm (rms) with a standard deviation of ±0.41 mm. The accuracy of the robotic system while targeting fixed points at different positions within the workspace is of 1.2 mm (rms) with a standard deviation of ±0.4 mm. After calibration, and due to close loop control, the absolute positioning accuracy was reduced to the navigation camera accuracy which is of 0.35 mm (rms). The implemented control allows the robot to compensate for small patient movements.

Sensors, Vol. 12, Pages 9411-9422: Dynamics of Ras Complexes Observed in Living Cells

Posted: 09 Jul 2012 12:00 AM PDT

K-Ras works as a switch in many important intracellular signaling pathways and plays important roles in cell growth, proliferation, differentiation and carcinogenesis. For signal transduction from K-Ras to Raf1, the best-characterized effector of K-Ras, the general view is that Ras recruits Raf1 from the cytoplasm to the cell membrane. To elucidate this process, we constructed a series of fusion proteins (including Raf1 and K-Ras fused with either fluorescent proteins or fluorescent protein fragments) to compare subcellular localizations of these proteins. Bimolecular fluorescence complementation (BiFC) and a co-transfection system were used. In the BiFC system, the K-Ras/Raf1 complexes were mainly located in the cell membrane, while the Raf1 control was uniformly distributed in the cytoplasm. However, the complexes of Raf1 and K-RasC185S, a K-Ras mutant which loses membrane-localization, were also able to accumulate in the cell membrane. In contrast, an apparent cytosolic distribution pattern was observed in cells co-transfected with mcerulean-Raf1 and EGFP-K-RasC185S, suggesting that the membrane localization of K-Ras/Raf1 complexes is not entirely dependent on K-Ras, and that other factors, such as the irreversible conformation formed between K-Ras and Raf1 may play a role. This study sheds light on the interaction between K-Ras and Raf1 and provides a practical method to elucidate the mechanism underlying K-Ras and Raf1 binding to the cell membrane.

Sensors, Vol. 12, Pages 9386-9410: AUV SLAM and Experiments Using a Mechanical Scanning Forward-Looking Sonar

Posted: 09 Jul 2012 12:00 AM PDT

Navigation technology is one of the most important challenges in the applications of autonomous underwater vehicles (AUVs) which navigate in the complex undersea environment. The ability of localizing a robot and accurately mapping its surroundings simultaneously, namely the simultaneous localization and mapping (SLAM) problem, is a key prerequisite of truly autonomous robots. In this paper, a modified-FastSLAM algorithm is proposed and used in the navigation for our C-Ranger research platform, an open-frame AUV. A mechanical scanning imaging sonar is chosen as the active sensor for the AUV. The modified-FastSLAM implements the update relying on the on-board sensors of C-Ranger. On the other hand, the algorithm employs the data association which combines the single particle maximum likelihood method with modified negative evidence method, and uses the rank-based resampling to overcome the particle depletion problem. In order to verify the feasibility of the proposed methods, both simulation experiments and sea trials for C-Ranger are conducted. The experimental results show the modified-FastSLAM employed for the navigation of the C-Ranger AUV is much more effective and accurate compared with the traditional methods.

Sensors, Vol. 12, Pages 9375-9385: Effect of Plasma Treatment on Multi-Walled Carbon Nanotubes for the Detection of H2S and SO2

Posted: 09 Jul 2012 12:00 AM PDT

H2S and SO2 are important characteristic gases of partial discharge (PD) generated by latent insulated defects in gas insulated switchgear (GIS). The detection of H2S and SO2 is of great significance in the diagnosis and assessment of the operating status of GIS. In this paper, we perform experiments on the gas sensitivity of unmodified multi-walled carbon nanotubes (MWNTs) and those modified by atmospheric pressure dielectric barrier discharge (DBD) air plasma at different times (30, 60 and 120 s) for H2S and SO2, respectively. The results show that the sensitivity and response time of modified MWNTs to H2S are both improved, whereas the opposite effects are observed for SO2. The modified MWNTs have almost zero sensitivity to SO2. Thus, the MWNTs modified by atmospheric pressure DBD air plasma present good selectivity to H2S, and have great potential in H2S detection.

Sensors, Vol. 12, Pages 9363-9374: Investigating the Quantitative Structure-Activity Relationships for Antibody Recognition of Two Immunoassays for Polycyclic Aromatic Hydrocarbons by Multiple Regression Methods

Posted: 09 Jul 2012 12:00 AM PDT

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants found in the environment. Immunoassays represent useful analytical methods to complement traditional analytical procedures for PAHs. Cross-reactivity (CR) is a very useful character to evaluate the extent of cross-reaction of a cross-reactant in immunoreactions and immunoassays. The quantitative relationships between the molecular properties and the CR of PAHs were established by stepwise multiple linear regression, principal component regression and partial least square regression, using the data of two commercial enzyme-linked immunosorbent assay (ELISA) kits. The objective is to find the most important molecular properties that affect the CR, and predict the CR by multiple regression methods. The results show that the physicochemical, electronic and topological properties of the PAH molecules have an integrated effect on the CR properties for the two ELISAs, among which molar solubility (Sm) and valence molecular connectivity index (3χv) are the most important factors. The obtained regression equations for RisC kit are all statistically significant (p < 0.005) and show satisfactory ability for predicting CR values, while equations for RaPID kit are all not significant (p > 0.05) and not suitable for predicting. It is probably because that the RisC immunoassay employs a monoclonal antibody, while the RaPID kit is based on polyclonal antibody. Considering the important effect of solubility on the CR values, cross-reaction potential (CRP) is calculated and used as a complement of CR for evaluation of cross-reactions in immunoassays. Only the compounds with both high CR and high CRP can cause intense cross-reactions in immunoassays.

Sensors, Vol. 12, Pages 9349-9362: Circulating MicroRNAs: Molecular Microsensors in Gastrointestinal Cancer

Posted: 09 Jul 2012 12:00 AM PDT

MicroRNAs (miRNAs) are small molecules of single strand non-coding RNAs, which are able to regulate gene expression. miRNAs have been involved in multiple cellular processes, such as proliferation, apoptosis and differentiation, thus alterations in miRNA expression have been shown to be directly linked with the pathological origin of multiple diseases, including cancer. In this way, during last few years, an increasing number of exciting advances have contributed to the understanding of miRNA roles in cancer. Moreover, researchers have exploited the special characteristics of miRNAs, such as the tissue and disease specificity or miRNA presence in blood, to explore their use as non-invasive tumour markers. In the present review, we summarize the current data on the potential usefulness of circulating miRNAs as diagnostic and prognostic tools in gastrointestinal tumours.

Rambo: The Video Game to debut at Gamescom 2012

Posted: 09 Jul 2012 12:43 AM PDT

The Rambo series should translate perfectly into video games, but previous adaptations on the NES, Sega Master System and the Sega Genesis didn't do the

Gem Cave Adventure

Posted: 09 Jul 2012 12:04 AM PDT

Explore hazardous caves on your epic quest for diamonds. Move from cave to cave and battle dangerous enemies and deadly traps!
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