Games |
- Icon Glue 1.1 - Easily create Apple icon images for apps. (Demo)
- Radiologik DJ 2013.2.6 - Mixer built specifically for radio DJs. (Demo)
- Marine Drugs, Vol. 11, Pages 623-642: Glycosylation of Conotoxins
- Molecules, Vol. 18, Pages 2840-2850: New Limonoids and a Dihydrobenzofuran Norlignan from the Roots of Toona sinensis
- Louth 'cannot provide jobs' required by future residents influx, group warns
- Molecules, Vol. 18, Pages 2821-2839: Apocynin: Chemical and Biophysical Properties of a NADPH Oxidase Inhibitor
- Molecules, Vol. 18, Pages 2803-2820: Characterization of Proanthocyanidins from Parkia biglobosa (Jacq.) G. Don. (Fabaceae) by Flow Injection Analysis — Electrospray Ionization Ion Trap Tandem Mass Spectrometry and Liquid Chromatography/Electrospray Ionization Mass Spectrometry
- Molecules, Vol. 18, Pages 2788-2802: Synthesis of New BINAP-Based Aminophosphines and Their 31P-NMR Spectroscopy
- Molecules, Vol. 18, Pages 2778-2787: Lactones 41. Synthesis and Microbial Hydroxylation of Unsaturated Terpenoid Lactones with p-Menthane Ring Systems
- Molecules, Vol. 18, Pages 2769-2777: Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone
- Molecules, Vol. 18, Pages 2763-2768: Antibacterial Activity Composition of the Fermentation Broth of Streptomyces djakartensis NW35
- Molecules, Vol. 18, Pages 2754-2762: Insecticidal and Feeding Deterrent Effects of Fraxinellone from Dictamnus dasycarpus against Four Major Pests
- Molecules, Vol. 18, Pages 2726-2753: Cell Suspension Culture of Eriobotrya japonica Regulates the Diabetic and Hyperlipidemic Signs of High-Fat-Fed Mice
- IJGI, Vol. 2, Pages 94-109: Quantifying Landscape-Scale Patterns of Temperate Forests over Time by Means of Neutral Simulation Models
- Remote Sensing, Vol. 5, Pages 1117-1133: Shifts in Global Vegetation Activity Trends
- Remote Sensing, Vol. 5, Pages 1091-1116: Enhanced Processing of 1-km Spatial Resolution fAPAR Time Series for Sugarcane Yield Forecasting and Monitoring
- Remote Sensing, Vol. 5, Pages 1066-1090: Multisensor NDVI-Based Monitoring of the Tundra-Taiga Interface (Mealy Mountains, Labrador, Canada)
- Remote Sensing, Vol. 5, Pages 1045-1065: Persistent Scatterer Interferometry (PSI) Technique for Landslide Characterization and Monitoring
- Remote Sensing, Vol. 5, Pages 1024-1044: River Courses Affected by Landslides and Implications for Hazard Assessment: A High Resolution Remote Sensing Case Study in NE Iraq–W Iran
- Micromachines, Vol. 4, Pages 22-33: Compact Mass Flow Meter based on a Micro Coriolis Flow Sensor
| Icon Glue 1.1 - Easily create Apple icon images for apps. (Demo) Posted: 01 Mar 2013 02:58 AM PST  Icon Glue is the easiest way to quickly create an Apple Icon Image (.icns) for your Mac app from a single 1024x1024 pixels sized PNG or TIFF image. Just open your image, select what you want to create (Icon Glue will remember these settings) and save it. You can also open an OS X application bundle to easily extract its icon withouth having to browse through the bundle's internal folder structure. Icon Glue can:
If you find a bug in this app, please report it to the bug tracker so I can fix it as soon as possible. You can reach the bug tracker directly via the "Icon Glue Support" link. New in Version 1.1:
Download Now This posting includes an audio/video/photo media file: Download Now |
| Radiologik DJ 2013.2.6 - Mixer built specifically for radio DJs. (Demo) Posted: 01 Mar 2013 02:52 AM PST  Radiologik DJ is the DJ live assistant specifically built for the needs of radio but very useful for all DJing needs, with the exception of club mix features. It features 3 main players and one library player, all with selectable individual audio outputs, detailed time calculations, a lot of fast and smooth iTunes integration, and Nicecast artist and title publishing. It is complemented by a free separate scheduler for full station automation. Radiologik DJ has a variety of editions available for purchase. Compare the differences and view the prices of each edition here.
Download Now This posting includes an audio/video/photo media file: Download Now |
| Marine Drugs, Vol. 11, Pages 623-642: Glycosylation of Conotoxins Posted: 01 Mar 2013 12:00 AM PST Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools employed in neurological studies and for drug development, because they target with exquisite specificity membrane receptors, transporters, and various ion channels in the nervous system. However, these peptides are known to contain a high frequency and variability of post-translational modifications—including sometimes O-glycosylation—which are of importance for biological activity. The potential application of specific conotoxins as neuropharmalogical agents and chemical probes requires a full characterization of the relevant peptides, including the structure of the carbohydrate part. In this review, the currently existing knowledge of O-glycosylation of conotoxins is described. |
| Posted: 01 Mar 2013 12:00 AM PST Two new limonoids, toonins A (1) and B (2), and one new dihydrobenzofuran norlignan, toonin C (3), were isolated from the roots of Toona sinensis together with the ten known compounds 4-methoxy-6-(2′,4′-dihydroxy-6′-methylphenyl)-pyran-2-one (4), bourjotinolone A (5), proceranone (6), matairesinol (7), 4-hydroxy-3-methoxybenzene-ethanol (8), syringic acid (9), isoscopoletin (10), lyoniresinol (11), aloeemodin (12), and β-sitosterol (13). Their structures were elucidated on the basis of one- and two-dimensional spectroscopic analysis. Isolation of compounds 4, 6–13 from this plant is reported here for the first time. |
| Louth 'cannot provide jobs' required by future residents influx, group warns Posted: 01 Mar 2013 02:01 AM PST Louth's economy 'cannot provide the new jobs' required by an influx of residents on a potential new housing development, a group has warned. |
| Posted: 01 Mar 2013 12:00 AM PST Apocynin is the most employed inhibitor of NADPH oxidase (NOX), a multienzymatic complex capable of catalyzing the one-electron reduction of molecular oxygen to the superoxide anion. Despite controversies about its selectivity, apocynin has been used as one of the most promising drugs in experimental models of inflammatory and neurodegenerative diseases. Here, we aimed to study the chemical and biophysical properties of apocynin. The oxidation potential was determined by cyclic voltammetry (Epa = 0.76V), the hydrophobicity index was calculated (logP = 0.83) and the molar absorption coefficient was determined (e275nm = 1.1 × 104 M−1 cm−1). Apocynin was a weak free radical scavenger (as measured using the DPPH, peroxyl radical and nitric oxide assays) when compared to protocatechuic acid, used here as a reference antioxidant. On the other hand, apocynin was more effective than protocatechuic acid as scavenger of the non-radical species hypochlorous acid. Apocynin reacted promptly with the non-radical reactive species H2O2 only in the presence of peroxidase. This finding is relevant, since it represents a new pathway for depleting H2O2 in cellular experimental models, besides the direct inhibition of NADPH oxidase. This could be relevant for its application as an inhibitor of NOX4, since this isoform produces H2O2 and not superoxide anion. The binding parameters calculated by fluorescence quenching showed that apocynin binds to human serum albumin (HSA) with a binding affinity of 2.19 × 104 M−1. The association did not alter the secondary and tertiary structure of HSA, as verified by synchronous fluorescence and circular dichroism. The displacement of fluorescent probes suggested that apocynin binds to site I and site II of HSA. Considering the current biomedical applications of this phytochemical, the dissemination of these chemical and biophysical properties can be very helpful for scientists and physicians interested in the use of apocynin. |
| Posted: 01 Mar 2013 12:00 AM PST The present study investigates the chemical composition of the African plant Parkia biglobosa (Fabaceae) roots and barks by Liquid Chromatography - Electrospray Ionization and Direct Injection Tandem Mass Spectrometry analysis. Mass spectral data indicated that B-type oligomers are present, namely procyanidins and prodelphinidins, with their gallate and glucuronide derivatives, some of them in different isomeric forms. The analysis evidenced the presence of up to 40 proanthocyanidins, some of which are reported for the first time. In this study, the antiradical activity of extracts of roots and barks from Parkia biglobosa was evaluated using DPPH method and they showed satisfactory activities. |
| Posted: 01 Mar 2013 12:00 AM PST BINAP aminophosphines are prevalent N,P-bidentate, chiral ligands for asymmetric catalysis. While modification via the BINAP-nitrogen linkage is well explored and has provided a diverse body of derivatives, modification of the other substituents of the phosphorous center is another avenue in generating new congeners of this important class of chiral ligands. Herein reported are new BINAP aryl aminophosphines with electron rich or deficient substituents on the aryl rings. This scalable synthesis converted readily available starting material, (S)-BINOL, to a key intermediate (S)-NOBIN, from which the final chiral aminophosphines were prepared via a palladium-catalyzed, phosphonylation reaction. The aryl substituents are able to modify the electronic properties of the phosphorous center as indicated by the range of 31P-NMR shifts of these new ligands. A computational analysis was performed to linearly quantitate contributions to the 31P-NMR shifts from both resonance and field effects of the substituents. This correlation may be useful for designing and preparing other related aminophosphines with varying ligand properties. |
| Posted: 01 Mar 2013 12:00 AM PST Racemic [(±)-4-isopropyl-1-methyl-7-oxa-cis-bicyclo[4.3.0]non-4-en-8-one] and optically active d,e-unsaturated lactones [(-)-(1R,6R)-4-isopropyl-1-methyl-7-oxabicyclo[4.3.0]non-4-en-8-one and (+)-(1S,6S)-4-isopropyl-1-methyl-7-oxabicyclo[4.3.0] non-4-en-8-one)] with the p-menthane system were obtained and their odoriferous properties were evaluated. Biotransformations of the racemic lactone with three fungal strains: Absidia cylindrospora AM336, Absidia glauca AM177 and Syncephalastrum racemosum AM105, were carried out. Microbial transformations afforded hydroxylactones with the hydroxy group in the allylic position. |
| Posted: 01 Mar 2013 12:00 AM PST The phytochemical study of Sida rhombifolia L. (Malvaceae) led to the isolation through chromatographic techniques of eleven secondary metabolites: sitosterol (1a) and stigmasterol (1b), sitosterol-3-O-b-D-glucopyranoside (2a) and stigmasterol-3-O-b-D-glucopyranoside (2b), phaeophytin A (3), 173-ethoxypheophorbide A (4), 132-hydroxy phaeophytin B (5), 173-ethoxypheophorbide B (6), 5,7-dihydroxy-4'-methoxyflavone (7), cryptolepinone (8) and a salt of cryptolepine (9). Their structures were identified by 1H- and 13C-NMR using one- and two-dimensional techniques. In addition, the vasorelaxant activity of cryptolepinone in rat mesenteric artery rings is reported herein for the first time. |
| Posted: 01 Mar 2013 12:00 AM PST The new compound Z-4-2 was isolated from the fermentation broth of Streptomyces djakartensis NW35, together with the known compound N-acetyltryptamine (Z-9-2) by bioassay-guided fractionation. Its chemical structure was elucidated as (E)-2-methoxy-1,4 naphthoquinone-1-oxime (Z-4-2) mainly by NMR analyses and MS spectral data. Their antibacterial activities against bacteria were evaluated by the filter paper method. The results of indicated that these compounds possess significant antibacterial activities. |
| Posted: 01 Mar 2013 12:00 AM PST Fraxinellone, a well-known and significant naturally occurring compound isolated from Meliaceae and Rutaceae spp. has been widely used as a drug for the treatment of tumors. On the other hand, fraxinellone exhibited a variety of insecticidal activities including feeding-deterrent activity, inhibition of growth, and larvicidal activity. The present study focused on the antifeedant and larvicidal activities of fraxinellone against the larvae of Lepidoptera, including Mythimna separata, Agrotis ypsilon, Plutella xylostella, and one kind of sanitary pest, Culux pipiens pallens. Meanwhile, the ovicidal activities and the effects of fraxinellone on the larval development of M. separata were also observed. The LC50 values of fraxinellone against 3rd instar larvae of M. separata, 2nd instar larvae of P. xylostella and 4th instar larvae of C. pipiens pallens were 15.95/6.43/3.60 × 10−2 mg mL−1, and its AFC50 values against 5th instar larvae of M. separata, 2nd instar larvae of P. xylostella and 2nd instar larvae of A. ypsilon were 10.73/7.93/12.58 mg mL−1, respectively. Compared with the control group, fraxinellone obviously inhibited the pupation rate and the growth of M. separata. Once M. separata was treated with fraxinellone at concentrations of 5.0, 10.0, and 20.0 mg mL−1, respectively, the stages from the larvae to adulthood and the egg hatching duration were prolonged to 1/2/3, and 4/3/4 days, respectively. Additionally, fraxinellone strongly inhibited the development rate and the egg hatch proportion of M. separata. |
| Posted: 01 Mar 2013 12:00 AM PST The present study investigates the anti-hyperlipidemic and antihyperglycemic effects and mechanism in high-fat (HF)-fed mice of cell suspension culture of Eriobotrya japonica (TA), which contains a great number of pentacyclic terpenoids. Firstly, C57BL/6J mice were randomly divided into two groups: the control (CON) group was fed with a low-fat diet (n = 9), whereas the experimental group was fed a 45% HF diet for 8 weeks. Afterwards, the CON group was treated with vehicle, whereas the HF group was subdivided into five groups and was orally given TA or rosiglitazone or not for 4 weeks. Blood and visceral adipose tissue, liver tissue and skeletal muscle were examined. Treatment with TA reduced body weight gain, weights of white adipose tissue (WAT) (including epididymal, perirenal, mesenteric WAT and visceral fat), and hepatic triacylglycerol content significantly without affecting food intake in diet-induced diabetic mice. TA effectively prevented HF diet-induced increases in the levels of blood glucose, insulin, leptin and HOMA-IR index (p < 0.001, p < 0.05, p < 0.05, p < 0.01, respectively) and attenuated insulin resistance. Treatment with TA, adipocytes in the visceral depots showed a reduction in size. TA effectively significantly increased the protein contents of phosphorylation of AMPK-α (Thr172) both in liver and adipose tissue. It is shown that TA exhibits hypolipidemic effect in HF-fed mice by decreasing gene expressions of fatty acid synthesis, including acyl-coenzyme A: diacylglycerol acyltransferase (DGAT) 2, which catalyzes the final step in the synthesis of triglycerides, and antidiabetic properties occurred as a result of decreased hepatic glucose production via phosphenolpyruvate carboxykinase (PEPCK) down- regulation, improved insulin sensitization and TA (at 1.0 g/kg dose) decreased expression of hepatic and adipose 11-β-hydroxysteroid dehydroxygenase (11β-HSD1) gene, which contributed in attenuating diabetic state. Futhermore, TA at doses of 0.5 and 1.0 g/kg had serum lipid-lowering action characterized by the inhibition of DGAT 1 expression. Thus, amelioration of diabetic and dyslipidemic state by TA in HF-fed mice occurred by regulation of PEPCK, DGAT2 and AMPK phosphorylation. |
| Posted: 01 Mar 2013 12:00 AM PST Several studies attempt to describe changes in the spatial patterns of forests over time, resorting to the comparison of landscape pattern indices (LPI), but new methods for quantifying landscape differences in a statistical context are necessary. In this paper, we quantified and assessed the statistical significance of the forests pattern changes, which have occurred since the end of WWII in Central Italy (Isernia). To do this; based on the proportion of forest cover (pi) and contagion (H) of three land cover maps (1954–1981–2006); we generated 100 forest maps with predictable results through the midpoint displacement algorithm. Then, for both observed and simulated maps, we computed a set of LPI (number of patches, cohesion, largest forest patch index and area weighted mean shape index) and we derived their empirical distributions; finally, we compared the empirical distributions using the non-parametric Kruskal-Wallis test. Our results show significant changes in the spatial pattern of forests and underline the process of natural forest re-growth, which, in the area, is constrained by "remnants" of traditional activities. The adopted approach could be extended to a large ensemble of landscapes and spatial scales and could become a standard procedure when comparing patterns in time. |
| Remote Sensing, Vol. 5, Pages 1117-1133: Shifts in Global Vegetation Activity Trends Posted: 01 Mar 2013 12:00 AM PST Vegetation belongs to the components of the Earth surface, which are most extensively studied using historic and present satellite records. Recently, these records exceeded a 30-year time span composed of preprocessed fortnightly observations (1981–2011). The existence of monotonic changes and trend shifts present in such records has previously been demonstrated. However, information on timing and type of such trend shifts was lacking at global scale. In this work, we detected major shifts in vegetation activity trends and their associated type (either interruptions or reversals) and timing. It appeared that the biospheric trend shifts have, over time, increased in frequency, confirming recent findings of increased turnover rates in vegetated areas. Signs of greening-to-browning reversals around the millennium transition were found in many regions (Patagonia, the Sahel, northern Kazakhstan, among others), as well as negative interruptions—"setbacks"—in greening trends (southern Africa, India, Asia Minor, among others). A minority (26%) of all significant trends appeared monotonic. |
| Posted: 01 Mar 2013 12:00 AM PST A processing of remotely-sensed Fraction of Absorbed Photosynthetically Active Radiation (fAPAR) time series at 1-km spatial resolution is established to estimate sugarcane yield over the state of São Paulo, Brazil. It includes selecting adequate time series according to the signal spatial purity, using thermal time instead of calendar time and smoothing temporally the irregularly sampled observations. A systematic construction of various metrics and their capacity to predict yield is explored to identify the best performance, and see how timely the yield forecast can be made. The resulting dataset not only reveals a strong spatio-temporal structure, but is also capable of detecting both absolute changes in biomass accumulation and changes in its inter-annual variability. Sugarcane yield can thus be estimated with a RMSE of 1.5 t/ha (or 2%) without taking into account the strong linear trend in yield increase witnessed in the past decade. Including the trend reduces the error to 0.6 t/ha, correctly predicting whether the yield in a given year is above or below the trend in 90% of cases. The methodological framework presented here could be applied beyond the specific case of sugarcane in São Paulo, namely to other crops in other agro-ecological landscapes, to enhance current systems for monitoring agriculture or forecasting yield using remote sensing. |
| Posted: 01 Mar 2013 12:00 AM PST The analysis of a series of five normalized difference vegetation index (NDVI) images produced information about a Labrador (Canada) portion of the tundra-taiga interface. The twenty-five year observation period ranges from 1983 to 2008. The series composed of Landsat, SPOT and ASTER images, provided insight into regional scale characteristics of the tundra-taiga interface that is usually monitored from coarse resolution images. The image set was analyzed by considering an ordinal classification of the NDVI to account for the cumulative effect of differences of near-infrared spectral resolutions, the temperature anomalies, and atmospheric conditions. An increasing trend of the median values in the low, intermediate and high NDVI classes is clearly marked while accounting for variations attributed to cross-sensor radiometry, phenology and atmospheric disturbances. An encroachment of the forest on the tundra for the whole study area was estimated at 0 to 60 m, depending on the period of observation, as calculated by the difference between the median retreat and advance of an estimated location of the tree line. In small sections, advances and retreats of up to 320 m are reported for the most recent four- and seven-year periods of observations. |
| Posted: 01 Mar 2013 12:00 AM PST : The measurement of landslide superficial displacement often represents the most effective method for defining its behavior, allowing one to observe the relationship with triggering factors and to assess the effectiveness of the mitigation measures. Persistent Scatterer Interferometry (PSI) represents a powerful tool to measure landslide displacement, as it offers a synoptic view that can be repeated at different time intervals and at various scales. In many cases, PSI data are integrated with in situ monitoring instrumentation, since the joint use of satellite and ground-based data facilitates the geological interpretation of a landslide and allows a better understanding of landslide geometry and kinematics. In this work, PSI interferometry and conventional ground-based monitoring techniques have been used to characterize and to monitor the Santo Stefano d'Aveto landslide located in the Northern Apennines, Italy. This landslide can be defined as an earth rotational slide. PSI analysis has contributed to a more in-depth investigation of the phenomenon. In particular, PSI measurements have allowed better redefining of the boundaries of the landslide and the state of activity, while the time series analysis has permitted better understanding of the deformation pattern and its relation with the causes of the landslide itself. The integration of ground-based monitoring data and PSI data have provided sound results for landslide characterization. The punctual information deriving from inclinometers can help in defining the actual location of the sliding surface and the involved volumes, while the measuring of pore water pressure conditions or water table level can suggest a correlation between the deformation patterns and the triggering factors. |
| Posted: 01 Mar 2013 12:00 AM PST The objective of this study is to understand the effect of landslides on the drainage network within the area of interest. We thus test the potential of rivers to record the intensity of landslides that affected their courses. The study area is located within the Zagros orogenic belt along the border between Iraq and Iran. We identified 280 landslides through nine QuickBird scenes using visual photo-interpretation. The total landslide area of 40.05 km2 and their distribution follows a NW–SE trend due to the tectonic control of main thrust faults. We observe a strong control of the landslides on the river course. We quantify the relationship between riverbed displacement and mass wasting occurrences using landslide sizes versus river offset and hypsometric integrals. Many valleys and river channels are curved around the toe of landslides, thus producing an offset of the stream which increases with the landslide area. The river offsets were quantified using two geomorphic indices: the river with respect to the basin midline (Fb); and the offset from the main river direction (Fd). Hypsometry and stream offset seem to be correlated. In addition; the analysis of selected river courses may give some information on the sizes of the past landslide events and therefore contribute to the hazard assessment. |
| Micromachines, Vol. 4, Pages 22-33: Compact Mass Flow Meter based on a Micro Coriolis Flow Sensor Posted: 01 Mar 2013 12:00 AM PST In this paper we demonstrate a compact ready-to-use micro Coriolis mass flow meter. The full scale flow is 1 g/h (for water at a pressure drop < 1 bar). It has a zero stability of 2 mg/h and an accuracy of 0.5% reading for both liquids and gases. The temperature drift between 10 and 50 °C is below 1 mg/h/°C. The meter is robust, has standard fluidic connections and can be read out by means of a PC or laptop via USB. Its performance was tested for several common gases (hydrogen, helium, nitrogen, argon and air) and liquids (water and isopropanol). As in all Coriolis mass flow meters, the meter is also able to measure the actual density of the medium flowing through the tube. The sensitivity of the measured density is ~1 Hz.m3/kg. |
| You are subscribed to email updates from Games To stop receiving these emails, you may unsubscribe now. | Email delivery powered by Google |
| Google Inc., 20 West Kinzie, Chicago IL USA 60610 | |
Комментариев нет:
Отправить комментарий