Games |
- Ecoute 3.0.8 - Play iTunes library without launching iTunes. (Free)
- MPEG2 Works 5 Advanced 5.0 - Convert movie files to MPEG2/MPEG1 DVD/SVCD/VCD. (Shareware)
- Magican 1.4.2 - Optimize your Mac. (Free)
- Viruses, Vol. 5, Pages 981-997: Correlation of Naturally Occurring HIV-1 Resistance to DEB025 with Capsid Amino Acid Polymorphisms
- Toxins, Vol. 5, Pages 590-604: Detection of Type A Trichothecene Di-Glucosides Produced in Corn by High-Resolution Liquid Chromatography-Orbitrap Mass Spectrometry
- Forests, Vol. 4, Pages 197-217: Spatial Characterization of Wildfire Orientation Patterns in California
- Agronomy, Vol. 3, Pages 248-255: Sustainable Production of Japanese Eggplants in a Piedmont Soil in Rotation with Winter Cover Crops
- BioShock Infinite cost $200 million to produce and market – Report
- Nutrients, Vol. 5, Pages 971-980: Total Vitamin D Assay Comparison of the Roche Diagnostics “Vitamin D Total” Electrochemiluminescence Protein Binding Assay with the Chromsystems HPLC Method in a Population with both D2 and D3 forms of Vitamin D
- Entropy, Vol. 15, Pages 1133-1149: Holographic Dark Information Energy: Predicted Dark Energy Measurement
- Entropy, Vol. 15, Pages 1116-1132: Evidence of Large-Scale Quantization in Space Plasmas
- Entropy, Vol. 15, Pages 1100-1115: A Maximum Entropy Approach to Loss Distribution Analysis
- IJMS, Vol. 14, Pages 6516-6517: Correction: Liang, J., et al. Antisense Oligonucleotide Against Clusterin Regulates Human Hepatocellular Carcinoma Invasion Through Transcriptional Regulation of Matrix Metalloproteinase-2 and E-Cadherin. Int. J. Mol. Sci. 2012, 13, 10594-10607
- Cory signing Rapture of the Nerds at Forbidden Planet London tomorrow
- IJMS, Vol. 14, Pages 6499-6515: Preparation of a Paeonol-Containing Temperature-Sensitive In Situ Gel and Its Preliminary Efficacy on Allergic Rhinitis
- Australian Police Bust International Crime Syndicate; Seize $600,000 in Casino Chips
- Fantastical 1.3.7 - Create calendar events using natural language. (Demo)
- Xpecial talks on Wildturtle as a sub versus playing with Chaox
- BioShock Infinite cost $200 million to produce and market – Report
- Sound Byte: Meet the Composer – BioShock series
| Ecoute 3.0.8 - Play iTunes library without launching iTunes. (Free) Posted: 22 Mar 2013 03:15 AM PDT  Ecoute plays your iTunes library. Music, videos, and podcasts goes into this small application that doesn't require iTunes to be launched to play your library. Some other cool features are included like search for missing artwork, last.fm, customizable themes, etc.. Version 3.0.8:
Download Now This posting includes an audio/video/photo media file: Download Now |
| MPEG2 Works 5 Advanced 5.0 - Convert movie files to MPEG2/MPEG1 DVD/SVCD/VCD. (Shareware) Posted: 22 Mar 2013 03:04 AM PDT  MPEG2 Works 5 Advanced is the ultimate all-in-one MPEG1/MPEG2 SD/HD encoder and movie re-conversion tool. The next evolution of MPEG2 Works is at hand. MPEG2 Works 5 has many improvements over version 4, including MUCH faster conversion and encoding. All sections were rewritten, and it has a redesigned interface to optimize and improve overall performance and ease of use. This is the ultimate tool for beginners just learning and for professionals who need one tool that does it all with minimal expense.
Version 5.0: Release notes were unavailable when this listing was updated. OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Magican 1.4.2 - Optimize your Mac. (Free) Posted: 22 Mar 2013 02:51 AM PDT  Magican lets you carry out several basic operations in a floating window. For instance, Magican monitors the network traffic in an absolutely new way, and the "Purge RAM" can help you quickly convert the inactive memory into free memory. In addition, you can also get the local weather forecast and terminate unnecessary processes in the floating window. Magican can help you locate all of the junk and virus-infected files on your Mac, and then "One-Click" helps to eliminate all of them. If your Mac has a virus-infected file, you can choose to trust it, delete it, or place it in "Quarantine". Of course, you may also still wish to know the real-time information on your Mac, so Magican can show it to you with pictorial symbols. All of the data is clearly displayed. Moreover, "Software" helps users completely uninstall any software with the use of a "Remove" button. Magican also helps users get discounted software from the App Store, and reminds you of any new app updates that are available. Users can also retrieve hardware information from the main window, which can be exported as text or image files.
Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 22 Mar 2013 12:00 AM PDT DEB025 (alisporivir) is a synthetic cyclosporine with inhibitory activity against human immunodeficiency virus type-1 (HIV-1) and hepatitis C virus (HCV). It binds to cyclophilin A (CypA) and blocks essential functions of CypA in the viral replication cycles of both viruses. DEB025 inhibits clinical HIV-1 isolates in vitro and decreases HIV-1 virus load in the majority of patients. HIV-1 isolates being naturally resistant to DEB025 have been detected in vitro and in nonresponder patients. By sequence analysis of their capsid protein (CA) region, two amino acid polymorphisms that correlated with DEB025 resistance were identified: H87Q and I91N, both located in the CypA-binding loop of the CA protein of HIV-1. The H87Q change was by far more abundant than I91N. Additional polymorphisms in the CypA-binding loop (positions 86, 91 and 96), as well as in the N-terminal loop of CA were detected in resistant isolates and are assumed to contribute to the degree of resistance. These amino acid changes may modulate the conformation of the CypA-binding loop of CA in such a way that binding and/or isomerase function of CypA are no longer necessary for virus replication. The resistant HIV-1 isolates thus are CypA-independent. |
| Posted: 22 Mar 2013 12:00 AM PDT The existence of di-glucosylated derivative of T-2 toxin in plant (corn powder) was confirmed for the first time in addition to that of HT-2 toxin. These masked mycotoxins (mycotoxin glucosides) were identified as T-2 toxin-di-glucoside (T2GlcGlc) and HT-2 toxin-di-glucoside (HT2GlcGlc) based on accurate mass measurements of characteristic ions and fragmentation patterns using high-resolution liquid chromatography-Orbitrap mass spectrometric (LC-Orbitrap MS) analysis. Although the absolute structure of T2GlcGlc was not clarified, two glucose molecules were suggested to be conjugated at 3-OH position in tandem when considering the structure of T-2 toxin. On the other hand, the specification of the structure seems to be more complicated in the case of HT2GlcGlc, since HT-2 toxin has two possible positions (at 3-OH and 4-OH) to be glusocylated. In addition, 15-monoacetoxyscirpenol-glucoside (MASGlc) was also detected in the identical sample. |
| Posted: 22 Mar 2013 12:00 AM PDT Using 100 years of fire perimeter maps, we investigate the existence of geographical patterns in fire orientation across California. We computed fire perimeter orientation, at the watershed level, using principal component analysis. Circular statistics were used to test for the existence of preferential fire perimeter orientations. Where perimeters displayed preferential orientation, we searched for evidence of orographic channeling by comparing mean fire orientation with watershed orientation. Results show that in California, 49% of the burnt area is associated with watersheds, where fires displayed preferential orientation. From these, 25% of the burnt area is aligned along the NE/SW orientation and 18% in the E/W orientation. In 27 out of 86 watersheds with preferential fire alignment, there is also correspondence between mean fire orientation and watershed orientation. Topographic influence on fire spread and dominant wind patterns during the fire season can account for the consistency in fire perimeter orientation in these regions. Our findings highlight the historical pattern of fire perimeter orientation and identify watersheds with potential orographic channeling. |
| Posted: 22 Mar 2013 12:00 AM PDT Eggplant is a popular vegetable consumed all over the world. Cover cropping is an efficient way of recycling nutrients and reducing inorganic fertilizer requirements to maintain the sustainability of the soil without affecting productivity and profitability. Eggplants (Solanum melongena) (Japanese varieties Hansel and Kamo) were grown in a Piedmont soil with two main treatments, cover crop (CC) and no cover crop (NC), and four sub-fertilizer treatments (T1: 0-0-0, T2: 56-28-112, T3: 84-56-168, and T4: 168-112-224 N-P-K kg/ha), using four replications. The Hansel variety eggplant yield was significantly higher than the Kamo variety. Eggplant yields from CC treatments for both varieties were significantly higher (p < 0.001) than the yields from NC treatments. No significant difference was observed in the yields between T1 and T2 treatments, but the yields from T3 were significantly higher than T1 and T2 and yields from T4 were significantly higher than T3 yields. N released through mineralization of cover crop mixture ranged from 13.33 g/kg at the beginning of the growing season and increased to 18.32 g/kg at the end of the growing season. These results suggest that Japanese eggplants can be successfully grown in the Piedmont area of North Carolina in rotation with cover crops for higher yields. |
| BioShock Infinite cost $200 million to produce and market – Report Posted: 21 Mar 2013 07:51 PM PDT Analysts estimate game development to have cost $100 million; additional $100 million spent on marketing and promotion.
According to a New York Times article citing unnamed analysts, BioShock Infinite may have cost its parent company Take-Two Interactive $100 million to develop, with a further $100 million spent to promote and market the game to the public. BioShock Infinite is the third instalment in the series and has been in development at Irrational Games for four years, with a 200 person team working on the project. The game follows on from 2007's BioShock, and 2010's BioShock 2. The cost of developing games has risen across the board in recent years. Last month, using a "hypothetical profitability model", Sterne Agee analyst Arvind Bhatia predicted that Grand Theft Auto V–s creation may cost in excess of $137.5 million based on a 250-person team during a five-year development period. An additional $69 million to $109.3 million is expected to be spent in marketing costs to raise awareness for the game. By comparison, during its six years of production--across four continents and through the hands of more than 800 developers--2011's Star Wars: The Old Republic reportedly cost publisher EA $200 million dollars in development costs alone. For more on BioShock Infinite, check out GameSpot's hour-long discussion with Irrational Games creative director Ken Levine. [UPDATE]: BioShock Infinite creative director Ken Levine has tweeted, refuting the claims made by the New York Times report. "200 million for Infinite? Did someone send some checks to the wrong address?" A spokesperson speaking on behalf of the game declined to provide GameSpot with an official statement clarifying the cost of development.
Read and Post Comments | Get the full article at GameSpot "BioShock Infinite cost $200 million to produce and market – Report" was posted by Dan Chiappini on Thu, 21 Mar 2013 19:51:50 -0700 |
| Posted: 22 Mar 2013 12:00 AM PDT This study compared two methods of assaying the 25-hydroxylated metabolites of cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2). A fully automated electrochemiluminescence assay from Roche Diagnostics and an HPLC based method from Chromsystems were used to measure vitamin D levels in surplus sera from 96 individuals, where the majority has the D2 form of the vitamin. Deming regression, concordance rate, correlation and Altman Bland agreement were performed. Seventy two subjects (75%) had a D2 concentration >10 nmol/L while the remaining twenty four subjects had vitamin D2 concentration of less than 10 nmol/L by HPLC. Overall, the Roche Diagnostics method showed a negative bias of −2.59 ± 4.11 nmol/L on the e602 as compared to the HPLC with a concordance rate of 84%. The concordance rate was 91% in samples with D2 of less than 10 nmol/L and 82% in those with D2 concentration >10 nmol/L. The overall correlation had an r value of 0.77. The r value was higher in samples with D2 levels of less than 10 nmol/L, r = 0.96, as compared to those with D2 values of greater than 10 nmol/L, r = 0.74. The observed bias had little impact on clinical decision and therefore is clinically acceptable. |
| Posted: 22 Mar 2013 12:00 AM PDT Several models have been proposed to explain the dark energy that is causing universe expansion to accelerate. Here the acceleration predicted by the Holographic Dark Information Energy (HDIE) model is compared to the acceleration that would be produced by a cosmological constant. While identical to a cosmological constant at low redshifts, z < 1, the HDIE model results in smaller Hubble parameter values at higher redshifts, z > 1, reaching a maximum difference of 2.6 ± 0.5% around z ~ 1.7. The next generation of dark energy measurements, both those scheduled to be made in space (ESA's Euclid and NASA's WFIRST missions) and those to be made on the ground (BigBOSS, LSST and Dark Energy Survey), should be capable of determining whether such a difference exists or not. In addition a computer simulation thought experiment is used to show that the algorithmic entropy of the universe always increases because the extra states produced by the accelerating expansion compensate for the loss of entropy from star formation. |
| Entropy, Vol. 15, Pages 1116-1132: Evidence of Large-Scale Quantization in Space Plasmas Posted: 22 Mar 2013 12:00 AM PDT In plasmas, Debye screening structures the possible correlations between particles. We identify a phase space minimum h* in non-equilibrium space plasmas that connects the energy of particles in a Debye sphere to an equivalent wave frequency. In particular, while there is no a priori reason to expect a single value of h* across plasmas, we find a very similar value of h* ≈ (7.5 ± 2.4)×10−22 J·s using four independent methods: (1) Ulysses solar wind measurements, (2) space plasmas that typically reside in stationary states out of thermal equilibrium and spanning a broad range of physical properties, (3) an entropic limit emerging from statistical mechanics, (4) waiting-time distributions of explosive events in space plasmas. Finding a quasi-constant value for the phase space minimum in a variety of different plasmas, similar to the classical Planck constant but 12 orders of magnitude larger may be revealing a new type of quantization in many plasmas and correlated systems more generally. |
| Entropy, Vol. 15, Pages 1100-1115: A Maximum Entropy Approach to Loss Distribution Analysis Posted: 22 Mar 2013 12:00 AM PDT In this paper we propose an approach to the estimation and simulation of loss distributions based on Maximum Entropy (ME), a non-parametric technique that maximizes the Shannon entropy of the data under moment constraints. Special cases of the ME density correspond to standard distributions; therefore, this methodology is very general as it nests most classical parametric approaches. Sampling the ME distribution is essential in many contexts, such as loss models constructed via compound distributions. Given the difficulties in carrying out exact simulation,we propose an innovative algorithm, obtained by means of an extension of Adaptive Importance Sampling (AIS), for the approximate simulation of the ME distribution. Several numerical experiments confirm that the AIS-based simulation technique works well, and an application to insurance data gives further insights in the usefulness of the method for modelling, estimating and simulating loss distributions. |
| Posted: 22 Mar 2013 12:00 AM PDT The original version of the paper reports that "OGX-011 is a second generation 21-mer oligonucleotide with a 20-O-(2-methoxy)-ethyl modification, generously provided by OncoGenex Technologies (OncoGenex, Vancouver, Canada)" [1] (p. 10602). OGX-011 was not provided by OncoGenex Technologies directly. Therefore, we would like to correct the wording to: "OGX-011 was obtained without the benefit of an agreement with OncoGenex, or The University British Columbia, or any other party". The authors would like to apologize for any inconvenience this may have caused to the readers of this journal. |
| Cory signing Rapture of the Nerds at Forbidden Planet London tomorrow Posted: 22 Mar 2013 12:55 AM PDT |
| Posted: 22 Mar 2013 12:00 AM PDT In this paper, the optimal composition of a paeonol temperature-sensitive in situ gel composed of poloxamer 407 (P407) was determined, and a preliminary study of its effect on allergic rhinitis was performed. The optimal composition of the paeonol temperature-sensitive in situ gel included 2% paeonol inclusion, 22% P407, 2% poloxamer 188 (P188) and 2% PEG6000, as assessed by thermodynamic and rheological studies. The toad palate model was employed to study the toxicity of the paeonol temperature-sensitive in situ gel on the nasal mucosa. The result of this experiment showed low toxicity to cilia, which allows the gel to be used for nasal administration. The Franz diffusion cell method was used to study the in vitro release of paeonol and suggested that the in vitro release was in line with the Higuchi equation. This result suggests that the paeonol could be absorbed into the body through mucous membranes and had some characteristics of a sustained effect. Finally, the guinea pig model of ovalbumin sensitized allergic rhinitis was used to evaluate the preliminary efficacy of the gel, with the paeonol temperature-sensitive in situ gel showing a significant effect on the guinea pig model of sensitized allergic rhinitis (AR). |
| Australian Police Bust International Crime Syndicate; Seize $600,000 in Casino Chips Posted: 21 Mar 2013 11:23 PM PDT Last week, a $33 million heist was reported from Crown Casino in Melbourne, Australia, home of the Aussie Millions and 2013 World Series of Poker Asia-Pacific . This week, while the PokerNews Live Reporting team tracks the progress of the 2013 PokerStars.net ANZPT Sydney Main Event , more international crime news has come out of Australia. This posting includes an audio/video/photo media file: Download Now |
| Fantastical 1.3.7 - Create calendar events using natural language. (Demo) Posted: 21 Mar 2013 08:59 PM PDT  Fantastical is the Mac calendar you'll actually enjoy using. Creating an event with Fantastical is quick, easy, and fun:
Your events have never looked better Plan your day in style with the most attractive calendar you've ever seen. Color-coding and beautiful design help you quickly make sense of your schedule. You can even change the number of events you want displayed, allowing you to focus on what's important. Need more info about an event? Just click on it and the event's important details will be displayed instantly. Edit and delete with ease Presenting the easiest and quickest way to change your events: select the event you want to change and take control of your event with a single click or keystroke. For example, add event notes to existing events. Enter the information that's important for you to remember and it will stay attached to your event. BYOC (Bring Your Own Calendar) Fantastical works with your favorite Mac calendar application: iCal, BusyCal, Entourage, or Outlook. You can even use your iCloud, MobileMe, Google Calendar or Yahoo! Calendar accounts: simply add them to iCal and you're all set. Version 1.3.7:
OS X 10.6.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Xpecial talks on Wildturtle as a sub versus playing with Chaox Posted: 21 Mar 2013 08:37 PM PDT Travis catches up with Xpecial to learn more about the sub Wildturtle versus his play style with Chaox.
Read and Post Comments | Get the full article at GameSpot "Xpecial talks on Wildturtle as a sub versus playing with Chaox" was posted by erickt on Thu, 21 Mar 2013 20:37:40 -0700 |
| BioShock Infinite cost $200 million to produce and market – Report Posted: 21 Mar 2013 07:51 PM PDT Analysts estimate game development to have cost $100 million; additional $100 million spent on marketing and promotion.
According to a New York Times article citing unnamed analysts, BioShock Infinite may have cost its parent company Take-Two Interactive $100 million to develop, with a further $100 million spent to promote and market the game to the public. BioShock Infinite is the third instalment in the series and has been in development at Irrational Games for four years, with a 200 person team working on the project. The game follows on from 2007's BioShock, and 2010's BioShock 2. The cost of developing games has risen across the board in recent years. Last month, using a "hypothetical profitability model", Sterne Agee analyst Arvind Bhatia predicted that Grand Theft Auto V–s creation may cost in excess of $137.5 million based on a 250-person team during a five-year development period. An additional $69 million to $109.3 million is expected to be spent in marketing costs to raise awareness for the game. By comparison, during its six years of production--across four continents and through the hands of more than 800 developers--2011's Star Wars: The Old Republic reportedly cost publisher EA $200 million dollars in development costs alone. For more on BioShock Infinite, check out GameSpot's hour-long discussion with Irrational Games creative director Ken Levine. [UPDATE]: BioShock Infinite creative director Ken Levine has tweeted, refuting the claims made by the New York Times report. "200 million for Infinite? Did someone send some checks to the wrong address?" A spokesperson speaking on behalf of the game declined to provide GameSpot with an official statement clarifying the cost of development.
Read and Post Comments | Get the full article at GameSpot "BioShock Infinite cost $200 million to produce and market – Report" was posted by Dan Chiappini on Thu, 21 Mar 2013 19:51:50 -0700 |
| Sound Byte: Meet the Composer – BioShock series Posted: 21 Mar 2013 06:45 PM PDT We had a lengthy chat with series composer Garry Schyman on his past work with the first two BioShock titles as well as the upcoming BioShock Infinite.
Get the full article at GameSpot "Sound Byte: Meet the Composer – BioShock series" was posted by Jonathan Toyad on Thu, 21 Mar 2013 18:45:30 -0700 |
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