понедельник, 26 марта 2012 г.

Games

Games

Find Any File 1.8 - Search your disks for files using various criteria.. (Shareware)

Posted: 25 Mar 2012 04:57 PM PDT



Find Any File searches your local disks for files by name, creation or modification date, size, or type and creator code (not by content, though).

As there are other tools with a similar search operation, here are the special features unique to Find Any File:

  • Has a new hierarchical view of the found items, making it much easier to browse 100s of items (see the screenshot).
  • Can run as root user, finding really any file on your disk, even those that are hidden from normal users.
  • Can save queries and run them again later.

Unlike Spotlight (i.e. the Finder's Find command), it does not access a pre-built database but searches the chosen volume directly. This allows you to find any file, even those inside packages and others excluded from Spotlight search. Hence it is great for finding system files, for example.

On the other hand, it may take a little longer than Spotlight, and it is only fast on HFS(+) volumes. But even on mounted network volumes of a Mac OS X server it can still be surprisingly fast.

Hence, this is not an entire replacement for Spotlight but it can come handy in certain, if not many, situations.

Version 1.8: New Features

  • Lots of new search criteria:
    • Name matches pattern: Lets you enter wildcards. Use "*" as a "don't care" placeholder. Examples: Looking for "*.pdf" finds all ending in ".pdf", looking for "Invoice*2011*" finds all that start with "invoice" and thereafter contain "2011".
    • Name contains words: Matches only file names that contain the given word(s). E.g. looking for "mac" would find "Mac OS.pdf" but not "Macintosh.pdf". You may enter multiple word in one line, separated by spaces.
    • Case sensitive: If set to "Yes", the case of entered names is matched for the search as well.
    • Label: Find specific labels. To find all items with any label, use "Label - equals - None" along with "Negate conditions - is true".
    • Pass Results to and Limit Amount: Passes the found items to the specified app instead of showing them in a window.
    • Folder Depth: Limits the search depth (also forces a "slow" recursive search).
    • It's possible to limit the search to visible, non-package and non-trashed items. When performing a "fast" search, these only set the display options, while with "slow" searches they actually avoid hidden folders and contents of packages and the trash, which makes "slow" searches faster, especially on network volumes.
  • New right-click options for found items:
    • Open With .... Works even with folders - you can open the folder in Terminal.app with it, for instance.
    • Labels can be set and cleared.
    • Make Visible and Make Invisible. Note that this works only with items whose names do not start with a period (".").
  • Items that are in the Trash can be hidden from the results.
Improvements
  • The Copy menu command on found items works now like the Finder's. For instance, you can then perform â

    Mac OS X 10.4.1 or later

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Advanced Mac Mailer 4.19 - Mailer for businesses.. (Shareware)

Posted: 26 Mar 2012 02:51 AM PDT



Advanced Mac Mailer - Effective communications are essential for business success. It is very beneficial to keep your business contacts promptly notified of such things as new products they might be interested in, complimenting offers or other updates. Email as a communication medium presents the most lucrative opportunities. Of course, if you have hundreds or thousands of clients, it is impossible to write a personal message to every one. You must also maintain a list of subscribers changing, adding and removing them as necessary. This becomes very hard even when you consider a list of a few thousand people. Advanced Mac Mailer certainly improves things drastically since it allows you to handle multiple lists with unlimited number of subscribers in each list, and any number of recipient fields used together with customer email address for message personalization. If you use a conventional email client to send your messages, it's a hit or miss situation whether or not your emails are actually delivered. The delivery depends on a multitude of factors some of which are within your control and some of which are out of your control. Advanced Mac Mailer takes a burden of removing 90% of most obvious problems of incompatibility and header mismatch by using the standard message delivery framework of Apple Mail. Thus for the outer world, your messages look indistinguishable from those actually sent with Apple Mail manually. Each recipient always receives a separate personalized message that has all the proper headers and fields filled in. All recipient information you save in Advanced Mac Mailer can be exported to a standard plain-text CSV file that is supported by vast majority of other programs. You can also import customer information from all other programs by using a CSV file as a data feed or you can simply choose to extract only email addresses from any file types.

Version 4.19: Release notes were unavailable when this listing was updated.

Mac OS X 10.5 or later

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Young minds test their skills against the greatest of them all

Posted: 26 Mar 2012 02:17 AM PDT

AWE: Garry Kasparov, the greatest chess player in the world, gently ponders a plan of attack as Ronan Ferreira, 8, gazes up at the grandmaster during a simultaneous match between Kasparov and 25 youngsters at the Sci-Bono Discovery Centre in Newtown, Joburg, yesterday.

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Applied Sciences, Vol. 2, Pages 260-276: Magnetically Separable Base Catalysts: Heterogeneous Catalysis vs. Quasi-Homogeneous Catalysis

Posted: 26 Mar 2012 12:00 AM PDT

The synthesis of magnetically separable quasi-homogeneous base catalyst and heterogeneous base catalyst is described. The quasi-homogeneous catalyst is achieved by supporting silane monomers functionalized with different amine groups directly on the surface of magnetite nanoparticles. The heterogeneous catalyst is prepared via a sol-gel process in which silane monomers containing different amine groups are copolymerized with tetraethoxysilane in the presence of magnetite nanoparticles functionalized with ionic liquid moieties. The reactivity of the quasi-homogeneous and the heterogeneous base catalysts is compared in the nitroaldol condensation.

Sensors, Vol. 12, Pages 3857-3867: A Fiber Optic Catalytic Sensor for Neutral Atom Measurements in Oxygen Plasma

Posted: 26 Mar 2012 12:00 AM PDT

The presented sensor for neutral oxygen atom measurement in oxygen plasma is a catalytic probe which uses fiber optics and infrared detection system to measure the gray body radiation of the catalyst. The density of neutral atoms can be determined from the temperature curve of the probe, because the catalyst is heated predominantly by the dissipation of energy caused by the heterogeneous surface recombination of neutral atoms. The advantages of this sensor are that it is simple, reliable, easy to use, noninvasive, quantitative and can be used in plasma discharge regions. By using different catalyst materials the sensor can also be applied for detection of neutral atoms in other plasmas. Sensor design, operation, example measurements and new measurement procedure for systematic characterization are presented.

Molecules, Vol. 17, Pages 3761-3773: Enhancement of Palmarumycin C12 and C13 Production in Liquid Culture of the Endophytic Fungus Berkleasmium sp. Dzf12 by Oligosaccharides from Its Host Plant Dioscorea zingiberensis

Posted: 26 Mar 2012 12:00 AM PDT

Three crude oligosaccharides were respectively prepared by acid hydrolysis of three polysaccharides, which were water-extracted polysaccharide (WEP), sodium hydroxide-extracted polysaccharide (SEP) and acid-extracted polysaccharide (AEP) from the rhizomes of Dioscorea zingiberensis. Among the three oligosaccharides, the crude oligosaccharide prepared by acid hydrolysis of WEP was found to be the most efficient elicitor to enhance the production of palmarumycins C12 and C13 in liquid culture of endophytic fungus Berkleasmium sp. Dzf12. When OW was applied to the medium at 300 mg/L on day 3 of culture, the maximal yields of palmarumycin C12 (87.96 mg/L) and palmarumycin C13 (422.28 mg/L) were achieved on day 15 of culture, which were 9.83 and 3.24-fold in comparison with those (8.95 and 130.43 mg/L) of control, respectively. The results indicate that addition of the oligosaccharides from the host plant D. zingiberensis should be an effective strategy for enhancing production of palmarumycins C12 and C13 in liquid culture of endophytic fungus Berkleasmium sp. Dzf12.

Molecules, Vol. 17, Pages 3751-3760: Determination of Rutin in Cigarette Tobacco, Filters, Mainstream Smoke and Burned Ash of Different Branded Cigarettes by High Performance Liquid Chromatography

Posted: 26 Mar 2012 12:00 AM PDT

Tobacco consists of at least 3,800 chemical constituents. Among them, rutin is an important polyphenolic secondary metabolite in tobacco, which has positive actions such as antiallergic, anti-inflammatory and vasoactive, antitumor, antibacterial, antiviral and anti-protozoal properties. A high performance liquid chromatography method was used to analyze rutin in tobacco and filters, mainstream smoke, and burned ash of ten varieties of cigarettes made in China. The chromatographic analysis was performed on a Hypersil ODS2 column with a gradient elution of acetonitrile and water at a flow rate of 1.0 mL/min. Detection was carried out at 350 nm using a photodiode array detector. The calibration curves for the determination of analytes showed good linearity over the investigated ranges (R2 > 0.9998). Precision and reproducibility were evaluated by six replicated analyses, and the R.S.D. values were less than 0.59% and 1.53%. The recoveries were between 98.47 and 100.84%. Under the optimized conditions, namely 45 mL/g of solvent to solid ratio, 30 min of extraction time and 200 W of ultrasound power, the concentrations of rutin in tobacco and filter, mainstream smoke, burned ash of different brands cigarettes were 10.20–63.98, 0.10–0.32, 0.06–0.16 and 0 μg/per cigarette, respectively.

Molecules, Vol. 17, Pages 3736-3750: Xanthatin Induces Cell Cycle Arrest at G2/M Checkpoint and Apoptosis via Disrupting NF-κB Pathway in A549 Non-Small-Cell Lung Cancer Cells

Posted: 26 Mar 2012 12:00 AM PDT

Xanthatin, a natural sesquiterpene lactone, has significant antitumor activity against a variety of cancer cells, yet little is known about its anticancer mechanism. In this study, we demonstrated that xanthatin had obvious dose-/time-dependent cytotoxicity against the human non-small-cell lung cancer (NSCLC) cell line A549. Flow cytometry analysis showed xanthatin induced cell cycle arrest at G2/M phase. Xanthatin also had pro-apoptotic effects on A549 cells as evidenced by Hoechst 33258 staining and annexin V-FITC staining. Mechanistic data revealed that xanthatin downregulated Chk1, Chk2, and phosphorylation of CDC2, which contributed to the cell cycle arrest. Xathatin also increased total p53 protein levels, decreased Bcl-2/Bax ratio and expression of the downstream factors procaspase-9 and procaspase-3, which triggered the intrinsic apoptosis pathway. Furthermore, xanthatin blocked phosphorylation of NF-κB (p65) and IκBa, which might also contribute to its pro-apoptotic effects on A549 cells. Xanthatin also inhibited TNFa induced NF-κB (p65) translocation. We conclude that xanthatin displays significant antitumor effects through cell cycle arrest and apoptosis induction in A549 cells. These effects were associated with intrinsic apoptosis pathway and disrupted NF-κB signaling. These results suggested that xanthatin may have therapeutic potential against NSCLC.

Micromachines, Vol. 3, Pages 225-243: Micromachined Flow Sensors in Biomedical Applications

Posted: 26 Mar 2012 12:00 AM PDT

Application fields of micromachined devices are growing very rapidly due to the continuous improvement of three dimensional technologies of micro-fabrication. In particular, applications of micromachined sensors to monitor gas and liquid flows hold immense potential because of their valuable characteristics (e.g., low energy consumption, relatively good accuracy, the ability to measure very small flow, and small size). Moreover, the feedback provided by integrating microflow sensors to micro mass flow controllers is essential to deliver accurately set target small flows. This paper is a review of some application areas in the biomedical field of micromachined flow sensors, such as blood flow, respiratory monitoring, and drug delivery among others. Particular attention is dedicated to the description of the measurement principles utilized in early and current research. Finally, some observations about characteristics and issues of these devices are also reported.

Polymers, Vol. 4, Pages 913-963: Water Soluble Polymers as Proton Exchange Membranes for Fuel Cells

Posted: 26 Mar 2012 12:00 AM PDT

The relentless increase in the demand for useable power from energy-hungry economies continues to drive energy-material related research. Fuel cells, as a future potential power source that provide clean-at-the-point-of-use power offer many advantages such as high efficiency, high energy density, quiet operation, and environmental friendliness. Critical to the operation of the fuel cell is the proton exchange membrane (polymer electrolyte membrane) responsible for internal proton transport from the anode to the cathode. PEMs have the following requirements: high protonic conductivity, low electronic conductivity, impermeability to fuel gas or liquid, good mechanical toughness in both the dry and hydrated states, and high oxidative and hydrolytic stability in the actual fuel cell environment. Water soluble polymers represent an immensely diverse class of polymers. In this comprehensive review the initial focus is on those members of this group that have attracted publication interest, principally: chitosan, poly (ethylene glycol), poly (vinyl alcohol), poly (vinylpyrrolidone), poly (2-acrylamido-2-methyl-1-propanesulfonic acid) and poly (styrene sulfonic acid). The paper then considers in detail the relationship of structure to functionality in the context of polymer blends and polymer based networks together with the effects of membrane crosslinking on IPN and semi IPN architectures. This is followed by a review of pore-filling and other impregnation approaches. Throughout the paper detailed numerical results are given for comparison to today's state-of-the-art Nafion® based materials.

Molecules, Vol. 17, Pages 3723-3735: Extracts of Lycoris aurea Induce Apoptosis in Murine Sarcoma S180 Cells

Posted: 26 Mar 2012 12:00 AM PDT

Lycoris species have been known since long ago as a multi-utility ethnomedicinal herbal in China. It has been reported to exhibit a number of properties such as anticancer, neuroprotective, and antibacterial activities. In the present study, the anticancer efficacy of dichloromethane extracts of Lycoris aurea (DELA), was evaluated both in vivo and in vitro using murine sarcoma 180 cells. To evaluate the effects of DELA on apoptotic cell death, flow cytometry and Western blotting were performed. DELA demonstrated promising inhibition effects on sarcoma 180 cells in vitro and a 53.49% inhibitory rate on cancer cells in vivo. DELA treatment increased thymus indices and spleen indices in vivo, indicating that it reduced tumours, but did not damage the main immune organs. The DELA-evoked increase in apoptotic cell death was accompanied by occurrence of cleaved caspase-3 and decreases in the ratio of Bcl-2/Bax. Further purification and LCMS analysis showed DELA contained homolycorine, 2α-hydroxyoduline, oduline, hippeastrine, 2α-hydroxy-6-O- methyloduline, and 2α-methoxy-6-O-methyloduline. These results indicate that DELA exerted its anticancer effects, at least in part, by inducing cancer cell apoptosis and thus can be considered as a potential candidate agent for treatment of cancer.

Molecules, Vol. 17, Pages 3708-3722: Analysis of Organic Volatile Flavor Compounds in Fermented Stinky Tofu Using SPME with Different Fiber Coatings

Posted: 26 Mar 2012 12:00 AM PDT

The organic volatile flavor compounds in fermented stinky tofu (FST) were studied using SPME-GC/MS. A total of 39 volatile compounds were identified, including nine esters, seven alcohols, five alkenes, four sulfides, three heterocycles, three carboxylic acids, three ketones, two aldehydes, one phenol, one amine and one ether. These compounds were determined by MS, and conformed by comparison of the retention times of the separated constituents with those of authentic samples and by comparison of retention indexes (RIs) of separated constituents with the RIs reported in the literature. The predominant volatile compound in FST was indole, followed by dimethyl trisulfide, phenol, dimethyl disulfide and dimethyl tetrasulfide. In order to find a better extraction time, the extraction times was optimized for each type of SPME fiber; the results show that the best extraction time for Carboxen/PDMS is 60 min, for PDMS/DVB 30 min, for DVB/CAR/PDMS 60 min and for PDMS 75 min. Of the four fibers used in this work, Carboxen/PDMS is found to be the most suitable to extract the organic volatile flavor compounds in fermented stinky tofu.

Molecules, Vol. 17, Pages 3690-3707: Coupling of Nanoporous Chromium, Aluminium-Containing Silicates with an Ionic Liquid for the Transformation of Glucose into 5-(Hydroxymethyl)-2-furaldehyde

Posted: 26 Mar 2012 12:00 AM PDT

Micro/mesoporous chromium, aluminium-containing silicates of the type TUD-1 (Al-TUD-1, Cr-TUD-1, CrAl-TUD-1) and zeolite BEA, Cr-BEA, and related composites BEA/TUD-1 and Cr-BEA/TUD-1, were prepared, characterised, and tested as solid acids coupled with the ionic liquid (IL) 1-butyl-3-methylimidazolium chloride ([bmim]Cl) as solvent, in the transformation of d-glucose into 5-(hydroxymethyl)-2-furaldehyde (Hmf), at 120 °C. The chromium-containing catalytic systems lead to considerably higher Hmf yields in comparison to the related systems without chromium. The IL is a favourable solvent for this target reaction (in terms of Hmf yields reached) compared to water or dimethylsulfoxide. A detailed study on the stabilities of the nanoporous solid acids in the IL medium is presented.

Sensors, Vol. 12, Pages 3831-3856: A Neuro-Inspired Spike-Based PID Motor Controller for Multi-Motor Robots with Low Cost FPGAs

Posted: 26 Mar 2012 12:00 AM PDT

In this paper we present a neuro-inspired spike-based close-loop controller written in VHDL and implemented for FPGAs. This controller has been focused on controlling a DC motor speed, but only using spikes for information representation, processing and DC motor driving. It could be applied to other motors with proper driver adaptation. This controller architecture represents one of the latest layers in a Spiking Neural Network (SNN), which implements a bridge between robotics actuators and spike-based processing layers and sensors. The presented control system fuses actuation and sensors information as spikes streams, processing these spikes in hard real-time, implementing a massively parallel information processing system, through specialized spike-based circuits. This spike-based close-loop controller has been implemented into an AER platform, designed in our labs, that allows direct control of DC motors: the AER-Robot. Experimental results evidence the viability of the implementation of spike-based controllers, and hardware synthesis denotes low hardware requirements that allow replicating this controller in a high number of parallel controllers working together to allow a real-time robot control.

Sensors, Vol. 12, Pages 3814-3830: A Variant Quorum Sensing System in Aeromonas veronii MTCC 3249

Posted: 26 Mar 2012 12:00 AM PDT

We have investigated the quorum sensing control in Aeromonas veronii MTCC 3249, originally isolated as A. culicicola from the midgut of Culex quinquefasciatus. Based on biosensor assays, the bacterium showed constant production of multiple acyl-homoserine lactones (AHLs) with increasing cell-density. The luxRI gene homologs, acuR (A. culicicola transcriptional Regulator) and acuI (A. culicicola autoInducer) were successfully amplified by inverse-PCR. Sequence analysis indicated acuRI were divergent from all known quorum sensing gene homologs in Aeromonas. Two localized regions in the C-terminal autoinducer binding domain of acuR showed indels suggesting variations in autoinducer specificity. Further, only a single copy of the quorum sensing genes was detected, suggesting a tight regulation of mechanisms under its control. Chromatography and further chemical analysis identified two AHLs in the culture supernatant: 6-carboxy-HHL (homoadipyl homoserine lactone), a novel AHL, and N-tetradecanoylhomoserine lactone. The existence of a potentially variant quorum sensing system might therefore, reflect in some way the ecological strategies adopted by this bacterium in the mosquito midgut.

Molecules, Vol. 17, Pages 3672-3689: The Feasibility of Enzyme Targeted Activation for Amino Acid/Dipeptide Monoester Prodrugs of Floxuridine; Cathepsin D as a Potential Targeted Enzyme

Posted: 26 Mar 2012 12:00 AM PDT

The improvement of therapeutic efficacy for cancer agents has been a big challenge which includes the increase of tumor selectivity and the reduction of adverse effects at non-tumor sites. In order to achieve those goals, prodrug approaches have been extensively investigated. In this report, the potential activation enzymes for 5¢-amino acid/dipeptide monoester floxuridine prodrugs in pancreatic cancer cells were selected and the feasibility of enzyme specific activation of prodrugs was evaluated. All prodrugs exhibited the range of 3.0–105.7 min of half life in Capan-2 cell homogenate with the presence and the absence of selective enzyme inhibitors. 5¢-O-L-Phenylalanyl-L-tyrosyl-floxuridine exhibited longer half life only with the presence of pepstatin A. Human cathepsin B and D selectively hydrolized 5¢-O-L-phenylalanyl-L-tyrosylfloxuridine and 5¢-O-L-phenylalanyl-L-glycylfloxuridine compared to the other tested prodrugs. The wide range of growth inhibitory effect by floxuridine prodrugs in Capan-2 cells was observed due to the different affinities of prodrug promoieties to enyzmes. In conclusion, it is feasible to design prodrugs which are activated by specific enzymes. Cathepsin D might be a good candidate as a target enzyme for prodrug activation and 5¢-O-L-phenylalanyl-L-tyrosylfloxuridine may be the best candidate among the tested floxuridine prodrugs.

GameSpot AU's Shippin' Out - March 26, 2012

Posted: 25 Mar 2012 11:01 PM PDT

GameSpot AU community manager James Kozanecki tells you what games are coming out in Australia in the week beginning March 26, 2012!

 

Read and Post Comments | Get the full article at GameSpot

"GameSpot AU's Shippin' Out - March 26, 2012" was posted by edmondt on Sun, 25 Mar 2012 23:01:34 -0700

BlazBlue devs announces Xblaze

Posted: 25 Mar 2012 10:26 PM PDT

New adventure title from Arc System Works to be out in winter 2012; platform yet to be announced.

Developer Arc System Works is known for fighting game titles such as the Guilty Gear and BlazBlue series. The company is planning on branching out into other genre avenues with the recent announcement of a new title called Xblaze.

According to a report on 4Gamer, the game is dubbed as the first game in an "adventure project" series and is slated to come out in winter 2012. BlazBlue producer Toshimichi Mori said that the second entry of the series is currently in the works. The slide presentation of Xblaze shown at the end of the official BlazBlue Continuum Shift 2 national tournament seems to indicate that the game will have ties to the BlazBlue story.

No platform has been announced for this project at this point in time. For more information on the recent console iteration of the fighting game, check out GameSpot's recent coverage on BlazBlue: Continuum Shift Extend.

Read and Post Comments | Get the full article at GameSpot

"BlazBlue devs announces Xblaze" was posted by Jonathan Toyad on Sun, 25 Mar 2012 22:26:25 -0700

Finding the Adventure in Journey

Posted: 25 Mar 2012 09:29 PM PDT

GameSpot AU's Jessica McDonell takes a look at the evolving classification of "Adventure Games" and whether contemporary games like Journey fit into it.

 

Read and Post Comments | Get the full article at GameSpot

"Finding the Adventure in Journey" was posted by edmondt on Sun, 25 Mar 2012 21:29:25 -0700

GameSpot Reports: Indie Game Development

Posted: 25 Mar 2012 09:23 PM PDT

GameSpot AU's Laura Parker speaks to Super Meat Boy developers Team Meat and the filmmakers behind Indie Game: The Movie about the highs and lows of indie game development.

 

Read and Post Comments | Get the full article at GameSpot

"GameSpot Reports: Indie Game Development" was posted by edmondt on Sun, 25 Mar 2012 21:23:52 -0700
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