Games |
- Nightmares From The Deep: The Cursed Heart CE 1.0 - Hidden object adventure game.. (Demo)
- Puzzle Craft - Screenshots
- Roccat Browser 2.5 - Fast Web browser with a variety of features.. (Free)
- Sensors, Vol. 12, Pages 11435-11450: Enhancing Health Care Delivery through Ambient Intelligence Applications
- Wii U: The good news and bad news after more quality time with Nintendo's new console at Gamescom
- Molecules, Vol. 17, Pages 10178-10191: A Synthetic Method to Access Symmetric and Non-Symmetric 2-(N,N'-disubstituted)guanidinebenzothiazoles
- Molecules, Vol. 17, Pages 10159-10177: Distribution of Primary and Specialized Metabolites in Nigella sativa Seeds, a Spice with Vast Traditional and Historical Uses
- Energies, Vol. 5, Pages 3178-3197: Optimization of Nitrogen and Metal Ions Supplementation for Very High Gravity Bioethanol Fermentation from Sweet Sorghum Juice Using an Orthogonal Array Design
- Molecules, Vol. 17, Pages 10142-10158: Acetylcholinesterase-Inhibiting Activity of Salicylanilide N-Alkylcarbamates and Their Molecular Docking
- Molecules, Vol. 17, Pages 10131-10141: Mechanistic Study of the Spiroindolones: A New Class of Antimalarials
- Molecules, Vol. 17, Pages 10119-10130: Dry Etching of Copper Phthalocyanine Thin Films: Effects on Morphology and Surface Stoichiometry
- Molecules, Vol. 17, Pages 10108-10118: Ameliorative Effects of Curculigoside from Curculigo orchioides Gaertn on Learning and Memory in Aged Rats
- Energies, Vol. 5, Pages 3167-3177: Research on the Gas Reburning in a Circulating Fluidized Bed (CFB) System Integrated with Biomass Gasification
- Molecules, Vol. 17, Pages 10094-10107: Activity of Spray-dried Microparticles Containing Pomegranate Peel Extract against Candida albicans
- Molecules, Vol. 17, Pages 10079-10093: 4-Ferrocenylpyridine- and 4-Ferrocenyl-3-ferrocenylmethyl-3,4-dihydropyridine-3,5-dicarbonitriles: Multi-Component Synthesis, Structures and Electrochemistry
- Molecules, Vol. 17, Pages 10072-10078: A New Cubitane Diterpenoid from the Soft Coral Sinularia crassa
- Molecules, Vol. 17, Pages 10065-10071: Inhibition of Burkholderia multivorans Adhesion to Lung Epithelial Cells by Bivalent Lactosides
- The Sims 3 Sunlit Tides - Screenshots
- Supermagical - Screenshots
- Lawsuit filed over Ark. casino measure rejection
Nightmares From The Deep: The Cursed Heart CE 1.0 - Hidden object adventure game.. (Demo) Posted: 24 Aug 2012 03:35 AM PDT In Nightmares From The Deep: The Cursed Heart CE, become Sarah Black, a museum owner, and dare to challenge a legendary pirate and rescue your daughter from a terrifying place known as the Skull Island. When you stand against a resurrected nightmare and his crew beware, as even with all your courage you may find more than you bargained for! And remember,"there is much more to this pirate captain that meets the eye…" Find the true nature of fear, adventure and love and discover the truth hidden deep in the sea in Nightmares from the Deep: The Cursed Heart! Features:
Mac OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now |
Posted: 24 Aug 2012 04:03 AM PDT FEATURES - Part town building sim, part match-three puzzler, Puzzle Craft blends two gameplay modes together for the first time ever. - Incredibly deep gameplay, there's always something to do! - Craft tools to aid with farming and mining. - Hire villagers to help out around the settlement. - Create special buildings to increase productivity! - Universal build; plays great on iPhone, iPod touch, and iPad. |
Roccat Browser 2.5 - Fast Web browser with a variety of features.. (Free) Posted: 24 Aug 2012 02:58 AM PDT Roccat Browser is an amazing browser from the fludium family. Roccat Browser is an amazingly fast Web browser, which has some great features such as:
Version 2.5:
Mac OS X 10.5 or later Download Now |
Posted: 24 Aug 2012 12:00 AM PDT This paper presents the implementation of a smart environment that employs Ambient Intelligence technologies in order to augment a typical hospital room with smart features that assist both patients and medical staff. In this environment various wireless and wired sensor technologies have been integrated, allowing the patient to control the environment and interact with the hospital facilities, while a clinically oriented interface allows for vital sign monitoring. The developed applications are presented both from a patient's and a doctor's perspective, offering different services depending on the user's role. The results of the evaluation process illustrate the need for such a service, leading to important conclusions about the usefulness and crucial role of AmI in health care. |
Wii U: The good news and bad news after more quality time with Nintendo's new console at Gamescom Posted: 24 Aug 2012 02:58 AM PDT Wii U is supposed to be out this year. It's never going to launch post-Christmas, so that means we're four months at most from launch. But having played |
Posted: 24 Aug 2012 12:00 AM PDT Symmetric and non-symmetric 2-(N-H, N-methyl, N-ethylenyl and N-aryl)guanidinebenzothiazoles were synthesized from the reaction of ammonia, methylamine, pyrrolidine and aniline with dimethyl benzo[d]thiazol-2-yl-carbono-dithioimidate (5) as intermediate. The products were characterized by 1H-, 13C-NMR spectroscopy and three of them by X-ray diffraction analysis. HN-phenyl protons formed intramolecular hydrogen bonds that assist the stereochemistry of the second substituent, whereas the HN-alkyl protons were involved in intermolecular hydrogen bonding. |
Posted: 24 Aug 2012 12:00 AM PDT Black cumin (Nigella sativa L., Ranunculaceae) is an annual herb commonly used in the Middle East, India and nowadays gaining worldwide acceptance. Historical and traditional uses are extensively documented in ancient texts and historical documents. Black cumin seeds and oil are commonly used as a traditional tonic and remedy for many ailments as well as in confectionery and bakery. Little is known however about the mechanisms that allow the accumulation and localization of its active components in the seed. Chemical and anatomical evidence indicates the presence of active compounds in seed coats. Seed volatiles consist largely of olefinic and oxygenated monoterpenes, mainly p-cymene, thymohydroquinone, thymoquinone, γ-terpinene and α-thujene, with lower levels of sesquiterpenes, mainly longifolene. Monoterpene composition changes during seed maturation. γ-Terpinene and α-thujene are the major monoterpenes accumulated in immature seeds, and the former is gradually replaced by p-cymene, carvacrol, thymo-hydroquinone and thymoquinone upon seed development. These compounds, as well as the indazole alkaloids nigellidine and nigellicine, are almost exclusively accumulated in the seed coat. In contrast, organic and amino acids are primarily accumulated in the inner seed tissues. Sugars and sugar alcohols, as well as the amino alkaloid dopamine and the saponin α-hederin accumulate both in the seed coats and the inner seed tissues at different ratios. Chemical analyses shed light to the ample traditional and historical uses of this plant. |
Posted: 24 Aug 2012 12:00 AM PDT Optimization of four parameters, i.e., zinc (Zn2+), magnesium (Mg2+), manganese (Mn2+) and yeast extract for bioethanol production from sweet sorghum juice by Saccharomyces cerevisiae NP 01 under very high gravity (VHG, 270 g·L−1 of total sugar) conditions was performed using an L9 (34) orthogonal array design. The fermentation was carried out at 30 °C in 500-mL air-locked Erlenmeyer flasks at the agitation rate of 100 rpm and the initial yeast cell concentration in the juice was approximately 5 × 107 cells·mL−1. The results showed that the order of influence was yeast extract > Mn2+ > Zn2+ > Mg2+ and the optimum nutrient concentrations for the ethanol fermentation were Zn2+, 0.01; Mg2+, 0.05; Mn2+, 0.04; and yeast extract, 9 g·L−1. The verification experiments under the optimum condition clearly indicated that the metals and nitrogen supplementation improved ethanol production efficiency under the VHG fermentation conditions. The ethanol concentration (P), yield (Yp/s) and productivity (Qp) were 120.58 ± 0.26 g·L−1, 0.49 ± 0.01 and 2.51 ± 0.01 g·L−1·h−1, respectively, while in the control treatment (without nutrient supplement) P, Yp/s and Qp were only 93.45 ± 0.45 g·L−1, 0.49 ± 0.00 and 1.30 ± 0.01 g·L−1·h−1, respectively. |
Posted: 24 Aug 2012 12:00 AM PDT A series of twenty-five novel salicylanilide N-alkylcarbamates were investigated as potential acetylcholinesterase inhibitors. The compounds were tested for their ability to inhibit acetylcholinesterase (AChE) from electric eel (Electrophorus electricus L.). Experimental lipophilicity was determined, and the structure-activity relationships are discussed. The mode of binding in the active site of AChE was investigated by molecular docking. All the discussed compounds expressed significantly higher AChE inhibitory activity than rivastigmine and slightly lower than galanthamine. Disubstitution by chlorine in C'(3,4) of the aniline ring and the optimal length of hexyl-undecyl alkyl chains in the carbamate moiety provided the most active AChE inhibitors. Monochlorination in C'(4) exhibited slightly more effective AChE inhibitors than in C'(3). Generally it can be stated that compounds with higher lipophilicity showed higher inhibition, and the activity of the compounds is strongly dependent on the length of the N-alkyl chain. |
Posted: 24 Aug 2012 12:00 AM PDT During the synthesis of the new antimalarial drug candidate NITD609, a high degree of diastereoselectivity was observed in the Pictet-Spengler reaction. By isolating both the 4E and 4Z imine intermediates, a systematic mechanistic study of the reaction under both kinetic and thermodynamic conditions was conducted. This study provides insight into the source of the diastereoselectivity for this important class of compounds. |
Posted: 24 Aug 2012 12:00 AM PDT We investigate the evolution of copper phthalocyanine thin films as they are etched with argon plasma. Significant morphological changes occur as a result of the ion bombardment; a planar surface quickly becomes an array of nanopillars which are less than 20 nm in diameter. The changes in morphology are independent of plasma power, which controls the etch rate only. Analysis by X-ray photoelectron spectroscopy shows that surface concentrations of copper and oxygen increase with etch time, while carbon and nitrogen are depleted. Despite these changes in surface stoichiometry, we observe no effect on the work function. The absorbance and X-ray diffraction spectra show no changes other than the peaks diminishing with etch time. These findings have important implications for organic photovoltaic devices which seek nanopillar thin films of metal phthalocyanine materials as an optimal structure. |
Posted: 24 Aug 2012 12:00 AM PDT This study was designed to evaluate the ameliorating effects of curculigoside from Curculigo orchioides Gaertn on learning and memory in aged rats. In the present study, the ameliorating effects of curculigoside were determined through animal behaviour studies (including step-down test and Y-maze test), and the possible mechanisms were explored by evaluation of the activity of acetylcholinesterase (AchE) and determination of the expression of BACE1. Oral adminstration of the curculigoside (20, 40 mg/kg/day) for 14 days can significantly improve the latency and number of errors in aged rats based on the behaviour study results. In addition, the activity of AchE can be decreased by treatment of the curculigoside (10, 20, 40 mg/kg/day). Moreover, the expression of BACE1 can be down-regulated in the hippocampus of aged rats treated with curculigoside. The results of our present work have indicated that curculigoside can improve cognitive function in aged animals, possibly by decreasing the activity of AchE in the cerebra and inhibiting the expression of BACE1 in the hippocampus. In conclusion, our results suggested that curculigoside can be possible developed as a new drug for the treatment of Alzheimer's disease in the future. |
Posted: 24 Aug 2012 12:00 AM PDT N2O emissions from coal fired fluidized-bed combustion are approximately 30–360 mg/Nm3, much higher than that from pulverized coal combustion (less than 30 mg/Nm3). One approach to reduce the N2O is to reburn the biomass gasification gas in the coal-fired fluidized bed. In this paper, the effects of gasified biomass reburning on the integrated boiler system were investigated by both simulation and experimental methods. The simulation as well as experimental results revealed that the increase of the reburning ratio would decrease the theoretical air volume and boiler efficiency, while it would increase the fuel gas volume, combustion and exhuast gas temperature. The experimental results also indicated that the N2O removal could reach as high as 99% when the heat ratio of biomass gas to coal is 10.5%. |
Posted: 24 Aug 2012 12:00 AM PDT Pomegranate has attracted interest from researchers because of its chemical composition and biological properties. It possesses strong antioxidant activity, with potential health benefits, and also antimicrobial properties. The aim of this study was to produce microparticles containing pomegranate extract by the spray-drying technique, utilizing alginate or chitosan as encapsulating agents. Characterization and antifungal assays were carried out. Production yields were about 40% for alginate microparticles and 41% for chitosan. Mean diameters were 2.45 µm and 2.80 µm, and encapsulation efficiencies were 81.9% and 74.7% for alginate and chitosan microparticles, respectively. The spray-drying process preserved the antifungal activity against Candida albicans. These results could be useful for developing dosage forms for treating candidiasis, and should be further investigated in in vivo models. |
Posted: 24 Aug 2012 12:00 AM PDT The reactions of 2-cyano-3-ferrocenylacrylonitrile (1) with malononitrile (2) in a MeOH/H2O or 2-PrOH/H2O medium in the presence of Na2CO3 afforded 6-alkoxy-2-amino-4-ferrocenylpyridine-3,5-dicarbonitriles 3a,b (multi-component condensation) and 6-alkoxy-2-amino-4-ferrocenyl-3-ferrocenylmethyl-3,4-dihydropyridine-3,5-dicarbonitriles 4a,b (multi-component cyclodimerization). Analogous reactions of 1 with 2 in an MeOH/H2O medium in the presence of NaOH, piperidine, or morpholine gave compounds 3a, 4a and 2-amino-4-ferrocenyl-6-hydroxy-, 6-piperidino- and 6-morpholinopyridine-3,5-dicarbonitriles 3c–e, respectively. The structures of the compounds 3b, 4a and 4b were established by the spectroscopic data and X-ray diffraction analysis. The electrochemical behaviour of compounds 3b, 3d and 4b was investigated by means of cyclic voltammetry. |
Posted: 24 Aug 2012 12:00 AM PDT A new cubitane diterpenoid, crassalone A (1), was isolated from the marine soft coral Sinularia crassa. The structure was determined by extensive spectroscopic analyses. Compound 1 is not cytotoxic (IC50 > 20 μg/mL) toward the four human cancer cell lines tested (HL60, MDA-MB-231, HCT-116 and DLD-1). |
Posted: 24 Aug 2012 12:00 AM PDT Burkholderia cepacia complex (Bcc) is an opportunistic pathogen in cystic fibrosis patients which is inherently resistant to antimicrobial agents. The mechanisms of attachment and pathogenesis of Bcc, a group of 17 species, are poorly understood. The most commonly identified Bcc species in newly colonised patients, Burkholderia multivorans, continues to be acquired from the environment. Development of therapies which can prevent or reduce the risk of colonization on exposure to Bcc in the environment would be a better alternative to antimicrobial agents. Previously, it has been shown that Bcc strains bound to many glycolipid receptors on lung epithelia. Using a real-time PCR method to quantify the levels of binding of B. multivorans to the lung epithelial cells, we have examined glycoconjugate derivatives for their potential to inhibit host cell attachment. Bivalent lactosides previously shown to inhibit galectin binding significantly reduced the attachment of B. multivorans to CF lung epithelial cells at micromolar concentrations. This was in contrast to monosaccharides and lactose, which were only effective in the millimolar range. Development of glycoconjugate therapies such as these, which inhibit attachment to lung epithelial cells, represent an alternative means of preventing infection with inherently antimicrobially resistant pathogens such as B. multivorans. |
The Sims 3 Sunlit Tides - Screenshots Posted: 24 Aug 2012 03:33 AM PDT On Sunlit Tides, Sims can enjoy a picnic on the beach, plan a secret rendezvous at an island waterfall, or cozy up to a loved one in the shade of a palm tree. They'll watch as the sun sinks into the sea and all their worries are swept away. Will your Sims find true love, or just have fun trying? Key Features Experience a relaxing and rejuvenating new world: Meet new Sims, discover new locations, and explore the beautiful beaches of Sunlit Tides! Play with new Sims and new stories: Professional rivalries, friendship, love and betrayal abound on the oasis of Sunlit Tides. Spend a relaxing day at one of the many beaches, explore the island's secret hideaways or take a relaxing steam in the sauna. Luxurious mansions, spacious jungle abodes, and homes with views of the lagoon or ocean are but a few of the many options for tropical living. Make new friends and meet old favorites, including honeymooners, Daniel and Mary-Sue Pleasant! Explore the benefits of the Steam-It-Up Sauna: Expand your game with this all-new item that provides gameplay benefits. Take a break from the worries of the world and refresh your body, mind and soul with a tranquil sojourn in a little slice of paradise! Experience a relaxing hydrotherapy soak in crystalline waters, rejuvenate with a revitalizing mud bath or simply sit back and enjoy the steam. The Steam-It-Up Sauna will soothe away your aches and pains and put your worried mind at ease. So sit back, relax and experience the exhilaration of paradise. |
Posted: 24 Aug 2012 03:13 AM PDT FEATURES - Simple and accessible controls, specially tailored for touch devices. Playing Supermagical is intuitive, easy, and super fun! - Colorful animation-styled graphics that will truly surprise you! This is one of the most detailed games ever made for mobile devices, with tons of levels full of smooth motion and amazing magical effects. - 3 individual and unique continents to explore, with a total of 71 different levels. This is a huge adventure with an epic ending! You'll have tons of fun from start to finish. - Win lots of stuff in Manuel's Couples Game and Piñatas! - 6 powerful warlocks will be at your command from your Magic Tower to fight the Minix. Combine their spectacular powers and watch the Minix run! - Fun Dialog Battles against your wicked sisters. You have to convince your Witch Sisters to leave your world NOW! Will you be able to pick the right answer? - Get all the magic ingredients and cook all four Ultramagic Spells that will help you in your quest. - Find all the cute and powerful pets! The Lovely Hamster, the Unisheep... They'll keep you company! - Ride the Epic Dragon or the Great White Tiger to explore new worlds and all their secrets! - Retina graphics support for iPhone and New iPad. - Gamecenter and the new gPotato mobile Achievements, including Facebook and Twitter support. - PLUS free future updates including 2 Player Cooperative Mode and Versus Mode! |
Lawsuit filed over Ark. casino measure rejection Posted: 24 Aug 2012 01:48 AM PDT A professional poker player has sued Arkansas election officials for rejecting the wording of a proposed ballot measure that would give her exclusive rights to operate casinos in the state. |
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