пятница, 24 августа 2012 г.

Games

Games


Nightmares From The Deep: The Cursed Heart CE 1.0 - Hidden object adventure game.. (Demo)

Posted: 24 Aug 2012 03:35 AM PDT



In Nightmares From The Deep: The Cursed Heart CE, become Sarah Black, a museum owner, and dare to challenge a legendary pirate and rescue your daughter from a terrifying place known as the Skull Island. When you stand against a resurrected nightmare and his crew beware, as even with all your courage you may find more than you bargained for! And remember,"there is much more to this pirate captain that meets the eye…" Find the true nature of fear, adventure and love and discover the truth hidden deep in the sea in Nightmares from the Deep: The Cursed Heart!

Features:

  • Amazing storyline
  • Astonishing sceneries
  • Clever puzzles
  • Collect 12 Cursed Doubloons
  • Look for Hidden Objects or switch to Mahjong instead
  • Face the fearsome Captain Remington and his crew



Mac OS X 10.5 or later

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This posting includes an audio/video/photo media file: Download Now

Puzzle Craft - Screenshots

Posted: 24 Aug 2012 04:03 AM PDT

FEATURES
- Part town building sim, part match-three puzzler, Puzzle Craft blends two gameplay modes together for the first time ever.
- Incredibly deep gameplay, there's always something to do!
- Craft tools to aid with farming and mining.
- Hire villagers to help out around the settlement.
- Create special buildings to increase productivity!
- Universal build; plays great on iPhone, iPod touch, and iPad.

Roccat Browser 2.5 - Fast Web browser with a variety of features.. (Free)

Posted: 24 Aug 2012 02:58 AM PDT



Roccat Browser is an amazing browser from the fludium family. Roccat Browser is an amazingly fast Web browser, which has some great features such as:
  • VisiTabs which gives a preview of the website in the tab.
  • Navigate Launchers- assign letters or words to navigate to webpages, there are already many preloaded ones
  • Ad-Remover built within the engine
  • Great internal engine effects, purple glows on inputs, hold down on text field for 5 seconds for them to enlarge.
  • Email-Previewer; tells you when a link is an email link and tells you the link
  • Change User Agents- View sites which need other browser, view apples videos which require Safari etc...
  • A choice of VisiTabs or normal tabs or both, a bookmarks bar which fully supports bookmarklets
  • Downloads files and programs really easily and fast
  • Gets 100/100 in the Acid3 test
  • New Download Manager and now has FullScreen Mode
  • Lovebyt.es integration for instant URL shortening.
  • Undercover Browsing
  • Social page sharing / online email sharing
  • eBuddy Widget (chat with your facebook, msn, yahoo messenger, ICQ and aim friends no matter what tab you are on)
  • English, French and German localization
  • Ability to Import Bookmarks
  • OS X 10.7 Lion fullscreen support
  • Roccat Munch cookie management
  • Auto reloader (5, 10, 15 or 30 seconds)
  • The amazing RClouds (beta) which allows you to backup your settings, open tabs, imported bookmarks, bookmarks, navigate launchers, history and much more. RClouds allows you to restore your backups to any Mac so your browsing session can be anywhere you want it to be!
  • RClouds Reset allows you to reset your browser to factory settings (especially useful when you've restored your data to a public computer.
  • Cinnamon on the RClouds now means faster updating as it intelligently looks for the servers with the least amount of traffic.
  • We have even purchased the rights of exclusivity with lovebyt.es so now only Roccat users can use the service!
Why not try Cookie Stumbler to manage Roccat's cookies in the most secure way?

Version 2.5:
  • Roccat has been updated with Retina graphics!
  • 29 Bug fixes including the titlebar buttons going over VisiTabs in Fullscreen mode bug and the ConfirmClose bug.
  • Introducing Roccat Flick: you can now share websites wirelessly with your friends over a wireless network with other Roccat Users (from version 2.5) and now with our newly released Roccat:Connect for iPhone, iPod Touch and iPad!
  • We have been working very closely with the team at Lovebyt.es and we have drastically improved our Lovebyt.es integration. Now Lovebyt.es opens in an RClouds style menu and shortens the website's URL without taking you away from the website you were on.
  • We also have some exciting new social features, we have been working with the latest API's from Facebook, and now you can update your Facebook status from any website you are on. The new system launches an RClouds style menu where you can easily update your status.
  • We have also updated the "Share Page with Facebook" feature to a similar system so it no longer takes you away from the site you are on.
  • We have removed the scrollbar from VisiTabs giving much more room for the site previews, simply navigate through them with your trackpad or mouse wheel.
  • New Gestures: use a three finger swipe right on the FusedBar (address bar) or toolbar to reload a page, and a three finger swipe to the left on the FusedBar or toolbar to stop a page loading. You can also do a three finger swipe down from the FusedBar to bring up the Facebook Status menu.
  • We have added two new menu items, one to go to the first tab and one to go to the last tab, making it even easier to navigate your tabs.
  • We have intergrated Google Maps with FusedBar, simply type locate and then a location to search in google Maps for example "Locate Florida" will find florida on the map, or "Locate night clubs in New York" it will show all night clubs in New York on the map.
  • Roccat now supports the WebGL standard for capable Macs, WebGL is a context of the canvas HTML element which provides a 3D graphics API without the need for Plugins. This means you will be able to use the new Google Maps- MapsGL for a smoother experience.
  • Check this link to see some of the things you can do with the standard: http://www.webgl.com/category/webgl-games/
  • Improvements in performance, stability, speed and security.
  • We have made changes to the eBuddy widget, fixing the problem which caused it to recently stop working, the eBuddy widget now automatically loads it's content without you having to press a button, it now also has a brand new look making the interface more simplistic.
  • New Items have been added to ConnectMenu, you can now update your Facebook status, add a Bookmark, share sites with Roccat Flick straight from ConnectMenu. The Facebook and Twitter page sharing menus now have icons too.
  • We have added keyboard shortcuts for backing up and restoring from RClouds
  • Runecats Download Manager now understands Gigabyte files rather than displaying them in Megabytes, it's has also been future proofed to understand Terabyte files and even Petabyte files!
  • We have added two new options to Auto Reloader, adding a reload every 2 seconds option and a reload every 60 seconds option.
  • Visual changes across the whole app.
  • We have introduced a new beautiful html5 search page called RuneSearch:Beaut, we have added quick access to his by typing beaut into your FusedBar.
  • Modified the Roccat useragent fixing warning messages.
  • Added the ability to share page with Pinterest from the social menu.
  • We have also launched RClouds 2.0 which now supports Roccat:Connect devices, Roccat Flick and now backs up and restores faster than ever.


Mac OS X 10.5 or later

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Sensors, Vol. 12, Pages 11435-11450: Enhancing Health Care Delivery through Ambient Intelligence Applications

Posted: 24 Aug 2012 12:00 AM PDT

This paper presents the implementation of a smart environment that employs Ambient Intelligence technologies in order to augment a typical hospital room with smart features that assist both patients and medical staff. In this environment various wireless and wired sensor technologies have been integrated, allowing the patient to control the environment and interact with the hospital facilities, while a clinically oriented interface allows for vital sign monitoring. The developed applications are presented both from a patient's and a doctor's perspective, offering different services depending on the user's role. The results of the evaluation process illustrate the need for such a service, leading to important conclusions about the usefulness and crucial role of AmI in health care.

Wii U: The good news and bad news after more quality time with Nintendo's new console at Gamescom

Posted: 24 Aug 2012 02:58 AM PDT

Wii U is supposed to be out this year. It's never going to launch post-Christmas, so that means we're four months at most from launch. But having played

Molecules, Vol. 17, Pages 10178-10191: A Synthetic Method to Access Symmetric and Non-Symmetric 2-(N,N'-disubstituted)guanidinebenzothiazoles

Posted: 24 Aug 2012 12:00 AM PDT

Symmetric and non-symmetric 2-(N-H, N-methyl, N-ethylenyl and N-aryl)guanidinebenzothiazoles were synthesized from the reaction of ammonia, methylamine, pyrrolidine and aniline with dimethyl benzo[d]thiazol-2-yl-carbono-dithioimidate (5) as intermediate. The products were characterized by 1H-, 13C-NMR spectroscopy and three of them by X-ray diffraction analysis. HN-phenyl protons formed intramolecular hydrogen bonds that assist the stereochemistry of the second substituent, whereas the HN-alkyl protons were involved in intermolecular hydrogen bonding.

Molecules, Vol. 17, Pages 10159-10177: Distribution of Primary and Specialized Metabolites in Nigella sativa Seeds, a Spice with Vast Traditional and Historical Uses

Posted: 24 Aug 2012 12:00 AM PDT

Black cumin (Nigella sativa L., Ranunculaceae) is an annual herb commonly used in the Middle East, India and nowadays gaining worldwide acceptance. Historical and traditional uses are extensively documented in ancient texts and historical documents. Black cumin seeds and oil are commonly used as a traditional tonic and remedy for many ailments as well as in confectionery and bakery. Little is known however about the mechanisms that allow the accumulation and localization of its active components in the seed. Chemical and anatomical evidence indicates the presence of active compounds in seed coats. Seed volatiles consist largely of olefinic and oxygenated monoterpenes, mainly p-cymene, thymohydroquinone, thymoquinone, γ-terpinene and α-thujene, with lower levels of sesquiterpenes, mainly longifolene. Monoterpene composition changes during seed maturation. γ-Terpinene and α-thujene are the major monoterpenes accumulated in immature seeds, and the former is gradually replaced by p-cymene, carvacrol, thymo-hydroquinone and thymoquinone upon seed development. These compounds, as well as the indazole alkaloids nigellidine and nigellicine, are almost exclusively accumulated in the seed coat. In contrast, organic and amino acids are primarily accumulated in the inner seed tissues. Sugars and sugar alcohols, as well as the amino alkaloid dopamine and the saponin α-hederin accumulate both in the seed coats and the inner seed tissues at different ratios. Chemical analyses shed light to the ample traditional and historical uses of this plant.

Energies, Vol. 5, Pages 3178-3197: Optimization of Nitrogen and Metal Ions Supplementation for Very High Gravity Bioethanol Fermentation from Sweet Sorghum Juice Using an Orthogonal Array Design

Posted: 24 Aug 2012 12:00 AM PDT

Optimization of four parameters, i.e., zinc (Zn2+), magnesium (Mg2+), manganese (Mn2+) and yeast extract for bioethanol production from sweet sorghum juice by Saccharomyces cerevisiae NP 01  under very high gravity (VHG, 270 g·L−1 of total sugar) conditions was performed using an L9 (34) orthogonal array design. The fermentation was carried out at 30 °C in 500-mL air-locked Erlenmeyer flasks at the agitation rate of 100 rpm and the initial yeast cell concentration in the juice was approximately 5 × 107 cells·mL−1. The results showed that the order of influence was yeast extract > Mn2+ > Zn2+ > Mg2+ and the optimum nutrient concentrations for the ethanol fermentation were Zn2+, 0.01; Mg2+, 0.05; Mn2+, 0.04; and yeast extract, 9 g·L−1. The verification experiments under the optimum condition clearly indicated that the metals and nitrogen supplementation improved ethanol production efficiency under the VHG fermentation conditions. The ethanol concentration (P), yield (Yp/s) and productivity (Qp) were 120.58 ± 0.26 g·L−1, 0.49 ± 0.01 and 2.51 ± 0.01 g·L−1·h−1, respectively, while in the control treatment (without nutrient supplement) P, Yp/s and Qp were only 93.45 ± 0.45 g·L−1, 0.49 ± 0.00 and 1.30 ± 0.01 g·L−1·h−1, respectively.

Molecules, Vol. 17, Pages 10142-10158: Acetylcholinesterase-Inhibiting Activity of Salicylanilide N-Alkylcarbamates and Their Molecular Docking

Posted: 24 Aug 2012 12:00 AM PDT

A series of twenty-five novel salicylanilide N-alkylcarbamates were investigated as potential acetylcholinesterase inhibitors. The compounds were tested for their ability to inhibit acetylcholinesterase (AChE) from electric eel (Electrophorus electricus L.). Experimental lipophilicity was determined, and the structure-activity relationships are discussed. The mode of binding in the active site of AChE was investigated by molecular docking. All the discussed compounds expressed significantly higher AChE inhibitory activity than rivastigmine and slightly lower than galanthamine. Disubstitution by chlorine in C'(3,4) of the aniline ring and the optimal length of hexyl-undecyl alkyl chains in the carbamate moiety provided the most active AChE inhibitors. Monochlorination in C'(4) exhibited slightly more effective AChE inhibitors than in C'(3). Generally it can be stated that compounds with higher lipophilicity showed higher inhibition, and the activity of the compounds is strongly dependent on the length of the N-alkyl chain.

Molecules, Vol. 17, Pages 10131-10141: Mechanistic Study of the Spiroindolones: A New Class of Antimalarials

Posted: 24 Aug 2012 12:00 AM PDT

During the synthesis of the new antimalarial drug candidate NITD609, a high degree of diastereoselectivity was observed in the Pictet-Spengler reaction. By isolating both the 4E and 4Z imine intermediates, a systematic mechanistic study of the reaction under both kinetic and thermodynamic conditions was conducted. This study provides insight into the source of the diastereoselectivity for this important class of compounds.

Molecules, Vol. 17, Pages 10119-10130: Dry Etching of Copper Phthalocyanine Thin Films: Effects on Morphology and Surface Stoichiometry

Posted: 24 Aug 2012 12:00 AM PDT

We investigate the evolution of copper phthalocyanine thin films as they are etched with argon plasma. Significant morphological changes occur as a result of the ion bombardment; a planar surface quickly becomes an array of nanopillars which are less than 20 nm in diameter. The changes in morphology are independent of plasma power, which controls the etch rate only. Analysis by X-ray photoelectron spectroscopy shows that surface concentrations of copper and oxygen increase with etch time, while carbon and nitrogen are depleted. Despite these changes in surface stoichiometry, we observe no effect on the work function. The absorbance and X-ray diffraction spectra show no changes other than the peaks diminishing with etch time. These findings have important implications for organic photovoltaic devices which seek nanopillar thin films of metal phthalocyanine materials as an optimal structure.

Molecules, Vol. 17, Pages 10108-10118: Ameliorative Effects of Curculigoside from Curculigo orchioides Gaertn on Learning and Memory in Aged Rats

Posted: 24 Aug 2012 12:00 AM PDT

This study was designed to evaluate the ameliorating effects of curculigoside from Curculigo orchioides Gaertn on learning and memory in aged rats. In the present study, the ameliorating effects of curculigoside were determined through animal behaviour studies (including step-down test and Y-maze test), and the possible mechanisms were explored by evaluation of the activity of acetylcholinesterase (AchE) and determination of the expression of BACE1. Oral adminstration of the curculigoside (20, 40 mg/kg/day) for 14 days can significantly improve the latency and number of errors in aged rats based on the behaviour study results. In addition, the activity of AchE can be decreased by treatment of the curculigoside (10, 20, 40 mg/kg/day). Moreover, the expression of BACE1 can be down-regulated in the hippocampus of aged rats treated with curculigoside. The results of our present work have indicated that curculigoside can improve cognitive function in aged animals, possibly by decreasing the activity of AchE in the cerebra and inhibiting the expression of BACE1 in the hippocampus. In conclusion, our results suggested that curculigoside can be possible developed as a new drug for the treatment of Alzheimer's disease in the future.

Energies, Vol. 5, Pages 3167-3177: Research on the Gas Reburning in a Circulating Fluidized Bed (CFB) System Integrated with Biomass Gasification

Posted: 24 Aug 2012 12:00 AM PDT

N2O emissions from coal fired fluidized-bed combustion are approximately 30–360 mg/Nm3, much higher than that from pulverized coal combustion (less than 30 mg/Nm3). One approach to reduce the N2O is to reburn the biomass gasification gas in the coal-fired fluidized bed. In this paper, the effects of gasified biomass reburning on the integrated boiler system were investigated by both simulation and experimental methods. The simulation as well as experimental results revealed that the increase of the reburning ratio would decrease the theoretical air volume and boiler efficiency, while it would increase the fuel gas volume, combustion and exhuast gas temperature. The experimental results also indicated that the N2O removal could reach as high as 99% when the heat ratio of biomass gas to coal is 10.5%.

Molecules, Vol. 17, Pages 10094-10107: Activity of Spray-dried Microparticles Containing Pomegranate Peel Extract against Candida albicans

Posted: 24 Aug 2012 12:00 AM PDT

Pomegranate has attracted interest from researchers because of its chemical composition and biological properties. It possesses strong antioxidant activity, with potential health benefits, and also antimicrobial properties. The aim of this study was to produce microparticles containing pomegranate extract by the spray-drying technique, utilizing alginate or chitosan as encapsulating agents. Characterization and antifungal assays were carried out. Production yields were about 40% for alginate microparticles and 41% for chitosan. Mean diameters were 2.45 µm and 2.80 µm, and encapsulation efficiencies were 81.9% and 74.7% for alginate and chitosan microparticles, respectively. The spray-drying process preserved the antifungal activity against Candida albicans. These results could be useful for developing dosage forms for treating candidiasis, and should be further investigated in in vivo models.

Molecules, Vol. 17, Pages 10079-10093: 4-Ferrocenylpyridine- and 4-Ferrocenyl-3-ferrocenylmethyl-3,4-dihydropyridine-3,5-dicarbonitriles: Multi-Component Synthesis, Structures and Electrochemistry

Posted: 24 Aug 2012 12:00 AM PDT

The reactions of 2-cyano-3-ferrocenylacrylonitrile (1) with malononitrile (2) in a MeOH/H2O or 2-PrOH/H2O medium in the presence of Na2CO3 afforded 6-alkoxy-2-amino-4-ferrocenylpyridine-3,5-dicarbonitriles 3a,b (multi-component condensation) and 6-alkoxy-2-amino-4-ferrocenyl-3-ferrocenylmethyl-3,4-dihydropyridine-3,5-dicarbonitriles 4a,b (multi-component cyclodimerization). Analogous reactions of 1 with 2 in an MeOH/H2O medium in the presence of NaOH, piperidine, or morpholine gave compounds 3a, 4a and 2-amino-4-ferrocenyl-6-hydroxy-, 6-piperidino- and 6-morpholinopyridine-3,5-dicarbonitriles 3c–e, respectively. The structures of the compounds 3b, 4a and 4b were established by the spectroscopic data and X-ray diffraction analysis. The electrochemical behaviour of compounds 3b, 3d and 4b was investigated by means of cyclic voltammetry.

Molecules, Vol. 17, Pages 10072-10078: A New Cubitane Diterpenoid from the Soft Coral Sinularia crassa

Posted: 24 Aug 2012 12:00 AM PDT

A new cubitane diterpenoid, crassalone A (1), was isolated from the marine soft coral Sinularia crassa. The structure was determined by extensive spectroscopic analyses. Compound 1 is not cytotoxic (IC50 > 20 μg/mL) toward the four human cancer cell lines tested (HL60, MDA-MB-231, HCT-116 and DLD-1).

Molecules, Vol. 17, Pages 10065-10071: Inhibition of Burkholderia multivorans Adhesion to Lung Epithelial Cells by Bivalent Lactosides

Posted: 24 Aug 2012 12:00 AM PDT

Burkholderia cepacia complex (Bcc) is an opportunistic pathogen in cystic fibrosis patients which is inherently resistant to antimicrobial agents. The mechanisms of attachment and pathogenesis of Bcc, a group of 17 species, are poorly understood. The most commonly identified Bcc species in newly colonised patients, Burkholderia multivorans, continues to be acquired from the environment. Development of therapies which can prevent or reduce the risk of colonization on exposure to Bcc in the environment would be a better alternative to antimicrobial agents. Previously, it has been shown that Bcc strains bound to many glycolipid receptors on lung epithelia. Using a real-time PCR method to quantify the levels of binding of B. multivorans to the lung epithelial cells, we have examined glycoconjugate derivatives for their potential to inhibit host cell attachment. Bivalent lactosides previously shown to inhibit galectin binding significantly reduced the attachment of B. multivorans to CF lung epithelial cells at micromolar concentrations. This was in contrast to monosaccharides and lactose, which were only effective in the millimolar range. Development of glycoconjugate therapies such as these, which inhibit attachment to lung epithelial cells, represent an alternative means of preventing infection with inherently antimicrobially resistant pathogens such as B. multivorans.

The Sims 3 Sunlit Tides - Screenshots

Posted: 24 Aug 2012 03:33 AM PDT

On Sunlit Tides, Sims can enjoy a picnic on the beach, plan a secret rendezvous at an island waterfall, or cozy up to a loved one in the shade of a palm tree. They'll watch as the sun sinks into the sea and all their worries are swept away. Will your Sims find true love, or just have fun trying?

Key Features
Experience a relaxing and rejuvenating new world: Meet new Sims, discover new locations, and explore the beautiful beaches of Sunlit Tides!

Play with new Sims and new stories:  Professional rivalries, friendship, love and betrayal abound on the oasis of Sunlit Tides. Spend a relaxing day at one of the many beaches, explore the island's secret hideaways or take a relaxing steam in the sauna. Luxurious mansions, spacious jungle abodes, and homes with views of the lagoon or ocean are but a few of the many options for tropical living. Make new friends and meet old favorites, including honeymooners, Daniel and Mary-Sue Pleasant!

Explore the benefits of the Steam-It-Up Sauna: Expand your game with this all-new item that provides gameplay benefits. Take a break from the worries of the world and refresh your body, mind and soul with a tranquil sojourn in a little slice of paradise! Experience a relaxing hydrotherapy soak in crystalline waters, rejuvenate with a revitalizing mud bath or simply sit back and enjoy the steam. The Steam-It-Up Sauna will soothe away your aches and pains and put your worried mind at ease. So sit back, relax and experience the exhilaration of paradise.

Supermagical - Screenshots

Posted: 24 Aug 2012 03:13 AM PDT

FEATURES
- Simple and accessible controls, specially tailored for touch devices.
Playing Supermagical is intuitive, easy, and super fun!
- Colorful animation-styled graphics that will truly surprise you!
This is one of the most detailed games ever made for mobile devices, with tons of levels full of smooth motion and amazing magical effects.
- 3 individual and unique continents to explore, with a total of 71 different levels.
This is a huge adventure with an epic ending! You'll have tons of fun from start to finish.
- Win lots of stuff in Manuel's Couples Game and Piñatas!
- 6 powerful warlocks will be at your command from your Magic Tower to fight the Minix.
Combine their spectacular powers and watch the Minix run!
- Fun Dialog Battles against your wicked sisters.
You have to convince your Witch Sisters to leave your world NOW! Will you be able to pick the right answer?
- Get all the magic ingredients and cook all four Ultramagic Spells that will help you in your quest.
- Find all the cute and powerful pets!
The Lovely Hamster, the Unisheep... They'll keep you company!
- Ride the Epic Dragon or the Great White Tiger to explore new worlds and all their secrets!
- Retina graphics support for iPhone and New iPad.
- Gamecenter and the new gPotato mobile Achievements, including Facebook and Twitter support.
- PLUS free future updates including 2 Player Cooperative Mode and Versus Mode!

Lawsuit filed over Ark. casino measure rejection

Posted: 24 Aug 2012 01:48 AM PDT

A professional poker player has sued Arkansas election officials for rejecting the wording of a proposed ballot measure that would give her exclusive rights to operate casinos in the state.

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