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- Acorn Story
- Nutrients, Vol. 4, Pages 1042-1057: Experimental Alcohol-Related Peripheral Neuropathy: Role of Insulin/IGF Resistance
- Nutrients, Vol. 4, Pages 1026-1041: Association between Polymorphisms in the Fatty Acid Desaturase Gene Cluster and the Plasma Triacylglycerol Response to an n-3 PUFA Supplementation
- Sensors, Vol. 12, Pages 11334-11359: Energy-Efficient Scheduling for Hybrid Tasks in Control Devices for the Internet of Things
- DVDRemaster 8.0.2 - Duplicate, burn or convert DVD movies to iPod, iPhone or Apple TV.. (Demo)
- Park Them All
- Pharmaceuticals, Vol. 5, Pages 837-852: Role of Transient Receptor Potential Vanilloid 1 in Inflammation and Autoimmune Diseases
- Energies, Vol. 5, Pages 3126-3136: Experimental Study on the Combustion and Microexplosion of Freely Falling Gelled Unsymmetrical Dimethylhydrazine (UDMH) Fuel Droplets
- Energies, Vol. 5, Pages 3110-3125: The Long-Term Prospects of Biofuels in the EU-15 Countries
- Molecules, Vol. 17, Pages 9931-9938: The Bioassay-Guided Isolation of Growth Inhibitors of Adult T-Cell Leukemia (ATL), from the Jamaican Plant Hyptis verticillata, and NMR Characterization of Hyptoside
- Molecules, Vol. 17, Pages 9912-9930: Anti-metastatic Semi-synthetic Sulfated Maltotriose C-C Linked Dimers. Synthesis and Characterisation
- Molecules, Vol. 17, Pages 9900-9911: Formation of Aldehyde and Ketone Compounds during Production and Storage of Milk Powder
- Company of Heroes 2 hands-on preview – War machines and wintry woes
- CopperCube 3.5 - Create interactive 3D scenes without programming.. (Demo)
- Molecules, Vol. 17, Pages 9887-9899: Straightforward Synthesis of Novel 1-(2′-α-O-D-Glucopyranosyl ethyl) 2-Arylbenzimidazoles
- Molecules, Vol. 17, Pages 9868-9886: Synthesis and Bioactivity Evaluation of New 6-Aryl-5-cyano Thiouracils as Potential Antimicrobial and Anticancer Agents
- IJERPH, Vol. 9, Pages 2986-3001: Simulation of Regionally Ecological Land Based on a Cellular Automation Model: A Case Study of Beijing, China
- IJERPH, Vol. 9, Pages 2964-2985: Children’s Exposures to Pyrethroid Insecticides at Home: A Review of Data Collected in Published Exposure Measurement Studies Conducted in the United States
- IJMS, Vol. 13, Pages 10336-10349: Effects of Rice Bran Oil on the Intestinal Microbiota and Metabolism of Isoflavones in Adult Mice
- IJMS, Vol. 13, Pages 10316-10335: Molecular Tools for Exploring Polyploid Genomes in Plants
| Posted: 17 Aug 2012 03:50 AM PDT Once upon a time there was a boy, who lived in a Fairy Forest. He wanted to make a great present to a special day, so he planted a small seed, that .. |
| Posted: 17 Aug 2012 12:00 AM PDT The mechanisms of alcohol-related peripheral neuropathy (ALPN) are poorly understood. We hypothesize that, like alcohol-related liver and brain degeneration, ALPN may be mediated by combined effects of insulin/IGF resistance and oxidative stress. Adult male Long Evans rats were chronically pair-fed with diets containing 0% or 37% ethanol (caloric), and subjected to nerve conduction studies. Chronic ethanol feeding slowed nerve conduction in the tibial (p = 0.0021) motor nerve, and not plantar sensory nerve, but it did not affect amplitude. Histological studies of the sciatic nerve revealed reduced nerve fiber diameters with increased regenerative sprouts, and denervation myopathy in ethanol-fed rats. qRT-PCR analysis demonstrated reduced mRNA levels of insulin, IGF-1, and IGF-2 polypeptides, IGF-1 receptor, and IRS2, and ELISAs revealed reduced immunoreactivity for insulin and IGF-1 receptors, IRS-1, IRS-4, myelin-associated glycoprotein, and tau in sciatic nerves of ethanol-fed rats (all p < 0.05 or better). The findings suggest that ALPN is characterized by (1) slowed conduction velocity with demyelination, and a small component of axonal degeneration; (2) impaired trophic factor signaling due to insulin and IGF resistance; and (3) degeneration of myelin and axonal cytoskeletal proteins. Therefore, ALPN is likely mediated by molecular and signal transduction abnormalities similar to those identified in alcoholic liver and brain degeneration. |
| Posted: 17 Aug 2012 12:00 AM PDT Eicosapentaenoic and docosahexaenoic acids have been reported to have a variety of beneficial effects on cardiovascular disease risk factors. However, a large inter-individual variability in the plasma lipid response to an omega-3 (n-3) polyunsaturated fatty acid (PUFA) supplementation is observed in different studies. Genetic variations may influence plasma lipid responsiveness. The aim of the present study was to examine the effects of a supplementation with n-3 PUFA on the plasma lipid profile in relation to the presence of single-nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene cluster. A total of 208 subjects from Quebec City area were supplemented with 3 g/day of n-3 PUFA, during six weeks. In a statistical model including the effect of the genotype, the supplementation and the genotype by supplementation interaction, SNP rs174546 was significantly associated (p = 0.02) with plasma triglyceride (TG) levels, pre- and post-supplementation. The n-3 supplementation had an independent effect on plasma TG levels and no significant genotype by supplementation interaction effects were observed. In summary, our data support the notion that the FADS gene cluster is a major determinant of plasma TG levels. SNP rs174546 may be an important SNP associated with plasma TG levels and FADS1 gene expression independently of a nutritional intervention with n-3 PUFA. |
| Posted: 17 Aug 2012 12:00 AM PDT In control devices for the Internet of Things (IoT), energy is one of the critical restriction factors. Dynamic voltage scaling (DVS) has been proved to be an effective method for reducing the energy consumption of processors. This paper proposes an energy-efficient scheduling algorithm for IoT control devices with hard real-time control tasks (HRCTs) and soft real-time tasks (SRTs). The main contribution of this paper includes two parts. First, it builds the Hybrid tasks with multi-subtasks of different function Weight (HoW) task model for IoT control devices. HoW describes the structure of HRCTs and SRTs, and their properties, e.g., deadlines, execution time, preemption properties, and energy-saving goals, etc. Second, it presents the Hybrid Tasks' Dynamic Voltage Scaling (HTDVS) algorithm. HTDVS first sets the slowdown factors of subtasks while meeting the different real-time requirements of HRCTs and SRTs, and then dynamically reclaims, reserves, and reuses the slack time of the subtasks to meet their ideal energy-saving goals. Experimental results show HTDVS can reduce energy consumption about 10%–80% while meeting the real-time requirements of HRCTs, HRCTs help to reduce the deadline miss ratio (DMR) of systems, and HTDVS has comparable performance with the greedy algorithm and is more favorable to keep the subtasks' ideal speeds. |
| DVDRemaster 8.0.2 - Duplicate, burn or convert DVD movies to iPod, iPhone or Apple TV.. (Demo) Posted: 17 Aug 2012 03:10 AM PDT  DVDRemaster recompresses large DVDs so they can be burned on a standard DVD or converts them so they can be watched on your video iPod, iPod Touch, iPhone, iPad Apple TV and many others. DVDRemaster accommodates both novices and experts with its simple but yet powerful interface. DVDRemaste also allows you to extract raw data streams from your DVD. These can be reused in other applications. Features:
Version 8.0.2:
Mac OS X 10.6 or later Download Now |
| Posted: 17 Aug 2012 03:19 AM PDT You have managed to get yourself into a tight spot. Drive your car through the area to park it perfectly. |
| Posted: 17 Aug 2012 12:00 AM PDT Transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel, is a receptor activated by high temperatures and chemical agonists such as the vanilloids and protons. Because of these properties, TRPV1 has emerged as a polymodal nocisensor of nociceptive afferent neurons. TRPV1 is thought to be a central transducer of hyperalgesia and a prime target for controlling pain pharmacologically because it is a point where many proalgesic pathways converge and it is upregulated and sensitized by inflammation and injury. However, whether TRPV1 agonists promote or inhibit inflammation remains unclear. We recently demonstrated that SA13353 (1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea), a novel TRPV1 agonist, inhibits tumor necrosis factor-a production by the activation of capsaicin-sensitive afferent neurons and reduces the severity of symptoms in kidney injury, lung inflammation, arthritis, and encephalomyelitis. These results suggest that TRPV1 agonists may act as anti-inflammatories in certain inflammatory and autoimmune conditions in vivo. Given the potential deleterious effects of inhibiting the population of channels with a protective function, caution should be taken in the use of potent TRPV1 antagonists as a general strategy to treat inflammation. Further studies are required to clarify the role of TRPV1 and neuropeptides, which are released because of TRPV1 activation in inflammation and autoimmune diseases. |
| Posted: 17 Aug 2012 12:00 AM PDT The increasing demand for high energy density fuels and the concern for their safety have propelled research in the field of gelled propellants, where understanding the combustion of single gelled fuel droplets is the first stage to predict the spray combustion characteristics. The experiments utilized single-isolated freely falling gelled unsymmetrical dimethylhydrazine (UDMH) droplets instead of the conventional suspended droplet approach, in order to eliminate the perturbation associated with the suspension mechanism. Morphological transformations of the gelled droplet involved in the combustion processes were monitored by employing a high-speed digital camera, while the effects of ambient pressure and oxygen concentration on burning rate constants were also studied. The experimental results show that four main phenomena (droplet deformation, bubble formation and growth, vapor jetting and luminous jetting flame with "horn" shape) and three distinct phases were identified in the droplet combustion process; the high yield stress and polymer chain structure of polymer gellant are responsible for the appearance of bubbles with almost the same order of magnitude as the droplets. Increasing the ambient pressure can increase the burning rate, postpone the appearance of microexplosions, and weaken microexplosion intensity; while increasing the ambient oxygen concentration can promote the appearance of microexplosions, strengthen microexplosion intensity and increase the burning rate. |
| Energies, Vol. 5, Pages 3110-3125: The Long-Term Prospects of Biofuels in the EU-15 Countries Posted: 17 Aug 2012 12:00 AM PDT The core objective of this paper is to analyze the energy and CO2 reduction potentials as well as the market prospects of biofuels in EU-15 in a dynamic framework till 2050. The most important result of this analysis is that 2nd generation biofuels might become economically competitive between 2020 and 2030, yet this can only be achieved if the following preconditions are fulfilled: (1) achievement of significant learning effects leading to considerably lower plant costs; (2) significant improvement of conversion efficiency from feedstock to fuel leading to lower feedstock costs and better ecological performance; (3) increases in conventional diesel and gasoline prices, e.g., due to CO2 based taxes. |
| Posted: 17 Aug 2012 12:00 AM PDT Through bioassay-guided isolation, five compounds with growth inhibitory activity on S1T, an adult T-cell leukemia (ATL) cell line, were isolated from the crude methanol extract of the aerial parts of Hyptis verticillata. |
| Posted: 17 Aug 2012 12:00 AM PDT This manuscript describes the preparation and the spectroscopic characterisation of semi-synthetic sulfated maltotriose C-C linked dimers (SMTCs) where the natural C-O-C anomeric bond was substituted by one direct central C-C bond. This C-C bond induces conformation and flexibility changes with respect to the usual anomeric bond. SMTCs neutral precursors came from maltotriosyl bromide electroreduction through maltotriosyl radical intermediate dimerisation. The new C-C bond configuration, named for convenience a,a, a,b and b,b as the natural anomeric bond, dictated the statistic ratio formation of three diastereoisomers. They were separated by silica gel flash chromatography followed by semi preparative HPLC chromatography. Each diastereoisomer was exhaustively sulfated to afford the corresponding SMTCs. SMTCs were huge characterised by NMR spectroscopy which provided the sulfation degree, too. a,a and a,b were found quite homogeneous samples with a high degree of sulfation (85–95%). b,b appeared a non-homogeneous sample whose average sulfation degree was evaluated at around 78%. Mass spectroscopy experiments confirmed the sulfation degree range. Some considerations were proposed about SMTCs structure-biological properties. |
| Posted: 17 Aug 2012 12:00 AM PDT Certain aldehyde and ketone compounds can be used as indicators, at a molecular level, of the oxidized flavor of milk powder instead of sensory evaluation. This study investigated the formation of aldehyde and ketone compounds as affected by the heat-related processing and storage of milk powder. The compounds were extracted by solid phase microextraction fiber and determined using gas chromatography-mass spectrometry. In the results, higher contents of hexanal, 2-heptanone, octanal and 3-octen-2-one were detected in concentrated milk and fresh milk powders than in raw milk and heated milk. The levels of these compounds increased with increasing time of storage of milk powder. Meanwhile, the DPPH radical scavenging activity decreased and peroxide value increased during the production and storage of milk powder. In addition, the pore volume distribution of milk powder particle was determined by nitrogen isotherm adsorption. The porosity of milk powder was significantly correlated to the changes of aldehyde and ketone compounds during storages periods of 3 months (r > 0.689, p < 0.05) and 6 months (r > 0.806, p < 0.01). Therefore attention should be paid to the detectable aldehyde and ketone molecules to control the oxidized flavor, which was influenced by pre-heating as well as concentration and drying during milk powder production. |
| Company of Heroes 2 hands-on preview – War machines and wintry woes Posted: 17 Aug 2012 03:01 AM PDT Never before have we played an RTS where our troops could die of hypothermia. Then we got hands-on time with Company of Heroes 2. We've sung the praises |
| CopperCube 3.5 - Create interactive 3D scenes without programming.. (Demo) Posted: 17 Aug 2012 02:30 AM PDT  CopperCube is a 3D editor to create interactive 3D scenes - as Flash .swf, standalone Windows .exe, Mac OS X .app or pure JavaScript via WebGL - without programming. Create 3D model viewers, 3D walkthroughs, 360° panoramas, camera flights or even full 3D games. CopperCube imports 17 different 3D file formats and includes a powerful 3D editor and lightmap generator. All 3D scenes can be scripted using Squirrel, Actionscript 3 or JavaScript. CopperCube can render 3D scenes on websites via Flash or WebGL if available, and on windows using Direct3D or OpenGL and uses a highspeed, hardware accelerated render engine to put out an incredible amount of polygons. When publishing your 3D scene as Flash SWF file it uses a highly optimized and ActionScript 3 based own 3D renderer and still supports advanced features such as BillBoards, Skyboxes, 3D sounds and real lightmaps. CopperCube .SWF 3D files can be easily integrated into your own SWF flash file, be at as beautiful animated 3D background or main 3D environment. It is easily possible to create camera flights or for example first person shooter style controlled walktroughs with CopperCube.
Mac OS X 10.4 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 17 Aug 2012 12:00 AM PDT A series of novel 1-(2′-α-O-D-glucopyranosyl ethyl) 2-arylbenzimidazoles has been prepared via one-pot glycosylation of ethyl-1-(2'-hydroxyethyl)-2-arylbenzimidazole-5-carboxylate derivatives. Synthesis of the 2-arylbenzimidazole aglycones from 4-fluoro-3-nitrobenzoic acid was accomplished in four high-yielding steps. The reduction and cyclocondensation steps for the aglycone synthesis proceeded efficiently under microwave irradiation to afford the appropriate benzimidazoles in excellent yields within 2–3 min. Glycosylation of the hydroxyethyl aglycones with the perbenzylated 1-hydroxy- glucopyranose, pretreated with the Appel-Lee reagent, followed by catalytic hydrogenolysis delivered the desired 1-(2′-α-O-D-glucopyranosyl ethyl) 2-aryl-benzimidazoles in a simple and straightforward manner. |
| Posted: 17 Aug 2012 12:00 AM PDT Several novel 6-aryl-5-cyano thiouracil derivatives were synthesized and explored for their activities as antibacterial, antifungal and anticancer agents. The antimicrobial evaluation revealed that compounds 7b and 7c possessed superior antibacterial activity against the Gram positive bacteria S. aureus and B. subtilis compared to the reference drug amoxicillin. Moreover, compound 4i was found to be a broad spectrum antimicrobial agent and it also exhibited the highest antifungal activity against C. albicans, even higher than the reference drug amphotericin B (MIC = 2.34, 3.00 μg/mL respectively). Selected compounds were tested for in vitro cytotoxicity at a single 10−5 M concentration in accordance to the NCI (USA) protocol. The preliminary screening results showed that most of the compounds had limited cytotoxic activity against renal cancer UO-31 and/or A498 cell lines. Nevertheless, compounds 6d and 6i displayed potent growth inhibitory effect toward non-small cell lung cancer HOP-92 and leukemia MOLT-4 cell lines, respectively. |
| Posted: 17 Aug 2012 12:00 AM PDT Ecological land is like the "liver" of a city and is very useful to public health. Ecological land change is a spatially dynamic non-linear process under the interaction between natural and anthropogenic factors at different scales. In this study, by setting up natural development scenario, object orientation scenario and ecosystem priority scenario, a Cellular Automation (CA) model has been established to simulate the evolution pattern of ecological land in Beijing in the year 2020. Under the natural development scenario, most of ecological land will be replaced by construction land and crop land. But under the scenarios of object orientation and ecosystem priority, the ecological land area will increase, especially under the scenario of ecosystem priority. When considering the factors such as total area of ecological land, loss of key ecological land and spatial patterns of land use, the scenarios from priority to inferiority are ecosystem priority, object orientation and natural development, so future land management policies in Beijing should be focused on conversion of cropland to forest, wetland protection and prohibition of exploitation of natural protection zones, water source areas and forest parks to maintain the safety of the regional ecosystem. |
| Posted: 17 Aug 2012 12:00 AM PDT Pyrethroid insecticides are frequently used to control insects in residential and agriculture settings in the United States and worldwide. As a result, children can be potentially exposed to pyrethroid residues in food and at home. This review summarizes data reported in 15 published articles from observational exposure measurement studies conducted from 1999 to present that examined children's (5 months to 17 years of age) exposures to pyrethroids in media including floor wipes, floor dust, food, air, and/or urine collected at homes in the United States. At least seven different pyrethroids were detected in wipe, dust, solid food, and indoor air samples. Permethrin was the most frequently detected (>50%) pyrethroid in these media, followed by cypermethrin (wipes, dust, and food). 3-phenoxybenzoic acid (3-PBA), a urinary metabolite of several pyrethroids, was the most frequently (≥67%) detected pyrethroid biomarker. Results across studies indicate that these children were likely exposed to several pyrethroids, but primarily to permethrin and cypermethrin, from several sources including food, dust, and/or on surfaces at residences. Dietary ingestion followed by nondietary ingestion were the dominate exposure routes for these children, except in homes with frequent pesticide applications (dermal followed by dietary ingestion). Urinary 3-PBA concentration data confirm that the majority of the children sampled were exposed to one or more pyrethroids. |
| Posted: 17 Aug 2012 12:00 AM PDT This study examined the effects of rice bran oil (RBO) on mouse intestinal microbiota and urinary isoflavonoids. Dietary RBO affects intestinal cholesterol absorption. Intestinal microbiota seem to play an important role in isoflavone metabolism. We hypothesized that dietary RBO changes the metabolism of isoflavonoids and intestinal microbiota in mice. Male mice were randomly divided into two groups: those fed a 0.05% daidzein with 10% RBO diet (RO group) and those fed a 0.05% daidzein with 10% lard control diet (LO group) for 30 days. Urinary amounts of daidzein and dihydrodaidzein were significantly lower in the RO group than in the LO group. The ratio of equol/daidzein was significantly higher in the RO group (p < 0.01) than in the LO group. The amount of fecal bile acids was significantly greater in the RO group than in the LO group. The composition of cecal microbiota differed between the RO and LO groups. The occupation ratios of Lactobacillales were significantly higher in the RO group (p < 0.05). Significant positive correlation (r = 0.591) was observed between the occupation ratios of Lactobacillales and fecal bile acid content of two dietary groups. This study suggests that dietary rice bran oil has the potential to affect the metabolism of daidzein by altering the metabolic activity of intestinal microbiota. |
| IJMS, Vol. 13, Pages 10316-10335: Molecular Tools for Exploring Polyploid Genomes in Plants Posted: 17 Aug 2012 12:00 AM PDT Polyploidy is a very common phenomenon in the plant kingdom, where even diploid species are often described as paleopolyploids. The polyploid condition may bring about several advantages compared to the diploid state. Polyploids often show phenotypes that are not present in their diploid progenitors or exceed the range of the contributing species. Some of these traits may play a role in heterosis or could favor adaptation to new ecological niches. Advances in genomics and sequencing technology may create unprecedented opportunities for discovering and monitoring the molecular effects of polyploidization. Through this review, we provide an overview of technologies and strategies that may allow an in-depth analysis of polyploid genomes. After introducing some basic aspects on the origin and genetics of polyploids, we highlight the main tools available for genome and gene expression analysis and summarize major findings. In the last part of this review, the implications of next generation sequencing are briefly discussed. The accumulation of knowledge on polyploid formation, maintenance, and divergence at whole-genome and subgenome levels will not only help plant biologists to understand how plants have evolved and diversified, but also assist plant breeders in designing new strategies for crop improvement. |
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