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- IJMS, Vol. 13, Pages 4255-4267: Pharmacological Assessment of the Medicinal Potential of Acacia mearnsii De Wild.: Antimicrobial and Toxicity Activities
- IJMS, Vol. 13, Pages 4233-4254: Carotenoids, Fatty Acid Composition and Heat Stability of Supercritical Carbon Dioxide-Extracted-Oleoresins
- IJMS, Vol. 13, Pages 4202-4232: Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health
- DwellClick 2.1.2 - Control your Mac with Mouse movements only.. (Shareware)
- Browser 1.1.4 - WebKit-based browser.. (Free)
- uTorrent 1.6.1 - Lightweight BitTorrent client (beta).. (Free)
- BitNami OSQA Stack 1.0rc-1 - Easy-to-install distribution of the OSQA application.. (Free)
- Grand Chase: Heroes - Screenshots
- Akai Katana - Screenshots
- Zepi:Dark HD - Screenshots
- Sustainability, Vol. 4, Pages 543-560: Analysis of Traits Related to Weed Competitiveness in Sweet Corn (Zea mays L.)
- The Splatters - Screenshots
- Legends of Aethereus - Screenshots
- Can Knockdown 2 - Screenshots
- Melbourne fighting tournament kicks off tomorrow
- Molecules, Vol. 17, Pages 3957-3968: 4-N,N-Dimethylaminopyridine Promoted Selective Oxidation of Methyl Aromatics with Molecular Oxygen
- Molecules, Vol. 17, Pages 3945-3956: Enzymatic Activity Enhancement of Non-Covalent Modified Superoxide Dismutase and Molecular Docking Analysis
- Nanomaterials, Vol. 2, Pages 92-112: Near-Infrared Fluorescent Nanoprobes for in Vivo Optical Imaging
- Doodle Snake - Screenshots
- Demolition Master - Screenshots
| Posted: 30 Mar 2012 12:00 AM PDT Acacia mearnsii De Wild. (Fabaceae) is a medicinal plant used in the treatment of microbial infections in South Africa without scientific validation of its bioactivity and toxicity. The antimicrobial activity of the crude acetone extract was evaluated by both agar diffusion and macrobroth dilution methods while its cytotoxicity effect was assessed with brine shrimp lethality assay. The study showed that both bacterial and fungal isolates were highly inhibited by the crude extract. The MIC values for the gram-positive bacteria (78.1–312.5) µg/mL, gram-negative bacteria (39.1–625) µg/mL and fungal isolates (625–5000) µg/mL differ significantly. The bacteria were more susceptible than the fungal strains tested. The antibiosis determination showed that the extract was more (75%) bactericidal than bacteriostatic (25%) and more fungicidal (66.67%) than fungistatic (33.33%). The cytotoxic activity of the extract was observed between 31.25 µg/mL and 500 µg/mL and the LC50 value (112.36 µg/mL) indicates that the extract was nontoxic in the brine shrimp lethality assay (LC50 > 100 μg/mL). These results support the use of A. mearnsii in traditional medicine for treatment of microbial infections. The extract exhibiting significant broad spectrum antimicrobial activity and nontoxic effects has potential to yield active antimicrobial compounds. |
| Posted: 30 Mar 2012 12:00 AM PDT The risk of chronic diseases has been shown to be inversely related to tomato intake and the lycopene levels in serum and tissue. Cis-isomers represent approximately 50%–80% of serum lycopene, while dietary lycopene maintains the isomeric ratio present in the plant sources with about 95% of all-trans-lycopene. Supercritical CO2 extraction (S-CO2) has been extensively developed to extract lycopene from tomato and tomato processing wastes, for food or pharmaceutical industries, also by using additional plant sources as co-matrices. We compared two S-CO2-extracted oleoresins (from tomato and tomato/hazelnut matrices), which showed an oil-solid bi-phasic appearance, a higher cis-lycopene content, and enhanced antioxidant ability compared with the traditional solvent extracts. Heat-treating, in the range of 60–100 °C, led to changes in the lycopene isomeric composition and to enhanced antioxidant activity in both types of oleoresins. The greater stability has been related to peculiar lycopene isomer composition and to the lipid environment. The results indicate these oleoresins are a good source of potentially healthful lycopene. |
| Posted: 30 Mar 2012 12:00 AM PDT Interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis (OA). These proinflammatory cytokines bind to their respective cell surface receptors and activate inflammatory signaling pathways culminating with the activation of nuclear factor κB (NF-κB), a transcription factor that can be triggered by a host of stress-related stimuli including, excessive mechanical stress and ECM degradation products. Once activated, NF-κB regulates the expression of many cytokines, chemokines, adhesion molecules, inflammatory mediators, and several matrix-degrading enzymes. Therefore, proinflammatory cytokines, their cell surface receptors, NF-κB and downstream signaling pathways are therapeutic targets in OA. This paper critically reviews the recent literature and outlines the potential prophylactic properties of plant-derived phytochemicals such as curcumin and resveratrol for targeting NF-κB signaling and inflammation in OA to determine whether these phytochemicals can be used as functional foods. |
| DwellClick 2.1.2 - Control your Mac with Mouse movements only.. (Shareware) Posted: 30 Mar 2012 02:59 AM PDT  DwellClick is an app that clicks the mouse for you, and lets you give your fingers a rest!
DwellClick lets you adopt a totally relaxed posture and use your Mac with mouse movements only. Once you discover a world without clicking, you will find you can use your Mac more enjoyably and with less effort. Work or play more efficiently and for longer, without tired and sore hands. You can work faster, because your hands actually spend less time on the mouse or trackpad. Or just lean back and browse, and enjoy web surfing with minimal effort. DwellClick works seamlessly with Mac OS X and has multiple intelligent features which help it keep out of your way and do its job, while you do your job. It works great with multi-touch trackpads and the Magic Mouse too. Version 2.1.2:
Mac OS X 10.6.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Browser 1.1.4 - WebKit-based browser.. (Free) Posted: 30 Mar 2012 02:56 AM PDT  Editor's Note: As some of our users have pointed out, Browser features adult-oriented icons and search modes that parents and guardians may not find appropriate for younger users. The developer has accordingly added the option of a Parental Control mode, which can be chosen on first running this application. Browser is a Browser. A browser with WebKit inside - thus there is no need to tell you about the browsing experience. There's simply is no better way to surf the web. So - why another one? Because browsing should be about finding - not searching. Finding websites, content, bookmarks and pages stored for reading later. Tag it, baby! Tired of searching for bookmarks? Need your brain for more important tasks than remembering URLs? That's why Browser allows to tag bookmarks and directly open them by simply searching for such a tag. And because sometimes a tag isn't enough - Browser also allows to make use of comments. Drobox. Enabled All bookmarks, all pages stored for later reading are automatically available on all your Macs. Incl. all your tags and comments. History. Repeating. But wouldn't it be great to actually have the complete history on all Macs available as well? Guess what. 12345. Fail. And because we all use such risky passwords, Browser will store secure ones for you. And you only have to remember a single one. Lots more.
Version 1.1.4:
Download Now This posting includes an audio/video/photo media file: Download Now |
| uTorrent 1.6.1 - Lightweight BitTorrent client (beta).. (Free) Posted: 30 Mar 2012 03:01 AM PDT  uTorrent is a lightweight BitTorrent client. While the interface has been polished and the overall size remains smaller than your average Facebook pic, µTorrent is now packed with some insanely powerful features:
Changes in 1.6.1 (26934)
Mac OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| BitNami OSQA Stack 1.0rc-1 - Easy-to-install distribution of the OSQA application.. (Free) Posted: 30 Mar 2012 03:05 AM PDT  BitNami OSQA Stack Native Installer is an easy-to-install distribution of the OSQA application. It includes pre-configured, ready-to-run versions of Apache, PostgreSQL and Django so users can get a OSQA installation up and running in minutes after answering a few questions. Windows, Linux and Mac OS X operating systems are supported. OSQA is a sophisticated Open Source Question and Answer System that can help you manage and grow online communities. OSQA is written in Python and powered by the Django application framework. Version 1.0rc-1:
Mac OS X 10.4 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Grand Chase: Heroes - Screenshots Posted: 30 Mar 2012 04:12 AM PDT |
| Posted: 30 Mar 2012 03:50 AM PDT Features: - Gorgeous hand-drawn artwork and lovingly rendered sprites - Full HD 16:9 support - Three gameplay modes: Origin (Arcade) Mode, Slash Mode and Climax Mode - Fully animated UI - Original Arcade settings optional for authentic experience - Online leaderboards and replays - Local 2-player co-op (Arcade mode only) |
| Posted: 30 Mar 2012 03:58 AM PDT Special bonuses will help survive at the cemetery and take a top position in GameCenter Leaderboard. Blood and metal achievements provide more excitement and challenge for gamers who love to unlock them. It takes some 5 minutes to set a new world record! The mysterious world of Zepi:Dark magic is calling for you... FEATURES: - Rabbit Hole; - simple and exiting gameplay both for adults, kids, and experienced sextons; - eye candy graphics and nice sound effects; - special power-ups for long chains (Good! Great! Excellent! Brilliant!); - many unique achievements to unlock; - good GameCenter support (Leaderboard, Achievements); - accelerometer support: hold your device in a comfortable way; - perfect time-killer: play any place and time, it takes just 5 minutes to set a new world record! - Facebook and Twitter integrated; |
| Posted: 30 Mar 2012 12:00 AM PDT Weed management in sweet corn can be costly; genetic improvements in sweet corn competitiveness may reduce this expense. Competitive ability can exist as weed suppressive ability (WSA), or crop tolerance (CT). Previous studies in corn have found year of hybrid release, maturity, plant height, leaf angle and leafiness may affect WSA, while hybrid era, maturity, and plant height may affect CT. However, many of these studies were limited to very few genotypes. The objective of this study was to assess the effects of phenomorphological traits on sweet corn competitiveness and the inheritance of these traits. An incomplete half-diallel from seven historic sweet corn inbred lines of varying morphologies was evaluated in a split-block randomized complete block design in three environments. Forage sorghum was interplanted in half of the blocks to act as a model weed. Significant differences among hybrids were generally found for both phenomorphological traits and traits measuring WSA and CT, such as sorghum biomass and yield stability, respectively. Crop plant height was most predictive of WSA and CT. In this set of genotypes, competitive ability may be passed with reasonable fidelity from parent to offspring, suggesting that sweet corn could be bred for competitive ability. |
| Posted: 30 Mar 2012 03:41 AM PDT Get creative to make the most out of every setting and put on the best show in town. |
| Legends of Aethereus - Screenshots Posted: 30 Mar 2012 03:34 AM PDT Features: - Challenge your friends to PvP or Co-op combat in your uniquely designed Combat Arena. - Partake in bold expeditions to capture extraordinary beasts that you can use to populate your Arena. - Decorate your city-state with statues in the likeness of you or your friend's characters or the wild beasts of your arena. - Design and create a variety of arena combat scenarios using your library of beasts, traps and contraptions that will dazzle your friends, amaze the crowd and make your arena one of the sought after combat meeting grounds. - Embark on a variety of procedurally generated expeditions with your friends discovering new lands and situations to overcome. - Design and build new gear, weapons and inventions to solve the many challenges that await you in the world of Aethereus. - Crafting and Materials system allows limitless customization - Expedition system creates infinite replayability - Physics-based combat system including traps, set-up weapons and interaction with environmental objects |
| Posted: 30 Mar 2012 03:23 AM PDT Show off your skills and impress your friends while collecting bonuses and knocking down cans moving on a conveyor! Can Knockdown 2 is like three top-notch games in one - it will keep you, your family and friends hooked for months to come! |
| Melbourne fighting tournament kicks off tomorrow Posted: 29 Mar 2012 10:11 PM PDT eSports fighting games tournament starts Saturday in Melbourne; GameSpot AU to stream the event live.
Get the full article at GameSpot "Melbourne fighting tournament kicks off tomorrow" was posted by James Kozanecki on Thu, 29 Mar 2012 22:11:21 -0700 |
| Posted: 30 Mar 2012 12:00 AM PDT 4-N,N-Dimethylaminopyridine (DMAP) as catalyst in combination with benzyl bromide was developed for the selective oxidation of methyl aromatics. DMAP exhibited higher catalytic activity than other pyridine analogues, such as 4-carboxypyridine, 4-cyanopyridine and pyridine. The sp3 hybrid carbon-hydrogen (C–H) bonds of different methyl aromatics were successfully oxygenated with molecular oxygen. The real catalyst is due to the formation of a pyridine onium salt from the bromide and DMAP. The onium salt was well characterized by NMR and the reaction mechanism was discussed. |
| Posted: 30 Mar 2012 12:00 AM PDT The enzyme activity of superoxide dismutase was improved in the pyrogallol autoxidation system by about 27%, after interaction between hydroxypropyl-β-cyclo- dextrin and superoxide dismutase. Fluorescence spectrometry was used to study the interaction between hydroxypropyl-β-cyclodextrin and superoxide dismutase at different temperatures. By doing this, it can be found that these interactions increase fluorescence sensitivity. In the meantime, the synchronous fluorescence intensity revealed the interaction sites to be close to the tryptophan (Trp) and tyrosine (Tyr) residues of superoxide dismutase. Furthermore, molecular docking was applied to explore the binding mode between the ligands and the receptor. This suggested that HP-β-CD interacted with the B ring, G ring and the O ring and revealed that the lysine (Lys) residues enter the nanocavity. It was concluded that the HP-β-CD caused specific conformational changes in SOD by non-covalent modification. |
| Posted: 30 Mar 2012 12:00 AM PDT Near-infrared (NIR) fluorescent probes offer advantages of high photon penetration, reduced light scattering and minimal autofluorescence from living tissues, rendering them valuable for noninvasive mapping of molecular events, assessment of therapeutic efficacy, and monitoring of disease progression in animal models. This review provides an overview of the recent development of the design and optical property of the different classes of NIR fluorescent nanoprobes associated with in vivo imaging applications. |
| Posted: 30 Mar 2012 03:06 AM PDT Features: - 5 great game modes - 3 control types - Global High Scores - Game Center - 7 cool achievements - 6 texture styles – Doodle & Glow & Winter & Wood & Halloween & Water - Pause option - Retina support - Facebook connect |
| Demolition Master - Screenshots Posted: 30 Mar 2012 03:02 AM PDT FEATURES: - 210 exciting levels - Support game social networks "GAME CENTER" - Supports the Retina Display on iPhone 4 (S) and iPod touch 4th gen - Supported multitasking in iOS 4* - 5* - Realistic graphic of explosions and destruction - Zoom in and zoom out in every level - Dynamic music - Vibration effects |
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