понедельник, 13 августа 2012 г.

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Biology, Vol. 1, Pages 277-296: HIV-1 Tat Binding to PCAF Bromodomain: Structural Determinants from Computational Methods

Posted: 13 Aug 2012 12:00 AM PDT

The binding between the HIV-1 trans-activator of transcription (Tat) and p300/(CREB-binding protein)-associated factor (PCAF) bromodomain is a crucial step in the HIV-1 life cycle. However, the structure of the full length acetylated Tat bound to PCAF has not been yet determined experimentally. Acetylation of Tat residues can play a critical role in enhancing HIV-1 transcriptional activation. Here, we have combined a fully flexible protein-protein docking approach with molecular dynamics simulations to predict the structural determinants of the complex for the common HIV-1BRU variant. This model reproduces all the crucial contacts between the Tat peptide 46SYGR(AcK)KRRQRC56 and the PCAF bromodomain previously reported by NMR spectroscopy. Additionally, inclusion of the entire Tat protein results in additional contact points at the protein-protein interface. The model is consistent with the available experimental data reported and adds novel information to our previous structural predictions of the PCAF bromodomain in complex with the rare HIVZ2 variant, which was obtained with a less accurate computational method. This improved characterization of Tat.PCAF bromodomain binding may help in defining the structural determinants of other protein interactions involving lysine acetylation.

Nanomaterials, Vol. 2, Pages 268-274: All-Solid-State Textile Batteries Made from Nano-Emulsion Conducting Polymer Inks for Wearable Electronics

Posted: 13 Aug 2012 12:00 AM PDT

A rollable and all-solid-state textile lithium battery based on fabric matrix and polymer electrolyte that allows flexibility and fast-charging capability is reported. When immerged into poly(3,4-ethylenedioxythiophene) (PEDOT) nano-emulsion inks, an insulating fabric is converted into a conductive battery electrode for a fully solid state lithium battery with the highest specific energy capacity of 68 mAh/g. This is superior to most of the solid-state conducting polymer primary and/or secondary batteries reported. The bending radius of such a textile battery is less than 1.5 mm while lightening up an LED. This new material combination and inherent flexibility is well suited to provide an energy source for future wearable and woven electronics.

Energies, Vol. 5, Pages 3033-3050: Power Control Design for Variable-SpeedWind Turbines

Posted: 13 Aug 2012 12:00 AM PDT

This paper considers power generation control in variable-speed variable-pitch horizontal-axis wind turbines operating at high wind speeds. A dynamic chattering torque control and a proportional integral (PI) pitch control strategy are proposed and validated using the National Renewable Energy Laboratory wind turbine simulator FAST (Fatigue, Aerodynamics, Structures, and Turbulence) code. Validation results show that the proposed controllers are effective for power regulation and demonstrate high-performances for all other state variables (turbine and generator rotational speeds; and smooth and adequate evolution of the control variables) for turbulent wind conditions. To highlight the improvements of the provided method, the proposed controllers are compared to relevant previously published studies.

F1 Race Stars: Hands-on with karting Kimi & Co

Posted: 13 Aug 2012 02:24 AM PDT

Single and multiplayer impressions of Codemasters' pocket rockets

Majic 1.0 - Get only what you need from JIRA.. (Free)

Posted: 13 Aug 2012 01:45 AM PDT



Majic is a JIRA 5 agile client for Mac OS X. It cuts out all the features except the ones you use most often (and throws in some extra time-saving tricks as well). And it's a 100% native OS X app, so you can spend a little bit less time in your sea of browser tabs.

  • JIRA 5+
  • OS X 10.7.3 or later


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Materials, Vol. 5, Pages 1361-1372: Effect of AlF3 on the Density and Elastic Properties of Zinc Tellurite Glass Systems

Posted: 13 Aug 2012 12:00 AM PDT

This paper presents the results of the physical and elastic properties of the ternary zinc oxyfluoro tellurite glass system. Systematic series of glasses (AlF3)x(ZnO)y(TeO2)z with x = 0–19, y = 0–20 and z = 80, 85, 90 mol% were synthesized by the conventional rapid melt quenching technique. The composition dependence of the physical, mainly density and molar volume, and elastic properties is discussed in term of the AlF3 modifiers addition that are expected to produce quite substantial changes in their physical properties. The absence of any crystalline peaks in the X-ray diffraction (XRD) patterns of the present glass samples indicates the amorphous nature. The addition of AlF3 lowered the values of the densities in ternary oxyfluorotellurite glass systems. The longitudinal and transverse ultrasonic waves propagated in each glass sample were measured using a MBS8020 ultrasonic data acquisition system. All the velocity data were taken at 5 MHz frequency and room temperature. The longitudinal modulus (L), shear modulus (G), Young's modulus (E), bulk modulus (K) and Poisson's ratio () are obtained from both velocities data and their respective density. Experimental data shows the density and elastic moduli of each AlF3-ZnO-TeO2 series are found strongly depend upon the glass composition. The addition of AlF3 modifiers into the zinc tellurite causes substantial changes in their density, molar volume as well as their elastic properties.

Materials, Vol. 5, Pages 1348-1360: A Review of Titanium Zirconium (TiZr) Alloys for Use in Endosseous Dental Implants

Posted: 13 Aug 2012 12:00 AM PDT

Dental implants made from binary titanium-zirconium (TiZr) alloys have shown promise as a high strength, yet biocompatible alternative to pure titanium, particularly for applications requiring small diameter implants. The aim of this review is to summarize existing literature reporting on the use of binary TiZr alloys for endosseous dental implant applications as tested in vitro, in animals and clinically. And furthermore to show that TiZr is "at least as good as" pure titanium in terms of biocompatibility and osseointergration. From the twelve papers that met the inclusion criteria, the current literature confirms that TiZr alloys produce small diameter implants with a strength up to 40% higher than conventional, cold-worked, grade IV titanium implants, and with a corrosion resistance and biocompatibility that is at least as good as pure titanium. The surface structure of TiZr is compatible with established surface treatments proven to aid in the osseointegration of titanium implants. Furthermore, binary TiZr alloys have been shown to achieve good osseointegration and high success rates both in animal and in clinical studies.

Script Timer 2.6.3 - Schedule the execution of scripts.. (Shareware)

Posted: 13 Aug 2012 01:37 AM PDT



Script Timer lets you schedule the execution of AppleScript, perl, and shell scripts, as well as Automator workflows and applications. Scheduling options include specific times of the day, week, month, or year, regular intervals ranging from one second to any number of weeks, when the computer enters or leaves an idle state, just before the computer goes to sleep or just after it wakes up, when you log into or out (except OS X 10.8) of your account, and when a specified application launches or quits. Using a feature called Dynamic Scheduling, you can also arrange for an AppleScript script to schedule on the fly one or more other scripts, applications, or workflows at a time of its choice.

Registered users receive at least eight additional useful scripts to schedule upon registration and free email support.



Version 2.6.3:
  • Compatibile with OS X 10.7 and 10.8.


OS X 10.6 or higher

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Chipoches

Posted: 13 Aug 2012 12:12 AM PDT

Can you slide the Slide chips to match the patterns? Work your mind as you battle 6 challenging levels.

Benefit in the memory of Amanda Plasse to be held in Chicopee

Posted: 13 Aug 2012 12:14 AM PDT

CHICOPEE - The family of murder victim Amanda L. Plasse are hoping to use the anniversary of her death to help the community.

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Molecules, Vol. 17, Pages 9716-9727: Diterpenoids from the Buds of Pinus banksiana Lamb.

Posted: 13 Aug 2012 12:00 AM PDT

Three new diterpenoids, namely 7α-hydroxyabieta-8,11,13,15-tetraen-18-oic acid, 7β,15,18-trihydroxyabieta-8,11,13-triene, 13,15-dihydroxypodocarpa-8,11,13-triene, and 12 other known compounds were isolated from buds of Pinus banksiana Lamb. All these compounds, except for 7-oxodehydroabietinol, were isolated for the first time from this plant. Their structures were elucidated by detailed spectroscopic studies and comparison with published data. All isolated compounds were tested for cytotoxic and antibacterial activities. Overall, two compounds, 7-oxodehydroabietinol and 18-nor-4,15-dihydroxyabieta-8,11,13-trien-7-one, showed moderate cytotoxicity against a human lung carcinoma cell line.

Molecules, Vol. 17, Pages 9697-9715: Corn Silk (Stigma Maydis) in Healthcare: A Phytochemical and Pharmacological Review

Posted: 13 Aug 2012 12:00 AM PDT

Corn silk (Stigma maydis) is an important herb used traditionally by the Chinese, and Native Americans to treat many diseases. It is also used as traditional medicine in many parts of the world such as Turkey, United States and France. Its potential antioxidant and healthcare applications as diuretic agent, in hyperglycemia reduction, as anti-depressant and anti-fatigue use have been claimed in several reports. Other uses of corn silk include teas and supplements to treat urinary related problems. The potential use is very much related to its properties and mechanism of action of its plant's bioactive constituents such as flavonoids and terpenoids. As such, this review will cover the research findings on the potential applications of corn silk in healthcare which include its phytochemical and pharmacological activities. In addition, the botanical description and its toxicological studies are also included.

Molecules, Vol. 17, Pages 9683-9696: Synthesis and Biological Evaluation of 3-Aryl-quinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives as Hypoxic Selective Anti-tumor Agents

Posted: 13 Aug 2012 12:00 AM PDT

A series of 3-aryl-2-quinoxaline-carbonitrile 1,4-di-N-oxide derivatives were designed, synthesized and evaluated for hypoxic and normoxic cytotoxic activity against human SMMC-7721, K562, KB, A549 and PC-3 cell lines. Many of these new compounds displayed more potent hypoxic cytotoxic activity compared with TX-402 and TPZ in the tumor cells based evaluation, which confirmed our hypothesis that the replacement of the 3-amine with the substituted aryl ring of TX-402 increases the hypoxic anti-tumor activity. The preliminary SAR revealed that 3-chloro was a favorable substituent in the phenyl ring for hypoxic cytotoxicity and 7-methyl or 7-methoxy substituted derivatives exhibited better hypoxic selectivity against most of the tested cell lines. The most potent compound, 7-methyl-3-(3-chlorophenyl)-quinoxaline-2-carbonitrile 1,4-dioxide (9h) was selected for further anti-tumor evaluation and mechanistic study. It also exhibited significant cytotoxic activity against BEL-7402, HepG2, HL-60, NCI-H460, HCT-116 and CHP126 cell lines in hypoxia with IC50 values ranging from 0.31 to 3.16 μM, and preliminary mechanism study revealed that 9h induced apoptosis in a caspase-dependent pathway.

Molecules, Vol. 17, Pages 9668-9682: Evaluation of Flavonoid Contents and Antioxidant Capacity of the Aerial Parts of Common and Tartary Buckwheat Plants

Posted: 13 Aug 2012 12:00 AM PDT

The analysis of major and minor flavonoids, and antioxidant capacity of stems, leaves, flowers, unripe seeds and ripe seeds of common and tartary buckwheat plants collected during different growth periods was addressed in this study. The highest rutin contents were observed in flowers and leaves collected from common and tartary buckwheat at early flowering as well as flowering and seed formation states. A low quercetin contents were found in all studied aerial part of buckwheat plants. Quercitrin (quercetin-3-rhamnoside) was only found in flowers collected at different growth periods while flavone C-glucosides were accumulated preferentially only in unripe seeds collected from common buckwheat at an early flowering state. The rank of antioxidant capacity provided for aerial parts of common and tartary buckwheat at early flowering state was as follows: flowers > leaves > stems. The highest contribution of rutin to the antioxidant capacity of the aerial parts of common and tartary buckwheat was found for stems followed by leaves, flowers and unripe seeds. The results demonstrate that flowers from common and tartary buckwheat collected at early flowering as well as flowering and seed formation states have the future potential to be a useful food ingredient.

Molecules, Vol. 17, Pages 9652-9667: Microwave Assisted Synthesis of Some New Thiazolopyrimidine, Thiazolodipyrimidine and Thiazolopyrimidothiazolopyrimidine Derivatives with Potential Antioxidant and Antimicrobial Activity

Posted: 13 Aug 2012 12:00 AM PDT

Biginelli reaction of ethyl acetoacetate, thiourea and the appropriate aromatic aldehyde was used to produce ethyl 4-aryl-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylates, that reacted with bromomalononitrile to give ethyl 3-amino-5-aryl-2-cyano-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylates rather than the isomeric 7H-thiazolo[3,2-a]pyrimidines. Thiazolopyrimidine derivatives reacted with carbon disulphide to yield ethyl 9-aryl-7-methyl-2,4-dithioxo-2,3,4,9-tetrahydro-1H-thiazolo[3,2-a:4,5-d']dipyrimidine-8-carboxylates, that reacted with phenacyl bromide to produce ethyl 8-methyl-10-(4-methoxyphenyl)-3-substituted-5-thioxo-2(un)subatituted-10H-thiazolo[3'',2'':1',2']pyrimido[4',5':4,5]thiazolo[3,2-a]pyrimidine-9-carboxylates. The aforementioned reactions were carried out using both conventional chemical methods and with the assistance of microwave irradaition. Comparison between both methods showed that the microwave assisted method is preferable because of the time reduction and yield improvements achieved. The new compounds were tested for their biological activity as antioxidants, antibacterial or antifungal agents. Some of the new compounds were found to have moderate to good antioxidant and antimicrobial activities.

Molecules, Vol. 17, Pages 9641-9651: Deoxycalyciphylline B, a Hepatotoxic Alkaloid from Daphniphyllum calycinum

Posted: 13 Aug 2012 12:00 AM PDT

Daphniphyllum calycinum (DC), a main component of Chinese patent drug Fengliao-Changweikang, is effectively used to cure bowel disease in the clinic. It was recorded that DC possessed slight toxicity, which was caused by the alkaloids existing in its extract. Unfortunately, to date the toxicity level and toxic constituents are still unclear. The present study is designed to illustrate the acute toxicity and induced organ damages of the total alkaloids as well as to determine the toxic constituents. Based on the above studies, not only was the acute toxicity determined but also hepatic toxicity was characterized by increased plasma biomarkers of ALT and AST and liver cell inflammatory infiltrate as well necrosis that was firstly observed. Significantly, deoxycalyciphylline B exhibited exactly the same hepatic toxicity so it was identified as the main toxic constituent in DC. An obvious dose-effect relationship between the toxic compound and induced hepatic injuries was also observed. Moreover, the Chinese patent drug Fengliao-Changweikang contained low levels of the toxic compound, compared with the total alkaloids. Therefore, this Chinese patent drug could be regarded to be safe in this point of view.

Dust: An Elysian Tail - Videos and Trailers

Posted: 13 Aug 2012 12:58 AM PDT

Combat

Ubuntu One 0.2.0 - Personal cloud service.. (Free)

Posted: 13 Aug 2012 12:21 AM PDT



Ubuntu One is the personal cloud that brings your digital life together, so you can enjoy your content, your way, wherever you are. With our suite of cloud services including storage, sync, sharing and streaming - you have immediate access to your music collection, favorite photos, videos, important documents and more, at any time and from any device.

Ubuntu One is easy to install and easy to use - everyone gets our sync services and 5 GB of storage for free, and if you pay a little extra, you can add Music Streaming and Storage to suit your own needs.

Find out more about our packages and prices.



Version 0.2.0:
  • App now runs as an agent.
  • Added option to make status menu icon black & white or colored.
  • Preference window no longer annoyingly resizes.
  • Show largest file size unit in the Storage section under Account.




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MacFlatplan 2.1.0.3.27 - Make a color-coded map of publication pages.. (Shareware)

Posted: 13 Aug 2012 12:02 AM PDT



MacFlatplan enables the user to make a color-coded map of all the pages of their publication, providing a complete overview of the relative location, page number, and category of content of every page.

Features:

  • You can do as many MacFlatplan document as you will.
  • Unlimited number of pages per publication.
  • You can import the colors and the publication information from another MacFlatplan document.
  • It's easy to drag pages to a new place.
  • You can handle the publication as the print sections or as one whole.
  • The Flatplan window chooses width which is suitable on your window, but you can change the width suitable for your printing paper.
  • You can copy and paste the page contents.
  • You can make your own custom page library use all of your publication planning.
  • Only one registration fee, no other fees.



Version 2.1.0.3.27:
  • New menu command on the Flatplan window: Undo.
  • Some internal improvements.


Mac OS X 10.4 or later

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Black Hole 1.3.1 - Remove sensitive information from your Mac.. (Free)

Posted: 12 Aug 2012 11:56 PM PDT



Black Hole is a powerful application that allows you to clear sensitive information from your Mac with a single click. Black Hole automates many operations such as quitting applications, removing recent items from application menus, emptying the Trash, and more. More time for you!

Version 1.3.1:
  • Retina graphics for the new MacBook Pros with Retina display.
  • Black Hole is signed for Gatekeeper support on OS X 10.8 Mountain Lion.
  • Added the ability to shut down, restart or put your Mac to sleep after cleanup.
  • The Recent Items cleaner can now clear Finder and Apple Menu recent items.
  • You can now use bash-like wildcard characters (*) in paths in the Files cleaner.
  • Added new Files cleaner rules for Firefox, Chrome and Opera (many of these use the new wildcards feature).
  • Added many additional rules submitted by users.
  • Black Hole now empties the trash on external volumes as well.
  • Occasional stall while the Volumes cleaner was running.
  • Fixed support links to redirect to the correct webpage.
  • Other small bug fixes.
  • Black Hole is now using ARC and is built using LLVM for better performance.


  • Mac OS X 10.7 or later
  • 64-bit processor


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