Games |
- AddressBook Cleaner 1.223 - Find and remove duplicate contacts from Address Book.. (Shareware)
- QSnipps 1.7.0 - Store and organize your favorite program snippets.. (Shareware)
- Vertigo 3.2 - Synth with 256 oscillators and sound morphing.. (Demo)
- RapidBot 1.0.1 - A page indexing utility for RapidWeaver.. (Demo)
- IJMS, Vol. 13, Pages 2769-2782: All-Trans Retinoic Acid Treatment Is Associated with Prohibitin Expression in Renal Interstitial Fibrosis Rats
- IJMS, Vol. 13, Pages 2763-2768: Isolation and Characterization of Polymorphic Microsatellite Loci from Metapenaeopsis barbata Using PCR-Based Isolation of Microsatellite Arrays (PIMA)
- IJMS, Vol. 13, Pages 2744-2762: Genome-Wide Analysis of a TaLEA-Introduced Transgenic Populus simonii × Populus nigra Dwarf Mutant
- Cancers, Vol. 4, Pages 244-256: Diagnostic Value of 11C-Methionine (MET) and 18F-Fluorothymidine (FLT) Positron Emission Tomography in Recurrent High-Grade Gliomas; Differentiation from Treatment-Induced Tissue Necrosis
- Molecules, Vol. 17, Pages 2491-2517: Sulfur-Functionalized N-Heterocyclic Carbene Complexes of Pd(II): Syntheses, Structures and Catalytic Activities
- Molecules, Vol. 17, Pages 2474-2490: Fluorescence-Based Multiplex Protein Detection Using Optically Encoded Microbeads
- Molecules, Vol. 17, Pages 2464-2473: SnCl2/TiCl3-Mediated Deoximation of Oximes in an Aqueous Solvent
- Tory Lord tells peers about a weird Internet scam at great length
- Ken MacLeod's Intrusion: a surveillance and bioscience dystopia with the best of intentions
- Polymers, Vol. 4, Pages 747-758: Antibacterial Activity of Four Human Beta-Defensins: HBD-19, HBD-23, HBD-27, and HBD-29
- Toxins, Vol. 4, Pages 157-190: The Interactions of Human Neutrophils with Shiga Toxins and Related Plant Toxins: Danger or Safety?
- The HotSpot - Mass Effect 3 - 2/29/12
- Entropy, Vol. 14, Pages 456-479: The Mathematical Structure of Information Bottleneck Methods
- Applied Sciences, Vol. 2, Pages 175-191: Self-Assembled Fluorinated Organogelators for Surface Modification
- Applied Sciences, Vol. 2, Pages 166-174: Reduction and Immobilization of Potassium Permanganate on Iron Oxide Catalyst by Fluidized-Bed Crystallization Technology
- Applied Sciences, Vol. 2, Pages 160-165: Scaling Law for Photon Transmission through Optically Turbid Slabs Based on Random Walk Theory
| AddressBook Cleaner 1.223 - Find and remove duplicate contacts from Address Book.. (Shareware) Posted: 01 Mar 2012 03:03 AM PST  AddressBook Cleaner is created for cleanup of Address Book on Mac to avoid duplicated contacts. Keep Address Book clean and contacts identical. Sometimes the sync process is going wrong somewhere along the line and creating duplicate lists of some contacts to build up. You need to take time to find out and delete the duplicated contacts by hand. AddressBook Cleaner is exactly such utility to help you find out all the contacts match the predefined fields, and mark the ones to be thrown, what you need to do is just run the application and perform simple clicks. Simple collation Automatically finding out repeated phone numbers and email addresses of contacts, and auto mark redundant ones to be deleted. Version 1.223:
Mac OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| QSnipps 1.7.0 - Store and organize your favorite program snippets.. (Shareware) Posted: 01 Mar 2012 02:55 AM PST  QSnipps helps you avoid wasting valuable time searching for re-usable pieces of code in your previous projects. Use QSnipps to store and organize all your favorite programming snippets. It doesn't matter if you're a Mac OS X or a Window OS user. QSnipps runs without a problem on both platforms. Sharing your snippets database across all your PC's or Mac's is very simple, because QSnipps has support for Dropbox, Live Mesh or any other similar software. Using QSearch, a small search window - part of QSnipps - that stays on top of all the other opened windows, it's really fast and easy to find and use the snippet you were looking for. Starting with version 1.7 Snipplr integration was added. Version 1.7.0:
Mac OS X 10.6.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Vertigo 3.2 - Synth with 256 oscillators and sound morphing.. (Demo) Posted: 01 Mar 2012 03:00 AM PST  Vertigo Mac is a 256 oscillators additive synth with resynthesis and sound morphing. Imports WAV audio and PNG images. It has a very accurate recreation of complex musical phrases, drumloops, speech and simple tones. Includes 128 presets. Version 3.2:
Audio Units, VST, RTAS host app. Download Now This posting includes an audio/video/photo media file: Download Now |
| RapidBot 1.0.1 - A page indexing utility for RapidWeaver.. (Demo) Posted: 01 Mar 2012 03:07 AM PST  RapidBot is the incredibly easy tool designed to create a robots.txt file for your site directly from RapidWeaver. Robots.txt file is retrieved by search engines, like Google and Bing, and used to state what pages need indexing and what must be ignored. A robot (also known as Spider or Web Crawler) is a program that automatically traverses the web's hypertext structure by retrieving a document and recursively retrieving all documents that are referenced. Don't forget that instructing search engines bots help you adding visibility to your site and let people reach you in a more efficient way excluding irrelevant contents. Only if search engines know what to do with your pages, they can give you a good ranking. RapidBot is a must-have SEO tool! Version 1.0.1:
Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 01 Mar 2012 12:00 AM PST This study was performed to investigate the association of prohibitin with renal interstitial fibrosis (RIF) lesion and to explore the association of all-trans retinoic acid (ATRA) treatment with prohibitin expression in RIF rats. Rats were divided into three groups: the sham operation group (SHO), the model group subjected to unilateral ureteral obstruction (UUO), and the model group treated with ATRA (GA). Renal tissues were collected at 14 and 28 days after surgery, and the relevant indicators were detected. In comparison with the SHO group, the RIF index in the UUO group was markedly elevated (p < 0.01), and the RIF index in the GA group was alleviated compared with that in the UUO group (p < 0.01). Compared with the SHO group, the expression of prohibitin (protein or mRNA) in the UUO group was significantly reduced (each p < 0.01). Prohibitin expression in the GA group was markedly increased when compared with that in the UUO (p < 0.01). The expression of TGF-β1 (protein and mRNA), protein expressions of Col-IV, fibronectin, α-SMA and cleaved Caspase-3, ROS generation and cell apoptosis index in the UUO group were markedly higher than those in the SHO group (all p < 0.01), and their expressions in the GA group were markedly down-regulated compared to those in the UUO group (all p < 0.01, respectively). The protein expression of prohibitin was negatively correlated with the RIF index, protein expression of TGF-β1, Col-IV, fibronectin, α-SMA or cleaved Caspase-3, ROS generation and the cell apoptosis index (each p < 0.01). In conclusion, lower expression of prohibitin is associated with the RIF, and ATRA treatment is associated with increased prohibitin, which can prevent the progression of RIF. |
| Posted: 01 Mar 2012 12:00 AM PST The red-spot prawn, Metapenaeopsis barbata, is a commercially important, widely distributed demersal species in the Indo-West Pacific Ocean. Overfishing has made its populations decline in the past decade. To study conservation genetics, eight polymorphic microsatellite loci were isolated. Genetic characteristics of the SSR (simple sequence repeat) fingerprints were estimated in 61 individuals from adjacent seas of Taiwan and China. The number of alleles, ranging from 2 to 4, as well as observed and expected heterozygosities in populations, ranging from 0.048 to 0.538, and 0.048 and 0.654, respectively, were detected. No deviation from Hardy–Weinberg expectations was detected at either locus. No significant linkage disequilibrium was detected in locus pairs. The polymorphic microsatellite loci will be useful for investigations of the genetic variation, population structure, and conservation genetics of this species. |
| Posted: 01 Mar 2012 12:00 AM PST A dwarf mutant (dwf1) was obtained among 15 transgenic lines, when TaLEA (Tamarix androssowii late embryogenesis abundant gene) was introduced into Populus simonii × Populus nigra by Agrobacterium tumefaciens-mediated transformation. Under the same growth conditions, dwf1 height was significantly reduced compared with the wild type and the other transgenic lines. Because only one transgenic line (dwf1) displayed the dwarf phenotype, we considered that T-DNA insertion sites may play a role in the mutant formation. The mechanisms underlying this effect were investigated using TAIL-PCR (thermal asymmetric interlaced PCR) and microarrays methods. According to the TAIL-PCR results, two flanking sequences located on chromosome IV and VIII respectively, were cloned. The results indicated the integration of two independent T-DNA copies. We searched for the potential genes near to the T-DNA insertions. The nearest gene was a putative poplar AP2 transcription factor (GI: 224073210). Expression analysis showed that AP2 was up-regulated in dwf1 compared with the wild type and the other transgenic lines. According to the microarrays results, a total of 537 genes involved in hydrolase, kinase and transcription factor activities, as well as protein and nucleotide binding, showed significant alterations in gene expression. These genes were expressed in more than 60 metabolic pathways, including starch, sucrose, galactose and glycerolipid metabolism and phenylpropanoids and flavonoid biosyntheses. Our transcriptome and T-DNA insertion sites analyses might provide some useful insights into the dwarf mutant formation. |
| Posted: 01 Mar 2012 12:00 AM PST We retrospectively evaluated the usefulness of combined measurement of L-methyl-[11C]methionine (MET) and 3'-deoxy-3'-[18F]fluorothymidine (FLT) positron emission tomography (PET) in the differential diagnosis between recurrent gliomas and necrotic lesions. Twenty-one patients with high-grade glioma, previously treated with surgery and radiotherapy with chemotherapy and first radiological suspicion of recurrence were enrolled. The uptake was assessed by the maximum standardized uptake value (SUVmax) and lesion-to-normal tissue count density ratio (L/N ratio). Of the 21 lesions, 15 were diagnosed recurrent gliomas and six were necrotic lesions. The average SUVmax was not significantly different between recurrent gliomas and necrotic lesions on either MET-PET or FLT-PET. The average L/N ratio of recurrent gliomas (3.36 ± 1.06) was significantly higher than that of necrotic lesions (2.18 ± 0.66) on MET-PET (p < 0.01) and the average L/N ratio of recurrent gliomas (7.01 ± 2.26) was also significantly higher than that of necrotic lesions (4.60 ± 1.23) on FLT-PET (p < 0.01). ROC curve analysis showed that the areas under the curves were high but not different between MET- and FLT-PET. PET studies using MET and FLT are useful in the differentiation of recurrent glioma from treatment-induced necrotic lesion. However, there is no complementary information in the differentiation with simultaneous measurements of MET- and FLT-PET. |
| Posted: 01 Mar 2012 12:00 AM PST N-heterocyclic carbenes (NHCs) can be easily modified by introducing functional groups at the nitrogen atoms, which leads to versatile coordination chemistry as well as diverse catalytic applications of the resulting complexes. This article summarizes our contributions to the field of NHCs bearing different types of sulfur functions, i.e., thioether, sulfoxide, thiophene, and thiolato. The experimental evidence for the truly hemilabile coordination behavior of a Pd(II) thioether-NHC complex has been reported as well. In addition, complexes bearing rigid CSC-pincer ligands have been synthesized and the reasons for pincer versus pseudo-pincer formation investigated. Incorporation of the electron-rich thiolato function resulted in the isolation of structurally diverse complexes. The catalytic activities of selected complexes have been tested in Suzuki-Miyaura, Mizoroki-Heck and hydroamination reactions. |
| Posted: 01 Mar 2012 12:00 AM PST Potential utilization of proteins for early detection and diagnosis of various diseases has drawn considerable interest in the development of protein-based multiplex detection techniques. Among the various techniques for high-throughput protein screening, optically-encoded beads combined with fluorescence-based target monitoring have great advantages over the planar array-based multiplexing assays. This review discusses recent developments of analytical methods of screening protein molecules on microbead-based platforms. These include various strategies such as barcoded microbeads, molecular beacon-based techniques, and surface-enhanced Raman scattering-based techniques. Their applications for label-free protein detection are also addressed. Especially, the optically-encoded beads such as multilayer fluorescence beads and SERS-encoded beads are successful for generating a large number of coding. |
| Posted: 01 Mar 2012 12:00 AM PST A simple procedure for SnCl2/TiCl3-mediated deoximation of ketoximes in an aqueous solvent is reported. Under the conditions developed in this effort, various ketones and aldehydes are produced in good to excellent yields. |
| Tory Lord tells peers about a weird Internet scam at great length Posted: 01 Mar 2012 01:51 AM PST
On February 16th, Lord David James of Blackheath (a Conservative life peer) spoke for 11 minutes in the UK House of Lords about a supposed $15 trillion federal reserve conspiracy that involved more gold than has ever been mined. It turned out he had fallen for a widespread scam.
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| Ken MacLeod's Intrusion: a surveillance and bioscience dystopia with the best of intentions Posted: 01 Mar 2012 01:27 AM PST Set in North London, Intrusion begins with the story of Hope, a mother who has become a pariah because she won't take "the fix," a pill that repairs known defects in a gestating fetus's genome. Hope has a "natural" toddler and is pregnant with her second, and England is in the midst of a transition from the fix being optional to being mandatory for anyone who doesn't have a "faith-based" objection. Hope's objection isn't based on religion, and she refuses to profess a belief she doesn't have, and so the net of social services and laws begins to close around her. MacLeod widens the story from Hope, and her husband Hugh (a carpenter working with carbon-sequestering, self-forming "New Wood") who has moved to London from an independent Scotland, and whose childhood hides a series of vivid hallucinations of ancient people from the Ice Age-locked past. Soon we're learning about the bioscientists who toil to improve the world's genomes, the academics who study their work, the refuseniks who defy the system in small and large ways, and the Naxals, city-burning wreckers who would obliterate all of society. The Naxals, along with a newly belligerent India and Russia, are a ready-made excuse for a war-on-terror style crackdown on every corner of human activity that includes ubiquitous CCTV, algorithmic behavior monitors, and drones in every corner of the sky. With Intrusion, MacLeod pays homage to Orwell, showing us how a society besotted with paternalistic, Cass Sunstein-style "nudging" of behavior can come to the same torturing, authoritarian totalitarianism of brutal Stalinism. MacLeod himself is a Marxist who is lauded by libertarians, and his unique perspective, combined with a flair for storytelling, yields up a haunting, gripping story of resistance, terror, and an all-consuming state that commits its atrocities with the best of intentions. |
| Posted: 01 Mar 2012 12:00 AM PST Human β-defensins (HBD) are a family of small antimicrobial peptides that play important roles in the innate and adaptive immune defenses against microbial infection. In this study, we predicted the mature sequences and assessed the antibacterial properties of synthetic HBD-19, HBD-23, HBD-27, and HBD-29 against three species of clinically relevant bacteria: Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. We also examined the cytotoxicity of each β-defensin to human cells. HBD-19 exhibited modest antibacterial effects against E. coli and S. aureus but had little effect on the growth of P. aeruginosa. HBD-23 exhibited substantial antibacterial effects against all three bacterial species and was particularly potent against the Gram-negative species, E. coli and P. aeruginosa. HBD-27 exerted modest antibacterial activity only towards S. aureus while HBD-29 had modest antibacterial activity for E. coli and P. aeruginosa. HBD-23 and HBD-27 showed little or no toxicity to human peripheral blood mononuclear cells, while HBD-19 and HBD-29 decreased cell viability by 20% at 30 μg/mL. |
| Posted: 01 Mar 2012 12:00 AM PST Shiga toxins and ricin are well characterized similar toxins belonging to quite different biological kingdoms. Plant and bacteria have evolved the ability to produce these powerful toxins in parallel, while humans have evolved a defense system that recognizes molecular patterns common to foreign molecules through specific receptors expressed on the surface of the main actors of innate immunity, namely monocytes and neutrophils. The interactions between these toxins and neutrophils have been widely described and have stimulated intense debate. This paper is aimed at reviewing the topic, focusing particularly on implications for the pathogenesis and diagnosis of hemolytic uremic syndrome. |
| The HotSpot - Mass Effect 3 - 2/29/12 Posted: 29 Feb 2012 05:04 PM PST Mass Effect 3 executive producer Casey Hudson makes his triumphant return to The HotSpot to talk about closing out Commander Shepard's trilogy. Read and Post Comments | Get the full article at GameSpot "The HotSpot - Mass Effect 3 - 2/29/12" was posted by tom on Wed, 29 Feb 2012 17:04:49 -0800 |
| Entropy, Vol. 14, Pages 456-479: The Mathematical Structure of Information Bottleneck Methods Posted: 01 Mar 2012 12:00 AM PST Information Bottleneck-based methods use mutual information as a distortion function in order to extract relevant details about the structure of a complex system by compression. One of the approaches used to generate optimal compressed representations is by annealing a parameter. In this manuscript we present a common framework for the study of annealing in information distortion problems. We identify features that should be common to any annealing optimization problem. The main mathematical tools that we use come from the analysis of dynamical systems in the presence of symmetry (equivariant bifurcation theory). Through the compression problem, we make connections to the world of combinatorial optimization and pattern recognition. The two approaches use very different vocabularies and consider different problems to be "interesting". We provide an initial link, through the Normalized Cut Problem, where the two disciplines can exchange tools and ideas. |
| Posted: 01 Mar 2012 12:00 AM PST A new class of alkyl- and perfluoroalkyl-containing urea and amide derivatives was synthesized from amino acid derivatives. Most of these compounds showed excellent gelation behavior in organic solvents at low concentrations. A few organogelators selected from the initial screening were used for surface modification of fibrous substrates to create hydrophobic and oleophobic composites. The hydrophobic and oleophobic behaviors of these composites were ascribed to a combination of increased surface roughness and the alkyl/fluorinated functionalities present in the gelator backbone. |
| Posted: 01 Mar 2012 12:00 AM PST A manganese immobilization technology in a fluidized-bed reactor (FBR) was developed by using a waste iron oxide (i.e., BT-3) as catalyst which is a by-product from the fluidized-bed Fenton reaction (FBR-Fenton). It was found that BT-3 could easily reduce potassium permanganate (KMnO4) to MnO2. Furthermore, MnO2 could accumulate on the surface of BT-3 catalyst to form a new Fe-Mn oxide. Laboratory experiments were carried out to investigate the KMnO4-reduction mechanism, including the effect of KMnO4 concentration, BT-3 dosage, and operational solution pH. The results showed that the pH solution was a significant factor in the reduction of KMnO4. At the optimum level, pHf 6, KMnO4 was virtually reduced in 10 min. A pseudo-first order reaction was employed to describe the reduction rate of KMnO4. |
| Posted: 01 Mar 2012 12:00 AM PST Past work has demonstrated the value of a random walk theory (RWT) to solve multiple-scattering problems arising in numerous contexts. This paper's goal is to investigate the application range of the RWT using Monte Carlo simulations and extending it to anisotropic media using scaling laws. Meanwhile, this paper also reiterates rules for converting RWT formulas to real physical dimensions, and corrects some errors which appear in an earlier publication. The RWT theory, validated by the Monte Carlo simulations and combined with the scaling law, is expected to be useful to study multiple scattering and to greatly reduce the computation cost. |
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