Games |
- Fabulous! It's the GamesRadar UK Podcast Question Box
- F1: Improved Button Best In First German GP Runs
- IJMS, Vol. 13, Pages 9142-9156: TRAIL and Paclitaxel Synergize to Kill U87 Cells and U87-Derived Stem-Like Cells In Vitro
- IJMS, Vol. 13, Pages 9129-9141: Pharmacokinetics and Tissue Distribution Study of Praeruptorin D from Radix Peucedani in Rats by High-Performance Liquid Chromatography (HPLC)
- IJMS, Vol. 13, Pages 9110-9128: HR4 Gene Is Induced in the Arabidopsis-Trichoderma atroviride Beneficial Interaction
- IJMS, Vol. 13, Pages 9097-9109: Curcumin Inhibits Glutamate Release from Rat Prefrontal Nerve Endings by Affecting Vesicle Mobilization
- IJMS, Vol. 13, Pages 9081-9096: The Structure Lacuna
- Nazi Explosions Meet Beautiful Landscape Paintings in This Video Game Concept Art
- IJMS, Vol. 13, Pages 9069-9080: Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL: A Potential Role for Macrophages in Trophoblast Apoptosis
- IJMS, Vol. 13, Pages 9051-9068: Ultrasonic-Assisted Enzymolysis to Improve the Antioxidant Activities of Peanut (Arachin conarachin L.) Antioxidant Hydrolysate
- IJMS, Vol. 13, Pages 9035-9050: Quantitative and Chemical Fingerprint Analysis for the Quality Evaluation of Isatis indigotica based on Ultra-Performance Liquid Chromatography with Photodiode Array Detector Combined with Chemometric Methods
- Marine Drugs, Vol. 10, Pages 1572-1581: Lochmolins A–G, New Sesquiterpenoids from the Soft Coral Sinularia lochmodes
- The Little Girl Nobody Liked
- Final Fantasy creator releases iOS game
- The trials of Hoodwink's development cycle
- DayZ Diaries - Part 4
- Hatsune Miku PS Vita bundle available in Asia this August
- Big in Japan July 9-15: Time Travelers
- Spotify 0.8.4.107 - Stream music, create playlists and more.. (Free)
- Black Omega 2.1.1 - High fidelity audio player.. (Demo)
| Fabulous! It's the GamesRadar UK Podcast Question Box Posted: 20 Jul 2012 03:15 AM PDT So this is the GamesRadar UK Podcast Question Box, our bi-weekly regular receptacle for all of your ponders and musings. By which we mean that every |
| F1: Improved Button Best In First German GP Runs Posted: 20 Jul 2012 12:00 AM PDT  Driving a heavily revised McLaren, Jenson Button paced opening practice Friday in Germany... |
| Posted: 20 Jul 2012 12:00 AM PDT U87-derived stem-like cells (U87-SLCs) were cultured using serum-free stem cell media and identified by both biological behaviors and markers. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and paclitaxel (PX), in combination or alone, was used to treat U87-MG human glioma cells (U87 cells) or U87-SLCs. The results showed that TRAIL/PX cannot only synergistically inhibit U87 cells but also U87-SLCs. We observed a significantly higher apoptotic rate in U87 cells simultaneously treated with TRAIL/PX for 24 h compared to cells treated with either drug alone. Furthermore, there was a remarkably higher apoptosis rate in U87-SLCs induced by the TRAIL/PX combination compared with either drug alone. Unlike the simultaneous treatment in U87 cells, U87-SLCs were pretreated for 24 h with 1 μmol/L of PX followed by 1000 ng/mL of TRAIL. Protein assays revealed that TRAIL/PX synergy was related to DR4, cleaved caspase-8 and cleaved caspase-3 upregulation, whereas the mitochondrial pathway was not involved in TRAIL-induced apoptosis. The present study indicates that PX can sensitize U87 cells and U87-SLCs to TRAIL treatment through an extrinsic pathway of cell apoptosis. The combined treatment of TRAIL and PX may be a promising glioma chemotherapy because of its successful inhibition of U87-SLCs, which are hypothesized to influence chemotherapeutic outcomes of gliomas. |
| Posted: 20 Jul 2012 12:00 AM PDT Praeruptorin D (PD), a major pyranocoumarin isolated from Radix Peucedani, exhibited antitumor and anti-inflammatory activities. The aim of this study was to investigate the pharmacokinetics and tissue distribution of PD in rats following intravenous (i.v.) administration. The levels of PD in plasma and tissues were measured by a simple and sensitive reversed-phase high-performance liquid chromatography (HPLC) method. The biosamples were treated by liquid-liquid extraction (LLE) with methyl tert-butyl ether (MTBE) and osthole was used as the internal standard (IS). The chromatographic separation was accomplished on a reversed-phase C18 column using methanol-water (75:25, v/v) as mobile phase at a flow rate of 0.8 mL/min and ultraviolet detection wave length was set at 323 nm. The results demonstrate that this method has excellent specificity, linearity, precision, accuracy and recovery. The pharmacokinetic study found that PD fitted well into a two-compartment model with a fast distribution phase and a relative slow elimination phase. Tissue distribution showed that the highest concentration was observed in the lung, followed by heart, liver and kidney. Furthermore, PD can also be detected in the brain, which indicated that PD could cross the blood-brain barrier after i.v. administration. |
| Posted: 20 Jul 2012 12:00 AM PDT Plants are constantly exposed to microbes, for this reason they have evolved sophisticated strategies to perceive and identify biotic interactions. Thus, plants have large collections of so-called resistance (R) proteins that recognize specific microbe factors as signals of invasion. One of these proteins is codified by the Arabidopsis thaliana HR4 gene in the Col-0 ecotype that is homologous to RPW8 genes present in the Ms-0 ecotype. In this study, we investigated the expression patterns of the HR4 gene in Arabidopsis seedlings interacting with the beneficial fungus Trichoderma atroviride. We observed the induction of the HR4 gene mainly at 96 hpi when the fungus interaction was established. Furthermore, we found that the HR4 gene was differentially regulated in interactions with the beneficial bacterium Pseudomonas fluorescens and the pathogenic bacterium P. syringae. When hormone treatments were applied to A. thaliana (Col-0), each hormone treatment induced changes in HR4 gene expression. On the other hand, the expression of the RPW8.1 and RPW8.2 genes of Arabidopsis ecotype Ms-0 in interaction with T. atroviride was assessed. Interestingly, these genes are interaction-responsive; in particular, the RPW8.1 gene shows a very high level of expression in the later stages of interaction. These results indicate that HR4 and RPW8 genes could play a role in the establishment of Arabidopsis interactions with beneficial microbes. |
| Posted: 20 Jul 2012 12:00 AM PDT Curcumin, one of the major constituents of Curcuma longa, has been shown to inhibit depolarization-evoked glutamate release from rat prefrontocortical nerve terminals by reducing voltage-dependent Ca2+ entry. This study showed that curcumin inhibited ionomycin-induced glutamate release and KCl-evoked FM1-43 release, suggesting that some steps after Ca2+ entry are regulated by curcumin. Furthermore, disrupting the cytoskeleton organization using cytochalasin D abolished the inhibitory action of curcumin on ionomycin-induced glutamate release. Mitogen-activated protein kinase kinase (MEK) inhibition also prevented the inhibitory effect of curcumin on ionomycin-induced glutamate release. Western blot analyses showed that curcumin decreased the ionomycin-induced phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and synaptic vesicle-associated protein synapsin I, the main presynaptic target of ERK. These results show that curcumin-mediated inhibition of glutamate release involves modulating downstream events by controlling synaptic vesicle recruitment and exocytosis, possibly through a decrease of MAPK/ERK activation and synapsin I phosphorylation, thereby decreasing synaptic vesicle availability for exocytosis. |
| IJMS, Vol. 13, Pages 9081-9096: The Structure Lacuna Posted: 20 Jul 2012 12:00 AM PDT Molecular symmetry is intimately connected with the classical concept ofthree-dimensional molecular structure. In a non-classical theory of wave-like interactionin four-dimensional space-time, both of these concepts and traditional quantum mechanicslose their operational meaning, unless suitably modified. A required reformulation shouldemphasize the importance of four-dimensional effects like spin and the symmetry effects ofspace-time curvature that could lead to a fundamentally different understanding of molecularsymmetry and structure in terms of elementary number theory. Isolated single moleculeshave no characteristic shape and macro-biomolecules only develop robust three-dimensionalstructure in hydrophobic response to aqueous cellular media. |
| Nazi Explosions Meet Beautiful Landscape Paintings in This Video Game Concept Art Posted: 20 Jul 2012 01:30 AM PDT Geoffroy Thoorens is a French concept artist who currently works at Quantic Dream, the developers of Heavy Rain and the upcoming Beyond: Two Souls. This posting includes an audio/video/photo media file: Download Now |
| Posted: 20 Jul 2012 12:00 AM PDT Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus. Herein we investigated tissue samples from 11 cases of spontaneous miscarriages and from 9 cases of elective terminations of pregnancy. Using immunohistochemistry and dual immunofluorescence we have demonstrated that in spontaneous miscarriages the DM are significantly increased. Additionally, we noted a significant up-regulation of macrophage FasL expression. Our results further support a dual role for DM during pregnancy and miscarriages. We hypothesize that the baseline DM population in normal pregnancy is in line with an M2 phenotype supporting the ongoing gestation. In contrast, during spontaneous miscarriages, the increased FasL-expressing population could be a part of an M1 phenotype participating in Fas/FasL-related apoptosis. Our results highlight a new aspect of macrophage biology in pregnancy physiology and pathophysiology. Further studies with larger samples are needed to verify the current results and evaluate their clinical impact. |
| Posted: 20 Jul 2012 12:00 AM PDT The objective of this work is to provide a theoretical basis for preparing peanut antioxidant hydrolysate in order to improve its antioxidant activities. Therefore, response surface methodology (RSM) based on the Box-Behnken design was used to optimize ultrasonic-assisted enzymolysis for the purpose of preparing peanut antioxidant hydrolysate. Results indicated that the DPPH free radical scavenging activity of peanut hydrolysate could reach 90.06% under the following optimum conditions: ultrasonic power of 150.0 w, reaction temperature of 62.0 °C, incubation time of 25.0 min, and initial pH value of 8.5. The DPPH free radical scavenging rate of peanut hydrolysate from ultrasonic-assisted enzymolysis improved comparing with that of peanut hydrolysate from protease hydrolysis alone. The peanut antioxidant hydrolysate was found to display eight improved kinds of antioxidant activities. In conclusion, the optimal ultrasonic-assisted enzymolysis technology conditions described in this paper, appear to be beneficial for preparing peanut antioxidant hydrolysate. |
| Posted: 20 Jul 2012 12:00 AM PDT A simple and reliable method of ultra-performance liquid chromatography with photodiode array detector (UPLC-PDA) was developed to control the quality of Radix Isatidis (dried root of Isatis indigotica) for chemical fingerprint analysis and quantitative analysis of eight bioactive constituents, including R,S-goitrin, progoitrin, epiprogoitrin, gluconapin, adenosine, uridine, guanosine, and hypoxanthine. In quantitative analysis, the eight components showed good regression (R > 0.9997) within test ranges, and the recovery method ranged from 99.5% to 103.0%. The UPLC fingerprints of the Radix Isatidis samples were compared by performing chemometric procedures, including similarity analysis, hierarchical clustering analysis, and principal component analysis. The chemometric procedures classified Radix Isatidis and its finished products such that all samples could be successfully grouped according to crude herbs, prepared slices, and adulterant Baphicacanthis cusiae Rhizoma et Radix. The combination of quantitative and chromatographic fingerprint analysis can be used for the quality assessment of Radix Isatidis and its finished products. |
| Posted: 20 Jul 2012 12:00 AM PDT Seven new sesquiterpenoids, lochmolins A–G (1–7), were isolated from a Taiwanese soft coral Sinularia lochmodes. The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds 1–4 were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protein in RAW264.7 macrophage cells. |
| Posted: 19 Jul 2012 08:02 PM PDT Platform: Flash —  A nice piece of interactive art, The Little Girl Nobody Liked is a picture-perfect picture book minigame by Deirdra Kiai. Even with all its multiple endings, it only clocks in at a couple minutes in length. Still, it's soothing, adorable, and subversive, and is just the thing to check out before an afternoon nap. Tagged as: browser, dkia, flash, free, game, ifiction, interactiveart, linux, mac, minigame, rating-g, windows |
| Final Fantasy creator releases iOS game Posted: 19 Jul 2012 10:01 PM PDT Hironobu Sakaguchi surfing game Party Wave is on iTunes for $1.99. Final Fantasy creator Hironobu Sakaguchi's latest game under his studio Mistwalker Corporation is now available. Party Wave, billed as an action game featuring sea surfing, is now on the iOS platform for $1.99 on iTunes. The game's objective is to lead a number of surfers to a surf spot, and then make them surf as long as possible without getting knocked out by obstructions, like coral and sea turtles. Players guide the surfers by touching them on the iPhone or iPad's touchscreen. Mistwalker's most recent game on consoles was The Last Story. The Japanese version came out last year; the North American version is slated to be out this August. For more information, check out GameSpot's review and recent article. Read and Post Comments | Get the full article at GameSpot "Final Fantasy creator releases iOS game" was posted by Jonathan Toyad on Thu, 19 Jul 2012 22:01:52 -0700 |
| The trials of Hoodwink's development cycle Posted: 19 Jul 2012 09:48 PM PDT We spoke to executive producer Amir Irwan about the development process and starting up E-One Studio.
Get the full article at GameSpot "The trials of Hoodwink's development cycle" was posted by Jonathan Toyad on Thu, 19 Jul 2012 21:48:13 -0700 |
| Posted: 19 Jul 2012 09:09 PM PDT The community encourages us to rack up a zombie kill count and try to fix a car, but a rolling start doesn't always mean you're better equipped. Sometimes, the bare basics are what you have to rely on to stand a chance. Follow GameSpot_AU on Twitch!
Read and Post Comments | Get the full article at GameSpot "DayZ Diaries - Part 4" was posted by edmondt on Thu, 19 Jul 2012 21:09:05 -0700 |
| Hatsune Miku PS Vita bundle available in Asia this August Posted: 19 Jul 2012 08:33 PM PDT Bundle to come with rhythm game, AR card, and green-white trooper pack.
 Gamers residing in Asia may not need to spend so much on importing the upcoming Hatsune Miku PS Vita bundle, as Sony Computer Entertainment Hong Kong will be selling it on Asian shores. The bundle will arrive on August 30, which is the same date that the PS Vita version of rhythm game Hatsune Miku: Project DIVA F will come out. For S$588 ($469), fans will get the game, a crystal white PS Vita with a custom Hatsune Miku design, a Hatsune Miku-themed protective film, a green-white trooper pack bag, a Hatsune Miku-themed AR card, and a 4GB memory card. The upcoming PS Vita game is the next iteration in the Hatsune Miku rhythm game series. New features include the scratch feature, where inputs can be made using the Vita's rear touchpad, and new costume designs to dress up the in-game singing idols. Read and Post Comments | Get the full article at GameSpot "Hatsune Miku PS Vita bundle available in Asia this August" was posted by Jonathan Toyad on Thu, 19 Jul 2012 20:33:33 -0700 |
| Big in Japan July 9-15: Time Travelers Posted: 19 Jul 2012 08:21 PM PDT Vita and 3DS versions of the Level-5 adventure title debuted at the bottom of the top 10; Pokemon Black/White 2 is still on top.
Even with the release of Level-5's adventure game Time Travelers, Pokemon Black and White 2 is still holding on to its top position in the recent Media Creates sales update for the week of July 9 to 15, selling 122,242 units and pushing its total sales to more than 2 million units. Time Travelers made its entrance at the lower part of the top 10. The PS Vita version was in eighth place, with 9332 units sold, while the 3DS version capped off the bottom part of the top 10, with 9054 units sold. The adventure game puts players in the shoes of multiple protagonists linked together by a catastrophe called the Lost Hole incident from 18 years ago in an alternate version of Tokyo. While the game is also for the PSP, that version will only be on sale from July 19. Other newcomers in the chart include the next entry in the Namco Bandai rhythm game Taiko no Tatsujin. The 3DS version, subtitled "Chibi Dragon to Fushiga no Orb", was in second place, with 65,462 units sold. Nintendo's first 3DS soccer game, Pocket Soccer League: Calcio Bit, was in third place, with 26,449 units sold. Former top-spot holders Atelier Ayesha and Persona 4: The Golden resided below the top 10, with the former at 12th place, and 6813 units sold, and the latter at 15th place, with 6001 units sold. The PS3 version of Anarchy Reigns did not last long in the top 10, either; the game was in 16th place, with 5717 units sold. In terms of recent hardware sales, the 3DS was still on top, with 47,063 units sold, while the PS3 trailed behind at 14,813 units. Sony's two handheld systems were still above the 10,000 unit mark; the PS Vita was at 13,427 units, while the PSP was at 11,004 units. Top Japan game sales of July 9-15 Software Hardware Read and Post Comments | Get the full article at GameSpot "Big in Japan July 9-15: Time Travelers" was posted by Jonathan Toyad on Thu, 19 Jul 2012 20:21:02 -0700 |
| Spotify 0.8.4.107 - Stream music, create playlists and more.. (Free) Posted: 19 Jul 2012 08:59 PM PDT  Spotify is a new way to enjoy music. Simply download and install, before you know it you'll be singing along to the genre, artist or song of your choice. With Spotify you are never far away from the song you want. There are no restrictions in terms of what you can listen to or when. Forget about the hassle of waiting for files to download and fill up your hard drive before you get round to organising them. Spotify is instant, fun and simple. Because music is social, Spotify allows you to share songs and playlists with friends, and even work together on collaborative playlists, Friday afternoon in the office might never be the same again! We're music lovers like everyone else. We want to connect millions of people with their favorite songs by creating a product that people love to use. We respect creativity and believe in fairly compensating artists for their work. We've cleared the rights to use the music you'll listen to in Spotify. Version 0.8.4.107: Release notes were unavailable when this listing was updated. Mac OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Black Omega 2.1.1 - High fidelity audio player.. (Demo) Posted: 19 Jul 2012 11:59 PM PDT  Black Omega is a high fidelity audio player guaranteed to render your music collection at bit perfect resolution. With over 14 years of personal research & development each audio decoder and output pathway has been fine tuned and perfected in order to seamlessly deliver a perfect audio stream. If you are an audiophile, like me, who has invested your time and money in purchasing the best DAC, amplifier and speakers so that you can listen to music with total clarity, variation and depth then Black Omega is the player for you. Features:
Version 2.1.1:
Download Now |
| You are subscribed to email updates from Games To stop receiving these emails, you may unsubscribe now. | Email delivery powered by Google |
| Google Inc., 20 West Kinzie, Chicago IL USA 60610 | |
Комментариев нет:
Отправить комментарий