Games |
- War of the Human Tanks - Screenshots
- Wonderbook: Diggs Nightcrawler - Screenshots
- Towers of Babble - Screenshots
- Brain Sciences, Vol. 2, Pages 319-331: Neurochemical Analysis of Primary Motor Cortex in Chronic Low Back Pain
- Crystals, Vol. 2, Pages 1210-1221: Electronic Structure of Cu(tmdt)2 Studied with First-Principles Calculations
- Nutrients, Vol. 4, Pages 1095-1119: Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease
- IJMS, Vol. 13, Pages 10478-10504: The Role of Free Radicals in the Aging Brain and Parkinson’s Disease: Convergence and Parallelism
- Molecules, Vol. 17, Pages 9990-9999: Release of Terpenes from Fir Wood during Its Long-Term Use and in Thermal Treatment
- IJMS, Vol. 13, Pages 10461-10477: Transforming Growth Factor-Beta-Induced Protein (TGFBI)/(βig-H3): A Matrix Protein with Dual Functions in Ovarian Cancer
- Wiinote 0.4.0 - Control Keynote and other applications with a Wii Remote.. (Shareware)
- PopClip 1.4.3 - Cut, copy and paste at your fingertips.. (Demo)
- Above & Below - Screenshots
- BICYCLE: 2m long, detailed, grotesque bike-ride through London
- Overlook Fing 2.1 - Command line tool for network and service discovery. . (Free)
- A Better Finder Rename 9.13 - File, photo, and MP3 batch renamer.. (Shareware)
- QMidi Pro 2.1.2 - MIDI and Karaoke player for the Mac.. (Shareware)
- QMidi Standard 2.1.2 - MIDI and Karaoke player for the Mac.. (Shareware)
- Polymers, Vol. 4, Pages 1517-1534: Polysaccharide-Based Hydrogels: The Key Role of Water in Affecting Mechanical Properties
- IJMS, Vol. 13, Pages 10441-10460: Species Differentiation of Chinese Mollitrichosiphum (Aphididae: Greenideinae) Driven by Geographical Isolation and Host Plant Acquirement
- Entropy, Vol. 14, Pages 1539-1552: Optimization of Two-Stage Peltier Modules: Structure and Exergetic Efficiency
| War of the Human Tanks - Screenshots Posted: 21 Aug 2012 04:31 AM PDT Features of the full game will include: - Fast-paced strategic battles in over 30 maps - Use resources earned from battles to develop new tanks - Customize your tanks with various modules to deadly effect - Multiple endings based on your performance - Replay the story keeping your previously earned units and resources - Free battle mode to practice and gather extra supplies - English localization features two all-new bonus maps, hand-drawn battle backgrounds and an improved user interface |
| Wonderbook: Diggs Nightcrawler - Screenshots Posted: 21 Aug 2012 04:23 AM PDT Diggs Nightcrawler is a bookworm private detective in Library City thrown into a world of crime and deception from the moment that YOU turn the page to his office. Watch as Diggs is framed for the murder of his best friend and boss Humpty Dumpty, then join him in his quest to clear his name and discover the villain behind the crime. Explore the shelves of Library City and meet characters from fiction to see what they know. And when Diggs gets in trouble, it's "over to you, Kid". Do you have what it takes to help Diggs get to the bottom of the mystery? Key Features · Original Story by Academy Awarding Winning Moonbot Studio Original plot and characters from the young and talented Moonbot studio, full of surprise, delight and wonder. Meet classic characters like you've never seen them before. · Unique Relationship Between Diggs and Player The player is integral to the story – the case, too big for Diggs to solve alone. Using the unique Wonderbook interactions, the player works in partnership with Diggs, manipulating the world to help him unravel the mystery. · Film Noir Inspired The art style, characters, narrative and gameplay are all inspired by classic film noir. |
| Towers of Babble - Screenshots Posted: 21 Aug 2012 04:15 AM PDT Played on a smaller 9x9 board, Towers of Babble allows players to play "traditional" horizontal and vertical moves as well as 3D STACKED moves! Swipe your finger across the screen to ROTATE the board in 3D, allowing you to plot your next move! The higher you stack, the more points you get. Get rewarded for using your intelligence and playing good words - not just for getting a "Triple Word" score! Features include: - TOTALLY FREE! - Play against the computer when you want to keep the game moving! Try to beat the computer in IMPOSSIBLE MODE! - Challenge Friends from your contact list, Facebook, via username, or get matched with a random opponent! - Over 60 Game Center Achievements and Leaderboards! - Purchasable Best Word Tokens allow you to play the best word on the board, giving you an edge over your opponent! |
| Posted: 21 Aug 2012 12:00 AM PDT The involvement of the primary motor cortex (M1) in chronic low back pain (LBP) is a relatively new concept. Decreased M1 excitability and an analgesic effect after M1 stimulation have been recently reported. However, the neurochemical changes underlying these functional M1 changes are unknown. The current study investigated whether neurochemicals specific to neurons and glial cells in both right and left M1 are altered. N-Acetylaspartate (NAA) and myo-inositol (mI) were measured with proton magnetic resonance spectroscopy in 19 subjects with chronic LBP and 14 healthy controls. We also examined correlations among neurochemicals within and between M1 and relationships between neurochemical concentrations and clinical features of pain. Right M1 NAA was lower in subjects with LBP compared to controls (p = 0.008). Left M1 NAA and mI were not significantly different between LBP and control groups. Correlations between neurochemical concentrations across M1s were different between groups (p = 0.008). There were no significant correlations between M1 neurochemicals and pain characteristics. These findings provide preliminary evidence of neuronal depression and altered neuronal-glial interactions across M1 in chronic LBP. |
| Posted: 21 Aug 2012 12:00 AM PDT We have studied the electronic structure of Cu(tmdt)2, a material related to single-component molecular conductors, by first-principles calculations. The total energy calculations for several different magnetic configurations show that there is strong antiferromagnetic (AFM) exchange coupling along the crystal a-axis. The electronic structures are analyzed in terms of the molecular orbitals near the Fermi level of isolated Cu(tmdt)2 molecule. This analysis reveals that the system is characterized by the half-filled pd σ(−) band whose intermolecular hopping integrals have strong one-dimensionality along the crystal a-axis. As the exchange splitting of the band is larger than the band width, the basic mechanism of the AFM exchange coupling is the superexchange. It will also be shown that two more ligand orbitals which are fairly insensitive to magnetism are located near the Fermi level. Because of the presence of these orbitals, the present calculation predicts that Cu(tmdt)2 is metallic even in its AFM state, being inconsistent with the available experiment. Some comments will be made on the difference between Cu(tmdt)2 and Cu(dmdt)2. |
| Posted: 21 Aug 2012 12:00 AM PDT The gastrointestinal (GI) microbiota is the collection of microbes which reside in the GI tract and represents the largest source of non-self antigens in the human body. The GI tract functions as a major immunological organ as it must maintain tolerance to commensal and dietary antigens while remaining responsive to pathogenic stimuli. If this balance is disrupted, inappropriate inflammatory processes can result, leading to host cell damage and/or autoimmunity. Evidence suggests that the composition of the intestinal microbiota can influence susceptibility to chronic disease of the intestinal tract including ulcerative colitis, Crohn's disease, celiac disease and irritable bowel syndrome, as well as more systemic diseases such as obesity, type 1 diabetes and type 2 diabetes. Interestingly, a considerable shift in diet has coincided with increased incidence of many of these inflammatory diseases. It was originally believed that the composition of the intestinal microbiota was relatively stable from early childhood; however, recent evidence suggests that diet can cause dysbiosis, an alteration in the composition of the microbiota, which could lead to aberrant immune responses. The role of the microbiota and the potential for diet-induced dysbiosis in inflammatory conditions of the GI tract and systemic diseases will be discussed. |
| Posted: 21 Aug 2012 12:00 AM PDT Free radical production and their targeted action on biomolecules have roles in aging and age-related disorders such as Parkinson's disease (PD). There is an age-associated increase in oxidative damage to the brain, and aging is considered a risk factor for PD. Dopaminergic neurons show linear fallout of 5–10% per decade with aging; however, the rate and intensity of neuronal loss in patients with PD is more marked than that of aging. Here, we enumerate the common link between aging and PD at the cellular level with special reference to oxidative damage caused by free radicals. Oxidative damage includes mitochondrial dysfunction, dopamine auto-oxidation, α-synuclein aggregation, glial cell activation, alterations in calcium signaling, and excess free iron. Moreover, neurons encounter more oxidative stress as a counteracting mechanism with advancing age does not function properly. Alterations in transcriptional activity of various pathways, including nuclear factor erythroid 2-related factor 2, glycogen synthase kinase 3β, mitogen activated protein kinase, nuclear factor kappa B, and reduced activity of superoxide dismutase, catalase and glutathione with aging might be correlated with the increased incidence of PD. |
| Posted: 21 Aug 2012 12:00 AM PDT Building structures made from fir wood are often attacked by wood-destroying insects for which the terpenes it contains serve as attractants. One of the possibilities for extending the lifetime of structures is to use older wood with a lower content of terpenes and/or thermally modified wood. The study evaluated the levels of terpenes in naturally aged fir wood (108, 146, 279, 287 and 390 years) and their decrease by thermal treatment (the temperature of 60 °C and 120 °C, treatment duration of 10 h). Terpenes were extracted from wood samples by hexane and analyzed by gas-chromatography mass-spectrometry (GC-MS). The results indicate that recent fir wood contained approximately 60 times more terpenes than the oldest wood (186:3.1 mg/kg). The thermal wood treatment speeded up the release of terpenes. The temperature of 60 °C caused a loss in terpenes in the recent fir wood by 62%, the temperature of 120 °C even by >99%. After the treatment at the temperature of 60 °C the recent fir wood had approximately the same quantity of terpenes as non-thermally treated 108 year old wood, i.e., approximately 60–70 mg/kg. After the thermal treatment at the temperature of 120 °C the quantity of terpenes dropped in the recent as well as the old fir wood to minimum quantities (0.7–1.1 mg/kg). The thermal treatment can thus be used as a suitable method for the protection of fir wood from wood-destroying insects. |
| Posted: 21 Aug 2012 12:00 AM PDT Transforming growth factor-beta-induced protein (TGFBI, also known as βig-H3 and keratoepithelin) is an extracellular matrix protein that plays a role in a wide range of physiological and pathological conditions including diabetes, corneal dystrophy and tumorigenesis. Many reports indicate that βig-H3 functions as a tumor suppressor. Loss of βig-H3 expression has been described in several cancers including ovarian cancer and promoter hypermethylation has been identified as an important mechanism for the silencing of the TGFBI gene. Our recent findings that βig-H3 is down-regulated in ovarian cancer and that high concentrations of βig-H3 can induce ovarian cancer cell death support a tumor suppressor role. However, there is also convincing data in the literature reporting a tumor-promoting role for βig-H3. We have shown βig-H3 to be abundantly expressed by peritoneal cells and increase the metastatic potential of ovarian cancer cells by promoting cell motility, invasion, and adhesion to peritoneal cells. Our findings suggest that βig-H3 has dual functions and can act both as a tumor suppressor or tumor promoter depending on the tumor microenvironment. This article reviews the current understanding of βig-H3 function in cancer cells with particular focus on ovarian cancer. |
| Wiinote 0.4.0 - Control Keynote and other applications with a Wii Remote.. (Shareware) Posted: 21 Aug 2012 02:54 AM PDT  Wiinote lets you control Keynote (and other applications) with a Wii Remote. All you need is a Wii Remote and a Bluetooth-enabled Mac. Version 0.4.0:
Download Now This posting includes an audio/video/photo media file: Download Now |
| PopClip 1.4.3 - Cut, copy and paste at your fingertips.. (Demo) Posted: 21 Aug 2012 02:50 AM PDT  PopClip puts Cut, Copy and Paste (and more!) at your fingertips, with a popover menu which appears when you select text on your Mac. How to use:
Version 1.4.3:
Mac OS X 10.6.6 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 21 Aug 2012 04:00 AM PDT Features aƒ» World War I plane combat action game. aƒ» Multiple types of enemies with different behavior. aƒ» Leveling up system with additional weapons and boosts. aƒ» Several power-ups to change the player shooting style. aƒ» Cumulating and tap activated power-ups. aƒ» Additional skins for the players plane. aƒ» Beautiful hand made levels. aƒ» Boss levels. aƒ» Buy additional armor, weapons, and many other things to increase the fun. aƒ» Many achievements. aƒ» Super weapons with combo mechanics. |
| BICYCLE: 2m long, detailed, grotesque bike-ride through London Posted: 21 Aug 2012 02:41 AM PDT
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| Overlook Fing 2.1 - Command line tool for network and service discovery. . (Free) Posted: 21 Aug 2012 02:41 AM PDT  Overlook Fing... Born from the ashes of Look@LAN, Fing is the ultimate command line tool for network and service discovery. Taking advantage of a brand new cross-platform network engine, it reaches an impressive discovery sharpness and speed: you're going to discover your whole network in few seconds and generate customized real-time reports. The network discovery provides you a complete view of any network in a very short time: fing smart discovery automatically detects the network type and uses the best technique to take the picture of it. The best results are surely achieved on ethernet networks (Wireless ones included), where fing is able to detect all network hosts, firewalled ones included, reaching 100% hit. The service discovery feature quickly detects active TCP services on a target host or network. This posting includes an audio/video/photo media file: Download Now |
| A Better Finder Rename 9.13 - File, photo, and MP3 batch renamer.. (Shareware) Posted: 21 Aug 2012 02:45 AM PDT  A Better Finder Rename is the most complete renaming solution available on the market today. That's why, since 1996, tens of thousands of hobbyists, professionals and businesses depend on A Better Finder Rename to organize and maintain files. A Better Finder Rename's user interface supports complex renaming tasks without sacrificing ease and speed of use. Simply drag the files you want to rename straight from the Finder into the large preview table or the application icon.. or use our Finder context menu and hot key. The Instant Preview feature eliminates guesswork and costly errors and helps you find the right settings quickly and accurately by providing as-you-type feedback. A Better Finder Rename offers a complete set of renaming options that are organized into 15 categories covering all the text, character, position, conversion and truncation features that you would expect from a file renamer, but it does not stop there. Photographers use the advanced sequence number and date & time features to clean up their portfolios or prepare photos for delivery to their client. A Better Finder Rename knows how to extract EXIF shooting date and time information from digital camera images and exploit them in creating sequence numbers or adding time and date information to the file name. Support for all major RAW formats (including JPEG, CRW, CR2, THM, NEF, TIFF, RAJ, ORF , MRW, DNG, PEF, SRF, etc.) extends this to professional photographers. A Better Finder Rename also deals gracefully with multiple shots captured in the same second. Version 9 adds support for extracting camera, lens, photo and color meta-data tags and using them in the new tag rename feature. You can now also re-order sequence numbers, alphabetical sequences or roman numeral series directly through dragging and dropping items in the preview list. System administrators, Web masters and other power users will appreciate the presence of advanced features, such as regular expression support, conversion to Windows NTFS/SMB compatible names, the ability to import file names from a database, a spreadsheet or any other source that can produce plain or tab-delimited text files. Last but not least, the ability to save a record of the current and new file names greatly facilitates tracking your files. Music lovers can use the built-in MP3/AAC support to exploit the id3 meta-data tags embedded in your most music files to create their own naming schemes for their music collection. Meta-data information from MP3, AAC, FLAC, OGG, APE, M4V and iTunes music store files are supported. The multi-step renaming feature allows multiple renaming steps to be combined to deal with complex renaming jobs in a single operation. Unlike other tools, A Better Finder Rename allows any number of renaming actions to be combined, re-ordered, copied and deleted.
Mac OS X 10.6 or later Download Now |
| QMidi Pro 2.1.2 - MIDI and Karaoke player for the Mac.. (Shareware) Posted: 21 Aug 2012 02:26 AM PDT  QMidi Pro is the ultimate MIDI/Karaoke player for the Mac. It can organize and play many types of media files, including MP3, movies and CD+G, and allows easy text editing/synchronization. It features real time pitch shifting, time stretching and the ability to display karaoke and movie content in full screen mode, even on a second monitor. Pro-only Features
Key Features
Version 2.1.2: Bug Fixes:
Mac OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| QMidi Standard 2.1.2 - MIDI and Karaoke player for the Mac.. (Shareware) Posted: 21 Aug 2012 02:30 AM PDT  QMidi Standard is the ultimate MIDI/Karaoke player for the Mac. It can organize and play many types of media files, including MP3, movies and CD+G, and allows easy text editing/synchronization. It features real time pitch shifting, time stretching and the ability to display karaoke and movie content in full screen mode, even on a second monitor. Key Features
Version 2.1.2: Bug Fixes:
Mac OS X 10.5 or later Download Now This posting includes an audio/video/photo media file: Download Now |
| Posted: 21 Aug 2012 12:00 AM PDT Different hydrogels were prepared starting from natural or semi-synthetic polysaccharides (carboxymethylcellulose, hyaluronic acid and chitosan) which were cross-linked by the addition of a cross-linking agent chosen according to the chemical groups present along the polymer chains. The cross-linking reaction allows for the formation of a three-dimensional network made of covalent bonds between the polymer chains, which is stable under physiological conditions. The presence of a substantial amount of water within the polysaccharide matrices makes such systems unique among hydrophilic gels. Water itself is responsible for some of their peculiar characteristics, one of which is their injectability which makes these hydrogels suitable for using as matrices for mini-invasive surgery and localized therapy. |
| Posted: 21 Aug 2012 12:00 AM PDT The impact of both the uplift of the Qinghai-Tibetan Plateau (QTP) and the separation of the Taiwan and Hainan Islands on the evolution of the fauna and flora in adjacent regions has been a topic of considerable interest. Mollitrichosiphum is a polyphagous insect group with a wide range of host plants (14 families) and distributions restricted to Southeast Asia. Based on the mitochondrial Cytochrome C Oxidase Subunit I (COI) and Cytochrome b (Cytb) genes, the nuclear elongation factor-1α (EF-1α) gene, and the detailed distribution and host plant data, we investigated the species differentiation modes of the Chinese Mollitrichosiphum species. Phylogenetic analyses supported the monophyly of Mollitrichosiphum. The divergence time of Mollitrichosiphum tenuicorpus (c. 11.0 mya (million years ago)), Mollitrichosiphum nandii and Mollitrichosiphum montanum (c. 10.6 mya) was within the time frame of the uplift of the QTP. Additionally, basal species mainly fed on Fagaceae, while species that fed on multiple plants diverged considerably later. Ancestral state reconstruction suggests that Fagaceae may be the first acquired host, and the acquisition of new hosts and the expansion of host range may have promoted species differentiation within this genus. Overall, it can be concluded that geographical isolation and the expansion of the host plant range may be the main factors driving species differentiation of Mollitrichosiphum. |
| Posted: 21 Aug 2012 12:00 AM PDT In this paper we undertake the theoretical analysis of a two-stage semiconductor thermoelectric module (TEM) which contains an arbitrary and different number of thermocouples, n1 and n2, in each stage (pyramid-styled TEM). The analysis is based on a dimensionless entropy balance set of equations. We study the effects of n1 and n2, the flowing electric currents through each stage, the applied temperatures and the thermoelectric properties of the semiconductor materials on the exergetic efficiency. Our main result implies that the electric currents flowing in each stage must necessarily be different with a ratio about 4.3 if the best thermal performance and the highest temperature difference possible between the cold and hot side of the device are pursued. This fact had not been pointed out before for pyramid-styled two stage TEM. The ratio n1/n2 should be about 8. |
Inspired by the 2012 London Olympic Games, young artist Ugo Gattoni intricately illustrates a cycle race through the streets of London. From elite athletes to cycle couriers, commuters, bankers, delivery boys, mums with kids, youths on stolen mountain bikes to fashionistas and hipsters on fixed gear bikes – pretty soon you will realize this is no ordinary road race! 
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