Games |
- Final Fantasy V - Screenshots
- Sensors, Vol. 13, Pages 4214-4224: Rapid and Highly Sensitive Detection of Lead Ions in Drinking Water Based on a Strip Immunosensor
- Sensors, Vol. 13, Pages 4192-4213: Photonic Crystal Structures with Tunable Structure Color as Colorimetric Sensors
- Sensors, Vol. 13, Pages 4170-4191: Quantitative Phase Imaging Techniques for the Study of Cell Pathophysiology: From Principles to Applications
- Sensors, Vol. 13, Pages 4157-4169: Development of an Optical Gas Leak Sensor for Detecting Ethylene, Dimethyl Ether and Methane
- IJMS, Vol. 14, Pages 7180-7192: Cadmium Tolerance and Removal from Cunninghamella elegans Related to the Polyphosphate Metabolism
- Cloud Mate 1.4.2 - Add a Finder-like interface to iCloud. (Commercial)
- NZBVortex 2.9.4 - Lightweight Usenet NZB download client. (Shareware)
- Picasa 3.9.15.36 - Organize, edit, and share your photos. (Free)
- Fan-pleasing Nintendo references in LEGO City Undercover
- Cory's schedule for EasterCon in Bradford
- IJMS, Vol. 14, Pages 7155-7179: Transcriptional Analysis of Drought-Induced Genes in the Roots of a Tolerant Genotype of the Common Bean (Phaseolus vulgaris L.)
- IJMS, Vol. 14, Pages 7140-7154: Effect of Opuntia humifusa Supplementation and Acute Exercise on Insulin Sensitivity and Associations with PPAR-γ and PGC-1α Protein Expression in Skeletal Muscle of Rats
- IJMS, Vol. 14, Pages 7109-7139: Skeletal Muscle Function during Exercise—Fine-Tuning of Diverse Subsystems by Nitric Oxide
- IJMS, Vol. 14, Pages 7089-7108: Roles of Rho GTPases in Intracellular Transport and Cellular Transformation
- IJMS, Vol. 14, Pages 7061-7088: Genetic Diversity Revealed by Single Nucleotide Polymorphism Markers in a Worldwide Germplasm Collection of Durum Wheat
- Midlands Arrests in Multi-State Gambling Ring
- Rising Storm - GDC Gameplay Demo
- Sony Embraces the Future of Indie
- TotalFinder 1.4.9 - Adds tabs, hotkeys, and other tweaks to the Finder. (Demo)
| Posted: 28 Mar 2013 04:24 AM PDT FEATURES - Customize characters with an unprecedented degree of freedom with the Job and Ability System – including the additional Gladiator, Cannoneer, Oracle, and Necromancer jobs! - Veteran character designer Kazuko Shibuya has returned to recreate the characters and graphics for a completely enhanced mobile experience! - Touch-screen controls and active-time battle system are optimized for fluid combat on mobile devices - This new mobile version also includes "The Sealed Temple" from the 2006 release, as well as the Tetsuya Nomura-designed optional boss Enuo, and an extraordinary soundtrack | ||
| Posted: 28 Mar 2013 12:00 AM PDT In this study, we have first developed a rapid and sensitive strip immunosensor based on two heterogeneously-sized gold nanoparticles (Au NPs) probes for the detection of trace lead ions in drinking water. The sensitivity was 4-fold higher than that of the conventional LFA under the optimized conditions. The visual limit of detection (LOD) of the amplified method for qualitative detection lead ions was 2 ng/mL and the LOD for semi-quantitative detection could go down to 0.19 ng/mL using a scanning reader. The method suffered from no interference from other metal ions and could be used to detect trace lead ions in drinking water without sample enrichment. The recovery of the test samples ranged from 96% to 103%. As the detection method could be accomplished within 15 min, this method could be used as a potential tool for preliminary monitoring of lead contamination in drinking water. | ||
| Posted: 28 Mar 2013 12:00 AM PDT Colorimetric sensing, which transduces environmental changes into visible color changes, provides a simple yet powerful detection mechanism that is well-suited to the development of low-cost and low-power sensors. A new approach in colorimetric sensing exploits the structural color of photonic crystals (PCs) to create environmentally-influenced color-changeable materials. PCs are composed of periodic dielectrics or metallo-dielectric nanostructures that affect the propagation of electromagnetic waves (EM) by defining the allowed and forbidden photonic bands. Simultaneously, an amazing variety of naturally occurring biological systems exhibit iridescent color due to the presence of PC structures throughout multi-dimensional space. In particular, some kinds of the structural colors in living organisms can be reversibly changed in reaction to external stimuli. Based on the lessons learned from natural photonic structures, some specific examples of PCs-based colorimetric sensors are presented in detail to demonstrate their unprecedented potential in practical applications, such as the detections of temperature, pH, ionic species, solvents, vapor, humidity, pressure and biomolecules. The combination of the nanofabrication technique, useful design methodologies inspired by biological systems and colorimetric sensing will lead to substantial developments in low-cost, miniaturized and widely deployable optical sensors. | ||
| Posted: 28 Mar 2013 12:00 AM PDT A cellular-level study of the pathophysiology is crucial for understanding the mechanisms behind human diseases. Recent advances in quantitative phase imaging (QPI) techniques show promises for the cellular-level understanding of the pathophysiology of diseases. To provide important insight on how the QPI techniques potentially improve the study of cell pathophysiology, here we present the principles of QPI and highlight some of the recent applications of QPI ranging from cell homeostasis to infectious diseases and cancer. | ||
| Posted: 28 Mar 2013 12:00 AM PDT In this paper, we present an approach to develop an optical gas leak sensor that can be used to measure ethylene, dimethyl ether, and methane. The sensor is designed based on the principles of IR absorption spectrum detection, and comprises two crossed elliptical surfaces with a folded reflection-type optical path. We first analyze the optical path and the use of this structure to design a miniature gas sensor. The proposed sensor includes two detectors (one to acquire the reference signal and the other for the response signal), the light source, and the filter, all of which are integrated in a miniature gold-plated chamber. We also designed a signal detection device to extract the sensor signal and a microprocessor to calculate and control the entire process. The produced sensor prototype had an accuracy of ±0.05%. Experiments which simulate the transportation of hazardous chemicals demonstrated that the developed sensor exhibited a good dynamic response and adequately met technical requirements. | ||
| Posted: 28 Mar 2013 12:00 AM PDT The aim of the present work was to study the cadmium effects on growth, ultrastructure and polyphosphate metabolism, as well as to evaluate the metal removal and accumulation by Cunninghamella elegans (IFM 46109) growing in culture medium. The presence of cadmium reduced growth, and a longer lag phase was observed. However, the phosphate uptake from the culture medium increased 15% when compared to the control. Moreover, C. elegans removed 70%–81% of the cadmium added to the culture medium during its growth. The C. elegans mycelia showed a removal efficiency of 280 mg/g at a cadmium concentration of 22.10 mg/L, and the removal velocity of cadmium was 0.107 mg/h. Additionally, it was observed that cadmium induced vacuolization, the presence of electron dense deposits in vacuoles, cytoplasm and cell membranes, as well as the distinct behavior of polyphosphate fractions. The results obtained with C. elegans suggest that precipitation, vacuolization and polyphosphate fractions were associated to cadmium tolerance, and this species demonstrated a higher potential for bioremediation of heavy metals. | ||
| Cloud Mate 1.4.2 - Add a Finder-like interface to iCloud. (Commercial) Posted: 28 Mar 2013 03:08 AM PDT  Cloud Mate adds a Finder-like interface to iCloud, and adds iCloud to the Finder. iCloud is great. iCloud splits all your content up by the app that created it. iCloud hides your Photo Stream. Cloud Mate sets those files free! Here are just some of the reasons we think you'll love Cloud Mate
Version 1.4.2:
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| NZBVortex 2.9.4 - Lightweight Usenet NZB download client. (Shareware) Posted: 28 Mar 2013 03:03 AM PDT  NZBVortex is a small, efficient, and powerful NZB client for OS X, optimized for performance and ease of use--a usenet client which really takes the pain out of usenet downloading the most efficient way. Please note: You need a subscription to a usenet server or one from your Internet provider. If you have any issues at all, contact us at info@nzbvortex.com. Features:
Version 2.9.4:
OS X 10.6 or later Download Now This posting includes an audio/video/photo media file: Download Now | ||
| Picasa 3.9.15.36 - Organize, edit, and share your photos. (Free) Posted: 28 Mar 2013 02:53 AM PDT  Picasa and Picasa Web Albums allows you to organize, edit, and upload your photos to the Web from your computer in quick, simple steps. Arrange your photos into folders and albums and erase their blemishes using powerful editing tools in Picasa. Then use Picasa Web Albums to share those perfected photos online with family, friends, and the world. Version 3.9.15.36: Release notes were unavailable when this listing was updated. OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now | ||
| Fan-pleasing Nintendo references in LEGO City Undercover Posted: 28 Mar 2013 03:20 AM PDT Super Cameo Party | ||
| Cory's schedule for EasterCon in Bradford Posted: 28 Mar 2013 02:40 AM PDT I'm heading to Bradford tomorrow for Eight Squared Con, the 2013 Eastercon. I'm appearing on several programme items: * Friday, 17h: Reading, Hawthorn Room * Saturday, 12h: "On Twitter, Everyone Can Hear You Scream," Boardroom (panel) * Saturday, 13h: Book launch for RAPTURE OF THE NERDS, Conservatory * Saturday, 19h: "Genre Get-Together: Science Fiction," Conservatory (signing) * Sunday, 12h: "Ready, Steady, Flash," Boardroom (live flash fiction writing) I'm also doing something in town on Saturday (details TBD) with the 1 in 12 Library Book Club.
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| Posted: 28 Mar 2013 12:00 AM PDT In Brazil, common bean (Phaseolus vulgaris L.) productivity is severely affected by drought stress due to low technology cultivation systems. Our purpose was to identify differentially expressed genes in roots of a genotype tolerant to water deficit (BAT 477) when submitted to an interruption of irrigation during its development. A SSH library was constructed taking as "driver" the genotype Carioca 80SH (susceptible to drought). After clustering and data mining, 1572 valid reads were obtained, resulting in 1120 ESTs (expressed sequence tags). We found sequences for transcription factors, carbohydrates metabolism, proline-rich proteins, aquaporins, chaperones and ubiquitins, all of them organized according to their biological processes. Our suppressive subtractive hybridization (SSH) library was validated through RT-qPCR experiment by assessing the expression patterns of 10 selected genes in both genotypes under stressed and control conditions. Finally, the expression patterns of 31 ESTs, putatively related to drought responses, were analyzed in a time-course experiment. Our results confirmed that such genes are more expressed in the tolerant genotype during stress; however, they are not exclusive, since different levels of these transcripts were also detected in the susceptible genotype. In addition, we observed a fluctuation in gene regulation over time for both the genotypes, which seem to adopt and adapt different strategies in order to develop tolerance against this stress. | ||
| Posted: 28 Mar 2013 12:00 AM PDT This study examined whether Opuntia humifusa (O. humifusa), which is a member of the Cactaceae family, supplementation and acute swimming exercise affect insulin sensitivity and associations with PPAR-γ and PGC-1α protein expression in rats. Thirty-two rats were randomly divided into four groups (HS: high fat diet sedentary group, n = 8; HE: high fat diet acute exercise group, n = 8; OS: 5% O. humifusa supplemented high fat diet sedentary group, n = 8; OE: 5% O. humifusa supplemented high fat diet acute exercise group, n = 8). Rats in the HE and OE swam for 120 min. before being sacrificed. Our results indicated that serum glucose level, fasting insulin level and homeostasis model assessment of insulin resistance (HOMA-IR) in OS were significantly lower compared to those of the HS (p < 0.01, p < 0.05, p < 0.05). In addition, PPAR-γ protein expression in the OS and OE was significantly higher than that of the HS and HE, respectively (p < 0.05, p < 0.01). PGC-1α and GLUT-4 protein expressions in the OS were significantly higher compared to those of the HS (p < 0.05, p < 0.05). From these results, O. humifusa supplementation might play an important role for improving insulin sensitivity through elevation of PPAR-γ, PGC-1α, and GLUT-4 protein expression in rat skeletal muscle. | ||
| Posted: 28 Mar 2013 12:00 AM PDT Skeletal muscle is responsible for altered acute and chronic workload as induced by exercise. Skeletal muscle adaptations range from immediate change of contractility to structural adaptation to adjust the demanded performance capacities. These processes are regulated by mechanically and metabolically induced signaling pathways, which are more or less involved in all of these regulations. Nitric oxide is one of the central signaling molecules involved in functional and structural adaption in different cell types. It is mainly produced by nitric oxide synthases (NOS) and by non-enzymatic pathways also in skeletal muscle. The relevance of a NOS-dependent NO signaling in skeletal muscle is underlined by the differential subcellular expression of NOS1, NOS2, and NOS3, and the alteration of NO production provoked by changes of workload. In skeletal muscle, a variety of highly relevant tasks to maintain skeletal muscle integrity and proper signaling mechanisms during adaptation processes towards mechanical and metabolic stimulations are taken over by NO signaling. The NO signaling can be mediated by cGMP-dependent and -independent signaling, such as S-nitrosylation-dependent modulation of effector molecules involved in contractile and metabolic adaptation to exercise. In this review, we describe the most recent findings of NO signaling in skeletal muscle with a special emphasis on exercise conditions. However, to gain a more detailed understanding of the complex role of NO signaling for functional adaptation of skeletal muscle (during exercise), additional sophisticated studies are needed to provide deeper insights into NO-mediated signaling and the role of non-enzymatic-derived NO in skeletal muscle physiology. | ||
| Posted: 28 Mar 2013 12:00 AM PDT Rho family GTPases belong to the Ras GTPase superfamily and transduce intracellular signals known to regulate a variety of cellular processes, including cell polarity, morphogenesis, migration, apoptosis, vesicle trafficking, viral transport and cellular transformation. The three best-characterized Rho family members are Cdc42, RhoA and Rac1. Cdc42 regulates endocytosis, the transport between the endoplasmic reticulum and Golgi apparatus, post-Golgi transport and exocytosis. Cdc42 influences trafficking through interaction with Wiskott-Aldrich syndrome protein (N-WASP) and the Arp2/3 complex, leading to changes in actin dynamics. Rac1 mediates endocytic and exocytic vesicle trafficking by interaction with its effectors, PI3kinase, synaptojanin 2, IQGAP1 and phospholipase D1. RhoA participates in the regulation of endocytosis through controlling its downstream target, Rho kinase. Interestingly, these GTPases play important roles at different stages of viral protein and genome transport in infected host cells. Importantly, dysregulation of Cdc42, Rac1 and RhoA leads to numerous disorders, including malignant transformation. In some cases, hyperactivation of Rho GTPases is required for cellular transformation. In this article, we review a number of findings related to Rho GTPase function in intracellular transport and cellular transformation. | ||
| Posted: 28 Mar 2013 12:00 AM PDT Evaluation of genetic diversity and genetic structure in crops has important implications for plant breeding programs and the conservation of genetic resources. Newly developed single nucleotide polymorphism (SNP) markers are effective in detecting genetic diversity. In the present study, a worldwide durum wheat collection consisting of 150 accessions was used. Genetic diversity and genetic structure were investigated using 946 polymorphic SNP markers covering the whole genome of tetraploid wheat. Genetic structure was greatly impacted by multiple factors, such as environmental conditions, breeding methods reflected by release periods of varieties, and gene flows via human activities. A loss of genetic diversity was observed from landraces and old cultivars to the modern cultivars released during periods of the Early Green Revolution, but an increase in cultivars released during the Post Green Revolution. Furthermore, a comparative analysis of genetic diversity among the 10 mega ecogeographical regions indicated that South America, North America, and Europe possessed the richest genetic variability, while the Middle East showed moderate levels of genetic diversity. | ||
| Midlands Arrests in Multi-State Gambling Ring Posted: 28 Mar 2013 12:25 AM PDT Federal investigators say it involved millions of dollars - and included high profile people. This posting includes an audio/video/photo media file: Download Now | ||
| Rising Storm - GDC Gameplay Demo Posted: 27 Mar 2013 07:02 PM PDT We check out flamethrowers and maps including Guadalcanal, Saipan, and Iwo Jima in Tripwire Interactive's latest WWII project.
Read and Post Comments | Get the full article at GameSpot "Rising Storm - GDC Gameplay Demo" was posted by sampsona on Wed, 27 Mar 2013 19:02:18 -0700 | ||
| Sony Embraces the Future of Indie Posted: 27 Mar 2013 02:45 PM PDT At GDC 2013, Sony revealed their plans to make the PlayStation ecosystem a friendlier place for small developers to publish.
Read and Post Comments | Get the full article at GameSpot "Sony Embraces the Future of Indie" was posted by Tyler on Wed, 27 Mar 2013 14:45:31 -0700 | ||
| TotalFinder 1.4.9 - Adds tabs, hotkeys, and other tweaks to the Finder. (Demo) Posted: 27 Mar 2013 08:59 PM PDT  TotalFinder adds tabs, hotkeys, and other tweaks to the Mac OS X Finder in OS X 10.7 and 10.8. Implemented features:
Version 1.4.9:
OS X 10.7 or later Download Now This posting includes an audio/video/photo media file: Download Now |
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