Games |
- All you need to write. Truly write. 1.0.2 - Clean and clutter-free text production.. (Demo)
- Sensors, Vol. 12, Pages 10930-10946: A Beacon Interval Shifting Scheme for Interference Mitigation in Body Area Networks
- Sensors, Vol. 12, Pages 10920-10929: Aircraft Aerodynamic Parameter Detection Using Micro Hot-Film Flow Sensor Array and BP Neural Network Identification
- Sensors, Vol. 12, Pages 10906-10919: Novel Fiber Optic Sensor Probe with a Pair of Highly Reflected Connectors and a Vessel of Water Absorption Material for Water Leak Detection
- Sensors, Vol. 12, Pages 10890-10905: Determination of Soil Pore Water Salinity Using an FDR Sensor Working at Various Frequencies up to 500 MHz
- Microarrays, Vol. 1, Pages 84-94: Quality Visualization of Microarray Datasets Using Circos
- Viruses, Vol. 4, Pages 1212-1234: Persistence versus Reversion of 3TC Resistance in HIV-1 Determine the Rate of Emergence of NVP Resistance
- Viruses, Vol. 4, Pages 1202-1211: Evaluation of the Operator Protection Factors Offered by Positive Pressure Air Suits against Airborne Microbiological Challenge
- Molecules, Vol. 17, Pages 9451-9461: Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives
- Molecules, Vol. 17, Pages 9443-9450: Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.
- A Las Vegas Vacation
- Molecules, Vol. 17, Pages 9426-9442: Antifungal Activity of Salicylanilides and Their Esters with 4-(Trifluoromethyl)benzoic Acid
- Information, Vol. 3, Pages 290-306: Review and Précis of Terrence Deacon’s Incomplete Nature: How Mind Emerged from Matter
- Cancers, Vol. 4, Pages 799-807: Endometrial Serous Carcinoma: Its Molecular Characteristics and Histology-Specific Treatment Strategies
- Bird Blast
- BlazBlue: Chrono Phantasma out in Japan arcades this winter
- DOTA 2 Diaries - Part 4: Humans Vs. Unfairness
- Battlefield 3 skipping Wii U - Report
- DayZ Diaries: Can GameSpot survive the zombpocaylpse?
- Command Center - PlanetSide 2 Episode 2
| All you need to write. Truly write. 1.0.2 - Clean and clutter-free text production.. (Demo) Posted: 07 Aug 2012 02:22 AM PDT  All you need to write. Truly write. Simple. Uncluttered. Sophisticated. Dropbox enabled. Retina-aware. "Less is more", as minimalist architect Mies van der Rohe says. Not only is this aphorism true in architecture, it's true in writing as well. No mess, no fuss. With All you need to write. Truly write., you don't need to worry about the glitz and glamour of eye-candy filling your screen, meaning less clutter, less distractions, and less troubles; Free's integrated automated environment helps you focus almost automatically on writing. Free helps you get more meaning out of your words with less distraction. No man is an island. Not even the best poet. Since we write to be widely read and understood, Our program's multi-format file support makes it easy to exchange files with the outside world. It inherently has read/write support to common and prevalent file formats like Word. Unlike most word processors, All you need to write. Truly write. stands apart from the rest with its user-friendly interface. Without the burdens of superfluous features common in other softwares, it truly turns your Mac into a supercharged typewriter. Because in the end - it is all about the words. Your words. Nothing else.
In addition, it has some nifty features and tools that will make it your tool of choice when it comes to writing - distraction free writing - in no time:
File Formats that can be read/imported and exported:
Version 1.0.2:
OS X 10.7.4 or later. Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 07 Aug 2012 12:00 AM PDT This paper investigates the issue of interference avoidance in body area networks (BANs). IEEE 802.15 Task Group 6 presented several schemes to reduce such interference, but these schemes are still not proper solutions for BANs. We present a novel distributed TDMA-based beacon interval shifting scheme that reduces interference in the BANs. A design goal of the scheme is to avoid the wakeup period of each BAN coinciding with other networks by employing carrier sensing before a beacon transmission. We analyze the beacon interval shifting scheme and investigate the proper back-off length when the channel is busy. We compare the performance of the proposed scheme with the schemes presented in IEEE 802.15 Task Group 6 using an OMNeT++ simulation. The simulation results show that the proposed scheme has a lower packet loss, energy consumption, and delivery-latency than the schemes of IEEE 802.15 Task Group 6. |
| Posted: 07 Aug 2012 12:00 AM PDT Air speed, angle of sideslip and angle of attack are fundamental aerodynamic parameters for controlling most aircraft. For small aircraft for which conventional detecting devices are too bulky and heavy to be utilized, a novel and practical methodology by which the aerodynamic parameters are inferred using a micro hot-film flow sensor array mounted on the surface of the wing is proposed. A back-propagation neural network is used to model the coupling relationship between readings of the sensor array and aerodynamic parameters. Two different sensor arrangements are tested in wind tunnel experiments and dependence of the system performance on the sensor arrangement is analyzed. |
| Posted: 07 Aug 2012 12:00 AM PDT The use of a fiber optic quasi-distributed sensing technique for detecting the location and severity of water leakage is suggested. A novel fiber optic sensor probe is devised with a vessel of water absorption material called as water combination soil (WCS) located between two highly reflected connectors: one is a reference connector and the other is a sensing connector. In this study, the sensing output is calculated from the reflected light signals of the two connectors. The first reflected light signal is a reference and the second is a sensing signal which is attenuated by the optical fiber bending loss due to the WCS expansion absorbing water. Also, the bending loss of each sensor probe is determined by referring to the total number of sensor probes and the total power budget of an entire system. We have investigated several probe characteristics to show the design feasibility of the novel fiber sensor probe. The effects of vessel sizes of the probes on the water detection sensitivity are studied. The largest vessel probe provides the highest sensitivity of 0.267 dB/mL, while the smallest shows relatively low sensitivity of 0.067 dB/mL, and unstable response. The sensor probe with a high output value provides a high sensitivity with various detection levels while the number of total installable sensor probes decreases. |
| Posted: 07 Aug 2012 12:00 AM PDT This paper presents the application of a frequency-domain reflectometry (FDR) sensor designed for soil salinity assessment of sandy mineral soils in a wide range of soil moisture and bulk electrical conductivity, through the determination of soil complex dielectric permittivity spectra in the frequency range 10–500 MHz. The real part of dielectric permittivity was assessed from the 380–440 MHz, while the bulk electrical conductivity was calculated from the 165–325 MHz range. The FDR technique allows determination of bulk electrical conductivity from the imaginary part of the complex dielectric permittivity, without disregarding the dielectric losses. The soil salinity status was determined using the salinity index, defined as a partial derivative of the soil bulk electrical conductivity with respect to the real part of the soil complex dielectric permittivity. The salinity index method enables determining the soil water electrical conductivity value. For the five sandy mineral soils that have been tested, the relationship between bulk electrical conductivity and the real part of dielectric permittivity is essentially linear. As a result, the salinity index method applied for FDR measurements may be adapted to field use after examination of loam and clayey soils. |
| Microarrays, Vol. 1, Pages 84-94: Quality Visualization of Microarray Datasets Using Circos Posted: 07 Aug 2012 12:00 AM PDT Quality control and normalization is considered the most important step in the analysis of microarray data. At present there are various methods available for quality assessments of microarray datasets. However there seems to be no standard visualization routine, which also depicts individual microarray quality. Here we present a convenient method for visualizing the results of standard quality control tests using Circos plots. In these plots various quality measurements are drawn in a circular fashion, thus allowing for visualization of the quality and all outliers of each distinct array within a microarray dataset. The proposed method is intended for use with the Affymetrix Human Genome platform (i.e., GPL 96, GPL570 and GPL571). Circos quality measurement plots are a convenient way for the initial quality estimate of Affymetrix datasets that are stored in publicly available databases. |
| Posted: 07 Aug 2012 12:00 AM PDT When HIV-1 is exposed to lamivudine (3TC) at inhibitory concentrations, resistant variants carrying the reverse transcriptase (RT) substitution M184V emerge rapidly. This substitution confers high-level 3TC resistance and increased RT fidelity. We established a novel in vitro system to study the effect of starting nevirapine (NVP) in 3TC-resistant/NNRTI-naïve clinical isolates, and the impact of maintaining versus dropping 3TC pressure in this setting. Because M184V mutant HIV-1 seems hypersusceptible to adefovir (ADV), we also tested the effect of ADV pressure on the same isolates. We draw four conclusions from our experiments simulating combination therapy in vitro. (1) The presence of low-dose (1 μM) 3TC prevented reversal to wild-type from an M184V mutant background. (2) Adding low-dose 3TC in the presence of NVP delayed the selection of NVP-associated mutations. (3) The presence of ADV, in addition to NVP, led to more rapid reversal to wild-type at position 184 than NVP alone. (4) ADV plus NVP selected for greater numbers of mutations than NVP alone. Inference about the "selection of mutation" is based on two statistical models, one at the viral level, more telling, and the other at the level of predominance of mutation within a population. Multidrug pressure experiments lend understanding to mechanisms of HIV resistance as they bear upon new treatment strategies. |
| Posted: 07 Aug 2012 12:00 AM PDT Laboratories throughout the world that perform work with Risk Group 4 Pathogens generally adopt one of two approaches within BSL-4 environments: either the use of positive pressure air-fed suits or using Class III microbiological safety cabinets and isolators for animal work. Within the UK at present, all laboratories working with Risk Group 4 agents adopt the use of Class III microbiological safety cabinet lines and isolators. Operator protection factors for the use of microbiological safety cabinets and isolators are available however; there is limited published data on the operator protection factors afforded by the use of positive pressure suits. This study evaluated the operator protection factors provided by positive pressure air suits against a realistic airborne microbiological challenge. The suits were tested, both intact and with their integrity compromised, on an animated mannequin within a stainless steel exposure chamber. The suits gave operator protection in all tests with an intact suit and with a cut in the leg. When compromised by a cut in the glove, a very small ingress of the challenge was seen as far as the wrist. This is likely to be due to the low airflow in the gloves of the suit. In all cases no microbiological penetration of the respiratory tract was observed. These data provide evidence on which to base safety protocols for use of positive pressure suits within high containment laboratories. |
| Posted: 07 Aug 2012 12:00 AM PDT Malaria and leishmaniasis are two of the World's most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against Plasmodium, but two of them showed good activity against Leishmania. Toxicity on VERO was correlated with leishmanicidal properties. |
| Posted: 07 Aug 2012 12:00 AM PDT A new clerodane-type diterpenoid, echinoclerodane A (1), was isolated from a Formosan gorgonian coral Echinomuricea sp. The structure of 1 was elucidated by spectroscopic methods. Echinoclerodane A (1) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cnidaria. Echinoclerodane A (1) exhibited moderate cytotoxicity toward MOLT-4, HL-60, DLD-1 and LoVo tumor cells and inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. |
| Posted: 07 Aug 2012 01:22 AM PDT With bellies full of pancakes and fire in our eyes, we marched out onto the casino floor ready for war. This posting includes an audio/video/photo media file: Download Now |
| Posted: 07 Aug 2012 12:00 AM PDT Searching for novel antimicrobial agents still represents a current topic in medicinal chemistry. In this study, the synthesis and analytical data of eighteen salicylanilide esters with 4-(trifluoromethyl)benzoic acid are presented. They were assayed in vitro as potential antimycotic agents against eight fungal strains, along with their parent salicylanilides. The antifungal activity of the presented derivatives was not uniform and moulds showed a higher susceptibility with minimum inhibitory concentrations (MIC) ³ 0.49 µmol/L than yeasts (MIC ³ 1.95 µmol/L). However, it was not possible to evaluate a range of 4-(trifluoromethyl)benzoates due to their low solubility. In general, the most active salicylanilide was N-(4-bromophenyl)-4-chloro-2-hydroxybenzamide and among esters, the corresponding 2-(4-bromophenylcarbamoyl)-5-chlorophenyl 4-(trifluoromethyl) benzoate exhibited the lowest MIC of 0.49 µmol/L. However, the esterification of salicylanilides by 4-(trifluoromethyl)benzoic acid did not result unequivocally in a higher antifungal potency. |
| Posted: 07 Aug 2012 12:00 AM PDT We review and summarize Terrence Deacon's book, Incomplete Nature: How Mind Emerged from Matter. |
| Posted: 07 Aug 2012 12:00 AM PDT Endometrial cancer is the fourth most common malignancy in women, with most cases being classified as early stage endometrioid tumors that carry a favorable prognosis. The endometrial serous histological subtype (ESC), however, while only accounting for 10% of all endometrial cancers is responsible for a disproportionate number of deaths. Unlike the estrogen-dependent, well differentiated endometrioid tumors, which are commonly associated with a younger age of onset, ESCs are estrogen-independent and tend to present at an advanced stage and in older women. Treatment for ESC entails aggressive surgery and multimodal adjuvant therapy. In this review, we describe the clinical behavior, molecular aspects, and treatment strategies for ESC. |
| Posted: 07 Aug 2012 12:36 AM PDT  You have 1 goal in this game, blasting all ducks! Upgrade your weapons and create awesome combos to win. |
| BlazBlue: Chrono Phantasma out in Japan arcades this winter Posted: 06 Aug 2012 11:54 PM PDT New sequel to BlazBlue series introduces three new fighters and overdrive system, location tests in session until August 12. Arc System Works announced a new sequel to the BlazBlue series during last week's Super Battle Opera Tougeki 2012 tournament held in Japan. Titled BlazBlue: Chrono Phantasma, the latest addition to the 2D fighting game series will feature three new characters: the muscular pugilist Azrael, the effeminate male Amane Nishiki who attacks with his plumage, and the female mercenary Bullet whose fighting style is similar to BlazBlue's Makoto. Existing fighters in the series will have new animation sprites and new moves to their repertoire. In addition, the game will feature a new overdrive system. Any character who activates overdrive mode in the middle of battle will gain specific battle properties that last for a set amount of time. Examples include Noel's overdrive which increases the speed of her drive attacks and Arakune's overdrive which lengthens the duration of his curses. Players can also perform a guard crush attack by expending a quarter of their drive gauge; the move will instantly break through an opponent's block. The sequel will be out in Japan arcades this winter, with location tests happening right now until August 12 across the country. No console versions have been announced at this point in time. For more information on the previous BlazBlue installment, check out GameSpot's coverage of BlazBlue: Continuum Shift. Read and Post Comments | Get the full article at GameSpot "BlazBlue: Chrono Phantasma out in Japan arcades this winter" was posted by Jonathan Toyad on Mon, 06 Aug 2012 23:54:40 -0700 |
| DOTA 2 Diaries - Part 4: Humans Vs. Unfairness Posted: 06 Aug 2012 11:53 PM PDT In an effort to teach by showing, Zorine plays a match against unfair bots while answering a wealth of community questions without fully realising what she's getting herself into. Follow us on Twitter and Twitch @GameSpot_AU!
Read and Post Comments | Get the full article at GameSpot "DOTA 2 Diaries - Part 4: Humans Vs. Unfairness" was posted by edmondt on Mon, 06 Aug 2012 23:53:27 -0700 |
| Battlefield 3 skipping Wii U - Report Posted: 06 Aug 2012 11:25 PM PDT DICE reportedly shelved Wii U Battlefield 3 over Origin dispute with Nintendo; it's now reportedly working on a "straight port" of Battlefield 4 for the Wii U.
Despite DICE's encouraging comments last year on the potential of the Wii U, the Battlefield developer has reportedly stopped work on a version of Battlefield 3 for Nintendo's console.
According to Wii U Daily, which cites an anonymous source, EA and DICE began work on a Wii U version of Battlefield 3, but stopped late last year, due to a "feud" with Nintendo over Origin's integration on the Wii U. The site reported that the development team from the shelved project was merged into the team working on Battlefield 4, which is reportedly working on a "straight port" of the game for the Wii U, featuring touchscreen controls. The site's source also reportedly told Wii U Daily that it remains unknown whether DICE is working on next-gen versions of Battlefield 4. Last month, EA confirmed that it is working on Battlefield 4, and that a beta for the game will take place in late 2013. Gamers can secure a spot in the beta by pre-ordering Medal of Honor: Warfighter, which is set to debut in October. GameSpot contacted EA for comment. The publisher replied: "This is an old rumour. Battlefield 3 is available for Xbox 360, PS3 and PC. The exclusive Battlefield 4 beta will be available in [...] 2013. Additional details regarding Battlefield 4 will be revealed at a later date." Read and Post Comments | Get the full article at GameSpot "Battlefield 3 skipping Wii U - Report" was posted by Laura Parker on Mon, 06 Aug 2012 23:25:50 -0700 |
| DayZ Diaries: Can GameSpot survive the zombpocaylpse? Posted: 06 Aug 2012 11:15 PM PDT We jump into the popular ArmA II mod and learn how to play, aided by the GameSpot community. Will we survive the waves of undead, or will other players be our undoing?
Get the full article at GameSpot "DayZ Diaries: Can GameSpot survive the zombpocaylpse?" was posted by Staff on Mon, 06 Aug 2012 23:15:31 -0700 |
| Command Center - PlanetSide 2 Episode 2 Posted: 06 Aug 2012 09:18 PM PDT Creative Director Matt Higby and Senior Art Director Tramell Isaac keep you up to date with the latest PlanetSide 2 news in another Command Center episode.
Read and Post Comments | Get the full article at GameSpot "Command Center - PlanetSide 2 Episode 2" was posted by DanM on Mon, 06 Aug 2012 21:18:18 -0700 |
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