четверг, 23 августа 2012 г.

Games

Games

Religions, Vol. 3, Pages 763-789: Charisma, Medieval and Modern

Posted: 23 Aug 2012 12:00 AM PDT

Popularized by the mass media, Max Weber's sociological concept of charisma now has a demotic meaning far from what Weber had in mind. Weberian charismatic leaders have followers, not fans, although, exceptionally, fans mutate into followers. This essay aims to trace some of the dimensions of Weberian charismatic religious leadership in comparative perspective, medieval and modern. Examples include: preachers, "double charisma," professors, "collective charisma," religious radicals, the economy of charisma, transgressive sexuality, demagogues, living saints.1

Entropy, Vol. 14, Pages 1578-1605: Stability of Accelerating Cosmology in Two Scalar-Tensor Theory: Little Rip versus de Sitter

Posted: 23 Aug 2012 12:00 AM PDT

We develop the general reconstruction scheme in two scalar model. The quintom-like theory which may describe (different) non-singular Little Rip or de Sitter cosmology is reconstructed. The number of scalar phantom dark energy models (with Little Rip cosmology or asymptotically de Sitter evolution) is presented. Stability issue of such dark energy cosmologies as well as the flow to fixed points are studied. The stability of Little Rip universe which leads to dissolution of bound objects sometime in future indicates that no classical transition to de Sitter space occurs. The possibility of unification of inflation with Little Rip dark energy in two scalar theory is briefly mentioned.

IJMS, Vol. 13, Pages 10647-10659: Molecular Mechanisms of Oligodendrocyte Injury in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Posted: 23 Aug 2012 12:00 AM PDT

New evidence has emerged over the last decade indicating that oligodendrocyte injury in multiple sclerosis (MS) is not a single unified phenomenon but rather a spectrum of processes ranging from massive immune destruction to a subtle cell death in the absence of significant inflammation. Experimentally, protection of oligodendrocytes against inflammatory injury results in protection against experimental autoimmune encephalitis, the animal model of multiple sclerosis. In this review, we will discuss the molecular mechanisms regulating oligodendrocyte injury and inflammatory demyelination. We draw attention to the injurious role of IFN-γ signaling in oligodendrocytes and the pro-inflammatory effect of their death. In conclusion, studying the molecular mechanisms of oligodendrocyte injury is likely to provide new perspective on the pathogenesis of MS and a rationale for cell protective therapies.

The 33 absolute worst photos from Gamescom 2012

Posted: 23 Aug 2012 02:54 AM PDT

Gamescom viewed through a lens pointing at the other end of the awesome-scale

LEGO Harry Potter: Years 5-7 - Screenshots

Posted: 23 Aug 2012 03:34 AM PDT

Fact sheet pending.

IJMS, Vol. 13, Pages 10630-10646: Optimization of Xylanase Production from Penicillium sp.WX-Z1 by a Two-Step Statistical Strategy: Plackett-Burman and Box-Behnken Experimental Design

Posted: 23 Aug 2012 12:00 AM PDT

The objective of the study was to optimize the nutrition sources in a culture medium for the production of xylanase from Penicillium sp.WX-Z1 using Plackett-Burman design and Box-Behnken design. The Plackett-Burman multifactorial design was first employed to screen the important nutrient sources in the medium for xylanase production by Penicillium sp.WX-Z1 and subsequent use of the response surface methodology (RSM) was further optimized for xylanase production by Box-Behnken design. The important nutrient sources in the culture medium, identified by the initial screening method of Placket-Burman, were wheat bran, yeast extract, NaNO3, MgSO4, and CaCl2. The optimal amounts (in g/L) for maximum production of xylanase were: wheat bran, 32.8; yeast extract, 1.02; NaNO3, 12.71; MgSO4, 0.96; and CaCl2, 1.04. Using this statistical experimental design, the xylanase production under optimal condition reached 46.50 U/mL and an increase in xylanase activity of 1.34-fold was obtained compared with the original medium for fermentation carried out in a 30-L bioreactor.

Entropy, Vol. 14, Pages 1553-1577: Permutation Entropy and Its Main Biomedical and Econophysics Applications: A Review

Posted: 23 Aug 2012 12:00 AM PDT

Entropy is a powerful tool for the analysis of time series, as it allows describing the probability distributions of the possible state of a system, and therefore the information encoded in it. Nevertheless, important information may be codified also in the temporal dynamics, an aspect which is not usually taken into account. The idea of calculating entropy based on permutation patterns (that is, permutations defined by the order relations among values of a time series) has received a lot of attention in the last years, especially for the understanding of complex and chaotic systems. Permutation entropy directly accounts for the temporal information contained in the time series; furthermore, it has the quality of simplicity, robustness and very low computational cost. To celebrate the tenth anniversary of the original work, here we analyze the theoretical foundations of the permutation entropy, as well as the main recent applications to the analysis of economical markets and to the understanding of biomedical systems.

IJMS, Vol. 13, Pages 10608-10629: Recent Advances on the Neuroprotective Potential of Antioxidants in Experimental Models of Parkinson’s Disease

Posted: 23 Aug 2012 12:00 AM PDT

Parkinson's disease (PD), a neurodegenerative movement disorder of the central nervous system (CNS) is characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain. Although the etiology of PD is not completely understood and is believed to be multifactorial, oxidative stress and mitochondrial dysfunction are widely considered major consequences, which provide important clues to the disease mechanisms. Studies have explored the role of free radicals and oxidative stress that contributes to the cascade of events leading to dopamine cell degeneration in PD. In general, in-built protective mechanisms consisting of enzymatic and non-enzymatic antioxidants in the CNS play decisive roles in preventing neuronal cell loss due to free radicals. But the ability to produce these antioxidants decreases with aging. Therefore, antioxidant therapy alone or in combination with current treatment methods may represent an attractive strategy for treating or preventing the neurodegeneration seen in PD. Here we summarize the recent discoveries of potential antioxidant compounds for modulating free radical mediated oxidative stress leading to neurotoxicity in PD.

IJMS, Vol. 13, Pages 10594-10607: Antisense Oligonucleotide Against Clusterin Regulates Human Hepatocellular Carcinoma Invasion Through Transcriptional Regulation of Matrix Metalloproteinase-2 and E-Cadherin

Posted: 23 Aug 2012 12:00 AM PDT

Secreted clusterin (sCLU) has been shown to be overexpressed in metastatic hepatocellular carcinoma (HCC) tissue, and its overexpression in HCC cells increases cell migration and the formation of liver metastatic tumor nodules in vivo. In this study, we tested the hypothesis that sCLU plays a role in the invasiveness of human HCC and may be associated with its metastatic spread. HCCLM3, a human hepatocellular carcinoma cell line, was transiently transfected with an antisense oligonucleotide (ASO) against sCLU (OGX-011). HepG2 liver hepatocellular cells were transiently transfected with the pc.DNA3.1-sCLU plasmid to overexpress sCLU, and subsequently evaluated for effects on invasion and the expression of molecules involved in invasion. We observed that suppression of the sCLU gene significantly reduced the invasive capability of the highly invasive HCCLM3 cells, and vice versa in the low invasive HepG2 cell line. The results revealed that knockdown of sCLU by OGX-011 resulted in a significant increase in the expression of E-cadherin and a decrease in matrix metalloproteinase-2 (MMP-2) gene transcription. Overexpression of sCLU by transfection with pc.DNA3.1-sCLU significantly decreased the expression of E-cadherin and increased MMP-2 gene transcription. These data were further verified by reverse transcription-PCR and Western blot analysis. A significant reduction in MMP-2 expression and an increase in E-cadherin expression in sCLU-knockdown HCCLM3 cells were observed, as well as a significant increase in MMP-2 expression and a decrease in E-cadherin expression in HepG2 cells overexpressing sCLU. These data indicate a role for sCLU in augmenting MMP-2 transcription and decreasing E-cadherin expression. Our data show the involvement of sCLU in human HCC invasion, and demonstrate that silencing sCLU gene expression inhibits the invasion of human HCC cells by inhibiting MMP-2 expression and promoting E-cadherin expression. Thus, OGX-011 could be an effective therapeutic agent for HCC.

GameSpot Asia Beat Ep. 8: They're All Going To LOL At You

Posted: 23 Aug 2012 01:01 AM PDT

We speak up about League of Legends and discuss what makes it so special among MOBA fans. We also bring up Team Fortress 2, Darksiders II and Sleeping Dogs.

 

Get the full article at GameSpot

"GameSpot Asia Beat Ep. 8: They're All Going To LOL At You" was posted by Jonathan Toyad on Thu, 23 Aug 2012 01:01:30 -0700

PlayStation 4 to support 4K resolution - Report

Posted: 22 Aug 2012 10:09 PM PDT

BGR reports Sony is planning to implement 4K resolution in its upcoming console as a way to draw consumers to 4K television sets.

 

Sony is reportedly planning to double the resolution of the PlayStation 3 for its next generation console, according to consumer electronics news site BGR.

BGR cites an anonymous source who reportedly told the site that Sony is planning to implement 4K resolution in the PlayStation 4, following the publisher's reportedly planned line-up of 80-inch XBR LED television sets sporting the same resolution. 4K has a horizontal pixel count of 4096, and is double the resolution of 1080p.

BGR claims Sony is implementing a larger scheme to push out 4K to consumers, liking it to the publisher's earlier efforts with 3D. The site says Sony's move to include support for 4K resolution media like games and movies in its next-gen console is part of an incentive to draw consumers to 4K television sets.

Development on the PlayStation 4 has been tracked back to 2010. Regarding when gamers might see the PS4, PlayStation CEO Andrew House has previously stated the publisher won't show the new hardware until it can demonstrate a "significant" leap over the PS3.

An analyst report predicts both Sony and Microsoft will have their respective future-generation consoles on store shelves by the end of next year. Sony's PS4 is rumored to boast the same graphics card as Microsoft's next Xbox.

For more on the PS4, check out GameSpot's rumor roundup feature.

Read and Post Comments | Get the full article at GameSpot

"PlayStation 4 to support 4K resolution - Report" was posted by Laura Parker on Wed, 22 Aug 2012 22:09:35 -0700

Ben 10: Alien Escape - Screenshots

Posted: 23 Aug 2012 03:14 AM PDT

Play as Jetray, Stinkfly and Big Chill as you fly through three different worlds in over 45 levels filled with mechanical menaces! Dodge laser turrets, zoom through closing gaps and shoot past heavy slammers to reach the finish line!

Earn Energy as you go to upgrade and earn powerful Alien abilities. Increase your speed and agility or crush your enemies with the Power Blast! Watch out for the new Underwater stage - coming soon featuring Ripjaws!

Critter Escape - Screenshots

Posted: 23 Aug 2012 03:21 AM PDT

FEATURES
• Stealth gameplay and puzzling levels test your brains and reaction speed.
• Cute central character with hilarious animations.
• Crazy, mutating power-ups change the way you play the game.
• Over 120 unique levels to escape from.
• Universal; will work on iPhone, iPod touch, and iPad.

Materials, Vol. 5, Pages 1508-1527: Heterogeneous Coordination Environments in Lithium-Neutralized Ionomers Identified Using 1H and 7Li MAS NMR

Posted: 23 Aug 2012 12:00 AM PDT

The carboxylic acid proton and the lithium coordination environments for precise and random Li-neutralized polyethylene acrylic acid P(E-AA) ionomers were explored using high speed solid-state 1H and 7Li MAS NMR. While the 7Li NMR revealed only a single Li coordination environment, the chemical shift temperature variation was dependent on the precise or random nature of the P(E-AA) ionomer. The 1H MAS NMR revealed two different carboxylic acid proton environments in these materials. By utilizing 1H-7Li rotational echo double resonance (REDOR) MAS NMR experiments, it was demonstrated that the proton environments correspond to different average 1H-7Li distances, with the majority of the protonated carboxylic acids having a close through space contact with the Li. Molecular dynamics simulations suggest that the shortest 1H-7Li distance corresponds to un-neutralized carboxylic acids directly involved in the coordination environment of Li clusters. These solid-state NMR results show that heterogeneous structural motifs need to be included when developing descriptions of these ionomer materials.

Materials, Vol. 5, Pages 1495-1507: Strain Measurements within Fibre Boards. Part II: Strain Concentrations at the Crack Tip of MDF Specimens Tested by the Wedge Splitting Method

Posted: 23 Aug 2012 12:00 AM PDT

This is the second part of an article series where the mechanical and fracture mechanical properties of medium density fiberboard (MDF) were studied. While the first part of the series focused on internal bond strength and density profiles, this article discusses the fracture mechanical properties of the core layer. Fracture properties were studied with a wedge splitting setup. The critical stress intensity factors as well as the specific fracture energies were determined. Critical stress intensity factors were calculated from maximum splitting force and two-dimensional isotropic finite elements simulations of the specimen geometry. Size and shape of micro crack zone were measured with electronic laser speckle interferometry. The process zone length was approx. 5 mm. The specific fracture energy was determined to be 45.2 ± 14.4 J/m2 and the critical stress intensity factor was 0.11 ± 0.02 MPa.

iAntivirus 1.1 - Protect your Mac from viruses.. (Free)

Posted: 23 Aug 2012 12:09 AM PDT



iAntivirus is essential virus protection built exclusively for your Mac. This simple yet powerful on-demand malware and virus scanner from Norton helps ensure you are protected from the latest threats. The all-new iAntivirus protects your iPhoto pictures, iTunes music and all of your Apple Stuff you can't live without. iAntivirus also scans your Facebook wall for malicious links to keep you protected from online fraud. iAntivirus includes definitions for both Mac and Windows threats. Updates to these definitions will be delivered regularly through Mac App Store updates.

Key features of iAntivirus:

  • Award-winning technology blocks threats before they damage your Mac, iPhoto® pictures, iTunes® media and other important Stuff.
  • Innovative "carousel" interfaces lets you use two fingers to swipe between your home folder and full system and other scanning options.
  • Lets you quickly and easily scan files by simply dragging and dropping them onto iAntivirus.
  • Built for speed from the ground up, so it won't get in the way of your Mac experience.
  • Works seamlessly against Windows threats too, to make sure the documents you share are safe for everyone.
  • Updates available regularly through the App Store to help detect the latest breaking threats.
Online threats targeting Macs are on the rise and iAntivirus is your first line of defense. It delivers essential protection to keep your Mac and your Stuff safe from the latest viruses.

Version 1.1:
  • Updated Virus and Malware Definitions
  • Option to display detailed description of threats
  • Improved organization of threats
  • Localization for Japanese-speaking users


  • OS X 10.6 or later
  • 64-bit processor


Download Now

Nukotoys latest to link virtual games with physical toys

Posted: 22 Aug 2012 10:50 PM PDT

For the digitally obsessed youth of so-called Generation Z, what is the definition of a toy? That's the question that Rodger Raderman and Doug Penman set out to answer in 2009 when the two parents founded a company called Nukotoys in San Francisco.

WiFiSpoof 1.0.3 - Change your WiFi MAC address.. (Free)

Posted: 22 Aug 2012 11:17 PM PDT



WiFiSpoof quickly and easily allows you to change your WiFi Mac address via HotKey or the System MenuBar.

Version 1.0.3:
  • Authentication dialog is now key when activated
  • Reorganized menu
  • Added an option to randomize address from menu


  • OS X 10.7 or later
  • 64-bit processor


Download Now

This posting includes an audio/video/photo media file: Download Now

DesktopUtility 1.2.8 - Quickly access useful system tasks.. (Free)

Posted: 22 Aug 2012 11:11 PM PDT



DesktopUtility is a tiny menubar application that allows you to hide your desktop, toggle file visibility, show your User Library (OS X 10.7+) or force empty the trash, easily and conveniently from the system menu bar.

Version 1.2.8:
  • Secure Delete authentication window is now key when activated


Mac OS X 10.6.6 or later

Download Now

This posting includes an audio/video/photo media file: Download Now

AUTOS: Barrett-Jackson Collector-Car Auction: Next Stop, Las Vegas

Posted: 23 Aug 2012 12:00 AM PDT


The fifth-annual collector-car auction gears up for the Sept. 20-22 event, with 20 hours of live coverage on SPEED TV.
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