понедельник, 4 марта 2013 г.

Games

Games

Type2Phone 2.0 - Use your Mac as a keyboard for your iOS device. (Commercial)

Posted: 04 Mar 2013 02:56 AM PST



Type2Phone lets you use your Mac as a Bluetooth keyboard to your iPhone, iPad or Apple TV.

Type text on your keyboard and it will appear on your iOS device.
Prepare text on your a Mac and then paste it to your mobile device.

  • Use your Mac as a keyboard to quickly type SMS text messages, notes, …
  • Reply to emails on accounts configured only on your iPhone
  • Communicate with friends over your iPhone: Facebook, Twitter, chat
  • Paste addresses, passwords, … from your Mac to your iPhone.
Supported iOS keyboard layouts:
  • U.S American
  • Arabic
  • Belgian
  • Brazilian (NEW in 2.0)
  • British
  • Canadian
  • Czech (NEW in 2.0)
  • Danish
  • Dutch
  • Dvorak
  • French
  • German
  • Hebrew
  • Hungarian
  • Italian
  • Japanese
  • Norwegian
  • Polish, Polish Pro
  • Portuguese
  • Serbian
  • Slovenian
  • Spanish
  • Swedish
  • Swiss-French
  • Swiss-German
  • Turkish, Turkish QWERTY (NEW in 2.0)


Version 2.0:
  • Dictation. Type2Phone accepts input from Mac OS X Mountain Lion dictation
  • Added a regular text field as alternative to the "key slide" animation
  • Added support for the Czech keyboard layout
  • Added support for Turkish and Turkish QWERTY keyboard layouts
  • Added support for the Brazilian keyboard layout
  • Option to automatically reconnect on wake from sleep
  • Option to automatically reconnect on first key press
  • Option to disconnect when sent to background
  • Option to disconnect when idle for 5 minutes
  • Option to swap backspace and delete keys. Enable in preferences
  • Improved support for EMACS-style keyboard shortcuts. Enable in preferences
  • Vastly improved AppleScript support: automatically reconnect, send raw HID key codes, …
  • Remember window position between launches
  • Added menu item to clear displayed text
  • Added menu items to interact with VoiceOver on iOS
  • Bug fixes to existing "key slide" animation
  • Added gratuitous "key fly" animation
  • Improved Accessibility support
  • Implemented application sandboxing


  • Mac with Bluetooth enabled
  • OS X 10.6.6 or later
  • iPhone (3GS or later), iPad (all models), iPod touch (3rd generation or later). iOS 3.2 or later
  • Apple TV with software version 5.2 (January 2013) or later


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Inside the prosecution of Aaron Swartz

Posted: 04 Mar 2013 03:00 AM PST


Quinn Norton -- who was romantically involved with Aaron Swartz for a long time, and was also his close friend -- has written a brutal, honest, infuriating, and brave account of her dealings with Steve Heymann, the prosecutor who hounded Aaron over his downloading of scientific journal articles. Heymann is a terror among Aaron's friends. Everyone I know who has met him has described him as a vicious, vindictive, authoritarian thug who destroys lives for giggles and notches on his bed-post.

Quinn's piece sheds light on the awful cruelty of the system, for which Aaron's case was a microcosm. America imprisons more people than any other country in the history of the world. 97% of those indicted by federal prosecutors are intimidated into pleading guilty, which means that if a prosecutor like Heymann decides you should go to jail, 97% of the time, you will be coerced into prison without even getting a chance to make a defense (the coercion relies on threats of decade upon decade of prison and bankruptcy for you and all you love should you try to fight).

At first they didn't ask me about Aaron. They were questioning me, trying to get me to admit I knew something. They made me retell everything Aaron had told me, but it was all taken directly from their own arrest record. The harsh questioning about me threw me off balance.

They leaned in and loomed over me physically, calling me a liar, scowling and pausing and narrowing their eyes at me. I was cowed. Much of the time I spent telling them the same things, that I didn't know what he'd been doing, that I never asked what the arrest was for when he called me. They told me that was unnatural; they didn't believe me. I wanted to say, "Of course I wouldn't ask! There was a chance I'd be dealing with you people."

They said I must have known something because I was connected with hackers. They knew this, they told me, because they'd read everything I'd ever written online. I bit my lip. I fought the urge to say "If I'd known, we wouldn't be here. There's no chance you would know a thing."

They said they knew we were close because they'd found a car seat in his apartment. I really did look at them like they were idiots at that point. We'd been together for years. A simple google query would show more than a car seat.

Life Inside the Aaron Swartz Investigation

Assassin's Creed IV: Black Flag to get exclusive PS4 features

Posted: 04 Mar 2013 02:17 AM PST

PlayStation 4 version of the game the best one to play, says Ubisoft.

 

Assassin's Creed IV: Black Flag will be getting exclusive features for the PlayStation 4, Ubisoft has announced.

Speaking to GameSpot at the game's reveal event in London, creative director Jean Guesdon said that the PlayStation 4 version of the game would be essentially "the same game" as its PlayStation 3 and Xbox 360 counterparts, "but we will also use some other features that we will talk more about later during the year."

A Ubisoft representative confirmed that the studio is looking into utilising the PlayStation 4's new controller, which features a touch pad on the front.

Ubisoft has already revealed that the PlayStation 3 version of Assassin's Creed IV will contain 60 minutes of exclusive content. This content will also be made available for the PlayStation 4 version.

Sony officially unveiled the PlayStation 4 in February, and Microsoft is rumoured to be announcing the Xbox 720 in April. Ubisoft has said Assassin's Creed IV will be coming to "next-generation platforms."

Even without the additional features, Guesdon says the PlayStation 4 version of the game will be the best version to play. "You can imagine that we will use [the PlayStation 4's] full capacity and the potential of the console. Just graphically speaking it will be really enhanced. Just think about the lighting, the physics, the ocean simulation that will be experienced."

Summing up the PS4 version of Assassin's Creed IV: Black Flag as "better looking, better simulation, and some more features."

Assassin's Creed IV: Black Flag is set across the Carribean in 1715 and stars a new protagonist, British privateer-turned-pirate Edward Kenway. Speaking about the team's decision to switch to a new protagonist, Guesdon said "Edward almost came naturally. We just wanted that brash young rebel that would totally fit into the pirate era."

When asked if Edward Kenway was an attempt to recreate fan-favourite character Ezio Auditore, Guesdon said "I think we all liked Ezio. But we're not trying to redo Ezio, right. We're doing Assassin's Creed IV: Black Flag. This is not AC2, this is not Brotherhood."

Assassin's Creed IV: Black Flag will be released this October. For more information on the game, check out GameSpot's preview.

Read and Post Comments | Get the full article at GameSpot

"Assassin's Creed IV: Black Flag to get exclusive PS4 features" was posted by Martin Gaston on Mon, 04 Mar 2013 02:17:36 -0800

Assassin's Creed IV: Black Flag Screens

Posted: 04 Mar 2013 02:15 AM PST

7 new shots posted.

     

Get the full article at GameSpot

"Assassin's Creed IV: Black Flag Screens" was posted on Mon, 04 Mar 2013 02:15:12 -0800

Assassin's Creed IV: Black Flag - Edward Kenway Trailer

Posted: 04 Mar 2013 02:00 AM PST

Check out an Assassin's Creed IV: Black Flag trailer featuring Edward Kenway, a pirate trained by assassins.

 

Read and Post Comments | Get the full article at GameSpot

"Assassin's Creed IV: Black Flag - Edward Kenway Trailer" was posted by MikeTao on Mon, 04 Mar 2013 02:00:18 -0800

Assassin's Creed IV: Black Flag - World Premiere Trailer

Posted: 04 Mar 2013 02:00 AM PST

Here's your first look at Assassin's Creed IV: Black Flag, due out later this year.

 

Read and Post Comments | Get the full article at GameSpot

"Assassin's Creed IV: Black Flag - World Premiere Trailer" was posted by MikeTao on Mon, 04 Mar 2013 02:00:13 -0800

Assassin's Creed IV: Black Flag Trailer Breakdown

Posted: 04 Mar 2013 02:00 AM PST

Kevin VanOrd and Giancarlo Varanini talk over all the details revealed in the new trailer for Assassin's Creed IV: Black Flag.

 

Read and Post Comments | Get the full article at GameSpot

"Assassin's Creed IV: Black Flag Trailer Breakdown" was posted by Tyler on Mon, 04 Mar 2013 02:00:09 -0800

Will Assassin's Creed IV: Black Flag Put the Series Back on Course?

Posted: 04 Mar 2013 02:00 AM PST

This year's Assassin's Creed hopes piracy will keep the series ticking along.

 

Get the full article at GameSpot

"Will Assassin's Creed IV: Black Flag Put the Series Back on Course?" was posted by Martin Gaston on Mon, 04 Mar 2013 02:00:06 -0800

IJMS, Vol. 14, Pages 5182-5197: Blood Translation Elongation Factor-1δ Is a Novel Marker for Cadmium Exposure

Posted: 04 Mar 2013 12:00 AM PST

Translation elongation factor-1d (TEF-1δ) has been identified as a novel cadmium-responsive proto-oncogene. However, it is still unclear whether TEF-1δ could be a potential biomarker of cadmium exposure. Rats were treated with CdCl2 at different concentrations (high dose 1.225, mid-dose 0.612 and low dose 0.306 mg/kg body weight, respectively) for 14 weeks, and the cadmium levels, weight coefficients, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), serum creatinine (SCR), 24-h urine protein (24hPro), urinary creatinine (Cr) and pathological features were determined. The TEF-1δ expression in white blood cells and multiple organs were examined by reverse transcription polymerase chain reaction (PCR) and were also confirmed with fluorescence quantitative PCR. A cadmium dose-dependent increase (p < 0.05) of cadmium levels in blood, urine, liver, kidney, heart and lung, and the weight coefficients was observed. The liver and renal function indictors including AST, ALT, SCR, BUN and 24hPro, were elevated in a cadmium dose-dependent manner (p < 0.05). Significant pathological changes in liver, kidney, heart and lung were indicated. The TEF-1δ expression was up-regulated in both blood and organs (p < 0.05). Moreover, the expression level of blood TEF-1δ was positively correlated to TEF-1δ expression level, cadmium level and toxicity in the organs (p < 0.01). This study indicates that blood TEF-1δ is a novel valuable biomarker for cadmium exposure and its organ toxicity.

IJMS, Vol. 14, Pages 5170-5181: EGFR Expression and KRAS and BRAF Mutational Status in Intestinal-Type Sinonasal Adenocarcinoma

Posted: 04 Mar 2013 12:00 AM PST

Accumulation of molecular alterations, including EGFR overexpression and mutations in KRAS and BRAF, contribute to colorectal carcinogenesis. Since intestinal-type adenocarcinoma (ITAC) of the nasal cavity and paranasal sinus has morphologic and phenotypic features that are usually indistinguishable from colorectal cancer (CRC), it is likely that both tumor types share equivalent genetic alterations. Data from a series of 43 patients treated surgically for ITAC in Montpellier, France between November 1998 and December 2012 were collected. Tumors were characterized for mutations in KRAS and BRAF as well as EGFR overexpression. Kaplan-Meier survival curves were constructed using overall survival as the primary end points. Patient survival was analyzed using the hazards ratio. Twenty seven tumors (63%) showed EGFR positivity and 30% exhibited a high expression level (+2/+3). KRAS mutations were detected in 43% of cases. BRAF mutations were identified in 3.6% of specimens. Patients with age superior to 60 years, metastatic status, and KRAS mutations had significant overall survival values (p = 0.026, p = 0.001 and p = 0.03, respectively). Our results indicate that KRAS mutations and EGFR expression are frequent in ITAC and that KRAS mutations predict good patient prognosis in ITAC. Finally, EGFR directed molecular treatments could be investigated in a subset of patients affected by ITAC.

Assassin’s Creed IV: Black Flag - Everything we know

Posted: 04 Mar 2013 02:31 AM PST

If you're looking for our reactions fo the news, check out the video

Harpooning whales with Blackbeard - Assassin's Creed IV interview

Posted: 04 Mar 2013 02:31 AM PST

We talk about the name, the location, and plenty more

The real pirates, events, and locations of Assassin's Creed IV

Posted: 04 Mar 2013 02:31 AM PST

Because there's much more to pirates than eyepatches and parrots

Radar Reacts: Assassin's Creed IV: Black Flag revealed!

Posted: 04 Mar 2013 02:31 AM PST

We're guessing you've already read our Assassin's Creed IV: Black Flag preview and caught up on the history of ACIV's pirates, and now you're all

Molecules, Vol. 18, Pages 2978-2987: The Identification and Characterization of Chitotriosidase Activity in Pancreatin from Porcine Pancreas

Posted: 04 Mar 2013 12:00 AM PST

The versatile oligosaccharide biopolymers, chitin and chitosan, are typically produced using enzymatic processes. However, these processes are usually costly because chitinases and chitosanases are available in limited quantities. Fortunately, a number of commercial enzymes can hydrolyze chitin and chitosan to produce long chain chitin or chitosan oligosaccharides. Here, a platform to screen for enzymes with chitinase and chitosanase activities using a single gel with glycol chitin or glycol chitosan as a substrate was applied. SDS-resistant chitinase and chitosanase activities were observed for pancreatin. Its chitotriosidase had an optimal hydrolysis pH of 4 in the substrate specificity assay. This activity was thermally unstable, but independent of 2-mercaptoethanol. This is the first time a chitotriosidase has been identified in the hog. This finding suggests that oligochitosaccharides can be mass-produced inexpensively using pancreatin.

Molecules, Vol. 18, Pages 2967-2977: Rare Syringyl Acylated Flavonol Glycosides from the Aerial Parts of Leonurus japonicus Houtt.

Posted: 04 Mar 2013 12:00 AM PST

Five new syringyl acylated flavonol glycosides, named leonurusoides A (1), B (2), C (3), D (4), and E (5), together with one known one 6 were obtained from the aerial parts of Leonurus japonicus. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, HRESI-TOF-MS, 1D and 2D NMR). Compounds 1-6 showed triglyceride (TG) accumulation inhibitory effects in free fatty acid-induced HepG2 cells.

Molecules, Vol. 18, Pages 2942-2966: Photo-Induced Cycloaddition Reactions of α-Diketones and Transformations of the Photocycloadducts

Posted: 04 Mar 2013 12:00 AM PST

Photocycloaddition, along with subsequent transformation of the photocycloadducts, provides expeditious ways to construct various structures. The photo-induced reactions of α-diketones have been reported to proceed via different reaction pathways with the involvement of one or two of the carbonyl groups. Photoinduced reactions of cyclic α-diketones including N-acetylisatin, phenanthrenequinone and isoquinolinetrione with different C=C containing compounds could take place via [2 + 2], [4 + 2] or [4 + 4] photocycloaddition pathways. We have investigated the photoreactions of these cyclic α-diketones with different types of alkenes and alkynes, with a focus on the unusual cascade reactions initiated by the photocycloaddition reactions of these cyclic α-diketones and the applications of these photocycloaddition reactions along with the transformation of the photocycloadducts. In this paper, we discuss the diverse photo-cycloaddition pathways found in the photocycloaddition of o-diones leading to various photocycloadducts and the potential applications of these reactions via further transformation reactions of the adducts.

Nutrients, Vol. 5, Pages 663-678: Extracts, Anthocyanins and Procyanidins from Aronia melanocarpa as Radical Scavengers and Enzyme Inhibitors

Posted: 04 Mar 2013 12:00 AM PST

Extracts, subfractions, isolated anthocyanins and isolated procyanidins B2, B5 and C1 from the berries and bark of Aronia melanocarpa were investigated for their antioxidant and enzyme inhibitory activities. Four different bioassays were used, namely scavenging of the diphenylpicrylhydrazyl (DPPH) radical, inhibition of 15-lipoxygenase (15-LO), inhibition of xanthine oxidase (XO) and inhibition of α-glucosidase. Among the anthocyanins, cyanidin 3-arabinoside possessed the strongest and cyanidin 3-xyloside the weakest radical scavenging and enzyme inhibitory activity. These effects seem to be influenced by the sugar units linked to the anthocyanidin. Subfractions enriched in procyanidins were found to be potent α-glucosidase inhibitors; they possessed high radical scavenging properties, strong inhibitory activity towards 15-LO and moderate inhibitory activity towards XO. Trimeric procyanidin C1 showed higher activity in the biological assays compared to the dimeric procyanidins B2 and B5. This study suggests that different polyphenolic compounds of A. melanocarpa can have beneficial effects in reducing blood glucose levels due to inhibition of α-glucosidase and may have a potential to alleviate oxidative stress.

Molecules, Vol. 18, Pages 2934-2941: Simultaneous Determination of Flavonoids, Isochlorogenic Acids and Triterpenoids in Ilex hainanensis Using High Performance Liquid Chromatography Coupled with Diode Array and Evaporative Light Scattering Detection

Posted: 04 Mar 2013 12:00 AM PST

A high performance liquid chromatography coupled with diode array and evaporative light scattering detection (HPLC-DAD-ELSD) method for simultaneous determination of eight major bioactive compounds including two flavonoids (rutin and eriodictyol-7-O-β-D-glucopyranoside), two isochlorogenic acids (isochlorogenic acid A and isochlorogenic acid C) and four triterpenoids (ilexhainanoside D, ilexsaponin A1, ilexgenin A and ursolic acid) in Ilex hainanensis has been developed for the first time. The 283 nm wavelength was chosen for determination of two flavonoids and two isochlorogenic acids. ELSD was applied to determine four triterpenoids. The analysis was performed on an Agilent Zorbax SB-C18 column (250 × 4.6 mm i.d., 5 µm) with gradient elution of 0.2% formic acid in water and acetonitrile. The method was validated for linearity, limit of detection, limit of quantification, precision, repeatability and accuracy. The proposed method has been successfully applied for simultaneous quantification of the analytes in four samples of Ilex hainanensis, which is helpful for quality control of this plant.

Molecules, Vol. 18, Pages 2924-2933: 5-Episinuleptolide Acetate, a Norcembranoidal Diterpene from the Formosan Soft Coral Sinularia sp., Induces Leukemia Cell Apoptosis through Hsp90 Inhibition

Posted: 04 Mar 2013 12:00 AM PST

5-Episinuleptolide acetate (5EPA), a cytotoxic norcembranoidal diterpene recently identified from the Formosan soft coral Sinularia sp., exhibited potent activity against the K562, Molt 4 and HL 60 cancer cell lines. The antiproliferative assay, as well as the annexin V-FITC/propidium iodide (PI) apoptotic assay, indicated that the HL 60 cell line is the most sensitive one towards 5EPA. This diterpenoid led to caspases -3, -8, and -9 activation as well as PARP cleavage. It also induced ROS generation, calcium accumulation and disruption of mitochondrial membrane potential. Additionally, the expression levels of Hsp90 protein and several client proteins were downregulated in response to 5EPA treatment. These results suggest that 5EPA's cytotoxic effect on HL 60 cells may be attributed to the inhibition of Hsp90 as well as the induction of mitochondrial stress which finally results in apoptotic cell death.
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