Games |
- Kinect Playfit - Screenshots
- Kinect Fun Labs - Screenshots
- Sleipnir 3.5.0.3 - Gesture focused web browser.. (Free)
- Phantom Cine Toolkit 3.1.2620 - QuickTime codec for Vision Research Cameras.. (Demo)
- Sponsored: Hitman: Sniper Challenge racks up 32 million kills, death toll continues to rise (which is a good thing)
- Crystals, Vol. 2, Pages 996-1016: Theoretical Studies on Phase Transitions in Quasi-One-Dimensional Molecular Conductors
- IJMS, Vol. 13, Pages 9014-9034: Hepatoprotective Effects of Berberis vulgaris L. Extract/β Cyclodextrin on Carbon Tetrachloride–Induced Acute Toxicity in Mice
- Toxins, Vol. 4, Pages 554-567: Humanized-Single Domain Antibodies (VH/VHH) that Bound Specifically to Naja kaouthia Phospholipase A2 and Neutralized the Enzymatic Activity
- Marine Drugs, Vol. 10, Pages 1545-1565: Atypical Reactive Center Kunitz-Type Inhibitor from the Sea Anemone Heteractis crispa
- Minion Master - Screenshots
- Rocket Race - Screenshots
- Diskobolos - Screenshots
- Moonlight: Mistress of Mischief - Screenshots
- HueBrix - Screenshots
- Escape the Virus: Swarm Survival - Screenshots
- IJMS, Vol. 13, Pages 8998-9013: Homology Modeling and Analysis of Structure Predictions of the Bovine Rhinitis B Virus RNA Dependent RNA Polymerase (RdRp)
- IJMS, Vol. 13, Pages 8987-8997: Antioxidant Property Enhancement of Sweet Potato Flour under Simulated Gastrointestinal pH
- Membranes, Vol. 2, Pages 440-447: Molecularly Imprinted Membranes
- HandBrake 0.9.8 - Versatile video encoder; convert any source to MPEG-4 and more.. (Free)
- Capo 2.1.6 - Slow down and learn to play your favorite songs.. (Shareware)
Posted: 19 Jul 2012 04:25 AM PDT |
Posted: 19 Jul 2012 04:35 AM PDT Show Off and Share. Post your favorite photo and video moments through KinectShare.com to any number of social networking sites, such as Facebook, Twitter and YouTube. Player Capture Stand in front of the Kinect sensor to create real-you avatars to play with and share. From the clothes you're wearing to your hairstyle, Kinect will capture your likeness in ways you've never seen before. • Kinect Me. Build an avatar that looks just like you! Just stand in front of the Kinect sensor and your face, hair, clothes and voice will make up your lifelike avatar. Pose for a photo shoot or put together a personalized flip book. • Bobble Head. Using your imagination, the fun with Bobble Head is endless! With the player capture technology, you can transform yourself into a babbling bobblehead you can share with friends, throw around or place on a virtual car dashboard and make wobble any way you want. Object Scanning Scan your favorite objects to create virtual toys. Hold an item in front of the sensor and let Kinect instantly create a full, interactive 3-D model from it. • Build a Buddy. Bring your stuff to life! Scan any object, choose different characteristics, mix in your own voice and watch your buddy spring into action. Interact with your buddy and create goofy videos. • Kinect Googly Eyes. Make your own puppet show! Place googly eyes on any item, and use your movement and voice to give it a unique personality. Animate your new friend and tell a story. Finger Tracking and Background Removal This July, increased tracking precision will enable greater expression and creativity. Let your fingers take control, and manipulate the screen with any one — or all — of your digits. Enhanced background removal functionality ... |
Sleipnir 3.5.0.3 - Gesture focused web browser.. (Free) Posted: 19 Jul 2012 03:11 AM PDT Sleipnir web browser for Mac with Smartphone and Web App Linker Freely browsing the web without having to think about unnecessary things with the rich selection of functions in Sleipnir. With Sleipnir, you can experience web browsing never seen before such as the extremely simple design, and the powerful operations that can be easily performed with just one hand. WIth extremely speedy gestures you can operate tabs at high speed as if magic by using the multi-touch and mouse supported gesture [TouchPaging]. You do not need to do all your daily browsing by clicking the small buttons on the screen because you can perform gestures such as switching, going to previous, and closing tabs with just one hand. Main functions:
Version 3.5.0.3:
Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
Phantom Cine Toolkit 3.1.2620 - QuickTime codec for Vision Research Cameras.. (Demo) Posted: 19 Jul 2012 03:33 AM PDT Phantom Cine Toolkit allows Mac OS X and Applications to work with Vision Research Cine Movies. With this toolkit, Finder is fully aware of these files, including support for Spotlight, Previews, and basic QuickTime Playback. Other applications that are QuickTime aware, will also work with Phantom Cine Movie file format. Vision Research creates and manufactures high speed digital cameras that can capture imagery at several thousand frames a second. Version 3.1.2620:
Download Now This posting includes an audio/video/photo media file: Download Now |
Posted: 19 Jul 2012 03:35 AM PDT Since Hitman: Sniper Challenge went live on May 15, online assassins have notched up an impressive 32 million kills. And we're sure every single one of |
Posted: 19 Jul 2012 12:00 AM PDT A review is given for recent theoretical studies on phase transitions in quasi-one-dimensional molecular conductors with a quarter-filled band. By lowering temperature, charge transfer salts exhibit a variety of transitions accompanying symmetry breaking, such as charge ordering, lattice dimerization, antiferromagnetic transition, spin-Peierls distortion, and so on. Analyses on microscopic quasi-one-dimensional models provide their systematic understandings, by the complementary use of different analytical and numerical techniques; they can reproduce finite-temperature phase transitions, whose results can be directly compared with experiments and give feedbacks to material design. |
Posted: 19 Jul 2012 12:00 AM PDT The present study investigated the capacity of formulated Berberis vulgaris extract/β-cyclodextrin to protect liver against CCl4-induced hepatotoxicity in mice. Formulated and non-formulated extracts were given orally (50 mg/kg/day) to mice for 7 days and were then intra-peritoneally injected with 1.0 mL/kg CCl4 on the 8th day. After 24 h of CCl4 administration, an increase in the levels of apartate-amino-transferase (AST), alanine-amino-transferase (ALT) and malondialdehyde (MDA) was found and a significant decrease in superoxide-dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione-peroxidase (GPx) levels could be detected. This was accompanied by extended centrilobular necrosis, steatosis, fibrosis and an altered ultrastructure of hepatocytes. Pre-treatment with formulated or non-formulated extract suppressed the increase in ALT, AST and MDA levels and restored the level of antioxidant enzymes at normal values. Histopathological and electron-microscopic examination showed milder liver damage in both pre-treated groups and the protective effect was more pronounced after the formulated extract was administered. Internucleosomal DNA fragmentation induced by CCl4 was reduced in the group which received non-formulated extract and absent in the group which received formulated extract. Taken together, our results suggest that Berberis vulgaris/β-cyclodextrin treatment prevents hepatic injury induced by CCl4 and can be considered for further nutraceutical studies. |
Posted: 19 Jul 2012 12:00 AM PDT Naja kaouthia (monocled cobra) venom contains many isoforms of secreted phospholipase A2 (sPLA2). The PLA2 exerts several pharmacologic and toxic effects in the snake bitten subject, dependent or independent on the enzymatic activity. N. kaouthia venom appeared in two protein profiles, P3 and P5, after fractionating the venom by ion exchange column chromatography. In this study, phage clones displaying humanized-camel single domain antibodies (VH/VHH) that bound specifically to the P3 and P5 were selected from a humanized-camel VH/VHH phage display library. Two phagemid transfected E. coli clones (P3-1 and P3-3) produced humanized-VHH, while another clone (P3-7) produced humanized-VH. At the optimal venom:antibody ratio, the VH/VHH purified from the E. coli homogenates neutralized PLA2 enzyme activity comparable to the horse immune serum against the N. kaouthia holo-venom. Homology modeling and molecular docking revealed that the VH/VHH covered the areas around the PLA2 catalytic groove and inserted their Complementarity Determining Regions (CDRs) into the enzymatic cleft. It is envisaged that the VH/VHH would ameliorate/abrogate the principal toxicity of the venom PLA2 (membrane phospholipid catabolism leading to cellular and subcellular membrane damage which consequently causes hemolysis, hemorrhage, and dermo-/myo-necrosis), if they were used for passive immunotherapy of the cobra bitten victim. The speculation needs further investigations. |
Posted: 19 Jul 2012 12:00 AM PDT The primary structure of a new Kunitz-type protease inhibitor InhVJ from the sea anemone Heteractis crispa (Radianthus macrodactylus) was determined by protein sequencing and cDNA cloning. InhVJ amino acid sequence was shown to share high sequence identity (up to 98%) with the other known Kunitz-type sea anemones sequences. It was determined that the P1 Thr at the reactive site resulted in a decrease of the Ki of InhVJ to trypsin and α-chymotrypsin (7.38 × 10−8 M and 9.93 × 10−7 M, respectively). By structure modeling the functional importance of amino acids at the reactive site as well as at the weak contact site were determined. The significant role of Glu45 for the orientation and stabilization of the InhVJ-trypsin complex was elucidated. We can suggest that there has been an adaptive evolution of the P1 residue at the inhibitor reactive site providing specialization or functional diversification of the paralogs. The appearance of a key so-called P1 Thr residue instead of Lys might lead to refinement of inhibitor specificity in the direction of subfamilies of serine proteases. The absence of Kv channel and TRPV1-receptor modulation activity was confirmed by electrophysiological screening tests. |
Posted: 19 Jul 2012 03:44 AM PDT Minion Master will boast a Deck Builder, 6 player co-op and versus multiplayer, a Level Editor, and a constantly expanding universe of Minions to control. Players who pre-order get instant access to the game's Alpha and Beta phases. Inspired by physical RPG board and card games whilst simultaneously adding in elements that are only possible in a virtual world. |
Posted: 19 Jul 2012 04:03 AM PDT Build the perfect rocket and then test it out on the launch pad. The goal of the game is to achieve the greatest distance. With 15 body styles, 10 rocket engines and 10 steering fins, you have lots of possibilities. Each rocket you build has attributes such as Fuel Capacity, Thrust, Control and Weight which all affect the way your rocket will fly! |
Posted: 19 Jul 2012 03:54 AM PDT Master 50 challenging missions to unlock perks like an aim assistant or an extra life. Start the high score hunt and challenge players all over the world to lead "THE List" and become the "Diskobolos champion". Game highlights - Arcade - Go on the hunt for the high score and challenge players from all over the world. Only one can be on THE list's top spot. - Depth- Skill is everything. Only players who figure out the complex high score system behind the gameplay, can max-out their score multiplier. - Content - 50 challenging missions require players to change their play style again and again in order to unlock all extras and achievements. - Variety - Use different items like the Power Disk, Slow Motion, or the screen clearing Interrupt to handle risky situations. - Individuality - Use up to four different perks like an aim assistant or a lifesaving Firewall to fit your individual play style. |
Moonlight: Mistress of Mischief - Screenshots Posted: 19 Jul 2012 03:25 AM PDT Features - Grid-based, puzzle gameplay with light stealth elements. - Two different castles, the Treasure Temple and the Frost Fortress, each with their own environmental hazards and enemy types. - 10 levels with unique puzzles and an ever-increasing repertoire of gameplay variation. |
Posted: 19 Jul 2012 03:36 AM PDT The rules are simple, your colored pathways can't cross each other and the entire grid must be filled on each level. Sounds easy? Forget it, each level will have a variety of challenging spaces placed on the grid, forcing your pathways to move in one direction, stop completely, or wrap around the screen to the other side. You may call them obstacles, but a true person of hubris would call them helpful clues to completing the puzzle! HUEBRIX starts easy, as any good puzzle should, but as you wind your way through over 100 levels you're going to start to sweat, we guarantee it. Best of all, you can download over 300 additional puzzles, each categorized by difficulty, just in case you need a little more practice in 'intermediate' level audacity. Conquer the super challenging modes and declare yourself smarter than all of your friends, or better yet, use our built in level editor to create your own mind twisting puzzles and share them with everyone! |
Escape the Virus: Swarm Survival - Screenshots Posted: 19 Jul 2012 03:17 AM PDT |
Posted: 19 Jul 2012 12:00 AM PDT Bovine Rhinitis B Virus (BRBV) is a picornavirus responsible for mild respiratory infection of cattle. It is probably the least characterized among the aphthoviruses. BRBV is the closest relative known to Foot and Mouth Disease virus (FMDV) with a ~43% identical polyprotein sequence and as much as 67% identical sequence for the RNA dependent RNA polymerase (RdRp), which is also known as 3D polymerase (3Dpol). In the present study we carried out phylogenetic analysis, structure based sequence alignment and prediction of three-dimensional structure of BRBV 3Dpol using a combination of different computational tools. Model structures of BRBV 3Dpol were verified for their stereochemical quality and accuracy. The BRBV 3Dpol structure predicted by SWISS-MODEL exhibited highest scores in terms of stereochemical quality and accuracy, which were in the range of 2Å resolution crystal structures. The active site, nucleic acid binding site and overall structure were observed to be in agreement with the crystal structure of unliganded as well as template/primer (T/P), nucleotide tri-phosphate (NTP) and pyrophosphate (PPi) bound FMDV 3Dpol (PDB, 1U09 and 2E9Z). The closest proximity of BRBV and FMDV 3Dpol as compared to human rhinovirus type 16 (HRV-16) and rabbit hemorrhagic disease virus (RHDV) 3Dpols is also substantiated by phylogeny analysis and root-mean square deviation (RMSD) between C-α traces of the polymerase structures. The absence of positively charged α-helix at C terminal, significant differences in non-covalent interactions especially salt bridges and CH-pi interactions around T/P channel of BRBV 3Dpol compared to FMDV 3Dpol, indicate that despite a very high homology to FMDV 3Dpol, BRBV 3Dpol may adopt a different mechanism for handling its substrates and adapting to physiological requirements. Our findings will be valuable in the design of structure-function interventions and identification of molecular targets for drug design applicable to Aphthovirus RdRps. |
Posted: 19 Jul 2012 12:00 AM PDT Sweet potato is known to be rich in healthful antioxidants, but the stability of its antioxidant properties under gastrointestinal pH is very much unknown. Hence, this study aimed to evaluate the changes in antioxidant properties (total contents of phenolics and flavonoids as well as antioxidant activity) of sweet potato flour (SPF) under simulated gastrointestinal pH conditions. It was found that the yield of SPF crude phenolic extract increased from 0.29 to 3.22 g/100 g SPF upon subjection to gastrointestinal pH conditions (p < 0.05). Also elevated significantly were the total phenolic content (TPC), total flavonoid content (TFC) and antioxidant activity of SPF (p < 0.05). In summary, the antioxidant properties of SPF were enhanced under gastrointestinal pH conditions, suggesting that SPF might possess a considerable amount of bound phenolic and other antioxidative compounds. The antioxidant properties of SPF are largely influenced by pH and thus might be enhanced during the in vivo digestive process. |
Membranes, Vol. 2, Pages 440-447: Molecularly Imprinted Membranes Posted: 19 Jul 2012 12:00 AM PDT Although the roots of molecularly imprinted polymers lie in the beginning of 1930s in the past century, they have had an exponential growth only 40–50 years later by the works of Wulff and especially by Mosbach. More recently, it was also proved that molecular imprinted membranes (i.e., polymer thin films) that show recognition properties at molecular level of the template molecule are used in their formation. Different procedures and potential application in separation processes and catalysis are reported. The influences of different parameters on the discrimination abilities are also discussed. |
HandBrake 0.9.8 - Versatile video encoder; convert any source to MPEG-4 and more.. (Free) Posted: 18 Jul 2012 08:59 PM PDT HandBrake is a GPL'd multiplatform, multithreaded video encoding tool. Supported Sources:
Version 0.9.8:
Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
Capo 2.1.6 - Slow down and learn to play your favorite songs.. (Shareware) Posted: 18 Jul 2012 08:59 PM PDT Capo is a musician's best friend. It lets you slow down your favorite songs, so you can hear the notes and learn how they are played. And, you can tab out your songs in record time atop a highly-detailed OpenCL-powered spectrogram display! It's your music Tab it out! Detect, and enter chords Pitch adjustment Markers Looping Music Export Effects Version 2.1.6:
Mac OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
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