пятница, 2 марта 2012 г.

Games

Games

Causality 4

Posted: 02 Mar 2012 03:38 AM PST

Get ready for some Causality History epiccnesss!! Kill the Stick Kingman in a castle siege, watch out for the hungry alligators and protect your hor..

Calculator + 1.2 - Advanced, extensible calculator.. (Commercial)

Posted: 02 Mar 2012 02:54 AM PST



Calculator + is an advanced, extensible calculator accepting natural (infix) formula notation. There are many built in functions and operators for common scientific and binary tasks. You can easily extend Calculator + with your own functions sets, or download predefined function sets from our website for business, science and astronomy for FREE!

Features:

  • Calculator + always opens a standard calculator window - however, you may open as many calculator windows as you like and save them as documents.
  • Calculator + also provides a history log that allows you to check and modify your input or just jump to any desired calculation from the log.
  • Calculator + also runs as a service, so you can just type a formula in nearly any Mac app, select it and run Calculator + from the Services Menu to compute the result.



Version 1.2:
  • Enhanced precision
  • Enhanced compatibility with Mac OS X 10.7 Lion


  • Mac OS X 10.6 or later
  • 64-bit processor


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Creck 1.0 - Tests the functionality of smartcard readers.. (Free)

Posted: 02 Mar 2012 03:00 AM PST



Creck is a utility that helps you to test the functionality of smartcard readers and check the status of the related system services. The title Creck stands for "Cardreader check".

Version 1.0: initial release.

  • Mac OS X 10.6 or later
  • 64-bit processor
  • Smartcard and smartcard reader


Download Now

Sensors, Vol. 12, Pages 2874-2898: Relocatable, Automated Cost-Benefit Analysis for Marine Sensor Network Design

Posted: 02 Mar 2012 12:00 AM PST

When designing sensor networks, we need to ensure they produce representative and relevant data, but this must be offset by the financial cost of placing sensors. We describe a novel automated method for generating and combining cost and benefit values to decide on the best sensor locations using information about the specific constraints available in most coastal locations. Costs in maintenance, negotiation, equipment, exposure and communication are estimated using hydrodynamic models and Electronic Navigation Charts. Benefits in maximum coverage and reducing overall error are also determined using model output. This method demonstrates equivalent accuracy at predicting the whole system to expert-chosen locations, whilst significantly reducing the estimated costs.

Molecules, Vol. 17, Pages 2587-2598: New Constituents from the Rhizomes of Egyptian Iris germanica L.

Posted: 02 Mar 2012 12:00 AM PST

Chemical investigation of the methanolic extract of the rhizomes of Iris germanica L. (Iridaceae) afforded two new compounds; irigenin S (7) and iriside A (12), together with ten known compounds: stigmasterol (1), a-irone (2), γ-irone (3), 3-hydroxy-5-methoxyacetophenone (4), irilone (5), irisolidone (6), irigenin (8), stigmasterol-3-O-β-D-glucopyranoside (9), irilone 4'-O-b-D-glucopyranoside (10) and iridin (11). Their structures were established by UV, IR, 1D (1H and 13C) and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to mass spectroscopic data and comparison with literature data. The methanolic extract was evaluated for its antimicrobial activity. Both the methanolic extract and the isolated flavonoids were tested for their anti-inflammatory activity.

Molecules, Vol. 17, Pages 2579-2586: Anti-Addition Mechanism in the Intramolecular Hydroalkoxylation of Alkenes Catalyzed by PVP-Stabilized Nanogold

Posted: 02 Mar 2012 12:00 AM PST

(1R*,4S*,4aR*,9aS*,10S*)-10-Hydroxy-10-phenyl-1,4a,9a,10-tetrahydro-1,4-methanoanthracen-9(4H)-one (1c) was prepared for the elucidation of the reaction mechanism of intramolecular hydroalkoxylation of alkenes catalyzed by gold nanoclusters stabilized by a hydrophilic polymer, poly(N-vinyl-2-pyrrolidone) (Au:PVP). It was found that the reaction proceeded via anti-addition of alcohol to the alkene assisted by p-activation of the gold clusters, which is the same mechanism as the hydroamination by toluenesulfonamides.

Molecules, Vol. 17, Pages 2567-2578: Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound

Posted: 02 Mar 2012 12:00 AM PST

The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.

Molecules, Vol. 17, Pages 2542-2566: The Artemisia L. Genus: A Review of Bioactive Essential Oils

Posted: 02 Mar 2012 12:00 AM PST

Numerous members of the Anthemideae tribe are important as cut flowers and ornamental crops, as well as being medicinal and aromatic plants, many of which produce essential oils used in folk and modern medicine and in the cosmetics and pharmaceutical industry. Essential oils generally have a broad spectrum of bioactivity, owing to the presence of several active ingredients that work through various modes of action. Due to their mode of extraction, mostly by distillation from aromatic plants, they contain a variety of volatile molecules such as terpenes, phenol-derived aromatic and aliphatic components. The large genus Artemisia L., from the tribe Anthemideae, comprises important medicinal plants which are currently the subject of phytochemical attention due to their biological and chemical diversity. Artemisia species, widespread throughout the world, are one of the most popular plants in Chinese traditional preparations and are frequently used for the treatment of diseases such as malaria, hepatitis, cancer, inflammation and infections by fungi, bacteria and viruses. Extensive studies of the chemical components of Artemisia have led to the identification of many compounds as well as essentials oils. This review summarizes some of the main reports on the chemistry and anti-infective activities of Artemisia. Li. essential oils from the data in the recent literature (2000–2011).

Molecules, Vol. 17, Pages 2529-2541: Tandem Three-Component Reactions of Aldehyde, Alkyl Acrylate, and Dialkylmalonate Catalyzed by Ethyl Diphenylphosphine

Posted: 02 Mar 2012 12:00 AM PST

A new highly efficient three-component reaction of alkyl acrylate, aldehyde and dialkyl malonate using ethyl diphenylphosphine as organocatalyst has been described. Various highly functional compounds bearing hydroxyl groups and the ester functions can be easily prepared in moderate to good yields according to our one-step procedure. The reactions are believed to proceed via Morita-Baylis-Hillman reactions of alkyl acrylate and aldehydes, followed by the Michael addition reactions of dialkyl malonates. Our reactions indicated that the intermediate species formed in the phosphine-catalyzed MBH reaction are an effective organic base to catalyze the Michael addition reactions of dialkyl malonates to the preformed MBH adducts.

Molecules, Vol. 17, Pages 2518-2528: Effects of Different Extraction Methods and Conditions on the Phenolic Composition of Mate Tea Extracts

Posted: 02 Mar 2012 12:00 AM PST

A simple and rapid HPLC method for determination of chlorogenic acid (5-O-caffeoylquinic acid) in mate tea extracts was developed and validated. The chromatography used isocratic elution with a mobile phase of aqueous 1.5% acetic acid-methanol (85:15, v/v). The flow rate was 0.8 mL/min and detection by UV at 325 nm. The method showed good selectivity, accuracy, repeatability and robustness, with detection limit of 0.26 mg/L and recovery of 97.76%. The developed method was applied for the determination of chlorogenic acid in mate tea extracts obtained by ethanol extraction and liquid carbon dioxide extraction with ethanol as co-solvent. Different ethanol concentrations were used (40, 50 and 60%, v/v) and liquid CO2 extraction was performed at different pressures (50 and 100 bar) and constant temperature (27 ± 1 °C). Significant influence of extraction methods, conditions and solvent polarity on chlorogenic acid content, antioxidant activity and total phenolic and flavonoid content of mate tea extracts was established. The most efficient extraction solvent was liquid CO2 with aqueous ethanol (40%) as co-solvent using an extraction pressure of 100 bar.

IJMS, Vol. 13, Pages 2827-2845: Gamma Radiation Induced Oxidation and Tocopherols Decrease in In-Shell, Peeled and Blanched Peanuts

Posted: 02 Mar 2012 12:00 AM PST

In-shell, peeled and blanched peanut samples were characterized in relation to proximate composition and fatty acid profile. No difference was found in relation to its proximate composition. The three major fatty acids were palmitic acid, oleic acid, and linoleic acid. In order to investigate irradiation and storage effects, peanut samples were submitted to doses of 0.0, 5.0, 7.5 or 10.0 kGy, stored for six months at room temperature and monitored every three months. Peanuts responded differently to irradiation, particularly with regards to tocopherol contents, primary and secondary oxidation products and oil stability index. Induction periods and tocopherol contents were negatively correlated with irradiation doses and decreased moderately during storage. α-Tocopherol was the most gamma radiation sensitive and peeled samples were the most affected. A positive correlation was found among tocopherol contents and the induction period of the oils extracted from irradiated samples. Gamma radiation and storage time increased oxidation compounds production. If gamma radiation is considered an alternative for industrial scale peanut conservation, in-shell samples are the best feedstock. For the best of our knowledge this is the first article with such results; this way it may be helpful as basis for future studies on gamma radiation of in-shell crops.

IJMS, Vol. 13, Pages 2810-2826: Variation in Stability of Endogenous Reference Genes in Fallopian Tubes and Endometrium from Healthy and Ectopic Pregnant Women

Posted: 02 Mar 2012 12:00 AM PST

RT-qPCR is commonly employed in gene expression studies in ectopic pregnancy. Most use RN18S1, β-actin or GAPDH as internal controls without validation of their suitability as reference genes. A systematic study of the suitability of endogenous reference genes for gene expression studies in ectopic pregnancy is lacking. The aims of this study were therefore to evaluate the stability of 12 reference genes and suggest those that are stable for use as internal control genes in fallopian tubes and endometrium from ectopic pregnancy and healthy non-pregnant controls. Analysis of the results showed that the genes consistently ranked in the top six by geNorm and NormFinder algorithms, were UBC, GAPDH, CYC1 and EIF4A2 (fallopian tubes) and UBC and ATP5B (endometrium). mRNA expression of NAPE-PLD as a test gene of interest varied between the groups depending on which of the 12 reference genes was used as internal controls. This study demonstrates that arbitrary selection of reference genes for normalisation in RT-qPCR studies in ectopic pregnancy without validation, risk producing inaccurate data and should therefore be discouraged.

IJMS, Vol. 13, Pages 2801-2809: An Electrochemical Method to Detect Gamma Glutamyl Transpeptidase

Posted: 02 Mar 2012 12:00 AM PST

Gamma glutamyl transpeptidase (GGT) is a transferase, which is of great importance in sustaining intracellular cysteine and glutathione levels. The abnormal expression of GGT is significantly associated with features of many metabolic syndromes (e.g., hepatocellular carcinoma). Therefore, it is essential to develop methods to detect GGT so as to monitor the physiological or pathological phenomena related to this species. In this work, by making use of a complex formed by Cu2+ and glutathione, which may exhibit excellent voltammetric response, we have proposed a novel potential electrochemical method for the detection of the enzyme. Results show that in the presence of GGT, the formation of Cu2+-glutathione complex on a working electrode will be disrupted, resulting in greatly depressed electrochemical signals. The primary method exhibits some advantages, such as it being fast, cost-efficient, and conveniently operated. It also has the potential to be further developed as an effective method in the quantitative detection of GGT in real samples.

Planet Blirp

Posted: 01 Mar 2012 07:50 PM PST

[Platform: Flash] Blast aliens on Planet Blirp, an sidescrolling action shooter from Helmet Games. A very familiar kind of game, though its variety of mission objectives and humorous storyline separate it from the pack. An emphasis on grinding and a steep learning curve mar the experience, but overall it is a solid time-waster.

IJMS, Vol. 13, Pages 2783-2800: Sequence Variants and Haplotype Analysis of Cat ERBB2 Gene: A Survey on Spontaneous Cat Mammary Neoplastic and Non-Neoplastic Lesions

Posted: 02 Mar 2012 12:00 AM PST

The human ERBB2 proto-oncogene is widely considered a key gene involved in human breast cancer onset and progression. Among spontaneous tumors, mammary tumors are the most frequent cause of cancer death in cats and second most frequent in humans. In fact, naturally occurring tumors in domestic animals, more particularly cat mammary tumors, have been proposed as a good model for human breast cancer, but critical genetic and molecular information is still scarce. The aims of this study include the analysis of the cat ERBB2 gene partial sequences (between exon 17 and 20) in order to characterize a normal and a mammary lesion heterogeneous populations. Cat genomic DNA was extracted from normal frozen samples (n = 16) and from frozen and formalin-fixed paraffin-embedded mammary lesion samples (n = 41). We amplified and sequenced two cat ERBB2 DNA fragments comprising exons 17 to 20. It was possible to identify five sequence variants and six haplotypes in the total population. Two sequence variants and two haplotypes show to be specific for cat mammary tumor samples. Bioinformatics analysis predicts that four of the sequence variants can produce alternative transcripts or activate cryptic splicing sites. Also, a possible association was identified between clinicopathological traits and the variant haplotypes. As far as we know, this is the first attempt to examine ERBB2 genetic variations in cat mammary genome and its possible association with the onset and progression of cat mammary tumors. The demonstration of a possible association between primary tumor size (one of the two most important prognostic factors) and the number of masses with the cat ERBB2 variant haplotypes reveal the importance of the analysis of this gene in veterinary medicine.

Metabolites, Vol. 2, Pages 254-267: Comparative Lipidomic Profiling of S. cerevisiae and Four Other Hemiascomycetous Yeasts

Posted: 02 Mar 2012 12:00 AM PST

Glycerophospholipids (GP) are the building blocks of cellular membranes and play essential roles in cell compartmentation, membrane fluidity or apoptosis. In addition, GPs are sources for multifunctional second messengers. Whereas the genome and proteome of the most intensively studied eukaryotic model organism, the baker's yeast (Saccharomyces cerevisiae), are well characterized, the analysis of its lipid composition is still at the beginning. Moreover, different yeast species can be distinguished on the DNA, RNA and protein level, but it is currently unknown if they can also be differentiated by determination of their GP pattern. Therefore, the GP compositions of five different yeast strains, grown under identical environmental conditions, were elucidated using high performance liquid chromatography coupled to negative electrospray ionization-hybrid linear ion trap-Fourier transform ion cyclotron resonance mass spectrometry in single and multistage mode. Using this approach, relative quantification of more than 100 molecular species belonging to nine GP classes was achieved. The comparative lipidomic profiling of Saccharomyces cerevisiae, Saccharomyces bayanus, Kluyveromyces thermotolerans, Pichia angusta, and Yarrowia lipolytica revealed characteristic GP profiles for each strain. However, genetically related yeast strains show similarities in their GP compositions, e.g., Saccharomyces cerevisiae and Saccharomyces bayanus.

Metabolites, Vol. 2, Pages 242-253: Human Metabolic Network: Reconstruction, Simulation, and Applications in Systems Biology

Posted: 02 Mar 2012 12:00 AM PST

Metabolism is crucial to cell growth and proliferation. Deficiency or alterations in metabolic functions are known to be involved in many human diseases. Therefore, understanding the human metabolic system is important for the study and treatment of complex diseases. Current reconstructions of the global human metabolic network provide a computational platform to integrate genome-scale information on metabolism. The platform enables a systematic study of the regulation and is applicable to a wide variety of cases, wherein one could rely on in silico perturbations to predict novel targets, interpret systemic effects, and identify alterations in the metabolic states to better understand the genotype-phenotype relationships. In this review, we describe the reconstruction of the human metabolic network, introduce the constraint based modeling approach to analyze metabolic networks, and discuss systems biology applications to study human physiology and pathology. We highlight the challenges and opportunities in network reconstruction and systems modeling of the human metabolic system.

Membranes, Vol. 2, Pages 134-197: Light Responsive Polymer Membranes: A Review

Posted: 02 Mar 2012 12:00 AM PST

In recent years, stimuli responsive materials have gained significant attention in membrane separation processes due to their ability to change specific properties in response to small external stimuli, such as light, pH, temperature, ionic strength, pressure, magnetic field, antigen, chemical composition, and so on. In this review, we briefly report recent progresses in light-driven materials and membranes. Photo-switching mechanisms, valved-membrane fabrication and light-driven properties are examined. Advances and perspectives of light responsive polymer membranes in biotechnology, chemistry and biology areas are discussed.

Materials, Vol. 5, Pages 377-384: A Study of Trimethylsilane (3MS) and Tetramethylsilane (4MS) Based α-SiCN:H/α-SiCO:H Diffusion Barrier Films

Posted: 02 Mar 2012 12:00 AM PST

Amorphous nitrogen-doped silicon carbide (α-SiCN:H) films have been used as a Cu penetration diffusion barrier and interconnect etch stop layer in the below 90-nanometer ultra-large scale integration (ULSI) manufacturing technology. In this study, the etching stop layers were deposited by using trimethylsilane (3MS) or tetramethylsilane (4MS) with ammonia by plasma-enhanced chemical vapor deposition (PECVD) followed by a procedure for tetra-ethoxyl silane (TEOS) oxide. The depth profile of Cu distribution examined by second ion mass spectroscopy (SIMs) showed that 3MS α-SiCN:H exhibited a better barrier performance than the 4MS film, which was revealed by the Cu signal. The FTIR spectra also showed the intensity of Si-CH3 stretch mode in the α-SiCN:H film deposited by 3MS was higher than that deposited by 4MS. A novel multi structure of oxygen-doped silicon carbide (SiC:O) substituted TEOS oxide capped on 4MS α-SiC:N film was also examined. In addition to this, the new multi etch stop layers can be deposited together with the same tool which can thus eliminate the effect of the vacuum break and accompanying environmental contamination.

A Better Finder Rename 9.01 - File, photo, and MP3 batch renamer.. (Shareware)

Posted: 01 Mar 2012 08:59 PM PST



A Better Finder Rename is the most complete renaming solution available on the market today. That's why, since 1996, tens of thousands of hobbyists, professionals and businesses depend on A Better Finder Rename to organize and maintain files.

A Better Finder Rename's user interface supports complex renaming tasks without sacrificing ease and speed of use. Simply drag the files you want to rename straight from the Finder into the large preview table or the application icon.. or use our Finder context menu and hot key.

The Instant Preview feature eliminates guesswork and costly errors and helps you find the right settings quickly and accurately by providing as-you-type feedback.

A Better Finder Rename offers a complete set of renaming options that are organized into 15 categories covering all the text, character, position, conversion and truncation features that you would expect from a file renamer, but it does not stop there.

Photographers use the advanced sequence number and date & time features to clean up their portfolios or prepare photos for delivery to their client. A Better Finder Rename knows how to extract EXIF shooting date and time information from digital camera images and exploit them in creating sequence numbers or adding time and date information to the file name. Support for all major RAW formats (including JPEG, CRW, CR2, THM, NEF, TIFF, RAJ, ORF , MRW, DNG, PEF, SRF, etc.) extends this to professional photographers. A Better Finder Rename also deals gracefully with multiple shots captured in the same second.

Version 9 adds support for extracting camera, lens, photo and color meta-data tags and using them in the new tag rename feature. You can now also re-order sequence numbers, alphabetical sequences or roman numeral series directly through dragging and dropping items in the preview list.

System administrators, web masters and other power users will appreciate the presence of advanced features, such as regular expression support, conversion to Windows NTFS/SMB compatible names, the ability to import file names from a database, a spreadsheet or any other source that can produce plain or tab-delimited text files. Last but not least, the ability to save a record of the current and new file names greatly facilitates tracking your files.

Music lovers can use the built-in MP3/AAC support to exploit the id3 meta-data tags embedded in your most music files to create their own naming schemes for their music collection. Meta-data information from MP3, AAC, FLAC, OGG, APE, M4V and iTunes music store files are supported.

The multi-step renaming feature allows multiple renaming steps to be combined to deal with complex renaming jobs in a single operation. Unlike other tools, A Better Finder Rename allows any number of renaming actions to be combined, re-ordered, copied and deleted.

Version 9.01:

  • allows you to automatically migrate version 8 droplets to the latest version.


Mac OS X 10.6 or later

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