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- IJMS, Vol. 14, Pages 7048-7060: Lipid Status of the Two High Latitude Fish Species, Leptoclinus maculatus and Lumpenus fabricii
- IJMS, Vol. 14, Pages 7032-7047: Disruption of AtWNK8 Enhances Tolerance of Arabidopsis to Salt and Osmotic Stresses via Modulating Proline Content and Activities of Catalase and Peroxidase
- IJMS, Vol. 14, Pages 7016-7031: Trends in Nanopharmaceutical Patents
- IJMS, Vol. 14, Pages 6981-7015: Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon
- IJMS, Vol. 14, Pages 6960-6980: Impact of Cell Wall Composition on Maize Resistance to Pests and Diseases
- IJMS, Vol. 14, Pages 6920-6959: MICAL, the Flavoenzyme Participating in Cytoskeleton Dynamics
- IJMS, Vol. 14, Pages 6903-6919: Beneficial Effects of the RESMENA Dietary Pattern on Oxidative Stress in Patients Suffering from Metabolic Syndrome with Hyperglycemia Are Associated to Dietary TAC and Fruit Consumption
- Leaf 1.2 - News reader with preview, sharing, and search capabilities. (Commercial)
- Cloud Mate 1.4 - Add a Finder-like interface to iCloud. (Commercial)
- Sleipnir 4.1.2 - Gesture-focused Web browser. (Free)
- BioShock: Infinite Graphics Comparison
- Battlefield 4 - Fishing in Baku Interview
- Army of Two: The Devil's Cartel Screens
- Battlefield 4 - Fishing in Baku Gameplay Trailer
- Battlefield 4 Screens
- Battlefield 4 TV Trailer
- Battlefield 4 confirmed for fall 2013
- World of Tanks Blitz coming to smartphones and tablets
- 4 Techno Indie Games in 4 Minutes
- Antibiotics, Vol. 2, Pages 182-190: Photobactericides—A Local Option against Multi-Drug Resistant Bacteria
| Posted: 27 Mar 2013 12:00 AM PDT A comparative study of the lipid status (i.e., the total lipid and phospholipid concentrations and the percentage of fatty acids of the total lipids) of adult specimens of daubed shanny (Leptoclinus maculatus) from Svalbard waters (Isfjord) and slender eel blenny (Lumpenus fabricii) from the White Sea (Onega Bay and Tersky shore) was performed to study the metabolism and functions of lipids of these fishes in ontogeny and under various ecological conditions. Slender eel blenny from both areas of the White Sea were distinguished by a high level of sphingomyelin compared with the daubed shanny from Svalbard, and the amount of total phospholipids was higher in slender eel blenny from Onega Bay than in slender eel blenny from the Tersky shore. The extent of saturation and the signature of polyenic fatty acids varied according to the specific species of the Stichaeidae family under study. These results demonstrate the differences in the trophoecological and hydrobiological conditions of habitations of these species and highlighted the importance of considering certain trends in the lipid profiles of these fishes as specific features of the organization of the ecological and biochemical mechanisms of adaptation. |
| Posted: 27 Mar 2013 12:00 AM PDT With no lysine kinases (WNKs) play important roles in plant growth and development. However, its role in salt and osmotic stress tolerance is unclear. Here, we report that AtWNK8 is mainly expressed in primary root, hypocotyl, stamen and pistil and is induced by NaCl and sorbitol treatment. Compared to the wild-type, the T-DNA knock-out wnk8 mutant was more tolerant to severe salinity and osmotic stresses, as indicated by 27% and 198% more fresh weight in the NaCl and sorbitol treatment, respectively. The wnk8 mutant also accumulated 1.43-fold more proline than the wild-type in the sorbitol treatment. Under NaCl and sorbitol stresses, catalase (CAT) activity in wnk8 mutant was 1.92- and 3.7-times of that in Col-0, respectively. Similarly, under salt and osmotic stress conditions, peroxidase (POD) activities in wnk8 mutant were 1.81- and 1.58-times of that in Col-0, respectively. Taken together, we revealed that maintaining higher CAT and POD activities might be one of the reasons that the disruption of AtWNK8 enhances the tolerance to salt stress, and accumulating more proline and higher activities of CAT and POD might result in the higher tolerance of WNK8 to osmotic stress. |
| IJMS, Vol. 14, Pages 7016-7031: Trends in Nanopharmaceutical Patents Posted: 27 Mar 2013 12:00 AM PDT Investment in nanotechnology is now a given constant by governments, research centers and companies in both more developed countries and emerging markets. Due to their characteristics, such as high stability, ability to enable antigen identification on specific cells in the human body and controlling the release of drugs and, therefore, improving therapies, nanoparticles have been the subject of research and patent applications in the pharmaceutical field. According to the Organization for Economic Co-operation and Development (OCDE), patent data can be used as a source of information in order to measure science and technology activities. Thereby, this paper presents an analysis based on patent documents related to nanotechnology in the pharmaceutical sector. As a result, the analysis of patents demonstrate primarily that nanobiotechnology attracts high levels of R&D investments, including nanoparticle-based chemotherapeutic agents/drugs, monoclonal antibody nanoparticle complexes and their role in drug delivery or contrast agents with non-toxic effects. |
| Posted: 27 Mar 2013 12:00 AM PDT The pineal hormone melatonin exerts its influence in the periphery through activation of two specific trans-membrane receptors: MT1 and MT2. Both isoforms are expressed in the islet of Langerhans and are involved in the modulation of insulin secretion from β-cells and in glucagon secretion from α-cells. De-synchrony of receptor signaling may lead to the development of type 2 diabetes. This notion has recently been supported by genome-wide association studies identifying particularly the MT2 as a risk factor for this rapidly spreading metabolic disturbance. Since melatonin is secreted in a clearly diurnal fashion, it is safe to assume that it also has a diurnal impact on the blood-glucose-regulating function of the islet. This factor has hitherto been underestimated; the disruption of diurnal signaling within the islet may be one of the most important mechanisms leading to metabolic disturbances. The study of melatonin–insulin interactions in diabetic rat models has revealed an inverse relationship: an increase in melatonin levels leads to a down-regulation of insulin secretion and vice versa. Elucidation of the possible inverse interrelationship in man may open new avenues in the therapy of diabetes. |
| Posted: 27 Mar 2013 12:00 AM PDT In cereals, the primary cell wall is built of a skeleton of cellulosic microfibrils embedded in a matrix of hemicelluloses and smaller amounts of pectins, glycoproteins and hydroxycinnamates. Later, during secondary wall development, p-coumaryl, coniferyl and sinapyl alcohols are copolymerized to form mixed lignins. Several of these cell wall components show a determinative role in maize resistance to pest and diseases. However, defense mechanisms are very complex and vary among the same plant species, different tissues or even the same tissue at different developmental stages. Thus, it is important to highlight that the role of the cell wall components needs to be tested in diverse genotypes and specific tissues where the feeding or attacking by the pathogen takes place. Understanding the role of cell wall constituents as defense mechanisms may allow modifications of crops to withstand pests and diseases. |
| IJMS, Vol. 14, Pages 6920-6959: MICAL, the Flavoenzyme Participating in Cytoskeleton Dynamics Posted: 27 Mar 2013 12:00 AM PDT MICAL (from the Molecule Interacting with CasL) indicates a family of recently discovered cytosolic, multidomain proteins, which uniquely couple an N-terminal FAD-containing monooxygenase-like domain to typical calponine homology, LIM and coiled-coil protein-interaction modules. Genetic and cell biology approaches have demonstrated an essential role of the catalytic activity of the monooxygenase-like domain in transducing the signal initiated by semaphorins interaction with their plexin receptors, which results in local actin cytoskeleton disassembly as part of fundamental processes that include differentiation, migration and cell-cell contacts in neuronal and non-neuronal cell types. This review focuses on the structure-function relations of the MICAL monooxygenase-like domain as they are emerging from the available in vitro studies on mouse, human and Drosophila MICAL forms that demonstrated a NADPH-dependent actin depolymerizing activity of MICAL. With Drosophila MICAL forms, actin depolymerization was demonstrated to be associated to conversion of Met44 to methionine sulfone through a postulated hydroxylating reaction. Arguments supporting the concept that MICAL effect on F-actin may be reversible will be discussed. |
| Posted: 27 Mar 2013 12:00 AM PDT Hyperglycemia and oxidative stress are conditions directly related to the metabolic syndrome (MetS), whose prevalence is increasing worldwide. This study aimed to evaluate the effectiveness of a new weight-loss dietary pattern on improving the oxidative stress status on patients suffering MetS with hyperglycemia. Seventy-nine volunteers were randomly assigned to two low-calorie diets (−30% Energy): the control diet based on the American Health Association criteria and the RESMENA diet based on a different macronutrient distribution (30% proteins, 30% lipids, 40% carbohydrates), which was characterized by an increase of the meal frequency (seven-times/day), low glycemic load, high antioxidant capacity (TAC) and high n-3 fatty acids content. Dietary records, anthropometrical measurements, biochemical parameters and oxidative stress biomarkers were analyzed before and after the six-month-long study. The RESMENA (Metabolic Syndrome Reduction in Navarra) diet specifically reduced the android fat mass and demonstrated more effectiveness on improving general oxidative stress through a greater decrease of oxidized LDL (oxLDL) values and protection against arylesterase depletion. Interestingly, oxLDL values were associated with dietary TAC and fruit consumption and with changes on body mass index (BMI), waist circumference, fat mass and triacilglyceride (TG) levels. In conclusion, the antioxidant properties of the RESMENA diet provide further benefits to those attributable to weight loss on patients suffering Mets with hyperglycemia. |
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| Cloud Mate 1.4 - Add a Finder-like interface to iCloud. (Commercial) Posted: 27 Mar 2013 02:59 AM PDT  Cloud Mate adds a Finder-like interface to iCloud, and adds iCloud to the Finder. iCloud is great. iCloud splits all your content up by the app that created it. iCloud hides your Photo Stream. Cloud Mate sets those files free! Here are just some of the reasons we think you'll love Cloud Mate
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| Sleipnir 4.1.2 - Gesture-focused Web browser. (Free) Posted: 27 Mar 2013 02:51 AM PDT  Sleipnir is a Web browser for Mac with Smartphone and Web App Linker. Freely browsing the Web without having to think about unnecessary things with the rich selection of functions in Sleipnir. With Sleipnir 3, you can experience Web browsing never seen before such as the extremely simple design, and the powerful operations that can be easily performed with just one hand. Extremely speedy gestures Main functions:
All phone numbers are clickable when using Sleipnir 3. By simply clicking that phone number, the phone number is sent to your smartphone, and you can start calling from your smartphone straight away. In order to user Smartphone App Linker, it is required to download the free app Sleipnir Linker that can be used on iPhone / iPad and Android, and a Fenrir pass ID that can be obtained for free. Web App Linker Version 4.1.2:
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| BioShock: Infinite Graphics Comparison Posted: 27 Mar 2013 01:32 AM PDT Curious to find out how the graphics of the PC, PS3 and 360 version of BioShock: Infinite compare? This video is for you.
Read and Post Comments | Get the full article at GameSpot "BioShock: Infinite Graphics Comparison" was posted by edmondt on Wed, 27 Mar 2013 01:32:21 -0700 |
| Battlefield 4 - Fishing in Baku Interview Posted: 26 Mar 2013 11:54 PM PDT Patrick Bach discusses how Battlefield 4's single player campaign was influence by multiplayer.
Read and Post Comments | Get the full article at GameSpot "Battlefield 4 - Fishing in Baku Interview" was posted by sampsona on Tue, 26 Mar 2013 23:54:36 -0700 |
| Army of Two: The Devil's Cartel Screens Posted: 26 Mar 2013 11:25 PM PDT 25 new shots posted.
Get the full article at GameSpot "Army of Two: The Devil's Cartel Screens" was posted on Tue, 26 Mar 2013 23:25:19 -0700 |
| Battlefield 4 - Fishing in Baku Gameplay Trailer Posted: 26 Mar 2013 11:04 PM PDT Check out 17 minutes of gameplay action in Battlefield 4.
Read and Post Comments | Get the full article at GameSpot "Battlefield 4 - Fishing in Baku Gameplay Trailer" was posted by erickt on Tue, 26 Mar 2013 23:04:00 -0700 |
| Posted: 26 Mar 2013 11:00 PM PDT 2 new shots posted.
Get the full article at GameSpot "Battlefield 4 Screens" was posted on Tue, 26 Mar 2013 23:00:03 -0700 |
| Posted: 26 Mar 2013 10:43 PM PDT Check out the 60 second TV trailer for Battlefield 4.
Read and Post Comments | Get the full article at GameSpot "Battlefield 4 TV Trailer" was posted by erickt on Tue, 26 Mar 2013 22:43:50 -0700 |
| Battlefield 4 confirmed for fall 2013 Posted: 26 Mar 2013 10:26 PM PDT DICE's new shooter arriving later this year for Xbox 360, PlayStation 3, and PC; runs on Frostbite 3; 17-minute gameplay trailer revealed.
Electronic Arts confirmed today that Battlefield 4 will launch this fall. No platforms were named in the game's official announcement, but its preorder page lists Xbox 360, PlayStation 3, and PC. A 17-minute gameplay trailer is embedded below.
 Battlefield 4 is powered by the Frostbite 3 engine, technology that EA said will "set a new standard for interactive entertainment in 2013." EA described Battlefield 4 as a "seminal moment" for the series, noting some of the franchise's multiplayer elements will be incorporated into single-player this time around. Battlefield 4's single-player campaign will also track players' progress, allowing gamers to compete head-to-head. In addition, players will be able to issue squad commands in Battlefield 4's single-player campaign. Lastly, EA announced today that those who preorder Battlefield 4 will receive a free "premium expansion." No further information about this add-on was divulged. A Battlefield 4 Digital Deluxe edition for PC will also be available exclusively through Origin. Gamers who preorder this version will also receive the aforementioned expansion, as well as access to the Battlefield 4 multiplayer beta.
Read and Post Comments | Get the full article at GameSpot "Battlefield 4 confirmed for fall 2013 " was posted by Eddie Makuch on Tue, 26 Mar 2013 22:26:02 -0700 |
| World of Tanks Blitz coming to smartphones and tablets Posted: 26 Mar 2013 09:55 PM PDT Wargaming has announced a free-to-play mobile MMO action title built specifically for smartphones and tablets; World of Tanks Blitz expected to grow the publisher's multiplatform strategy.
Wargaming has revealed plans to expand its multiplatform efforts with the announcement of World of Tanks Blitz, a free-to-play MMO title for smartphones and tablets.
 According to the publisher, the new title was inspired by the PC version of World of Tanks. World of Tanks Blitz will feature touchscreen controls, 7 vs. 7 PvP battles and the series' trademark combination of action, teamwork and strategic gameplay. Nations appearing in the game include USA, Germany, and USSR, and the roster of vehicles will include medium tanks, heavy tanks and tank destroyers. According to Wargaming, World of Tanks Blitz will join the recently announced World of Tanks Generals, a browser-based TCG set in the World of Tanks universe, as an example of the company's vision to expand their multiplatform strategy into the mobile space. Wargaming said both games will fit into the soon-to-be-launched Wargaming.net Service, which will reportedly see all Wargaming titles unified under a single login system. Read and Post Comments | Get the full article at GameSpot "World of Tanks Blitz coming to smartphones and tablets" was posted by Laura Parker on Tue, 26 Mar 2013 21:55:06 -0700 |
| 4 Techno Indie Games in 4 Minutes Posted: 26 Mar 2013 08:49 PM PDT We check out PWN: Combat Hacking, Time Surfer, Electronic Super Joy, and Drop That Beat Like An Ugly Baby at PAX East 2013
Read and Post Comments | Get the full article at GameSpot "4 Techno Indie Games in 4 Minutes" was posted by Wern on Tue, 26 Mar 2013 20:49:13 -0700 |
| Posted: 27 Mar 2013 12:00 AM PDT The use of light-activated bactericidal agents—photobactericides—is suggested in local infection in order to conserve conventional antibacterials for more systemic disease. Local administration of a photobactericide such as methylene blue coupled with locally-targeted red light illumination ensures the production of non-specific reactive oxygen species and thus a rapid and localised antibacterial response, regardless of the conventional resistance status. To this end, the response of photobactericides to conventional resistance mechanisms, and their potential use in infection, is discussed. |
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