четверг, 16 августа 2012 г.

Games

Games

Sketch 2.1 - Vector drawing application.. (Demo)

Posted: 16 Aug 2012 03:24 AM PDT



Sketch is a innovative and fresh look at vector drawing for the Mac. Its intentionally minimalist design is based upon a drawing space of unlimited size and layers, free of palettes, panels, menus, windows, and controls. Though simple to use, it offers powerful vector drawing and text tools like perfect Boolean operations, Symbols and powerful Rulers, Guides and Grids.



Version 2.1:

Major Features:

  • Graphics updated for Retina display.
  • Improved rendering quality and speed of inner shadows & glows.
  • Improved accuracy of working with small layers.
  • Layers can now sit between pixel boundaries.
Artboard Enhancements:
  • You can now open a preview of an artboard in a separate window.
  • When moving an artboard, Sketch can now move the layers inside the artboard along with it.
  • You can now duplicate artboards including the layers inside it.
  • You can now scale artboards up along with the layers they contain. Perfect for making more detailed Retina assets.
  • When switching between artboards, if you have a layout grid turned on, the grid will now be in the centre of the artboard instead of on the left.
  • Restyled the artboards so they look and work more like individual canvasses.
  • You can now automatically hide the layers that are not visible within the current artboard.
  • Zoom between artboard switching. With this option turned on, switching from (in this case) a 256Ã.

    OS X 10.6 or later

    Download Now

This posting includes an audio/video/photo media file: Download Now

The Cinematic Joys Of The Last Of Us

Posted: 16 Aug 2012 01:56 AM PDT

Sony's The Last Of Us presentation wasn't the action-packed explosion frenzy expected, but boy was it good.

 

Get the full article at GameSpot

"The Cinematic Joys Of The Last Of Us" was posted by Mark Walton on Thu, 16 Aug 2012 01:56:30 -0700

Europa Universalis IV: The Original Grand Strategy Game

Posted: 16 Aug 2012 01:31 AM PDT

The king of strategy games is back! Paradox Studio manager Johan Andersson takes us through the newest features.

 

Read and Post Comments | Get the full article at GameSpot

"Europa Universalis IV: The Original Grand Strategy Game" was posted by Tyler on Thu, 16 Aug 2012 01:31:29 -0700

EA's Gamescom Press Conference in 5 Minutes

Posted: 16 Aug 2012 01:26 AM PDT

Want to know what EA is up to at Europe's biggest trade show? Guy and Chris break it down for you.

 

Read and Post Comments | Get the full article at GameSpot

"EA's Gamescom Press Conference in 5 Minutes" was posted by Tyler on Thu, 16 Aug 2012 01:26:08 -0700

EA's Frank Gibeau: "I've seen new consoles from Sony and Microsoft"

Posted: 16 Aug 2012 12:23 AM PDT

President of EA Labels confirms new hardware from major manufacturers; believes free-to-play will become the dominant pricing model for the industry.

 

The rumour mill regarding new hardware from both Microsoft and Sony has been particularly active of late. On Microsoft's side, general manager Brian Hall name-dropped a "new Xbox" earlier this month, while on Sony's side SCE UK boss Fergal Gara reaffirmed the company's commitment to retail "whenever the next cycle starts".

One key player for both consoles is EA's president of labels Frank Gibeau, whose company has pledged to spend $80 million on next-gen this year. And, during his keynote address at the Gamescom opening ceremony, Gibeau confirmed not only that new machines from both Microsoft and Sony exist, but that he has seen them.

"I've seen both of them", he teased during his speech about the future of the industry as he saw it. "Ten years ago we used to measure our market in terms of 200 million people. Now we are at a billion people playing games and we have a straight line view on 2 billion," he predicted.

Gibeau also reaffirmed EA's commitment to free-to-play, showing off the new Command & Conquer, which is built using developer DICE's Frostbite 2 engine. "Free to play will become the dominant pricing model by the end of the decade," he added.

Read and Post Comments | Get the full article at GameSpot

"EA's Frank Gibeau: "I've seen new consoles from Sony and Microsoft" " was posted by Guy Cocker on Thu, 16 Aug 2012 00:23:36 -0700

Rabbids Land Gamescom 2012 Trailer

Posted: 15 Aug 2012 10:45 PM PDT

Check out a Gamescom 2012 trailer for Rabbids Land, launching later this year for WiiU.

 

Read and Post Comments | Get the full article at GameSpot

"Rabbids Land Gamescom 2012 Trailer" was posted by MikeTao on Wed, 15 Aug 2012 22:45:55 -0700

SOEmote - EverQuest II Launch Trailer

Posted: 15 Aug 2012 10:42 PM PDT

SOEmote is now live for EverQuest II.

 

Read and Post Comments | Get the full article at GameSpot

"SOEmote - EverQuest II Launch Trailer" was posted by MikeTao on Wed, 15 Aug 2012 22:42:57 -0700

Marvel Avengers: Battle for Earth - Gamescom 2012 Trailer

Posted: 15 Aug 2012 10:08 PM PDT

Here's a German version of a Gamescom 2012 premiere trailer for Marvel Avengers: Battle for Earth.

 

Read and Post Comments | Get the full article at GameSpot

"Marvel Avengers: Battle for Earth - Gamescom 2012 Trailer" was posted by MikeTao on Wed, 15 Aug 2012 22:08:04 -0700

Final Fantasy VII - Legacy Trailer

Posted: 15 Aug 2012 10:03 PM PDT

Final Fantasy VII is available for download now.

 

Read and Post Comments | Get the full article at GameSpot

"Final Fantasy VII - Legacy Trailer" was posted by MikeTao on Wed, 15 Aug 2012 22:03:18 -0700

King's Bounty: Warriors of the North Gamescom 2012 Trailer

Posted: 15 Aug 2012 10:02 PM PDT

Check out the debut trailer for King's Bounty: Warriors of the North.

Read and Post Comments | Get the full article at GameSpot

"King's Bounty: Warriors of the North Gamescom 2012 Trailer" was posted by MikeTao on Wed, 15 Aug 2012 22:02:24 -0700

Far Cry 3 Gamescom 2012 Trailer

Posted: 15 Aug 2012 09:41 PM PDT

A Gamescom 2012 trailer for Far Cry 3 that's fittingly in German.

 

Read and Post Comments | Get the full article at GameSpot

"Far Cry 3 Gamescom 2012 Trailer" was posted by MikeTao on Wed, 15 Aug 2012 21:41:58 -0700

Dark Souls: Prepare to Die Edition - Gamescom 2012 Trailer

Posted: 15 Aug 2012 09:24 PM PDT

Check out a Gamescom 2012 premiere trailer for Dark Souls: Prepare to Die Edition.

 

Read and Post Comments | Get the full article at GameSpot

"Dark Souls: Prepare to Die Edition - Gamescom 2012 Trailer" was posted by MikeTao on Wed, 15 Aug 2012 21:24:17 -0700

Capcom Gamescom 2012 Mash-up

Posted: 15 Aug 2012 07:21 PM PDT

Missed the Capcom press conference but don't want to miss out on the best bits? Check out this mash up featuring crazy DMC action, Lost Planet 3 space beasties, and a very exciting new title.

 

Read and Post Comments | Get the full article at GameSpot

"Capcom Gamescom 2012 Mash-up" was posted by DanM on Wed, 15 Aug 2012 19:21:17 -0700

JFB, Vol. 3, Pages 588-600: Cell Growth on Different Types of Ultrananocrystalline Diamond Thin Films

Posted: 16 Aug 2012 12:00 AM PDT

Unique functional materials provide a platform as scaffolds for cell/tissue regeneration. Investigation of cell-materials' chemical and biological interactions will enable the application of more functional materials in the area of bioengineering, which provides a pathway to the novel treatment for patients who suffer from tissue/organ damage and face the limitation of donation sources. Many studies have been made into tissue/organ regeneration. Development of new substrate materials as platforms for cell/tissue regeneration is a key research area. Studies discussed in this paper focus on the investigation of novel ultrananocrystalline diamond (UNCD) films as substrate/scaffold materials for developmental biology. Specially designed quartz dishes have been coated with different types of UNCD films and cells were subsequently seeded on those films. Results showed the cells' growth on UNCD-coated culture dishes are similar to cell culture dishes with little retardation, indicating that UNCD films have no or little inhibition on cell proliferation and are potentially appealing as substrate/scaffold materials. The mechanisms of cell adhesion on UNCD surfaces are proposed based on the experimental results. The comparisons of cell cultures on diamond-powder-seeded culture dishes and on UNCD-coated dishes with matrix-assisted laser desorption/ionization—time-of-flight mass spectroscopy (MALDI-TOF MS) and X-ray photoelectron spectroscopy (XPS) analyses provided valuable data to support the mechanisms proposed to explain the adhesion and proliferation of cells on the surface of the UNCD platform.

Viruses, Vol. 4, Pages 1289-1304: Whole Genomic Analysis of Human G1P[8] Rotavirus Strains From Different Age Groups in China

Posted: 16 Aug 2012 12:00 AM PDT

G1P[8] rotaviruses are an important cause of diarrhea in humans in China. To date, there are no reports on the whole genomic analysis of the Chinese G1P[8] rotaviruses. To determine the origin and overall genetic makeup of the recent Chinese G1P[8] strains, the whole genomes of three strains, RVA/Human-wt/CHN/E1911/2009/G1P[8], RVA/Human-tc/CHN/R588/2005/G1P[8] and RVA/Human-tc/CHN/Y128/2004/G1P[8], detected in an infant, a child and an adult, respectively, were analyzed. Strains E1911, R588 and Y128 exhibited a typical Wa-like genotype constellation. Except for the NSP3 gene of E1911, the whole genomes of strains E1911, R588 and Y128 were found to be more closely related to those of the recent Wa-like common human strains from different countries than those of the prototype G1P[8] strain, or other old strains. On the other hand, the NSP3 gene of E1911 was genetically distinct from those of Y128, R588, or other Wa-like common human strains, and appeared to share a common origin with those of the porcine-like human G9 strains, providing evidence for intergenotype reassortment events. Comparisons of the amino acid residues defining the VP7 and VP4 antigenic domains revealed several mismatches between these Chinese G1P[8] strains and the G1 and P[8] strains contained in the currently licensed rotavirus vaccines RotarixTM and RotaTeqTM.

IJMS, Vol. 13, Pages 10257-10267: Evaluation of Antioxidant Properties and Mineral Composition of Purslane (Portulaca oleracea L.) at Different Growth Stages

Posted: 16 Aug 2012 12:00 AM PDT

The main objective of this research was to appraise the changes in mineral content and antioxidant attributes of Portulaca oleracea over different growth stages. The antioxidant activity was measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric-reducing antioxidant power (FRAP) assays. The iodine titration method was used to determine the ascorbic acid content (AAC). DPPH scavenging (IC50) capacity ranged from 1.30 ± 0.04 to 1.71 ± 0.04 mg/mL, while the ascorbic acid equivalent antioxidant activity (AEAC) values were 229.5 ± 7.9 to 319.3 ± 8.7 mg AA/100 g, total phenol content (TPC) varied from 174.5 ± 8.5 to 348.5 ± 7.9 mg GAE/100 g. AAC 60.5 ± 2.1 to 86.5 ± 3.9 mg/100 g and FRAP 1.8 ± 0.1 to 4.3 ± 0.1 mg GAE/g. There was good correlation between the results of TPC and AEAC, and between IC50 and FRAP assays (r2 > 0.9). The concentrations of Ca, Mg, K, Fe and Zn increased with plant maturity. Calcium (Ca) was negatively correlated with sodium (Na) and chloride (Cl), but positively correlated with magnesium (Mg), potassium (K), iron (Fe) and zinc (Zn). Portulaca olerecea cultivars could be used as a source of minerals and antioxidants, especially for functional food and nutraceutical applications.

IJMS, Vol. 13, Pages 10236-10256: The Complete Mitochondrial Genome of the Pink Stem Borer, Sesamia inferens, in Comparison with Four Other Noctuid Moths

Posted: 16 Aug 2012 12:00 AM PDT

The complete 15,413-bp mitochondrial genome (mitogenome) of Sesamia inferens (Walker) (Lepidoptera: Noctuidae) was sequenced and compared with those of four other noctuid moths. All of the mitogenomes analyzed displayed similar characteristics with respect to gene content, genome organization, nucleotide comparison, and codon usages. Twelve-one protein-coding genes (PCGs) utilized the standard ATN, but the cox1 gene used CGA as the initiation codon; cox1, cox2, and nad4 genes had the truncated termination codon T in the S. inferens mitogenome. All of the tRNA genes had typical cloverleaf secondary structures except for trnS1(AGN), in which the dihydrouridine (DHU) arm did not form a stable stem-loop structure. Both the secondary structures of rrnL and rrnS genes inferred from the S. inferens mitogenome closely resembled those of other noctuid moths. In the A+T-rich region, the conserved motif "ATAGA" followed by a long T-stretch was observed in all noctuid moths, but other specific tandem-repeat elements were more variable. Additionally, the S. inferens mitogenome contained a potential stem-loop structure, a duplicated 17-bp repeat element, a decuplicated segment, and a microsatellite "(AT)7", without a poly-A element upstream of the trnM in the A+T-rich region. Finally, the phylogenetic relationships were reconstructed based on amino acid sequences of mitochondrial 13 PCGs, which support the traditional morphologically based view of relationships within the Noctuidae.

IJMS, Vol. 13, Pages 10229-10235: Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors

Posted: 16 Aug 2012 12:00 AM PDT

We recently succeeded in purifying a novel multipotential progenitor or stem cell population from bone marrow stromal cells (BMSCs). This population exhibited a very high frequency of colony forming units-osteoblast (CFU-O; 100 times higher than in BMSCs) and high expression levels of osteoblast differentiation markers. Furthermore, large masses of mineralized tissue were observed in in vivo transplants with this new population, designated highly purified osteoprogenitors (HipOPs). We now report the detailed presence and localization of HipOPs and recipient cells in transplants, and demonstrate that there is a strong relationship between the mineralized tissue volume formed and the transplanted number of HipOPs.

IJMS, Vol. 13, Pages 10212-10228: Mitochondrial Adaptations to Oxidative Stress Confer Resistance to Apoptosis in Lymphoma Cells

Posted: 16 Aug 2012 12:00 AM PDT

Acquired resistance to drugs commonly used for lymphoma treatment poses a significant barrier to improving lymphoma patient survival. Previous work with a lymphoma tissue culture model indicates that selection for resistance to oxidative stress confers resistance to chemotherapy-induced apoptosis. This suggests that adaptation to chronic oxidative stress can contribute to chemoresistance seen in lymphoma patients. Oxidative stress-resistant WEHI7.2 cell variants in a lymphoma tissue culture model exhibit a range of apoptosis sensitivities. We exploited this phenotype to test for mitochondrial changes affecting sensitivity to apoptosis in cells made resistant to oxidative stress. We identified impaired release of cytochrome c, and the intermembrane proteins adenylate kinase 2 and Smac/DIABLO, indicating inhibition of the pathway leading to permeabilization of the outer mitochondrial membrane. Blunting of a glucocorticoid-induced signal and intrinsic mitochondrial resistance to cytochrome c release contributed to both points of resistance. The level of Bcl-2 family members or a difference in Bim induction were not contributing factors. The extent of cardiolipin oxidation following dexamethasone treatment, however, did correlate with apoptosis resistance. The differences found in the variants were all proportionate to the degree of resistance to glucocorticoid treatment. We conclude that tolerance to oxidative stress leads to mitochondrial changes that confer resistance to apoptosis.

IJMS, Vol. 13, Pages 10193-10211: Structural and Oxidative Changes in the Kidney of Crucian Carp Induced by Silicon-Based Quantum Dots

Posted: 16 Aug 2012 12:00 AM PDT

Silicon-based quantum dots were intraperitoneally injected in Carassius auratus gibelio specimens and, over one week, the effects on renal tissue were investigated by following their distribution and histological effects, as well as antioxidative system modifications. After three and seven days, detached epithelial cells from the basal lamina, dilated tubules and debris in the lumen of tubules were observed. At day 7, nephrogenesis was noticed. The reduced glutathione (GSH) concentration decreased in the first three days and started to rise later on. The superoxide dismutase (SOD) activity increased only after one week, whereas catalase (CAT) was up-regulated in a time-dependent manner. The activities of glutathione reductase (GR) and glutathione peroxidise (GPX) decreased dramatically by approximately 50% compared to control, whereas the glutathione-S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH) increased significantly after 3 and 7 days of treatment. Oxidative modifications of proteins and the time-dependent increase of Hsp70 expression were also registered. Our data suggest that silicon-based quantum dots induced oxidative stress followed by structural damages. However, renal tissue is capable of restoring its integrity by nephron development.
Автор: на

Комментариев нет:

Отправить комментарий

Подписаться на: Комментарии к сообщению (Atom)