Games |
- cf/x cookie cutter 1.0.0 - Cut your photos into shapes.. (Demo)
- Mail Archiver X 2.7.4.3.392 - Mail archiving, cleaning and browsing.. (Demo)
- Porthole 1.1.0 - Stream any audio to your Airport devices.. (Demo)
- Insects, Vol. 3, Pages 402-409: Comparison of Three Bed Bug Management Strategies in a Low-Income Apartment Building
- Viruses, Vol. 4, Pages 424-446: Interplay between Interferon-Mediated Innate Immunity and Porcine Reproductive and Respiratory Syndrome Virus
- Crystals, Vol. 2, Pages 159-175: Mechanical and Thermal Dehydrogenation of Lithium Alanate (LiAlH4) and Lithium Amide (LiNH2) Hydride Composites
- Future Internet, Vol. 4, Pages 362-371: Collaboration between Professionals: The Use of Videoconferencing for Delivering E-Health
- Remote Sensing, Vol. 4, Pages 975-986: An Empirical Assessment of Temporal Decorrelation Using the Uninhabited Aerial Vehicle Synthetic Aperture Radar over Forested Landscapes
- Entropy, Vol. 14, Pages 665-686: Experimental Test of the “Special State” Theory of Quantum Measurement
- Sensors, Vol. 12, Pages 4466-4478: An Advanced Compiler Designed for a VLIW DSP for Sensors-Based Systems
- GAME not dead - jobs and stores saved as high street retailer finds buyer
- Revel, Atlantic City's newest casino set to open
- Sensors, Vol. 12, Pages 4447-4465: Gamma Irradiation of Magnetoresistive Sensors for Planetary Exploration
- Applied Sciences, Vol. 2, Pages 315-326: Anomalous Magnetization Enhancement and Frustration in the Internal Magnetic Order on (Fe0.69Co0.31)B0.4 Nanoparticles
- Applied Sciences, Vol. 2, Pages 303-314: Effects of Superparamagnetic Nanoparticle Clusters on the Polymerase Chain Reaction
- IJMS, Vol. 13, Pages 4321-4339: Toward the Understanding of the Metabolism of Levodopa I. DFT Investigation of the Equilibrium Geometries, Acid-Base Properties and Levodopa-Water Complexes
- IJMS, Vol. 13, Pages 4295-4320: Salivary Defense Proteins: Their Network and Role in Innate and Acquired Oral Immunity
- IJMS, Vol. 13, Pages 4281-4294: Evolution of Microsatellite Loci of Tropical and Temperate Anguilla Eels
- IJMS, Vol. 13, Pages 4268-4280: CARD15/NOD2, CD14 and Toll-like 4 Receptor Gene Polymorphisms in Saudi Patients with Crohn’s Disease
- Molecules, Vol. 17, Pages 4047-4132: Advanced Fluorescence Microscopy Techniques—FRAP, FLIP, FLAP, FRET and FLIM
| cf/x cookie cutter 1.0.0 - Cut your photos into shapes.. (Demo) Posted: 02 Apr 2012 03:00 AM PDT  A cookie cutter, as everyone knows, is a piece of metal or plastic, bent into an easily recognizable shape (heart, moon, angel, flower etc.).The shape is pressed into fresh cookie dough in order to quickly cut out the shape. The cut out shape is then transferred to the oven and baked into a cookie.cf/x uses the same metaphor to quickly cut out a shape from any photo. In cf/x cookie cutter, all you do is select the shape, place it on your photo, and - boom - you have a perfectly cut out from your photo. Version 1.0.0:
Download Now This posting includes an audio/video/photo media file: Download Now |
| Mail Archiver X 2.7.4.3.392 - Mail archiving, cleaning and browsing.. (Demo) Posted: 02 Apr 2012 02:51 AM PDT  Mail Archiver X protects one of your Mac-based small business' most important assets: your email.
Version 2.7.4.3.392:
Mac OS X 10.6.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Porthole 1.1.0 - Stream any audio to your Airport devices.. (Demo) Posted: 02 Apr 2012 02:54 AM PDT  Porthole is a tool that lets you stream the music from your favorite music player such as Spotify or Last FM to your Apple AirPort Express or Apple TV? That's just what Porthole does for you: one click transfers all audio, not just iTunes, from your Mac to your AirPlay device. Porthole focusses on being elegant and simple to use. The setup wizard will have you going in no-time. Version 1.1.0:
Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 02 Apr 2012 12:00 AM PDT Bed bug (Cimex lectularius L.) infestations are currently controlled by a variety of non-chemical and chemical methods. There have been few studies on the comparative effectiveness of these control techniques. We evaluated three bed bug management strategies in an apartment building: (1) non-chemical methods only (n = 9); (2) insecticides only (n = 6); and (3) integrated pest management including both non-chemical methods and insecticides (n = 9). The apartments were one-bedroom units occupied by seniors or people with disabilities. Bed bug numbers in each apartment were determined by visual inspection and/or installing intercepting devices under bed and sofa legs. The median (min, max) bed bug counts in the non-chemical methods only, insecticides only, and integrated pest management (IPM) treatment were: 4 (1, 57), 19 (1, 250), and 14 (1, 219), respectively prior to the treatments. The apartments were retreated if found necessary during biweekly to monthly inspections. After 10 weeks, bed bugs were found to be eliminated from 67, 33, and 44% of the apartments in the three treatment groups, respectively. The final (after 10 weeks) median (min, max) bed bug counts in the non-chemical methods only, insecticides only, and IPM treatment were: 0 (0, 134), 11.5 (0, 58), and 1 (0, 38), respectively. There were no significant differences in the speed of bed bug count reduction or the final bed bug counts. Lack of resident cooperation partially contributed to the failure in eliminating bed bugs from some of the apartments. Results of this study suggest that non-chemical methods can effectively eliminate bed bugs in lightly infested apartments. |
| Posted: 02 Apr 2012 12:00 AM PDT Innate immunity is the first line of defense against viral infection, and in turn, viruses have evolved to evade host immune surveillance. As a result, viruses may persist in host and develop chronic infections. Type I interferons (IFN-α/β) are among the most potent antiviral cytokines triggered by viral infections. Porcine reproductive and respiratory syndrome (PRRS) is a disease of pigs that is characterized by negligible induction of type I IFNs and viral persistence for an extended period. For IFN production, RIG-I/MDA5 and JAK-STAT pathways are two major signaling pathways, and recent studies indicate that PRRS virus is armed to modulate type I IFN responses during infection. This review describes the viral strategies for modulation of type I IFN responses. At least three non‑structural proteins (Nsp1, Nsp2, and Nsp11) and a structural protein (N nucleocapsid protein) have been identified and characterized to play roles in the IFN suppression and NF-κB pathways. Nsp's are early proteins while N is a late protein, suggesting that additional signaling pathways may be involved in addition to the IFN pathway. The understanding of molecular bases for virus-mediated modulation of host innate immune signaling will help us design new generation vaccines and control PRRS. |
| Posted: 02 Apr 2012 12:00 AM PDT Hydrogen storage properties of the (nLiAlH4 + LiNH2) hydride composite where n = 1, 3, 11.5 and 30, synthesized by high energy ball milling have been investigated. The composite with the molar ratio n = 1 releases large quantities of H2 (up to ~5 wt.%) during ball milling up to 100–150 min. The quantity of released H2 rapidly decreases for the molar ratio n = 3 and is not observed for n = 11.5 and 30. The XRD studies indicate that the H2 release is a result of a solid state decomposition of LiAlH4 into (1/3)Li3AlH6 + (2/3)Al + H2 and subsequently decomposition of (1/3)Li3AlH6 into LiH + (1/3)Al + 0.5H2. Apparently, LiAlH4 is profoundly destabilized during ball milling by the presence of a large quantity of LiNH2 (37.7 wt.%) in the n = 1 composite. The rate of dehydrogenation at 100–170 °C (at 1 bar H2) is adversely affected by insufficient microstructural refinement, as observed for the n = 1 composite, which was milled for only 2 min to avoid H2 discharge during milling. XRD studies show that isothermal dehydrogenation of (nLiAlH4 + LiNH2) occurs by the same LiAlH4 decomposition reactions as those found during ball milling. The ball milled n = 1 composite stored under Ar at 80 °C slowly discharges large quantities of H2 approaching 3.5 wt.% after 8 days of storage. |
| Posted: 02 Apr 2012 12:00 AM PDT This article explores the ways in which collaboration between professionals using videoconferencing affects the e-health delivered to patients. In Norway, general practitioners (GPs) and specialists routinely hold videoconferences. Observations of 42 VC meetings, each lasting from 5 to 40 min, were analysed in terms of the interactions. In addition, five semi-structured, face-to-face interviews were conducted, each lasting from 20 to 70 minutes. Statements were selected to illustrate the content of the interactions and how collaborative work affects the delivery of healthcare. Successful collaborative work provides practitioners with a new way of thinking: exchanging information and knowledge between levels of care in order to provide the best treatment for patients locally. The regularity makes the collaborative work a two-way achievement. GPs receive decision support and second opinions, and specialists receive information and opportunities to follow up. How the professionals manage their work (i.e., collaborating) may benefit their patients. The regular use of videoconferencing will furnish professionals with enhanced resources for the meeting of patients' demands in the future. Regularly informing one another and exchanging knowledge, benefits the professionals by providing increased certainty with regard to their medical decisions, and it benefits the patients because they will feel satisfied with the competence of the specialists where they live. |
| Posted: 02 Apr 2012 12:00 AM PDT We present an empirical assessment of the impact of temporal decorrelation on interferometric coherence measured over a forested landscape. A series of repeat-pass interferometric radar images with a zero spatial baseline were collected with UAVSAR (Uninhabited Aerial Vehicle Synthetic Aperture Radar), a fully polarimetric airborne L-band radar system. The dataset provided temporal separations of 45 minutes, 2, 7 and 9 days. Coincident airborne lidar and weather data were collected. We theoretically demonstrate that UAVSAR measurement accuracy enables accurate quantification of temporal decorrelation. Data analysis revealed precipitation events to be the main driver of temporal decorrelation over the acquisition period. The experiment also shows temporal decorrelation increases with canopy height, and this pattern was found consistent across forest types and polarization. |
| Posted: 02 Apr 2012 12:00 AM PDT An experimental test of the "special state" theory of quantum measurement is proposed. It should be feasible with present-day laboratory equipment and involves a slightly elaborated Stern–Gerlach setup. The "special state" theory is conservative with respect to quantum mechanics, but radical with respect to statistical mechanics, in particular regarding the arrow of time. In this article background material is given on both quantum measurement and statistical mechanics aspects. For example, it is shown that future boundary conditions would not contradict experience, indicating that the fundamental equal-a-priori-probability assumption at the foundations of statistical mechanics is far too strong (since future conditioning reduces the class of allowed states). The test is based on a feature of this theory that was found necessary in order to recover standard (Born) probabilities in quantum measurements. Specifically, certain systems should have "noise" whose amplitude follows the long-tailed Cauchy distribution. This distribution is marked by the occasional occurrence of extremely large signals as well as a non-self-averaging property. The proposed test is a variant of the Stern–Gerlach experiment in which protocols are devised, some of which will require the presence of this noise, some of which will not. The likely observational schemes would involve the distinction between detection and non-detection of that "noise". The signal to be detected (or not) would be either single photons or electric fields (and related excitations) in the neighborhood of the ends of the magnets. |
| Posted: 02 Apr 2012 12:00 AM PDT The VLIW architecture can be exploited to greatly enhance instruction level parallelism, thus it can provide computation power and energy efficiency advantages, which satisfies the requirements of future sensor-based systems. However, as VLIW codes are mainly compiled statically, the performance of a VLIW processor is dominated by the behavior of its compiler. In this paper, we present an advanced compiler designed for a VLIW DSP named Magnolia, which will be used in sensor-based systems. This compiler is based on the Open64 compiler. We have implemented several advanced optimization techniques in the compiler, and fulfilled the O3 level optimization. Benchmarks from the DSPstone test suite are used to verify the compiler. Results show that the code generated by our compiler can make the performance of Magnolia match that of the current state-of-the-art DSP processors. |
| GAME not dead - jobs and stores saved as high street retailer finds buyer Posted: 02 Apr 2012 01:49 AM PDT
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| Revel, Atlantic City's newest casino set to open Posted: 02 Apr 2012 01:28 AM PDT In this March 28, 2012, photo, Ludmilla Kaliafa, an E-Dealer at Revel in Atlantic City N.J., chats with gamblers on the first night the $2.4 billion casino resort allowed people to gamble. This posting includes an audio/video/photo media file: Download Now |
| Posted: 02 Apr 2012 12:00 AM PDT A limited number of Anisotropic Magnetoresistive (AMR) commercial-off-the-shelf (COTS) magnetic sensors of the HMC series by Honeywell, with and without integrated front-end electronics, were irradiated with gamma rays up to a total irradiation dose of 200 krad (Si), following the ESCC Basic Specification No. 22900. Due to the magnetic cleanliness required for these tests a special set-up was designed and successfully employed. Several parameters of the sensors were monitored during testing and the results are reported in this paper. The authors conclude that AMR sensors without front-end electronics seem to be robust against radiation doses of up to 200 krad (Si) with a dose rate of 5 krad (Si)/hour and up to a resolution of tens of nT, but sensors with an integrated front-end seem to be more vulnerable to radiation. |
| Posted: 02 Apr 2012 12:00 AM PDT We have studied the internal magnetic order of 3-nm (Fe0.69Co0.31)0.6B0.4 amorphous nanoparticles. These nanoparticles were dispersed in a non-magnetic matrix (non-interacting nanoparticles) to contrast them with the powder samples, where strong interparticle interactions are present. In similar fashion to the bulk alloy, this system exhibits a saturation magnetization maximum as a function of Fe composition near 69 at% Fe for the powder and dispersed samples at all temperatures. The saturation magnetization (MS) of the dispersed sample shows anomalous behavior, revealing frustration in the internal magnetic order of the particles. Unexpectedly, the MS of the non-interacting sample at low temperatures is larger than the corresponding bulk alloy or the calculated value of MS for the same Fe-Co composition. By contrast, the powder sample has low MS values and it is approximately constant in temperature. |
| Posted: 02 Apr 2012 12:00 AM PDT The polymerase chain reaction (PCR) method is widely used for the reproduction and amplification of specific DNA segments, and a novel PCR method using nanomaterials such as gold nanoparticles has recently been reported. This paper reports on the effects of superparamagnetic nanoparticles on PCR amplification without an external magnetic field, and clarifies the mechanism behind the effects of superparamagnetic particle clusters on PCR efficiency by estimating the structures of such clusters in PCR. It was found that superparamagnetic nanoparticles tend to inhibit PCR amplification depending on the structure of the magnetic nanoparticle clusters. The paper also clarifies that Taq polymerase is captured in the spaces formed among magnetic nanoparticle clusters, and that it is captured more efficiently as a result of their motion from heat treatment in PCR thermal cycles. Consequently, Taq polymerase that should be used in PCR is reduced in the PCR solution. These outcomes will be applied to novel PCR techniques using magnetic particles in an external magnetic field. |
| Posted: 02 Apr 2012 12:00 AM PDT Levodopa (LD) is used to increase dopamine level for treating Parkinson's disease. The major metabolism of LD to produce dopamine is decarboxylation. In order to understand the metabolism of LD; the electronic structure of levodopa was investigated at the Density Functional DFT/B3LYP level of theory using the 6-311+G** basis set, in the gas phase and in solution. LD is not planar, with the amino acid side chain acting as a free rotator around several single bonds. The potential energy surface is broad and flat. Full geometry optimization enabled locating and identifying the global minimum on this Potential energy surface (PES). All possible protonation/deprotonation forms of LD were examined and analyzed. Protonation/deprotonation is local in nature, i.e., is not transmitted through the molecular framework. The isogyric protonation/deprotonation reactions seem to involve two subsequent steps: First, deprotonation, then rearrangement to form H-bonded structures, which is the origin of the extra stability of the deprotonated forms. Natural bond orbital (NBO) analysis of LD and its deprotonated forms reveals detailed information of bonding characteristics and interactions across the molecular framework. The effect of deprotonation on the donor-acceptor interaction across the molecular framework and within the two subsystems has also been examined. Attempts to mimic the complex formation of LD with water have been performed. |
| Posted: 02 Apr 2012 12:00 AM PDT There are numerous defense proteins present in the saliva. Although some of these molecules are present in rather low concentrations, their effects are additive and/or synergistic, resulting in an efficient molecular defense network of the oral cavity. Moreover, local concentrations of these proteins near the mucosal surfaces (mucosal transudate), periodontal sulcus (gingival crevicular fluid) and oral wounds and ulcers (transudate) may be much greater, and in many cases reinforced by immune and/or inflammatory reactions of the oral mucosa. Some defense proteins, like salivary immunoglobulins and salivary chaperokine HSP70/HSPAs (70 kDa heat shock proteins), are involved in both innate and acquired immunity. Cationic peptides and other defense proteins like lysozyme, bactericidal/permeability increasing protein (BPI), BPI-like proteins, PLUNC (palate lung and nasal epithelial clone) proteins, salivary amylase, cystatins, prolin-rich proteins, mucins, peroxidases, statherin and others are primarily responsible for innate immunity. In this paper, this complex system and function of the salivary defense proteins will be reviewed. |
| Posted: 02 Apr 2012 12:00 AM PDT Anguilla eels are divided into temperate and tropical eels, based on their major distributions. The present study collected two temperate eels, Anguilla japonica and Anguilla anguilla, and two tropical eels, Anguilla marmorata and Anguilla bicolor pacifica, to examine two questions: do temperate and tropical Anguilla eels have different genetic polymorphic patterns?; and do temperate Anguilla japonica and Anguilla anguilla have a closer relationship to each other than to tropical eels? In total, 274 sequences were cloned and sequenced from six conserved microsatellite loci to examine polymorphic patterns of these four catadromous eels. Different mutational events, including substitutions, and repeat-unit deletions and insertions, appeared in major regions, while different point mutations were observed in flanking regions. The results implied that parallel patterns of microsatellite sequences occurred within both tropical and temperate freshwater eels. Consensus flanking sequences of six homologous loci from each of the four species were constructed. Genetic distances ranged from 0.044 (Anguilla bicolor pacifica vs. Anguilla marmorata) to 0.061 (Anguilla marmorata vs. Anguilla anguilla). The tree topology suggests the hypothesis of Anguilla japonica and Anguilla anguilla being a sister group must be rejected. |
| Posted: 02 Apr 2012 12:00 AM PDT Crohn's disease (CD) is a multifactorial disease with a genetic component and an observed association with genes related to the innate immune response. Polymorphisms in the CARD15/NOD2 gene, in addition to functional variants of the toll-like receptor-4 (TLR4) and CD14 genes, have been associated with the development of Crohn's disease. There is no information about the frequency of these polymorphisms in the Saudi population. We examined the frequency of the three major CARD15/NOD2 risk alleles (Leu1007fsinsC, Arg702Trp, and Gly908Arg) and the TLR4 (Thr399Il) polymorphism as well as a functional polymorphism in the promoter of the CD14–159C/T in 46 Saudi CD patients and 50 matched controls. Genotyping was performed by allele-specific PCR or by restriction fragment length polymorphism (PCR-RFLP) analysis. The mutant genotype frequencies of the Leu1007fsinsC, Arg702Trp and Gly908Arg in the patient group were 6.5, 21.7 and 6.5%, respectively, compared with frequencies of 0, 4 and 2%, respectively, in the control group. There were 15 patients who carried the mutant alleles for all three CARD15/NOD2 variants, Leu1007fsinsC, Arg702Trp and Gly908Arg, while none of the control candidates carried the three alleles. This genetic study provides evidence that the three major CARD15/NOD2 variant alleles and the CD14 −159C/T polymorphism are associated with Crohn's disease (CD) susceptibility in the Saudi population; however, there is no evidence that the TLR4 (Thr399Il) or CARD15/NOD2 polymorphisms can be considered risk factors for Crohn's disease. |
| Posted: 02 Apr 2012 12:00 AM PDT Fluorescence microscopy provides an efficient and unique approach to study fixed and living cells because of its versatility, specificity, and high sensitivity. Fluorescence microscopes can both detect the fluorescence emitted from labeled molecules in biological samples as images or photometric data from which intensities and emission spectra can be deduced. By exploiting the characteristics of fluorescence, various techniques have been developed that enable the visualization and analysis of complex dynamic events in cells, organelles, and sub-organelle components within the biological specimen. The techniques described here are fluorescence recovery after photobleaching (FRAP), the related fluorescence loss in photobleaching (FLIP), fluorescence localization after photobleaching (FLAP), Förster or fluorescence resonance energy transfer (FRET) and the different ways how to measure FRET, such as acceptor bleaching, sensitized emission, polarization anisotropy, and fluorescence lifetime imaging microscopy (FLIM). First, a brief introduction into the mechanisms underlying fluorescence as a physical phenomenon and fluorescence, confocal, and multiphoton microscopy is given. Subsequently, these advanced microscopy techniques are introduced in more detail, with a description of how these techniques are performed, what needs to be considered, and what practical advantages they can bring to cell biological research. |
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