понедельник, 18 марта 2013 г.

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IJMS, Vol. 14, Pages 6205-6222: Combinatorial Analysis of Secretory Immunoglobulin A (sIgA) Expression in Plants

Posted: 18 Mar 2013 12:00 AM PDT

Delivery of secretory immunoglobulin A (sIgA) to mucosal surfaces as a passive immunotherapy agent is a promising strategy to prevent infectious diseases. Recombinant sIgA production in plants requires the co-expression of four transcriptional units encoding the light chain (LC), heavy chain (HC), joining chain (JC) and secretory component (SC). As a way to optimize sIgA production in plants, we tested the combinatorial expression of 16 versions of a human sIgA against the VP8* rotavirus antigen in Nicotiana benthamiana, using the recently developed GoldenBraid multigene assembly system. Each sIgA version was obtained by combining one of the two types of HC (α1 and α2) with one of the two LC types (k and λ) and linking or not a KDEL peptide to the HC and/or SC. From the analysis of the anti-VP8* activity, it was concluded that those sIgA versions carrying HCα1 and LCλ provided the highest yields. Moreover, ER retention significantly increased antibody production, particularly when the KDEL signal was linked to the SC. Maximum expression levels of 32.5 μg IgA/g fresh weight (FW) were obtained in the best performing combination, with an estimated 33% of it in the form of a secretory complex.

IJMS, Vol. 14, Pages 6187-6204: A Novel Moderate Constitutive Promoter Derived from Poplar (Populus tomentosa Carrière)

Posted: 18 Mar 2013 12:00 AM PDT

A novel sequence that functions as a promoter element for moderate constitutive expression of transgenes, designated as the PtMCP promoter, was isolated from the woody perennial Populus tomentosa. The PtMCP promoter was fused to the GUS reporter gene to characterize its expression pattern in different species. In stable Arabidopsis transformants, transcripts of the GUS reporter gene could be detected by RT-PCR in the root, stem, leaf, flower and silique. Further histochemical and fluorometric GUS activity assays demonstrated that the promoter could direct transgene expression in all tissues and organs, including roots, stems, rosette leaves, cauline leaves and flowers of seedlings and maturing plants. Its constitutive expression pattern was similar to that of the CaMV35S promoter, but the level of GUS activity was significantly lower than in CaMV35S promoter::GUS plants. We also characterized the promoter through transient expression in transgenic tobacco and observed similar expression patterns. Histochemical GUS staining and quantitative analysis detected GUS activity in all tissues and organs of tobacco, including roots, stems, leaves, flower buds and flowers, but GUS activity in PtMCP promoter::GUS plants was significantly lower than in CaMV35S promoter::GUS plants. Our results suggested that the PtMCP promoter from poplar is a constitutive promoter with moderate activity and that its function is presumably conserved in different species. Therefore, the PtMCP promoter may provide a practical choice to direct moderate level constitutive expression of transgenes and could be a valuable new tool in plant genetic engineering.

Is Pippa Middleton A Gambling Advocate?

Posted: 18 Mar 2013 02:26 AM PDT

Royals, and their families, are known to be extremely conservative-with money, recreation and pretty much everything else.

IJMS, Vol. 14, Pages 6170-6186: The Lipid Transfer Protein StarD7: Structure, Function, and Regulation

Posted: 18 Mar 2013 12:00 AM PDT

The steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins constitute a family of evolutionarily conserved and widely expressed proteins that have been implicated in lipid transport, metabolism, and signaling. The 15 well-characterized mammalian START domain-containing proteins are grouped into six subfamilies. The START domain containing 7 mRNA encodes StarD7, a member of the StarD2/phosphatidylcholine transfer protein (PCTP) subfamily, which was first identified as a gene overexpressed in a choriocarcinoma cell line. Recent studies show that the StarD7 protein facilitates the delivery of phosphatidylcholine to the mitochondria. This review summarizes the latest advances in StarD7 research, focusing on the structural and biochemical features, protein-lipid interactions, and mechanisms that regulate StarD7 expression. The implications of the role of StarD7 in cell proliferation, migration, and differentiation are also discussed.

IJMS, Vol. 14, Pages 6157-6169: LC-MS/MS Determination of Isoprostanes in Plasma Samples Collected from Mice Exposed to Doxorubicin or Tert-Butyl Hydroperoxide

Posted: 18 Mar 2013 12:00 AM PDT

Isoprostanes are stable products of arachidonic acid peroxidation and are regarded as the most reliable markers of oxidative stress in vivo. Here we describe the LC-MS/MS procedure enabling simultaneous determination of four regioisomers (8-iso prostaglandin F2α, 8-iso-15(R)-prostaglandin F2α, 11β-prostaglandin F2α, 15(R)-prostaglandin F2α) in plasma samples collected from mice. The four plasma isoprostanes are determined by LC–ESI-MS/MS with deuterated 8-iso-PGF2α-d4 as an internal standard (I.S.). For plasma samples spiked with the isoprostanes at a level of 200 pg/mL each, the method imprecision has been below 7.1% and mean inaccuracy equaled 8.7%. The applicability of the proposed approach has been verified by the assessment of changes in isoprostane levels in plasma samples derived from mice exposed to tert-butyl hydroperoxide (TBHP), a model inducer of oxidative stress, or to antitumor drug doxorubicin (DOX) known for potent stimulation of redox cycling. Compared to the control group of mice, both oxidative stress inducers tested increased the levels of three out of four isoprostanes in exposed animals; 11β-prostaglandin F2α being the exception. The greatest rise was observed in the case of 15(R)-prostaglandin F2α, by about 50% and 70% in plasma samples derived from mice exposed to DOX and TBHP, respectively.

IJMS, Vol. 14, Pages 6144-6156: CentroidAlign-Web: A Fast and Accurate Multiple Aligner for Long Non-Coding RNAs

Posted: 18 Mar 2013 12:00 AM PDT

Due to the recent discovery of non-coding RNAs (ncRNAs), multiple sequence alignment (MSA) of those long RNA sequences is becoming increasingly important for classifying and determining the functional motifs in RNAs. However, not only primary (nucleotide) sequences, but also secondary structures of ncRNAs are closely related to their function and are conserved evolutionarily. Hence, information about secondary structures should be considered in the sequence alignment of ncRNAs. Yet, in general, a huge computational time is required in order to compute MSAs, taking secondary structure information into account. In this paper, we describe a fast and accurate web server, called CentroidAlign-Web, which can handle long RNA sequences. The web server also appropriately incorporates information about known secondary structures into MSAs. Computational experiments indicate that our web server is fast and accurate enough to handle long RNA sequences. CentroidAlign-Web is freely available from http://centroidalign.ncrna.org/.

IJMS, Vol. 14, Pages 6116-6143: Cadmium-Induced Pathologies: Where Is the Oxidative Balance Lost (or Not)?

Posted: 18 Mar 2013 12:00 AM PDT

Over the years, anthropogenic factors have led to cadmium (Cd) accumulation in the environment causing various health problems in humans. Although Cd is not a Fenton-like metal, it induces oxidative stress in various animal models via indirect mechanisms. The degree of Cd-induced oxidative stress depends on the dose, duration and frequency of Cd exposure. Also the presence or absence of serum in experimental conditions, type of cells and their antioxidant capacity, as well as the speciation of Cd are important determinants. At the cellular level, the Cd-induced oxidative stress either leads to oxidative damage or activates signal transduction pathways to initiate defence responses. This balance is important on how different organ systems respond to Cd stress and ultimately define the pathological outcome. In this review, we highlight the Cd-induced oxidant/antioxidant status as well as the damage versus signalling scenario in relation to Cd toxicity. Emphasis is addressed to Cd-induced pathologies of major target organs, including a section on cell proliferation and carcinogenesis. Furthermore, attention is paid to Cd-induced oxidative stress in undifferentiated stem cells, which can provide information for future therapies in preventing Cd-induced pathologies.

Gears of War: Judgment - GR Review

Posted: 17 Mar 2013 01:50 PM PDT

Just another cog in the war.   When Marcus Fenix hung up his doo-rag, shaved his soul patch, and called it a day at the end of Gears of War 3, I nearly shed a manly tear with him. "What's left, Anya?", indeed. The COG army had warred with the Locusts for five long years, and the Pendulum Wars took as many, if not more, lives before that. While Marcus, Anya, Dom (lol), and others get to stay at their Island getaway a little longer, Baird and Cole have been sent back in time to the initial underground-monster onslaught.   With a few new friends, the second-string Gears get starring roles and maybe even a chance to get emotional too. People Can Fly, of Bulletstorm fame, and Epic Games teamed up to reach deep and feed their fan base one more game. Can the formula continue to pay off, or is it time to take this war machine to the shop?

  In the "Judgment" campaign, Lieutenant Damon Baird and young Thrashball star Augustus Cole are joined by two newcomers: Sofia Hendrik, fresh from the academy, and Garren Paduk, UIR turned Gear who talks in a funny Russian accent. Some military asshole puts Baird on trial for an unknown reason and now each member of Kilo squad must narrate their testimony in the form of levels. This allows for the new "Declassified" missions, sub-objectives or parameters that will add to your score for the level. Oh yeah, there's a three-star scoring system now too, one you are constantly reminded of.   Some Declassified objectives set a timer and kill you if you take too long to finish. It's all the thrill of autoerotic asphyxiation in video game form. Sometimes it can make the player feel incredibly powerful. An early parameter gave my team of AI numbskulls four minutes to finish ...

IJMS, Vol. 14, Pages 6106-6115: Comparative Analysis of Serum (Anti)oxidative Status Parаmeters in Healthy Persons

Posted: 18 Mar 2013 12:00 AM PDT

Five antioxidant and two oxidative stress assays were applied to serum samples of 43 healthy males. The antioxidant tests showed different inter-assay correlations. A very good correlation of 0.807 was observed between the ferric reducing ability of plasma (FRAP) and total antioxidant status (TAS) assay and also a fair correlation of 0.501 between the biological antioxidant potential (BAP) and TAS assay. There was no statistically significant correlation between the BAP and FRAP assay. The anti-oxidant assays have a high correlation with uric acid, especially the TAS (0.922) and FRAP assay (0.869). The BAP assay has a much lower and no statistically significant correlation with uric acid (0.302), which makes BAP more suitable for the antioxidant status. The total thiol assay showed no statistically significant correlation with uric acid (0.114). The total thiol assay, which is based on a completely different principle, showed a good and statistically significant correlation with the BAP assay (0.510) and also to the TAS assay, but to a lower and not significant extent (0.279) and not with the FRAP assay (−0.008). The oxy-adsorbent test (OXY) assay has no correlation with any of the other assays tested. The oxidative stress assays, reactive oxygen metabolites (ROM) and total oxidant status (TOS), based on a different principle, do not show a statistically significant correlation with the serum samples in this study. Both assays showed a negative, but not significant, correlation with the antioxidant assays. In conclusion, the ROM, TOS, BAP and TTP assays are based on different principles and will have an additional value when a combination of these assays will be applied in large-scale population studies.

Antibiotics, Vol. 2, Pages 163-181: Resistance-Nodulation-Division Multidrug Efflux Pumps in Gram-Negative Bacteria: Role in Virulence

Posted: 18 Mar 2013 12:00 AM PDT

Resistance-Nodulation-Division (RND) efflux pumps are one of the most important determinants of multidrug resistance (MDR) in Gram-negative bacteria. With an ever increasing number of Gram-negative clinical isolates exhibiting MDR phenotypes as a result of the activity of RND pumps, it is clear that the design of novel effective clinical strategies against such pathogens must be grounded in a better understanding of these pumps, including their physiological roles. To this end, recent evidence suggests that RND pumps play an important role in the virulence of Gram-negative pathogens. In this review, we discuss the important role RND efflux pumps play in different facets of virulence including colonization, evasion of host defense mechanisms, and biofilm formation. These studies provide key insights that may ultimately be applied towards strategies used in the design of effective therapeutics against MDR Gram negative bacterial pathogens.

Antibiotics, Vol. 2, Pages 115-162: An Environmental Risk Assessment for Human-Use Trimethoprim in European Surface Waters

Posted: 18 Mar 2013 12:00 AM PDT

An environmental risk assessment (ERA) for the aquatic compartment in Europe from human use was developed for the old antibiotic Trimethoprim (TMP), comparing exposure and effects. The exposure assessment is based on European risk assessment default values on one hand and is refined with documented human use figures in Western Europe from IMS Health and measured removal in wastewater treatment on the other. The resulting predicted environmental concentrations (PECs) are compared with measured environmental concentrations (MECs) from Europe, based on a large dataset incorporating more than 1800 single MECs. On the effects side, available chronic ecotoxicity data from the literature were complemented by additional, new chronic results for fish and other organisms. Based on these data, chronic-based deterministic predicted no effect concentrations (PNECs) were derived as well as two different probabilistic PNEC ranges. The ERA compares surface water PECs and MECs with aquatic PNECs for TMP. Based on all the risk characterization ratios (PEC÷PNEC as well as MEC÷PNEC) and risk graphs, there is no significant risk to surface waters.

Molecules, Vol. 18, Pages 3502-3528: Technologies for the Synthesis of mRNA-Encoding Libraries and Discovery of Bioactive Natural Product-Inspired Non-Traditional Macrocyclic Peptides

Posted: 18 Mar 2013 12:00 AM PDT

In this review, we discuss emerging technologies for drug discovery, which yields novel molecular scaffolds based on natural product-inspired non-traditional peptides expressed using the translation machinery. Unlike natural products, these technologies allow for constructing mRNA-encoding libraries of macrocyclic peptides containing non-canonical sidechains and N-methyl-modified backbones. The complexity of sequence space in such libraries reaches as high as a trillion (>1012), affording initial hits of high affinity ligands against protein targets. Although this article comprehensively covers several related technologies, we discuss in greater detail the technical development and advantages of the Random non-standard Peptide Integration Discovery (RaPID) system, including the recent identification of inhibitors against various therapeutic targets.

Molecules, Vol. 18, Pages 3479-3501: Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents

Posted: 18 Mar 2013 12:00 AM PDT

Twenty-five polysubstituted phthalazinone derivatives were synthesized and tested for their antifungal activity against a panel of pathogenic and clinically important yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2-methylphthalazin-1(2H)-one (5) exhibited a remarkable antifungal activity against standardised strains of dermatophytes and Cryptococcus neoformans, as well as against some clinical isolates. A physicochemical study performed on compound 5 revealed its conformational and electronic characteristics, providing us with useful data for the future design of novel related antifungal analogues.

Molecules, Vol. 18, Pages 3467-3478: The Ameliorative Effects of L-2-Oxothiazolidine-4-Carboxylate on Acetaminophen-Induced Hepatotoxicity in Mice

Posted: 18 Mar 2013 12:00 AM PDT

The aim of the study was to investigate the ameliorative effects and the mechanism of action of L-2-oxothiazolidine-4-carboxylate (OTC) on acetaminophen (APAP)-induced hepatotoxicity in mice. Mice were randomly divided into six groups: normal control group, APAP only treated group, APAP + 25 mg/kg OTC, APAP + 50 mg/kg OTC, APAP + 100 mg/kg OTC, and APAP + 100 mg/kg N-acetylcysteine (NAC) as a reference control group. OTC treatment significantly reduced serum alanine aminotransferase and aspartate aminotransferase levels in a dose dependent manner. OTC treatment was markedly increased glutathione (GSH) production and glutathione peroxidase (GSH-px) activity in a dose dependent manner. The contents of malondialdehyde and 4-hydroxynonenal in liver tissues were significantly decreased by administration of OTC and the inhibitory effect of OTC was similar to that of NAC. Moreover, OTC treatment on APAP-induced hepatotoxicity significantly reduced the formation of nitrotyrosin and terminal deoxynucleotidyl transferase dUTP nick end labeling positive areas of liver tissues in a dose dependent manner. Furthermore, the activity of caspase-3 in liver tissues was reduced by administration of OTC in a dose dependent manner. The ameliorative effects of OTC on APAP-induced liver damage in mice was similar to that of NAC. These results suggest that OTC has ameliorative effects on APAP-induced hepatotoxicity in mice through anti-oxidative stress and anti-apoptotic processes.

VMware Fusion 5.0.3 - Run Windows and more without rebooting. (Demo)

Posted: 17 Mar 2013 08:59 PM PDT



VMware Fusion 5 has been revamped to take advantage of new technologies only available in Mountain Lion, Windows 8 and the latest Macs to deliver a Windows on Mac experience never seen before. Available at a price of $49.99, VMware Fusion 5 comes loaded with more than 70 new features including better performance, faster graphics and an enhanced UI geared for productivity.

Switching From a PC to a Mac Made Easy VMware Fusion's migration assistant for Windows makes it a breeze to switch from a PC to a Mac.

Run Your Favorite Windows Programs Run Windows programs alongside Mac applications without rebooting.

Use specific Windows-only devices on your Mac Use Windows-only USB or Bluetooth devices on your Mac.

The Perfect Complement to Boot Camp No more choosing between Windows or Mac at startup! Run windows programs side-by-side with Mac applications.

Running Windows Programs on a Mac is easy Run Windows programs the same way you use Mac applications with seamless copy-and-paste, drag-and-drop, networking and printing that "just work". Launch and interact with Windows programs as if they were Mac applications.

Made by the Virtualization Leader VMware Fusion 5 brings the stability and reliability that can only be delivered by the leader in virtualization.

We've Got You Covered 18 months of free email support and a 12-month complimentary subscription to McAfee VirusScan Plus to protect your Windows environment.

Version 5.0.3:

  • VMware Fusion 5.0.3 is a maintenance release that resolves some known issues. It is a free upgrade for all VMware Fusion 5 users.
  • Added support for Boot Camp partitions on 3TB disk drives.
  • Improved the cursor performance for select applications, especially when in Unity mode.
  • McAfee AntiVirus Plus updated with Windows 8 support.
  • Resolved an issue that could result in blurry graphics under certain circumstances.
  • Resolved an issue that resulted in horizontal scrolling being reversed in Unity mode.
  • Resolved an issue with displaying Office 2013 applications on some recent Macs.
  • Improvements to vSockets.


  • 2GB RAM (4GB recommended)
  • OS X 10.6.7 or later (10.7 recommended)
  • A copy of Windows (if you'll be installing Windows)


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Alfred 2.0.1 - Quick launcher for apps and more. (Free)

Posted: 17 Mar 2013 08:59 PM PDT



Alfred is an award-winning productivity application for OS X. Alfred saves you time when you search for files online or on your Mac. Be more productive with hotkeys, keywords, and file actions at your fingertips.

Loads of app-launching, file-searching goodness - free for you to download and use with no strings attached. Alfred is the ultimate productivity tool for your Mac. Get it and see for yourself.

Get the Powerpack Discover the Powerpack, a set of incredibly powerful features, built on top of the robust core of Alfred and integrated with OS X.

  • Single license: £15 for single user
  • Family license: £25 for 5 users under one roof
  • Mega Supporter: £30 Single User with Free Lifetime Upgrades



Version 2.0.1:
  • v1 Settings Migration button in Alfred's General prefs for upgrading users
  • Allow smaller prefs height for 11" Airs and 13" MacBooks
  • Add an 'Edit Details' on the right click workflow popup in the workflows list, does the same as double clicking
  • Fix dictionary prefs to show popup if localised name is missing for a language
  • Show Alfred preferences with keyword 'alfred' and don't show Alfred 2.app in the search results (once cache is cleared)
  • Force find apps marked as MDSystemFile such as Emacs, MacVim. Will also find e.g. Screen Sharing.app if containing folder is added to scope
  • enter auto complete on snip keyword (missing internal UID). e.g. type sn, press return on placeholder, filter snippet
  • Resilience against font not found for Menlo in Preferences causing prefs to malfunction
  • Allow cmd+a as hotkey again, a number of v1 users were using cmd+a to show Alfred
  • Fix plain text paste template workflow, now works correctly
  • Trim a URL before opening it allowing for pasted URLs with trailing newlines to work


OS X 10.6 or later

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Duplicate Annihilator 4.4.2 - Find and delete duplicates in iPhoto. (Shareware)

Posted: 17 Mar 2013 08:59 PM PDT



Duplicate Annihilator takes on the time consuming task comparing the images in your iPhoto library using effective algorithms to make sure that no duplicate escapes.

When found, the duplicate will either be marked with a description of your choice to make it searchable or simply moved to iPhotos trashcan.

Duplicate Annihilator detects:
  • Duplicates
  • Imported thumbnails
  • Missing image files


Version 4.4.2:
  • Minor fixes


  • OS X 10.4 or later
  • iPhoto 5 or later


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Sandvox 2.7.7 - Easily build eye-catching Web sites. (Demo)

Posted: 17 Mar 2013 08:59 PM PDT



Sandvox is for Mac users who want to create a professional looking website quickly and easily. With Sandvox, you don't need to be a Web genius to build a stylish, feature-rich, standards-compliant website that's functional and user friendly. Sandvox's drag and drop interface lets you watch your website take shape and come to life as you build it. And, once finished, you can upload your site to your favorite host.

Whether you're a new website creator or a seasoned professional, you can make use of Sandvox to build the website of your dreams. New users can build a professional looking website in minutes and professional users can build an advanced, multimedia-rich site in no time at all.

Version 2.7.7:

Twitter

  • Twitter is starting to disable direct access to feeds, breaking Sandvox's Twitter object. Existing objects continue to work when published, but will guide you how to transition to Twitter's preferred approach.
Publishing
  • Improves compatibility with bad FTPS servers for customers on OS X 10.7 and earlier
Objects & Pages
  • Restores Inspector functionality when editing inside an object, such as a Text Box
  • Missing, size-less images can be selected for correction or deletion
  • For video objects, allow the poster type to be changed even when preload checkbox is chosen
Other Changes
  • Minor Design fixes
  • Help documentation updates



  • OS X 10.6.6 or later
  • Quartz-Extreme-capable Mac required for some features


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Contactizer Pro 3.8.16 - Manage, share and organize personal and business information. (Demo)

Posted: 17 Mar 2013 08:59 PM PDT



Contactizer Pro is the amazing all-in-one solution for managing, sharing and organizing your personal and business information. Following the prodigious success of it first release, Contactizer Pro 3.8 raises your contact management experience to be more efficient, productive and enjoyable. Contactizer Pro brings a wealth of powerful PIM features, an innovative interface into a clean, elegant and intuitive package specifically built for Mac OS X.

Core Capabilities:

  • Ability to manage projects and track their progress.
  • Summarizes automatically all contact-related information in a single view.
  • Link Apple Mail email messages to appropriate contacts in real time.
  • Impressive collaborative Sharing via Bonjour. No more server requirement.
  • Tag contacts, tasks, events, communications, projects with multiple category labels.
  • Interconnect all Contactizer objects including reciprocal relationships.
  • HTML email template builder included.
  • Event Manager with meeting organization and more.
  • Invitation follow-up management for Tasks & Events.
  • Task type definition connected to concrete follow-up actions(phone call, send fax, write email,...).
  • Synchronization with iSync that makes data available for digital devices.
  • All Contactizer lists support Smart Groups that make your data even more organized.
  • Built-in Google Map Search service for contact addresses location.
  • Bluetooth phone pairing for incoming calls notifications and direct dialing.
  • Quick edit any Contactizer data direcly in the Detail View.


Version 3.8.16:
  • Improves OS X 10.8 Moutain Lion compatibility and overall stability.
  • Fixes a dozen of issues and is highly recommended for all users of Contactizer 3.8.


OS X 10.6 or later

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VueScan 9.2.11 - Scanner software with advanced features. (Demo)

Posted: 17 Mar 2013 08:59 PM PDT



VueScan is a scanning program that works with most high-quality flatbed and film scanners to produce scans that have excellent color fidelity and color balance. VueScan is easy to use, and has advanced features for restoring faded colors, batch scanning and other features used by professional photographers.

Why should you use VueScan?

  • Easy to use - just run VueScan, press Preview, adjust the cropping, then press Scan.
  • Accurate colors - uses ICC profiles and IT8 calibration.
  • Powerful - dozens of advanced options.
  • Faster workflow - can edit one image while the next image is being scanned (most scanner software won't let you work with one image while another is being scanned).
  • Simple to install - installing VueScan changes nothing on your system, installs nothing in your operating system and all other scanner software will continue to function.
  • Award winning - 2002 "Best Utility", Mac Addict Magazine.
The list of supported scanners is available here.

The list of supported digital camera RAW files is available here.

You can improve your Optical Character Recognition (OCR) results if you download a dictionary containing common US English, French, Dutch and UK English words. Put this file (vuedict.dat) in the same directory as the VueScan program. You can choose the language using the "Output|OCR text language" option.

Version 9.2.11:

  • Added native support for 74 Samsung printer/scanner/copiers
  • Of these, 53 Samsung scanners are network capable
  • These network capable scanners will also work with VueScan Mobile
  • No longer needs WIA driver on Windows or ICA driver on Mac OS X
  • No Samsung drivers needed on Mac OS X and Linux


  • OS X 10.5 or later


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