пятница, 27 июля 2012 г.

Games

Games

MacPorts 2.1.2 - Install opensource software on Darwin OSes (was DarwinPorts).. (Free)

Posted: 27 Jul 2012 03:15 AM PDT

MacPorts Project's main goal is to provide an easy way to install various open-source software products on the Darwin OS family (OpenDarwin, Mac OS X and Darwin).

Version 2.1.2: Release notes were unavailable when this listing was updated.

OS X 10.7 or later

Download Now

Friendz 5.0a5 - Messaging system for Xbox Live members.. (Free)

Posted: 27 Jul 2012 03:23 AM PDT



Friendz is a simple application for seeing what your xbox live friends are up to. You can send messages, and reply to ones that have been sent to you. You can also send, accept and reject friend requests. Friendz also has a status item in the menu bar for quick access to your online friends.

  • This update requires Mac OS 10.7
  • New version. Version 4 has been discontinued.
  • Follow me on twitter for any news or if you wanna get in touch!


  • Mac OS X 10.6.8 or later.
  • An Xbox.com account.
  • Growl for notifications.


Download Now

F1: Hamilton Leads McLaren 1-2 In First Hungary Practice

Posted: 27 Jul 2012 12:00 AM PDT


Lewis Hamilton paced opening practice Friday at the Hungaroring while teammate Jenson Button was a close second...

Epic Raiders - Screenshots

Posted: 27 Jul 2012 03:44 AM PDT

REAL-TIME COMBAT
Lead your party into real-time combat against enemy forces

MULTIPLAYER PVP
Play with friends, join teams and come out on tope in real-time multiplayer PVP

EXPANSIVE DUNGEON MODE
Discover specialty items and earn rewards while fighting in Dungeon Mode

ENDLESS PARTY CUSTOMIZATION
Change your party with a wide variety of characters, play characters in over thousands of combinations of colorful armor and weaponry

CRYSTAL CLEAR HD
Featuring supreme visuals for intense gameplay

BIKES: 290 MPH From A Standing Start In One Mile

Posted: 25 Jul 2012 12:00 AM PDT


Brock's Performance proudly congratulates the land-speed racers who used an array of its off-the-shelf products to score 15 records at the Loring Timing Association's Maine Event.

Shatter Crash - Screenshots

Posted: 27 Jul 2012 03:37 AM PDT

FAST AND FURIOUS PUZZLE SOLVING
Race against the clock, create huge block combos, and stay one step ahead of the encroaching sphere.

CHARACTER CUSTOMIZATION AND LEVELING
Shatter Crash takes action puzzle games to the next level with a customizable character with equipment leveling.

RESPONSIVE AND INTUITIVE TOUCH CONTROLS
Move around Nodes, activate programs, and drop blocks - all with simple button taps and swipes.

SIMPLE NAVIGATION
Easy to use controls allow effortless navigation through the network to locate hidden programs and free nanobots.

Spy vs Spy (iOs) - Screenshots

Posted: 27 Jul 2012 03:21 AM PDT

Spy vs Spy features:
- Online + Local Multiplayer Support - sabotage and intrigue included.
- 16 Brand New Embassies – for a total of 24.
- Play alone in Custom Matches for all 24 embassies, each with 5 levels of difficulty – you select the IQ of the opposing spy.
- Retina graphics for the new iPad and iPhone.
- New, full screen club-to-club Combat in Modern mode.
- Modern & Retro game modes – both featuring Simulvision™, Simulplay™ and your very own Trapulator™.
- 5 types of Booby-Traps - play as the famous Black and White spies from MAD Magazine.
- Integrated Game Center Leaderboards and Achievements.
- Includes the original theme music plus 4 new remixes.
- Universal app - play on iPad, iPhone, and iPod touch

Spy vs Spy - Screenshots

Posted: 27 Jul 2012 03:13 AM PDT

Spy vs Spy features:
- Online + Local Multiplayer Support - sabotage and intrigue included.
- 16 Brand New Embassies – for a total of 24.
- Play alone in Custom Matches for all 24 embassies, each with 5 levels of difficulty – you select the IQ of the opposing spy.
- Retina graphics for the new iPad and iPhone.
- New, full screen club-to-club Combat in Modern mode.
- Modern & Retro game modes – both featuring Simulvision™, Simulplay™ and your very own Trapulator™.
- 5 types of Booby-Traps - play as the famous Black and White spies from MAD Magazine.
- Integrated Game Center Leaderboards and Achievements.
- Includes the original theme music plus 4 new remixes.
- Universal app - play on iPad, iPhone, and iPod touch

IJMS, Vol. 13, Pages 9502-9513: Thermal Studies of Zn(II), Cd(II) and Hg(II) Complexes of Some N-Alkyl-N-Phenyl-Dithiocarbamates

Posted: 27 Jul 2012 12:00 AM PDT

The thermal decomposition of Zn(II), Cd(II) and Hg(II) complexes of N-ethyl-N-phenyl and N-butyl-N-phenyl dithiocarbamates have been studied using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The products of the decomposition, at two different temperatures, were further characterized by scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). The results show that while the zinc and cadmium complexes undergo decomposition to form metal sulphides, and further undergo oxidation forming metal oxides as final products, the mercury complexes gave unstable volatiles as the final product.

IJMS, Vol. 13, Pages 9489-9501: Detection of Differential Levels of Proteins in the Urine of Patients with Endometrial Cancer: Analysis Using Two-Dimensional Gel Electrophoresis and O-Glycan Binding Lectin

Posted: 27 Jul 2012 12:00 AM PDT

Cancers can cause some proteins to be aberrantly excreted or released in the urine, which can be used as biomarkers. To screen for potential biomarkers for endometrial cancer (ECa), the urinary proteins from patients who were newly diagnosed with early stage ECa and untreated controls were separated using two-dimensional gel electrophoresis (2-DE) and followed by image analysis. The altered levels of zinc alpha-2 glycoprotein, alpha 1-acid glycoprotein, and CD59 were detected in the patients compared to the controls. In addition, the urine of the ECa patients was also found to contain relatively lower levels of a fragment of nebulin when the 2-DE separated urinary proteins were probed using champedak galactose binding (CGB) lectin. The different levels of the nebulin fragment were further validated by subjecting the urinary protein samples to CGB lectin affinity chromatography and analysis of the bound fractions by LC-MS/MS. Our data is suggestive of the potential use of the differentially expressed urinary proteins as biomarkers for ECa although this requires further extensive validation on clinically representative populations.

Casino Del Sol to offer online gaming

Posted: 27 Jul 2012 01:49 AM PDT

The new gaming is just for fun, since betting for money on the internet is illegal.

This posting includes an audio/video/photo media file: Download Now

Entropy, Vol. 14, Pages 1343-1356: Bearing Fault Diagnosis Based on Multiscale Permutation Entropy and Support Vector Machine

Posted: 27 Jul 2012 12:00 AM PDT

Bearing fault diagnosis has attracted significant attention over the past few decades. It consists of two major parts: vibration signal feature extraction and condition classification for the extracted features. In this paper, multiscale permutation entropy (MPE) was introduced for feature extraction from faulty bearing vibration signals. After extracting feature vectors by MPE, the support vector machine (SVM) was applied to automate the fault diagnosis procedure. Simulation results demonstrated that the proposed method is a very powerful algorithm for bearing fault diagnosis and has much better performance than the methods based on single scale permutation entropy (PE) and multiscale entropy (MSE).

Entropy, Vol. 14, Pages 1317-1342: Equivalence of Partition Functions Leads to Classification of Entropies and Means

Posted: 27 Jul 2012 12:00 AM PDT

We derive a two-parameter family of generalized entropies, Spq, and means mpq. To this end, assume that we want to calculate an entropy and a mean for n non-negative real numbers {x1,…,xn}. For comparison, we consider {m1,…,mk} where mi = m for all i = 1,…,k and where m and k are chosen such that the lp and lq norms of {x1,…,xn} and {m1,…,mk} coincide. We formally allow k to be real. Then, we define k, log k, and m to be a generalized cardinality kpq, a generalized entropy Spq, and a generalized mean mpq respectively. We show that this family of entropies includes the Shannon and Rényi entropies and that the family of generalized means includes the power means (such as arithmetic, harmonic, geometric, root-mean-square, maximum, and minimum) as well as novel means of Shannon-like and Rényi-like forms. A thermodynamic interpretation arises from the fact that the lp norm is closely related to the partition function at inverse temperature β = p. Namely, two systems possess the same generalized entropy and generalized mean energy if and only if their partition functions agree at two temperatures, which is also equivalent to the condition that their Helmholtz free energies agree at these two temperatures.

Cells, Vol. 1, Pages 372-395: Regulation of Autophagy by Glucose in Mammalian Cells

Posted: 27 Jul 2012 12:00 AM PDT

Autophagy is an evolutionarily conserved process that contributes to maintain cell homeostasis. Although it is strongly regulated by many extracellular factors, induction of autophagy is mainly produced by starvation of nutrients. In mammalian cells, the regulation of autophagy by amino acids, and also by the hormone insulin, has been extensively investigated, but knowledge about the effects of other autophagy regulators, including another nutrient, glucose, is more limited. Here we will focus on the signalling pathways by which environmental glucose directly, i.e., independently of insulin and glucagon, regulates autophagy in mammalian cells, but we will also briefly mention some data in yeast. Although glucose deprivation mainly induces autophagy via AMPK activation and the subsequent inhibition of mTORC1, we will also comment other signalling pathways, as well as evidences indicating that, under certain conditions, autophagy can be activated by glucose. A better understanding on how glucose regulates autophagy not only will expand our basic knowledge of this important cell process, but it will be also relevant to understand common human disorders, such as cancer and diabetes, in which glucose levels play an important role.

Cells, Vol. 1, Pages 346-371: Autophagy in Trypanosomatids

Posted: 27 Jul 2012 12:00 AM PDT

Autophagy is a ubiquitous eukaryotic process that also occurs in trypanosomatid parasites, protist organisms belonging to the supergroup Excavata, distinct from the supergroup Opistokontha that includes mammals and fungi. Half of the known yeast and mammalian AuTophaGy (ATG) proteins were detected in trypanosomatids, although with low sequence conservation. Trypanosomatids such as Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are responsible for serious tropical diseases in humans. The parasites are transmitted by insects and, consequently, have a complicated life cycle during which they undergo dramatic morphological and metabolic transformations to adapt to the different environments. Autophagy plays a major role during these transformations. Since inhibition of autophagy affects the transformation, survival and/or virulence of the parasites, the ATGs offer promise for development of drugs against tropical diseases. Furthermore, various trypanocidal drugs have been shown to trigger autophagy-like processes in the parasites. It is inferred that autophagy is used by the parasites in an—not always successful—attempt to cope with the stress caused by the toxic compounds.

IJERPH, Vol. 9, Pages 2636-2657: DNA Damage and Repair in Human Cancer: Molecular Mechanisms and Contribution to Therapy-Related Leukemias

Posted: 27 Jul 2012 12:00 AM PDT

Most antitumour therapies damage tumour cell DNA either directly or indirectly. Without repair, damage can result in genetic instability and eventually cancer. The strong association between the lack of DNA damage repair, mutations and cancer is dramatically demonstrated by a number of cancer-prone human syndromes, such as xeroderma pigmentosum, ataxia-telangiectasia and Fanconi anemia. Notably, DNA damage responses, and particularly DNA repair, influence the outcome of therapy. Because DNA repair normally excises lethal DNA lesions, it is intuitive that efficient repair will contribute to intrinsic drug resistance. Unexpectedly, a paradoxical relationship between DNA mismatch repair and drug sensitivity has been revealed by model studies in cell lines. This suggests that connections between DNA repair mechanism efficiency and tumour therapy might be more complex. Here, we review the evidence for the contribution of carcinogenic properties of several drugs as well as of alterations in specific mechanisms involved in drug-induced DNA damage response and repair in the pathogenesis of therapy-related cancers.

IJERPH, Vol. 9, Pages 2620-2635: Association Study of Genes Associated to Asthma in a Specific Environment, in an Asthma Familial Collection Located in a Rural Area Influenced by Different Industries

Posted: 27 Jul 2012 12:00 AM PDT

Eight candidate genes selected in this study were previously associated with gene-environment interactions in asthma in an urban area. These genes were analyzed in a familial collection from a founder and remote population (Saguenay–Lac-Saint-Jean; SLSJ) located in an area with low air levels of ozone but with localized areas of relatively high air pollutant levels, such as sulphur dioxide, when compared to many urban areas. Polymorphisms (SNPs) were extracted from the genome-wide association study (GWAS) performed on the SLSJ familial collection. A transmission disequilibrium test (TDT) was performed using the entire family sample (1,428 individuals in 254 nuclear families). Stratification according to the proximity of aluminium, pulp and paper industries was also analyzed. Two genes were associated with asthma in the entire sample before correction (CAT and NQO1) and one was associated after correction for multiple analyses (CAT). Two genes were associated when subjects were stratified according to the proximity of aluminium industries (CAT and NQO1) and one according to the proximity of pulp and paper industries (GSTP1). However, none of them resisted correction for multiple analyses. Given that the spatial pattern of environmental exposures can be complex and inadequately represented by a few stationary monitors and that exposures can also come from sources other than the standard outdoor air pollution (e.g., indoor air, occupation, residential wood smoke), a new approach and new tools are required to measure specific and individual pollutant exposures in order to estimate the real impact of gene-environment interactions on respiratory health.

IJERPH, Vol. 9, Pages 2608-2619: Foodborne Pathogens Recovered from Ready-to-Eat Foods from Roadside Cafeterias and Retail Outlets in Alice, Eastern Cape Province, South Africa: Public Health Implications

Posted: 27 Jul 2012 12:00 AM PDT

This study assessed the microbiological quality of various ready-to-eat foods sold in Alice, South Africa. Microbiological analysis was conducted on 252 samples which included vegetables, potatoes, rice, pies, beef and chicken stew. The isolates were identified using biochemical tests and the API 20E, API 20NE and API Listeria kits; results were analyzed using the one-way-ANOVA test. Bacterial growth was present in all the food types tested; high levels of total aerobic count were observed in vegetables, 6.8 ± 0.07 followed by rice, 6.7 ± 1.7 while pies had the lowest count (2.58 ± 0.24). Organisms isolated included: Listeria spp. (22%), Enterobacter spp. (18%), Aeromonas hydrophila (12%), Klebsiella oxytoca (8%), Proteus mirabilis (6.3%), Staphylococcus aureus (3.2%) and Pseudomonas luteola (2.4%). Interestingly, Salmonella spp. and Escherichia coli were not isolated in any of the samples. There was a statistically significant difference (p < 0.05) in the prevalence of foodborne pathogens from hygienic and unhygienic cafeterias. The results indicated that most of the ready-to-eat food samples examined in this study did not meet bacteriological quality standards, therefore posing potential risks to consumers. This should draw the attention of the relevant authorities to ensure that hygienic standards are improved to curtain foodborne infections.

Crystals, Vol. 2, Pages 1067-1083: Photoinduced Phase Transition in Strongly Electron-Lattice and Electron–Electron Correlated Molecular Crystals

Posted: 27 Jul 2012 12:00 AM PDT

Strongly electron-lattice- and electron-electron-correlated molecular crystals, such as charge transfer (CT) complexes, are often sensitive to external stimuli, e.g., photoexcitation, due to the cooperative or competitive correlation of various interactions present in the crystals. These crystals are thus productive targets for studying photoinduced phase transitions (PIPTs). Recent advancements in research on the PIPT of CT complexes, especially Et2Me2Sb[Pd(dmit)2]2 and (EDO-TTF)2PF6, are reviewed in this report. The former exhibits a photoinduced insulator-to-insulator phase transition with clearly assigned spectral change. We demonstrate how to find the dynamics of PIPT using this system. The latter exhibits a photoinduced hidden state as an initial PIPT process. Wide energy ranged time-resolved spectroscopy can probe many kinds of photo-absorption processes, i.e., intra-molecular and inter-molecular electron excitations and intramolecular and electron-molecular vibrations. The photoinduced spectral changes in these photo-absorption processes reveal various aspects of the dynamics of PIPT, including electronic structural changes, lattice structural changes, and molecular deformations. The complexities of the dynamics of the latter system were revealed by our measurements.

Crystals, Vol. 2, Pages 1058-1066: Crystal and Molecular Structures of Two 2-Aminothiophene Derivatives

Posted: 27 Jul 2012 12:00 AM PDT

The crystal and molecular structures of two 2-aminothiophene derivatives, potential allosteric enhancers at the human A1 adenosine receptor, are reported. (2-Amino-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)(phenyl)methanone (1) crystallizes in the orthorhombic space group Pna21 (a = 9.2080(4) Å, b = 14.0485(7) Å, c = 10.3826(6) Å), and (2-amino-5-ethylthiophen-3-yl)(2-chlorophenyl)methanone (2) crystalizes in the monoclinic P21/c space group with unit cell parameters a = 10.6092(8) Å, b = 10.8355(8) Å, c = 11.1346(9) Å, β = 98.643(6)Å. In both molecules the intramolecular N–H···O=C hydrogen bonds close six-membered planar rings and significantly influence the molecular conformation. Intermolecular N–H···O bonds connect the molecules in infinite chains along a in case of 1, and along b in 2; in each case the appropriate unit cell axis is approximately 10 Å long.
Автор: на

Комментариев нет:

Отправить комментарий

Подписаться на: Комментарии к сообщению (Atom)