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- Energies, Vol. 5, Pages 2849-2873: Submarine Slope Failure Primed and Triggered by Bottom Water Warming in Oceanic Hydrate-Bearing Deposits
- F1 2012: Turning an already great simulation into a better video game
- Water, Vol. 4, Pages 580-596: Grey Water Reuse for Agricultural Purposes in the Jordan Valley: Household Survey Results in Deir Alla
- Future Internet, Vol. 4, Pages 688-699: Traditional Practice vs. New Tools and Routines in Stroke Treatment
- Religions, Vol. 3, Pages 662-680: Saving Renaissance and Reformation: History, Grammar, and Disagreements with the Dead
- Religions, Vol. 3, Pages 646-661: Penitence, Confession, and the Power of Submission in Late Medieval Women's Religious Communities
- Forests, Vol. 3, Pages 614-631: Spatio-Temporal Trends of Oak Decline and Mortality under Periodic Regional Drought in the Ozark Highlands of Arkansas and Missouri
- The Chaos Within Sudoku - a Richter Scale of Difficulty
- UltraMixer 4.0.0 - Pro DJ mixing software (beta).. (Demo)
- Glims 1.0 - Optimize Safari with an array of supplementary features (beta).. (Free)
- Molecules, Vol. 17, Pages 9421-9425: A New Natural Lactone from Dimocarpus longan Lour. Seeds
- Molecules, Vol. 17, Pages 9413-9420: N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study
- IJMS, Vol. 13, Pages 9785-9797: The Metalloporphyrin Antioxidant, MnTE-2-PyP, Inhibits Th2 Cell Immune Responses in an Asthma Model
- IJMS, Vol. 13, Pages 9769-9784: Structural and Catalytic Differences between Two FADH2-Dependent Monooxygenases: 2,4,5-TCP 4-Monooxygenase (TftD) from Burkholderia cepacia AC1100 and 2,4,6-TCP 4-Monooxygenase (TcpA) from Cupriavidus necator JMP134
- IJMS, Vol. 13, Pages 9754-9768: Constituents from Vigna vexillata and Their Anti-Inflammatory Activity
- Sensors, Vol. 12, Pages 10820-10833: A Linear, Millimetre Displacement-to-Frequency Transducer
- Sensors, Vol. 12, Pages 10810-10819: Development of a Plastic-Based Microfluidic Immunosensor Chip for Detection of H1N1 Influenza
- id Software closes mobile operations to focus on Doom 4
- Monolingual 1.5.1 - Remove unwanted OS X language resources.. (Free)
- Sensors, Vol. 12, Pages 10788-10809: Vision-Based Sensor for Early Detection of Periodical Defects in Web Materials
| Posted: 06 Aug 2012 12:00 AM PDT Many submarine slope failures in hydrate-bearing sedimentary deposits might be directly triggered, or at least primed, by gas hydrate dissociation. It has been reported that during the past 55 years (1955–2010) the 0–2000 m layer of oceans worldwide has been warmed by 0.09 °C because of global warming. This raises the following scientific concern: if warming of the bottom water of deep oceans continues, it would dissociate natural gas hydrates and could eventually trigger massive slope failures. The present study explored the submarine slope instability of oceanic gas hydrate-bearing deposits subjected to bottom water warming. One-dimensional coupled thermal-hydraulic-mechanical (T-H-M) finite difference analyses were performed to capture the underlying physical processes initiated by bottom water warming, which includes thermal conduction through sediments, thermal dissociation of gas hydrates, excess pore pressure generation, pressure diffusion, and hydrate dissociation against depressurization. The temperature rise at the seafloor due to bottom water warming is found to create an excess pore pressure that is sufficiently large to reduce the stability of a slope in some cases. Parametric study results suggest that a slope becomes more susceptible to failure with increases in thermal diffusivity and hydrate saturation and decreases in pressure diffusivity, gas saturation, and water depth. Bottom water warming can be further explored to gain a better understanding of the past methane hydrate destabilization events on Earth, assuming that more reliable geological data is available. |
| F1 2012: Turning an already great simulation into a better video game Posted: 06 Aug 2012 03:00 AM PDT From a F1 fan's point of view, Codemasters Birmingham is the best thing that could have happened to the official F1 video game license. The team |
| Posted: 06 Aug 2012 12:00 AM PDT Installation of decentralized grey water treatment systems in small rural communities contributes to a more sustainable water supply. In order to gauge community attitudes about collection and use of grey water, a door-to-door survey in the farming community of Deir Alla, Jordan was conducted by Royal Scientific Society interviewers. Outcomes of a detailed survey, designed specifically for this project, offer insights on people's views on general water and wastewater issues, as well as their motivation, practices and concerns related to using grey water treatment for a portion of their household wastewater and reuse of the treated grey water for irrigation. A total of 47 respondents from different socio-economic background, aged over 18 years, from this community in the Jordan valley took part in the survey. The level of formal education of the respondents was low, and most of households' incomes were below the poverty line in Jordan. Most of the respondents reported that the quality of water supplied by public network is acceptable, but the quantity is insufficient to meet their demand, with supplies being delivered to the household once a week. Respondents relied on the public water network as a first-most important resource (85.1%), and 57.4% of the respondent relied on private water tankers as a second-most important resource in addition to the public network. However, 6% of the respondents relied only on private water tankers with no access to the public network. Storage tanks are common practice in all the houses in order to store enough water for at least one week. The survey responses provide evidence that rural communities are willing to accept reuse of treated grey water for irrigation. Furthermore, some of people in the studied area are willing to learn more about grey water treatment and reuse in order to operate grey water systems for irrigation purposes. Water scarcity in this rural area of Jordan is the main determinant of willingness to reuse the grey water, rather than socio-economic variables. |
| Posted: 06 Aug 2012 12:00 AM PDT In Norway, it is a national goal to provide more patients with thrombolytic treatment. A referring hospital and a specialist hospital have implemented videoconferencing (VC) equipment to share knowledge and discuss stroke patients, regarding thrombolytic treatment. VC has only been used four times within the 19 months that the service has been available. The objective in this article is to increase the understanding of the contradiction between the need for knowledge-sharing through VC technology, as well as the reasons for low frequency of use when discussing stroke patients. Semi-structured interviews were conducted with 13 professionals. The results illustrate how the technology per se is not the reason for the low frequency use. Health care is shaped by behavior, traditional rules, standards and division of labor. By using cultural historical activity theory (CHAT) as a framework, we illustrate the importance of understanding the historic way of performing an activity to be able to expand the treatment activity in the future. |
| Posted: 06 Aug 2012 12:00 AM PDT Renaissance and Reformation used to serve historians as the main terms with which to refer to European history from roughly 1300–1600. Today those terms are commonly replaced with early modern history, and the periodization of European history into ancient, medieval, and modern periods itself is looking increasingly suspect. There are good reasons for those changes. But they obscure both the significance of disagreements dividing the living from the dead and the significance of grammar, in the fundamental sense of grammar advanced by Wittgenstein, for treating such disagreements. Renaissance and Reformation have the advantage of doing just the opposite: they confront us with both those disagreements and the significance of grammar. That makes them very much worth keeping. |
| Posted: 06 Aug 2012 12:00 AM PDT This article argues that depictions of penance and confession in late medieval "Sisterbooks," which were written by women religious for communal use, show that medieval women understood religious authority to be enhanced through submission and service to community members. These collections of the lives and reminiscences of deceased sisters and father confessors construct idealized piety and religious authority through public acts of obedience and submission which built a reputation for sanctity, not just for the individual penitent, but for her entire community. Thus in the Sisterbooks, obedience to a confessor or spiritual director for both male and female penitents shifts the locus of spiritual authority from the confessor to the penitent and her community through communal observation and evaluation. These medieval Christian women understood the relationships between confessors and confessants as one which conferred power and authority to the penitent, complicating Foucault's influential claim that the sacrament of confession granted all power to the confessor who heard sins in secret. In the Sisterbooks, interactions between women religious and their confessors are depicted as relational, complex, and constantly in flux. |
| Posted: 06 Aug 2012 12:00 AM PDT At the forest landscape/region level, based on annual Forest Inventory and Analysis plot data from 1999 to 2010, oak decline and mortality trends for major oak species (groups) were examined in the Ozark Highlands of Arkansas and Missouri. Oak decline has elevated cumulative mortality of red oak species to between 11 and 15 percent in terms of relative density and basal area of standing dead oak trees, respectively. These values are three to five times higher than for white oak group and non-oak species. Oak decline and associated escalating mortality have occurred primarily in red oak species while the white oak group has maintained a relatively stable mortality rate that is comparable to non-oak species. Cross-correlation analyses indicate that mortality in the red oak group was significantly correlated with the growing season Palmer drought severity index (PDSI) and usually lagged two to three years following single drought events. Moreover, based on the past 17 years PDSI data, it appears that the cumulative impacts of drought may last up to 10 years. The Ozark Highlands experienced a severe drought extending from 1998 to 2000 and another milder drought from 2005 to 2006. These drought events triggered the escalation of mortality starting around year 2000. Spatially, high red oak mortality sites (hot spots with proportional basal area mortality > 0.12) initially occurred in the central Ozarks and spread gradually over most of the Ozark Highlands as regional droughts continued. In contrast, sites with elevated white oak and non-oak mortality occurred sporadically, mainly in the southern portion (Arkansas) of the Ozark Highlands. During the most recent inventory period (2006–2010), over 60%, 7% and 5% of red oak, white oak and non-oak groups, respectively, had relative mortality rates of > 12%. |
| The Chaos Within Sudoku - a Richter Scale of Difficulty Posted: 06 Aug 2012 02:22 AM PDT But before we go into the detail let's look at what this means for Sudoku enthusiasts. |
| UltraMixer 4.0.0 - Pro DJ mixing software (beta).. (Demo) Posted: 06 Aug 2012 02:00 AM PDT  UltraMixer is a professional DJ mixing software which enables you to mix digital music in various formats such as MP3, WMA, OGG, WAV or CDs in real time. All you need is a sound card. The DJ's turntables are replaced by two digital SoundPlayers, the "vinyls" are available within seconds through the integrated FileArchive. No matter whether you want to use UltraMixer for a professional gig or at a private party or as virtual jukebox in restaurants, hair studios or medical surgeries - it will prove the right choice! UltraMixer is the first DJ software in the world that is available for the most popular operating systems: Mac OS X, Linux, and Windows. There are three versions of UltraMixer available: the Free-Edition and the Basic-Edition for private users and the Advanced-Edition for high demands and commerical use. All versions are integrated in one program, and can be activated through the appropriate licence keys. This enables the user to switch to a more advanced version without any problems. Version 4.0.0: Release notes were unavailable when this listing was updated. Mac OS X 10.6 or later Download Now |
| Glims 1.0 - Optimize Safari with an array of supplementary features (beta).. (Free) Posted: 06 Aug 2012 02:13 AM PDT  Glims adds a cocktail of features to Safari (Tabs, Thumbnails, Full Screen, Search Engines, Search Suggestions, Forms autocomplete on, Dated download folders, Type Ahead ...) Current features list:
Pre-Safari 5.1 only:
Version 1.0 (build 34): Safari 6:
New and Fixed:
Download Now This posting includes an audio/video/photo media file: Download Now |
| Molecules, Vol. 17, Pages 9421-9425: A New Natural Lactone from Dimocarpus longan Lour. Seeds Posted: 06 Aug 2012 12:00 AM PDT A new natural product named longanlactone was isolated from Dimocarpus longan Lour. seeds. Its structure was determined as 3-(2-acetyl-1H-pyrrol-1-yl)-5-(prop-2-yn-1-yl)dihydrofuran-2(3H)-one by spectroscopic methods and HRESIMS. |
| Posted: 06 Aug 2012 12:00 AM PDT A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed. |
| Posted: 06 Aug 2012 12:00 AM PDT MnTE-2-PyP, a superoxide dismutase mimetic, inhibited OVA-induced airway inflammation in mice suggesting an effect on Th2 responsiveness. Thus, we hypothesized that MnTE-2-PyP may alter dendritic cell-Th2 interactions. Bone marrow derived dendritic cells (DC) and OVA323-339-specific Th2 cells were cultured separately in the presence or absence of MnTE-2-PyP for 3 days prior to the co-culturing of the two cell types in the presence of an OVA323-339 peptide and in some cases stimulated with CD3/CD28. MnTE-2-PyP-pretreated DC inhibited IL-4, IL-5 and IFNγ production and inhibited Th2 cell proliferation in the DC-Th2 co-culturing system in the presence of the OVA323-339 peptide. Similar results were obtained using the CD3/CD28 cell-activation system; the addition of MnTE-2-PyP inhibited Th2 cell proliferation. MnTE-2-PyP suppressed CD25 expression on OVA-specific Th2 cells, which implied that MnTE-2-PyP can inhibit the activation of Th2 cells. MnTE-2-PyP also down-regulated co-stimulatory molecules: CD40, CD80 and CD86 on immature DC. Our studies suggest that the major mechanism by which MnTE-2-PyP inhibits airway inflammation is by acting on the DC and suppressing Th2 cell proliferation and activation. |
| Posted: 06 Aug 2012 12:00 AM PDT 2,4,5-TCP 4-monooxygenase (TftD) and 2,4,6-TCP 4-monooxygenase (TcpA) have been discovered in the biodegradation of 2,4,5-trichlorophenol (2,4,5-TCP) and 2,4,6-trichlorophenol (2,4,6-TCP). TcpA and TftD belong to the reduced flavin adenine dinucleotide (FADH2)-dependent monooxygenases and both use 2,4,6-TCP as a substrate; however, the two enzymes produce different end products. TftD catalyzes a typical monooxygenase reaction, while TcpA catalyzes a typical monooxygenase reaction followed by a hydrolytic dechlorination. We have previously reported the 3D structure of TftD and confirmed the catalytic residue, His289. Here we have determined the crystal structure of TcpA and investigated the apparent differences in specificity and catalysis between these two closely related monooxygenases through structural comparison. Our computational docking results suggest that Ala293 in TcpA (Ile292 in TftD) is possibly responsible for the differences in substrate specificity between the two monooxygenases. We have also identified that Arg101 in TcpA could provide inductive effects/charge stabilization during hydrolytic dechlorination. The collective information provides a fundamental understanding of the catalytic reaction mechanism and the parameters for substrate specificity. The information may provide guidance for designing bioremediation strategies for polychlorophenols, a major group of environmental pollutants. |
| Posted: 06 Aug 2012 12:00 AM PDT The seeds of Vigna genus are important food resources and there have already been many reports regarding their bioactivities. In our preliminary bioassay, the chloroform layer of methanol extracts of V. vexillata demonstrated significant anti-inflammatory bioactivity. Therefore, the present research is aimed to purify and identify the anti-inflammatory principles of V. vexillata. One new sterol (1) and two new isoflavones (2,3) were reported from the natural sources for the first time and their chemical structures were determined by the spectroscopic and mass spectrometric analyses. In addition, 37 known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. Among the isolates, daidzein (23), abscisic acid (25), and quercetin (40) displayed the most significant inhibition of superoxide anion generation and elastase release. |
| Sensors, Vol. 12, Pages 10820-10833: A Linear, Millimetre Displacement-to-Frequency Transducer Posted: 06 Aug 2012 12:00 AM PDT The paper presents a novel linear, high-fidelity millimetre displacement-to-frequency transducer, based on the resistive conversion of displacement into a proportional voltage, and then frequency. The derivation of the nonlinearity, fidelity and sensitivity of the transducer is presented. Experimental results confirm that a displacement of 0–100 mm is converted into a frequency range of 0–100 kHz, with a normalised fidelity factor of 99.91%, and a worst-case nonlinearity of less than 0.08%. Tests using laboratory standards show that a displacement of 10 mm is transduced with an accuracy of ±0.6%, and a standard deviation of 530 Hz. Estimates included in the paper show that the transducer could cost less than 1% of existing systems for millimeter displacement measurement. |
| Posted: 06 Aug 2012 12:00 AM PDT Lab-on-a-chip can provide convenient and accurate diagnosis tools. In this paper, a plastic-based microfluidic immunosensor chip for the diagnosis of swine flu (H1N1) was developed by immobilizing hemagglutinin antigen on a gold surface using a genetically engineered polypeptide. A fluorescent dye-labeled antibody (Ab) was used for quantifying the concentration of Ab in the immunosensor chip using a fluorescent technique. For increasing the detection efficiency and reducing the errors, three chambers and three microchannels were designed in one microfluidic chip. This protocol could be applied to the diagnosis of other infectious diseases in a microfluidic device. |
| id Software closes mobile operations to focus on Doom 4 Posted: 05 Aug 2012 07:06 PM PDT id Software co-founder John Carmack confirmed during QuakeCon 2012 that his studio has shut down its mobile gaming division to concentrate on completing Doom 4.
id Software co-founder and technical director John Carmack has confirmed that the studio has closed down its mobile gaming operations in order to focus on the development of Doom 4.
Carmack revealed his studio's decision during his keynote speech at this year's QuakeCon. "We did make the decision to close up our mobile development, which saddens me a lot, in that I love doing the mobile work," Carmack said during his keynote. "But we had some developers on there that we wanted to bring on to the Doom 4 project. "I hope we get back to mobile in various ways in the future, but the big real aim is blockbuster, AAA titles, and for id that means Doom 4." Carmack revealed that his studio is sitting on a finished iOS project, but gave no more details. The studio head also stayed silent on the topic of Doom 4's release date, saying that the project "will be done when it's done", and that "every decade, there will be a Doom, but hopefully we can do better than that". Doom 4 has been the subject of several cancellation rumours over the last two years. Last October, word spread that Doom 4 was "indefinitely postponed. At the time, Bethesda replied by saying: "Games are done when they are done, and no title under development at id has been postponed--indefinitely or otherwise." The publisher was again forced to reassure gamers of Doom 4's existence earlier this year, saying: "Doom 4 is not cancelled. When we are ready to talk about it, we'll let folks know." The game's existence was first acknowledged in May 2008, when the developer sent out a press release stating that production had begun on the game. At the 2011 Electronic Entertainment Expo (E3), Carmack said that the core team on Rage would move to Doom 4 development following the release of its latest shooter. Read and Post Comments | Get the full article at GameSpot "id Software closes mobile operations to focus on Doom 4" was posted by Laura Parker on Sun, 05 Aug 2012 19:06:15 -0700 |
| Monolingual 1.5.1 - Remove unwanted OS X language resources.. (Free) Posted: 05 Aug 2012 08:59 PM PDT  Monolingual is a program for removing unnecesary language resources from Mac OS X, in order to reclaim several hundred megabytes of disk space. It requires at least Mac OS X 10.5 (Leopard) and also works on Mac OS X 10.6 (Snow Leopard). I don't know about you, but I use my computer in only one (human) language--English. And I'm willing to bet that you do too, albeit perhaps not English. So why do you have a bunch of localization files for the Mac OS X operating system filling up your hard drive? Enter Monolingual -- a handy utility for reclaiming your space for more useful things...like international mp3 files, email or whatever you like. Monolingual was written by J. Schrier and I. Stein, and is released under the GNU General Public License. Source code is available. Japanese localization by Takehiko Hatatani, Polish localization by Mariusz Ostrowski, Swedish localization by Joel Arvidsson, German localization and documentation by Alex Thurley and Ingmar Stein, Icon by Adam Betts.
Mac OS X 10.7 or later Download Now |
| Posted: 06 Aug 2012 12:00 AM PDT During the production of web materials such as plastic, textiles or metal, where there are rolls involved in the production process, periodically generated defects may occur. If one of these rolls has some kind of flaw, it can generate a defect on the material surface each time it completes a full turn. This can cause the generation of a large number of surface defects, greatly degrading the product quality. For this reason, it is necessary to have a system that can detect these situations as soon as possible. This paper presents a vision-based sensor for the early detection of this kind of defects. It can be adapted to be used in the inspection of any web material, even when the input data are very noisy. To assess its performance, the sensor system was used to detect periodical defects in hot steel strips. A total of 36 strips produced in ArcelorMittal Avilés factory were used for this purpose, 18 to determine the optimal configuration of the proposed sensor using a full-factorial experimental design and the other 18 to verify the validity of the results. Next, they were compared with those provided by a commercial system used worldwide, showing a clear improvement. |
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