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- House panel dilutes casino bill, restores funding
- Viruses, Vol. 5, Pages 954-980: Hepatitis C Virus-Induced Mitochondrial Dysfunctions
- Viruses, Vol. 5, Pages 928-953: Protective Effect of Surfactant Protein D in Pulmonary Vaccinia Virus Infection: Implication of A27 Viral Protein
- Viruses, Vol. 5, Pages 902-927: Lost in Transcription: Molecular Mechanisms that Control HIV Latency
- Aiming for America - Australian COD Championship Wrap-up
- Next Xbox leak points to always online requirement
- IJMS, Vol. 14, Pages 6487-6498: RUFY, Rab and Rap Family Proteins Involved in a Regulation of Cell Polarity and Membrane Trafficking
- IJMS, Vol. 14, Pages 6467-6486: Differential Expression of Genes Associated with the Progression of Renal Disease in the Kidneys of Liver-Specific Glucokinase Gene Knockout Mice
- Skype 6.3.60.582 - Voice-over-internet phone and chat software. (Free)
- Mac DVDRipper Pro 4.0.5 - The best way to copy, backup, and convert DVDs. (Shareware)
- IJMS, Vol. 14, Pages 6454-6466: UPR Signal Activation by Luminal Sensor Domains
- IJMS, Vol. 14, Pages 6436-6453: Thermostable Mismatch-Recognizing Protein MutS Suppresses Nonspecific Amplification during Polymerase Chain Reaction (PCR)
- PartyPoker Premier League VI: Cates Wins Group A Heat 2; Duhamel Retains Overall Lead
- Monster Hunter 3 Ultimate - GR Review
- Monster Hunter 3 Ultimate (3DS) - GR Review
- Monster Hunter 3 Ultimate (3DS) - Screenshots
- INDYCAR: 2013 Season Preview PT 2
- Powerball Winning Numbers for 03/20/2013
- Powerball Estimated Jackpot for 03/23/2013
- Mega Millions Winning Numbers for 03/19/2013
| House panel dilutes casino bill, restores funding Posted: 21 Mar 2013 02:24 AM PDT A panel of Indiana House lawmakers stripped most provisions of a gambling bill Wednesday, setting up a potential showdown with senators who approved a gambling expansion last month. |
| Viruses, Vol. 5, Pages 954-980: Hepatitis C Virus-Induced Mitochondrial Dysfunctions Posted: 21 Mar 2013 12:00 AM PDT Chronic hepatitis C is characterized by metabolic disorders and a microenvironment in the liver dominated by oxidative stress, inflammation and regeneration processes that lead in the long term to hepatocellular carcinoma. Many lines of evidence suggest that mitochondrial dysfunctions, including modification of metabolic fluxes, generation and elimination of oxidative stress, Ca2+ signaling and apoptosis, play a central role in these processes. However, how these dysfunctions are induced by the virus and whether they play a role in disease progression and neoplastic transformation remains to be determined. Most in vitro studies performed so far have shown that several of the hepatitis C virus (HCV) proteins localize to mitochondria, but the consequences of these interactions on mitochondrial functions remain contradictory, probably due to the use of artificial expression and replication systems. In vivo studies are hampered by the fact that innate and adaptive immune responses will overlay mitochondrial dysfunctions induced directly in the hepatocyte by HCV. Thus, the molecular aspects underlying HCV-induced mitochondrial dysfunctions and their roles in viral replication and the associated pathology need yet to be confirmed in the context of productively replicating virus and physiologically relevant in vitro and in vivo model systems. |
| Posted: 21 Mar 2013 12:00 AM PDT Vaccinia virus (VACV) was used as a surrogate of variola virus (VARV) (genus Orthopoxvirus), the causative agent of smallpox, to study Orthopoxvirus infection. VARV is principally transmitted between humans by aerosol droplets. Once inhaled, VARV first infects the respiratory tract where it could encounter surfactant components, such as soluble pattern recognition receptors. Surfactant protein D (SP-D), constitutively present in the lining fluids of the respiratory tract, plays important roles in innate host defense against virus infection. We investigated the role of SP-D in VACV infection and studied the A27 viral protein involvement in the interaction with SP-D. Interaction between SP-D and VACV caused viral inhibition in a lung cell model. Interaction of SP-D with VACV was mediated by the A27 viral protein. Binding required Ca2+ and interactions were blocked in the presence of excess of SP-D saccharide ligands. A27, which lacks glycosylation, directly interacted with SP-D. The interaction between SP-D and the viral particle was also observed using electron microscopy. Infection of mice lacking SP-D (SP-D-/-) resulted in increased mortality compared to SP-D+/+ mice. Altogether, our data show that SP-D participates in host defense against the vaccinia virus infection and that the interaction occurs with the viral surface protein A27. |
| Viruses, Vol. 5, Pages 902-927: Lost in Transcription: Molecular Mechanisms that Control HIV Latency Posted: 21 Mar 2013 12:00 AM PDT Highly active antiretroviral therapy (HAART) has limited the replication and spread of the human immunodeficiency virus (HIV). However, despite treatment, HIV infection persists in latently infected reservoirs, and once therapy is interrupted, viral replication rebounds quickly. Extensive efforts are being directed at eliminating these cell reservoirs. This feat can be achieved by reactivating latent HIV while administering drugs that prevent new rounds of infection and allow the immune system to clear the virus. However, current approaches to HIV eradication have not been effective. Moreover, as HIV latency is multifactorial, the significance of each of its molecular mechanisms is still under debate. Among these, transcriptional repression as a result of reduced levels and activity of the positive transcription elongation factor b (P-TEFb: CDK9/cyclin T) plays a significant role. Therefore, increasing levels of P-TEFb expression and activity is an excellent strategy to stimulate viral gene expression. This review summarizes the multiple steps that cause HIV to enter into latency. It positions the interplay between transcriptionally active and inactive host transcriptional activators and their viral partner Tat as valid targets for the development of new strategies to reactivate latent viral gene expression and eradicate HIV. |
| Aiming for America - Australian COD Championship Wrap-up Posted: 20 Mar 2013 09:28 PM PDT Eight teams enter, only two get a shot at the International scene. Find out what went down at the Australian COD Championships featuring Team Immunity and Mindfreak eSports, and what happened with the YouTube Vs. Hip Hop celebrity show match!
Read and Post Comments | Get the full article at GameSpot "Aiming for America - Australian COD Championship Wrap-up" was posted by edmondt on Wed, 20 Mar 2013 21:28:03 -0700 |
| Next Xbox leak points to always online requirement Posted: 21 Mar 2013 02:12 AM PDT Screenshots seemingly taken from the Durango Xbox Development Kit describe Microsoft's upcoming console as an always online device, as previously |
| Posted: 21 Mar 2013 12:00 AM PDT Cell survival, homeostasis and cell polarity rely on the control of membrane trafficking pathways. The RUN domain (comprised of the RPIP8, UNC-14, and NESCA proteins) has been suggested to be implicated in small GTPase-mediated membrane trafficking and cell polarity. Accumulating evidence supports the hypothesis that the RUN domain-containing proteins might be responsible for an interaction with a filamentous network linked to actin cytoskeleton and/or microtubules. In addition, several downstream molecules of PI3K are involved in regulation of the membrane trafficking by interacting with vesicle-associated RUN proteins such as RUFY family proteins. In this review, we summarize the background of RUN domain research with an emphasis on the interaction between RUN domain proteins including RUFY proteins (designated as RUN and FYVE domain-containing proteins) and several small GTPases with respect to the regulation of cell polarity and membrane trafficking on filamentous network |
| Posted: 21 Mar 2013 12:00 AM PDT Liver glucokinase (GCK) deficient mice possess mild renal complications associated with diabetes. To investigate the progression of kidney disease and identify candidate genes involved in the pathogenesis of renal damage, we examined changes in tissue structure and gene expression in the kidneys of liver-specific GCK knockout (gckw/−) mice and age-matched normal wild-type control (gckw/w) mice as they aged. Suppression subtractive hybridization (SSH) was used to identify candidate genes that showed a pattern of differential expression between kidneys of gckw/− and gckw/w mice at 60 weeks of age. Differential expression of the candidate genes was examined by real-time qPCR in liver-specific gckw/− and gckw/w mice at 16, 26, 40, 60, and 85 weeks of age. Among the candidate genes, only glutathione peroxidase-3 (GPX3) was confirmed to show differential expression by qPCR in the 60-week old mice, however two others genes, MALAT1 and KEG, showed significant changes at other ages. This study shows that liver-specific glucokinase deficient mice display changes in kidney morphology by 40 weeks of age, and that renal complication may be correlated with a reduction in GPX3 levels. Since decreased GPX3 mRNA expression was observed at 26 weeks, which is younger than the age when pathological changes can be seen in kidney biopsies, GPX3 may serve as an early marker for kidney damage. |
| Skype 6.3.60.582 - Voice-over-internet phone and chat software. (Free) Posted: 20 Mar 2013 08:59 PM PDT  Skype allows you to talk to friends, family and co-workers across the Internet without the inconvenience of long distance telephone charges. Using peer-to-peer data transmission technology, Skype eliminates the central server as a middle manager. Today, millions of individuals and businesses are taking advantage of Skype's diverse communication features:
Version 6.3.60.582: Release notes were unavailable when this listing was updated.
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| Mac DVDRipper Pro 4.0.5 - The best way to copy, backup, and convert DVDs. (Shareware) Posted: 20 Mar 2013 08:59 PM PDT  Mac DVDRipper Pro is the DVD backup solution that lets you protect your DVDs from scratches, save your batteries by reading your movies from your hard disk, manage your collection with just a few clicks, time-shift your rental, backup your DVD collection, and much more! Mac DVDRipper Pro allows you to copy all your DVDs on your Mac so you can easily view them without having to spend your battery on spinning you optical drive. Mac DVDRipper Pro analyzes the DVD and uses intelligent algorithms to ensure proper rips. It is the best at what it does, at an unbeatable price! You can try it for free before buying, Mac DVDRipper Pro will work without any limitations for your first 5 rips. When using the disc image mode, you can also burn directly to another DVD from the application. Version 4.0.5:
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| IJMS, Vol. 14, Pages 6454-6466: UPR Signal Activation by Luminal Sensor Domains Posted: 21 Mar 2013 12:00 AM PDT The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis. The presence of unfolded protein is detected by the ER-luminal sensor domains of the three UPR-transducer proteins IRE1, PERK, and ATF6, which then propagate the signal to the cytosol. In this review, we discuss the various mechanisms of action that have been proposed on how the sensor domains detect the presence of unfolded protein to activate downstream UPR signaling. |
| Posted: 21 Mar 2013 12:00 AM PDT Polymerase chain reaction (PCR)-related technologies are hampered mainly by two types of error: nonspecific amplification and DNA polymerase-generated mutations. Here, we report that both errors can be suppressed by the addition of a DNA mismatch-recognizing protein, MutS, from a thermophilic bacterium. Although it had been expected that MutS has a potential to suppress polymerase-generated mutations, we unexpectedly found that it also reduced nonspecific amplification. On the basis of this finding, we propose that MutS binds a mismatched primer-template complex, thereby preventing the approach of DNA polymerase to the 3' end of the primer. Our simple methodology improves the efficiency and accuracy of DNA amplification and should therefore benefit various PCR-based applications, ranging from basic biological research to applied medical science. |
| PartyPoker Premier League VI: Cates Wins Group A Heat 2; Duhamel Retains Overall Lead Posted: 20 Mar 2013 10:10 PM PDT The second heat of Group A of the Party Poker Premier League VI ended Tuesday night with Dan "Jungleman" Cates sitting behind all the chips. |
| Monster Hunter 3 Ultimate - GR Review Posted: 20 Mar 2013 11:54 PM PDT Lather, rinse, repeat. I admit I've never had much interest in the Monster Hunter series over the years. It's on the level of a Call of Duty or Grand Theft Auto in Japan, but three things kept me from picking up any of the previous games: I didn't have a PSP; I didn't have anyone to play co-op with; and when Monster Hunter Tri landed on the Wii with online multiplayer in 2010, I no longer had a Wii to play it on. But with millions of fans supporting the franchise in Japan, I've always had Monster Hunter on the brain in some capacity or another. How could a franchise with such a huge base be so unappealing to me and much of the Western market? In the process of reviewing Monster Hunter 3 Ultimate, a port of Tri for 3DS and Wii U, I tried to look for the elements that make the series so compelling for so many, and why it took me until now to jump on board and love Monster Hunter. |
| Monster Hunter 3 Ultimate (3DS) - GR Review Posted: 20 Mar 2013 11:44 PM PDT Lather, rinse, repeat. I admit I've never had much interest in the Monster Hunter series over the years. It's on the level of a Call of Duty or Grand Theft Auto in Japan, but three things kept me from picking up any of the previous games: I didn't have a PSP; I didn't have anyone to play co-op with; and when Monster Hunter Tri landed on the Wii with online multiplayer in 2010, I no longer had a Wii to play it on. But with millions of fans supporting the franchise in Japan, I've always had Monster Hunter on the brain in some capacity or another. How could a franchise with such a huge base be so unappealing to me and much of the Western market? In the process of reviewing Monster Hunter 3 Ultimate, a port of Tri for 3DS and Wii U, I tried to look for the elements that make the series so compelling for so many, and why it took me until now to jump on board and love Monster Hunter. |
| Monster Hunter 3 Ultimate (3DS) - Screenshots Posted: 20 Mar 2013 11:31 PM PDT This latest iteration of Monster Hunter 3 features not only touchscreen functionality for both the Wii U GamePad and 3DS touch screen, but also interactivity between the two Nintendo platforms. |
| INDYCAR: 2013 Season Preview PT 2 Posted: 21 Mar 2013 12:00 AM PDT  Dive into the second part of SPEED.com's three-part IndyCar Season preview, featuring Dragon Racing, ECR, Ganassi, KV, Panther and Panther DRR. |
| Powerball Winning Numbers for 03/20/2013 Posted: 20 Mar 2013 10:05 PM PDT 13 - 14 - 17 - 43 - 54 Powerball 15 |
| Powerball Estimated Jackpot for 03/23/2013 Posted: 20 Mar 2013 10:05 PM PDT Annuitized: $320 Million Cash Value: $198.3 Million |
| Mega Millions Winning Numbers for 03/19/2013 Posted: 20 Mar 2013 10:05 PM PDT 3 - 6 - 14 - 21 - 37 MegaBall 35 Megaplier 3 |
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