Games |
- Magic Alliance - Screenshots
- ConnecticOns - Screenshots
- Atmosphere, Vol. 3, Pages 213-228: Numerical Simulation of the Global Neutral Wind System of the Earth’s Middle Atmosphere for Different Seasons
- IJMS, Vol. 13, Pages 2918-2938: Computational Identification and Modeling of Crosstalk between Phosphorylation, O-β-glycosylation and Methylation of FoxO3 and Implications for Cancer Therapeutics
- IJMS, Vol. 13, Pages 2893-2917: Pro-Inflammatory S100A8 and S100A9 Proteins: Self-Assembly into Multifunctional Native and Amyloid Complexes
- Grow
- IJMS, Vol. 13, Pages 2877-2892: An Oligodeoxynucleotide That Induces Differentiation of Bone Marrow Mesenchymal Stem Cells to Osteoblasts in Vitro and Reduces Alveolar Bone Loss in Rats with Periodontitis
- IJMS, Vol. 13, Pages 2863-2876: Development and Characterization of 18 Novel EST-SSRs from the Western Flower Thrips, Frankliniella occidentalis (Pergande)
- IJMS, Vol. 13, Pages 2846-2862: Astragalin from Cassia alata Induces DNA Adducts in Vitro and Repairable DNA Damage in the Yeast Saccharomyces cerevisiae
- Societies, Vol. 2, Pages 1-13: Privileged Mobility in an Age of Globality
- Molecules, Vol. 17, Pages 2704-2713: Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components
- Molecules, Vol. 17, Pages 2683-2703: Chemical and Antimicrobial Evaluation of Supercritical and Conventional Sideritis scardica Griseb., Lamiaceae Extracts
- Molecules, Vol. 17, Pages 2675-2682: Bioactive Phenolic Amides from Celtis africana
- Activity & Expense Tracker 5.9.4.1 - Time management and project tracking for business owners.. (Demo)
- Windownaut 0.90 - Lightweight window manager.. (Shareware)
- Inventory Tracker Plus 2.9.5 - Track product supply.. (Demo)
- Small Business Tracker Deluxe 1.9.5 - Time, expense, and contract tracker.. (Shareware)
- Activity & Expense Tracker Plus 1.9.4.1 - Project tracking, personal time management app.. (Demo)
- Molecules, Vol. 17, Pages 2663-2674: Rapid and Sensitive LC-MS/MS Method for the Determination of Metoprolol in Beagle Dog Plasma with a Simple Protein Precipitation Treatment and Its Pharmacokinetic Applications
- Molecules, Vol. 17, Pages 2643-2662: A Microwave-Assisted Bismuth Nitrate-Catalyzed Unique Route Toward 1,4-Dihydropyridines
| Posted: 05 Mar 2012 03:28 AM PST Estates must be reconstructed, alliances forged, and soldiers must be assembled and trained to defeat the evil ransacking clan. Pick up your weapons and get ready for the battle of the century. Only through keen strategy can Epoch Land rise from the ashes and be victorious. Join the many soldiers and share the social experience online. Play now with others online and start assembling an army for Epoch Land. Features: - Vivid combat gameplay - Distinctive style of modeling a variety of cartoon style characters. - Choose from the various types of soldiers - Battle the many vicious evil bosses - Clash over a hundred battles - Mesmerizing magic effects - Explore the vast area of Epoch Land - Socialize with friends - Many achievements to earn |
| Posted: 05 Mar 2012 03:22 AM PST Features: - Cool physics puzzler - Mind bending puzzles - Great colourful graphics and music - 3 zones, 10 rounds per zone - 20 custom rounds - Built in game level editor to create your own brain busting puzzles! - Round records - Share scores on Facebook |
| Posted: 05 Mar 2012 12:00 AM PST A non-hydrostatic model of the global neutral wind system of the Earth's atmosphere, developed earlier, is utilized to simulate the large-scale global circulation of the middle atmosphere for conditions of different seasons. In the model calculations, not only the horizontal components, but also the vertical component of the neutral wind velocity, are obtained by means of a numerical solution of a generalized Navier-Stokes equation for compressible gas, so the hydrostatic equation is not applied. Moreover, the global temperature field is assumed to be a given distribution, (i.e., the input parameter of the model) and obtained from one of the existing empirical models. The results of simulation indicate that the horizontal non-uniformity of the neutral gas temperature, which is distinct in different seasons, ought to considerably influence the formation of the global neutral wind system in the middle atmosphere, in particular, the large-scale circumpolar vortices of the northern and southern hemispheres. |
| Posted: 05 Mar 2012 12:00 AM PST FoxO3 is a member of the forkhead class of transcription factors and plays a major role in the regulation of diverse cellular processes, including cell cycle arrest, DNA repair, and protection from stress stimuli by detoxification of reactive oxygen species. In addition, FoxO3 is a tumor suppressor and has been considered as a novel target for cancer therapeutics. Phosphorylation of FoxO3 via the AKT, IKK, and ERK pathways leads to deregulation, cytoplasmic retention, degradation of FoxO3 and favors tumor progression. Identification of the amino acid residues that are the target of different posttranslational modifications (PTMs) provides a foundation for understanding the molecular mechanisms of FoxO3 modifications and associated outcomes. In addition to phosphorylation, serine and threonine residues of several proteins are regulated by a unique type of PTM known as O-β-glycosylation, which serves as a functional switch. We sought to investigate the crosstalk of different PTMs on the FoxO3 which leads to the onset/progression of various cancers and that could also potentially be targeted as a therapeutic point of intervention. A computational workflow and set of selection parameters have been defined for the identification of target sites and crosstalk between different PTMs. We identified phosphorylation, O-β-GlcNAc modification, and Yin Yang sites on Ser/Thr residues, and propose a potential novel mechanism of crosstalk between these PTMs. Furthermore, methylation potential of human FoxO3 at arginine and lysine residues and crosstalk between methylation and phosphorylation have also been described. Our findings may facilitate the study of therapeutic strategies targeting posttranslational events. |
| Posted: 05 Mar 2012 12:00 AM PST S100A8 and S100A9 are EF-hand Ca2+ binding proteins belonging to the S100 family. They are abundant in cytosol of phagocytes and play critical roles in numerous cellular processes such as motility and danger signaling by interacting and modulating the activity of target proteins. S100A8 and S100A9 expression levels increased in many types of cancer, neurodegenerative disorders, inflammatory and autoimmune diseases and they are implicated in the numerous disease pathologies. The Ca2+ and Zn2+-binding properties of S100A8/A9 have a pivotal influence on their conformation and oligomerization state, including self-assembly into homo- and heterodimers, tetramers and larger oligomers. Here we review how the unique chemical and conformational properties of individual proteins and their structural plasticity at the quaternary level account for S100A8/A9 functional diversity. Additional functional diversification occurs via non-covalent assembly into oligomeric and fibrillar amyloid complexes discovered in the aging prostate and reproduced in vitro. This process is also regulated by Ca2+and Zn2+-binding and effectively competes with the formation of the native complexes. High intrinsic amyloid-forming capacity of S100A8/A9 proteins may lead to their amyloid depositions in numerous ailments characterized by their elevated expression patterns and have additional pathological significance requiring further thorough investigation. |
| Posted: 04 Mar 2012 03:39 PM PST [Platform: Mobile (Android)] Ever feel like a small fish in a big pond? Well, Grow can help you reconcile that feeling. You play as a small fish in a variety of habitats, ranging from a tiny jar to the less-than-tiny ocean. Your mission is simple: eat anything smaller than you so you can get bigger! In some levels you will have to eat a certain number of fish to progress, while in others you must simply survive for a certain amount of time. |
| Posted: 05 Mar 2012 12:00 AM PST To investigate the effect of oligodeoxynucleotides (ODNs) on the differentiation of rat bone marrow mesenchymal stem cells (BMSCs) to osteoblasts, in order to find a candidate ODN with potential for the treatment of periodontitis, a series of ODNs were designed and selected to test their effect on the promotion of the differentiation of BMSCs to osteoblasts in vitro and on the repair of periodontal tissue in rats with periodontitis. It was found that MT01, one of the ODNs with the sequences of human mitochondrial DNA, stimulated the proliferation of BMSCs, the differentiation of BMSCs to osteoblasts and mRNA expression of bone-associated factors including Runx2, Osterix, OPG, RANKL and collagen I in vitro. In vivo study showed that MT01 prevented the loss of alveolar bone in the rats with periodontitis and induced the production of proteins of OPG and Osterix in the bone tissue. These results indicated that MT01 could induce differentiation of BMSCs to osteoblasts and inhibit the alveolar bone absorption in rats with periodontitis. |
| Posted: 05 Mar 2012 12:00 AM PST The western flower thrips, Frankliniella occidentalis (Pergande), is an invasive species and the most economically important pest within the insect order Thysanoptera. For a better understanding of the genetic makeup and migration patterns of F. occidentalis throughout the world, we characterized 18 novel polymorphic EST-derived microsatellites. The mutational mechanism of these EST-SSRs was also investigated to facilitate the selection of appropriate combinations of markers for population genetic studies. Genetic diversity of these novel markers was assessed in 96 individuals from three populations in China (Harbin, Dali, and Guiyang). The results showed that all these 18 loci were highly polymorphic; the number of alleles ranged from 2 to 15, with an average of 5.50 alleles per locus. The observed (HO) and expected (HE) heterozygosities ranged from 0.072 to 0.707 and 0.089 to 0.851, respectively. Furthermore, only two locus/population combinations (WFT144 in Dali and WFT50 in Guiyang) significantly deviated from Hardy–Weinberg equilibrium (HWE). Pairwise FST analysis showed a low but significant differentiation (0.026 < FST < 0.032) among all three pairwise population comparisons. Sequence analysis of alleles per locus revealed a complex mutational pattern of these EST-SSRs. Thus, these EST-SSRs are useful markers but greater attention should be paid to the mutational characteristics of these microsatellites when they are used in population genetic studies. |
| Posted: 05 Mar 2012 12:00 AM PST Reverse phase-solid phase extraction from Cassia alata leaves (CaRP) was used to obtain a refined extract. Higher than wild-type sensitivity to CaRP was exhibited by 16 haploid Saccharomyces cerevisiae mutants with defects in DNA repair and membrane transport. CaRP had a strong DPPH free radical scavenging activity with an IC50 value of 2.27 µg mL−1 and showed no pro-oxidant activity in yeast. CaRP compounds were separated by HPLC and the three major components were shown to bind to DNA in vitro. The major HPLC peak was identified as kampferol-3-O-β-D-glucoside (astragalin), which showed high affinity to DNA as seen by HPLC-UV measurement after using centrifugal ultrafiltration of astragalin-DNA mixtures. Astragalin-DNA interaction was further studied by spectroscopic methods and its interaction with DNA was evaluated using solid-state FTIR. These and computational (in silico) docking studies revealed that astragalin-DNA binding occurs through interaction with G-C base pairs, possibly by intercalation stabilized by H-bond formation. |
| Societies, Vol. 2, Pages 1-13: Privileged Mobility in an Age of Globality Posted: 05 Mar 2012 12:00 AM PST By 2050, the world's population of international migrants is estimated to top 400 million. A small but growing number of those migrants are leaving well-developed, affluent countries best known for receiving immigrants to settle in less well-developed countries better known for sending migrants. These migrants of relative privilege, many of them retirees, are motivated primarily by a desire to enhance their quality of life. Although this migratory flow receives much less attention than more familiar, and reverse, movements of laborers or refugees, its implications for the destination sites, sites of origin, and study of international migration generally are significant. This article will examine the contemporary border crossing of privileged migrants, the economic, political and cultural stakes for the countries and individuals involved, and the implications of incorporating privileged mobility into the study of global migration and transnationalism. |
| Posted: 05 Mar 2012 12:00 AM PST In this study, Rosmarinus officinalis L. essential oil and three of its main components 1,8-cineole (27.23%), α-pinene (19.43%) and β-pinene (6.71%) were evaluated for their in vitro antibacterial activities and toxicology properties. R. officinalis L. essential oil possessed similar antibacterial activities to α-pinene, and a little bit better than β-pinene, while 1,8-cineole possessed the lowest antibacterial activities. R. officinalis L. essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% (IC50) values on SK-OV-3, HO-8910 and Bel-7402 were 0.025‰, 0.076‰ and 0.13‰ (v/v), respectively. The cytotoxicity of all the test samples on SK-OV-3 was significantly stronger than on HO-8910 and Bel-7402. In general, R. officinalis L. essential oil showed greater activity than its components in both antibacterial and anticancer test systems, and the activities were mostly related to their concentrations. |
| Posted: 05 Mar 2012 12:00 AM PST Sideritis scardica Griseb., Lamiaceae (ironwort, mountain tea), an endemic plant of the Balkan Peninsula, has been used in traditional medicine in the treatment of antimicrobial infections, gastrointestinal complaints, inflammation and rheumatic disorders. This study reports a comparison between conventional (hydrodistillation HD and solvent extraction SE) and alternative (supercritical carbon dioxide SC CO2) extraction methods regarding the qualitative and quantitative composition of the obtained extracts as analyzed by GC and GC-MS techniques and their anitimicrobial activity. Different types of extracts were tested, the essential oil EO obtained by HD, EO-CO2 and AO-CO2 obtained by SC CO2 at different preasures 10 and 30 MPa, at 40 °C, respectively, and the fractions A, B, C and D obtained by successive solvent extraction (SE) A: ethanol, B: diethyl ether, C: ethyl acetate and D: n-butanol). While EO was characterized by the presence of the high percentage of oxygenated monoterpenes and sesquiterpenes (30.01 and 25.54%, respectively), the rest of the investigated samples were the most abundant in fatty acids and their esters and diterpenes (from 16.72 to 71.07% for fatty acids and their esters, and from 23.30 to 72.76%, for diterpenes). Microbial susceptibility tests revealed the strong to moderate activity of all investigated extracts against the tested microorganisms (MIC from 40 to 2,560 μg/mL). Although differences in the chemical compositions determined by GC and GC-MS analysis were established, the displayed antimicrobial activity was similar for the all investigated extracts. |
| Molecules, Vol. 17, Pages 2675-2682: Bioactive Phenolic Amides from Celtis africana Posted: 05 Mar 2012 12:00 AM PST Nine compounds have been isolated for the first time from Celtis africana, namely trans-N-coumaroyltyramine (1), trans-N-feruloyltyramine (2), trans-N-caffeoyltyramine (3), lauric acid (4), oleic acid (5), palmitic acid (6), lupeol (7), β-sitosterol (8) and oleanolic acid (9), respectively. Their structures have been elucidated by different spectroscopic techniques. The isolated compounds were screened for their antioxidant, anti-inflammatory and acetylcholinestrease enzyme inhibitory activities. Compounds 1–3 showed significant antioxidant and anti-inflammatory activities and weak to moderate acetylcholinestrease enzyme inhibition activity. |
| Posted: 04 Mar 2012 09:00 PM PST Activity & Expense Tracker is an electronic timesheet and Time Management Tool that helps you to keep track of all your projects and their related tasks and expenses. You can generate invoices and reports which can be printed or exported to your word processor or spreadsheet program. Users can set preferences for time format, currency symbol, colors and more. Version 5.9.4.1:
Mac OS X 10.2 or later Download Now |
| Windownaut 0.90 - Lightweight window manager.. (Shareware) Posted: 05 Mar 2012 01:55 AM PST  Windownaut is a lightweight and robust window manager. It allows you to easily resize, move and add a variety of new control options to windows. Free during beta versions. $3.99 thereafter for a license enabling use on up to five computers. This beta version is usable until 29-April-2012. An updated beta will be released before then so that you may continue using it. Features
Version 0.90:
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| Inventory Tracker Plus 2.9.5 - Track product supply.. (Demo) Posted: 04 Mar 2012 09:00 PM PST Inventory Tracker Plus helps you keep track of products and supplies. Generate reports on inventory for printing orexporting to other programs. Also includes an InvoiceCreator, Contact Tracker, Schedule Tracker, Task Trackerand Universal Calculator. Users can set preferences fortime format, currency symbol, colors and more. Version 2.9.5:
Mac OS X 10.2 or later Download Now |
| Small Business Tracker Deluxe 1.9.5 - Time, expense, and contract tracker.. (Shareware) Posted: 04 Mar 2012 09:00 PM PST Small Business Tracker Deluxe is productivity software that allows self-employed professionals, or small businesses, to keep track of their time, expense, contacts, schedules, invoices and even inventory. Small Business Tracker Deluxe includes Activity Expense Tracker, Invoice Tracker, Password Tracker, Contact Tracker, Schedule Tracker, Task Tracker, Vehicle Expense Tracker, Version Tracker, Writer's Helper, Inventory Tracker and the Universal Calculator. Users can set preferences for time format, currency symbol, colors and more. Small Business Tracker runs on and shares data between most computers including, Windows 95/98/2000/NT/XP, Macintosh and many UNIX operating systems. Free 10 day trial. Version 1.9.5: Release notes were unavailable when this listing was updated. Mac OS X 10.2 or later Download Now |
| Activity & Expense Tracker Plus 1.9.4.1 - Project tracking, personal time management app.. (Demo) Posted: 04 Mar 2012 09:00 PM PST Activity & Expense Tracker Plus includes an electronic timesheet and Time Management Tool that helps you to keep track of all your projects and their related tasks and expenses. You can generate invoices and reports which can be printed or exported to your word processor or spreadsheet program. Also included is a Contact Tracker (with a form letter generator), an Invoice Tracker, a Password Tracker and the Universal Calculator. Version 1.9.4.1:
Mac OS X 10.2 or later Download Now |
| Posted: 05 Mar 2012 12:00 AM PST : A rapid LC-MS/MS method with good accuracy and sensitivity was developed and validated for the pharmacokinetics study of metoprolol (MP) in beagle dogs. The plasma samples were simply precipitated by methanol and then analyzed by LC-MS/MS. An Ultimate XB-C18 column (150 × 2.1 mm ID, 5 μm) was used for separation, with methanol-water containing 0.2% formic acid (65:35, v/v) as the mobile phase at a flow rate of 0.2 mL/min. Monitoring ions of MP and internal standard (hydroxypioglitazone) were m/z 268.1/115.6 and m/z 373.1/150.2, respectively. The linear range was 3.03–416.35 ng/mL with an average correlation coefficient of 0.9996, and the limit of quantification was 3.03 ng/mL. The intra- and inter-day precision was less than 15%. At low, middle and high concentrations, the recovery, the matrix effect and the accuracy was in the range of 76.06%–95.25%, 93.67%–104.19% and 95.20%–99.96% respectively. The method was applied for the pharmacokinetics study of MP tartrate tablets (50 mg). The AUC0-t, Tmax and Cmax were respectively 919.88 ± 195.67 μg/L·h, 0.96 ± 0.33 h, 349.12 ± 78.04 ng/mL. |
| Posted: 05 Mar 2012 12:00 AM PST The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives. Bismuth nitrate pentahydrate under microwave irradiation is proven to act as a very efficient catalyst for a one-pot, three-component synthesis of 1,4-dihydropyridines in excellent yields from diverse amines/ammonium acetate, aldehydes and 1,3-dicarbonyl compounds within 1–3 min under solvent-free conditions. The present environmentally benign procedure for the synthesis of 1,4-dihydropyridines is suitable for library synthesis and it will find application in the synthesis of potent biologically active molecules. The excellent yield and extreme rapidity of the method is due to a concurrent effect of the catalyst and microwave irradiation. |
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